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Microba Research Discovery Report

Analysis: Aim 1 Longitudinal Treatment Effect

Functional profiles: MetaCyc Pathway

Quantitative visualisation of the top most abundant microbial functions identified in the analysed samples.

Scaled heatmap of most abundant features ordered by study group

Features were filtered by mean abundance. Samples were first ordered by study group and then clustered within each study group. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Heatmap of most abundant features ordered by study group

Features were filtered by mean abundance. Samples were first ordered by study group and then clustered within each study group. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Scaled heatmap of all features

Profiles were clustered by hierarchical clustering. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

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Heatmap of all features

Profiles were clustered by hierarchical clustering. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Scaled heatmap of top most abundant features filtered by mean abundance

Profiles were clustered by hierarchical clustering. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Heatmap of top most abundant features filtered by mean abundance

Profiles were clustered by hierarchical clustering. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Scaled heatmap of top most abundant features filtered by max abundance

Profiles were clustered by hierarchical clustering. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Heatmap of top most abundant features filtered by max abundance

Profiles were clustered by hierarchical clustering. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Scaled heatmap of top most variable features

Profiles were clustered by hierarchical clustering. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

MetaCyc Pathway

Functional Alpha Diversity

This page provides an overview of the functional alpha diversity of the analysed sample. Alpha diversity was measured using the Shannon index and functional richnes. Richness measures the total number of gene functions present in each sample. Shannon index combines richness and evenness.

Methods:

Shannon diversity was compared using linear mixed effect regression, including Participant as a random effect (intercept), and Treatment as a fixed effect. Effect tested: Treatment. Richness was compared using linear mixed effect regression, including Participant as a random effect (intercept), and Treatment as a fixed effect. Effect tested: Treatment. Data was rarefied to 16649 reads.

Index: Richness

Index: Shannon index

Summary Table

Index rarefiedTo P lmer condition effect Mean Pos Mean Abundance Median Abundance Mean Treatmentpost_treatment Median Treatmentpost_treatment SD Treatmentpost_treatment Mean Treatmentpre_treatment Median Treatmentpre_treatment SD Treatmentpre_treatment Fold Change Log2(Treatmentpre_treatment/Treatmentpost_treatment) Positive samples Positive Treatmentpost_treatment Positive Treatmentpre_treatment Positive_Treatmentpost_treatment_percent Positive_Treatmentpre_treatment_percent
Shannon 16649 0.57 5.3 5.3 5.3 5.3 5.3 0.15 5.3 5.3 0.13 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
Richness 16649 0.18 400 400 390 390 380 60 400 390 56 0.037 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
Download diversity values in csv format . On some platforms (including Windows) you may need to change the suffix from .txt or .html to .csv before opening the file in a spreadsheet program, like Excel.

Functional clustering and ordination

Microbial functions were analyzed using supervised and unsupervised multivariate techniques. Functional profiles were ordinated using the unsupervised methods Principal Coordinates Analysis (PCoA), Non-Metric Multidimensional Scaling (NMDS) and Principal Component Analysis (PCA). The supervised methods Adonis and Redundancy analysis (RDA) were used to assess if variance in the functional profiles was significantly associated with the study condition. A guide explaining these methods can be found here. Sparse Partial Least Square Discriminant Analysis (sPLS-DA) from the MixMc package was additionaly used to extract features associated with the condition of interest.

Unsupervised ordination

Interactive PCA (clr transformed)

Please click here to view an interactive 3D PCA.

MetaCyc Pathway

Univariate analysis of microbial functions

Differentially abundant microbial functions were identified using the univariate methods ANOVA or LMER (linear mixed effect regression) on clr transformed relative abundance data, Fisher's exact test, and Aldex2 (ANOVA-like Differential Expression). Aldex2 was run on read count data. Fisher's exact test was used to test for diffrerences in the presence and absence (detection rate) of microbial functions across study groups.

LMER is used for repeated measures data, using random effects to control for correlation between samples from the same subject. Fixed effects are included for treatment groups, time, and treatment over time, where appropriate. The LMER P values correspond to a nested model test of the significance of including the corresponding fixed effect.

ALDEx2 uses subsampling (Bayesian sampling) to estimate the underlying technical variation. For each subsample instance, center log-ratio transformed data is statistically compared across study groups and computed P values are corrected for multiple testing using the Benjamini–Hochberg procedure. The expected P value (mean P value) is reported, which are those that would likely have been observed if the same samples had been run multiple times. The expected values are reported for both the distribution of P values and for the distribution of Benjamini–Hochberg corrected values.

Function P lmer condition effect (sqrt) FDR lmer condition effect (sqrt) Pbonf lmer condition effect (sqrt) P lmer condition effect (clr) FDR lmer condition effect (clr) Pbonf lmer condition effect (clr) Mean Pos Mean Abundance Median Abundance Mean Treatmentpost_treatment Median Treatmentpost_treatment SD Treatmentpost_treatment Mean Treatmentpre_treatment Median Treatmentpre_treatment SD Treatmentpre_treatment Fold Change Log2(Treatmentpre_treatment/Treatmentpost_treatment) Positive samples Positive Treatmentpost_treatment Positive Treatmentpre_treatment Positive_Treatmentpost_treatment_percent Positive_Treatmentpre_treatment_percent
PWY-5481~pyruvate fermentation to (S)-lactate 0.37 0.97 1 0.75 0.98 1 0.013 0.013 0.014 0.012 0.014 0.0035 0.014 0.014 0.0052 0.22 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
P108-PWY~pyruvate fermentation to propanoate I 0.89 0.98 1 0.48 0.91 1 0.002 0.00075 0 0.00089 0 0.0023 0.00061 0 0.0011 -0.54 14 / 38 (37%) 6 / 19 (32%) 8 / 19 (42%) 0.316 0.421
CITRULLINE-DEG-PWY~L-citrulline degradation 0.45 0.97 1 0.32 0.91 1 0.019 0.019 0.019 0.02 0.02 0.0041 0.019 0.019 0.0032 -0.074 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5084~2-oxoglutarate decarboxylation to succinyl-CoA 0.29 0.97 1 0.47 0.91 1 0.0016 0.00017 0 0.00014 0 6e-04 0.00019 0 0.00064 0.44 4 / 38 (11%) 2 / 19 (11%) 2 / 19 (11%) 0.105 0.105
PWY-7183~pyrimidine nucleobases salvage I 0.29 0.97 1 0.65 0.96 1 0.011 0.011 0.011 0.011 0.01 0.0025 0.012 0.011 0.0035 0.13 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5026~indole-3-acetate biosynthesis V (bacteria and fungi) 0.73 0.97 1 0.83 0.99 1 0.00054 0.00031 0.00012 3e-04 0.00012 0.00037 0.00032 0.00012 0.00058 0.093 22 / 38 (58%) 10 / 19 (53%) 12 / 19 (63%) 0.526 0.632
PWY-6385~peptidoglycan biosynthesis III (mycobacteria) 0.86 0.97 1 0.69 0.96 1 0.0098 0.0098 0.008 0.0098 0.0096 0.0042 0.0098 0.0074 0.0083 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
COBALSYN-PWY~superpathway of adenosylcobalamin salvage from cobinamide I 0.65 0.97 1 0.5 0.93 1 0.0048 0.0048 0.0045 0.0049 0.0048 0.0019 0.0046 0.0044 0.0014 -0.091 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5653~NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 0.46 0.97 1 0.24 0.91 1 0.0093 0.0093 0.0094 0.0095 0.0094 0.0021 0.0091 0.0094 0.0026 -0.062 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
ARABCAT-PWY~L-arabinose degradation I 0.66 0.97 1 0.59 0.94 1 0.0041 0.0041 0.0029 0.0042 0.0032 0.0028 0.0041 0.0029 0.0045 -0.035 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
SERSYN-PWY~L-serine biosynthesis I 0.62 0.97 1 0.97 0.99 1 0.011 0.011 0.0095 0.01 0.0095 0.0033 0.011 0.0095 0.0067 0.14 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
SORBDEG-PWY~D-sorbitol degradation II 0.0018 0.33 0.96 0.042 0.91 1 0.0012 0.0012 0.00092 0.0016 0.0015 0.0011 0.00074 0.00081 0.00047 -1.1 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
PWY-5198~factor 420 biosynthesis 0.87 0.97 1 0.97 0.99 1 0.00022 2.3e-05 0 2.1e-05 0 7.3e-05 2.5e-05 0 7.6e-05 0.25 4 / 38 (11%) 2 / 19 (11%) 2 / 19 (11%) 0.105 0.105
NAD-BIOSYNTHESIS-III~NAD biosynthesis III (from nicotinamide) 0.18 0.97 1 0.25 0.91 1 0.00019 1.5e-05 0 2.4e-06 0 1.1e-05 2.7e-05 0 8.3e-05 3.5 3 / 38 (7.9%) 1 / 19 (5.3%) 2 / 19 (11%) 0.0526 0.105
PWY-6620~guanine and guanosine salvage 0.84 0.97 1 0.42 0.91 1 0.0092 0.0092 0.0095 0.0093 0.0097 0.0016 0.0092 0.0094 0.0023 -0.016 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-40~putrescine biosynthesis I 0.78 0.97 1 0.5 0.93 1 0.0058 0.0057 0.0046 0.0056 0.0045 0.0034 0.0057 0.0048 0.0038 0.026 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-7969~5-hydroxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP 0.59 0.97 1 0.39 0.91 1 0.0049 0.0049 0.0047 0.005 0.0047 0.0018 0.0047 0.0046 0.0014 -0.089 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7226~guanosine deoxyribonucleotides de novo biosynthesis I 0.53 0.97 1 0.25 0.91 1 0.0017 0.0014 0.00066 0.0014 0.00053 0.0022 0.0013 0.00067 0.0016 -0.11 31 / 38 (82%) 14 / 19 (74%) 17 / 19 (89%) 0.737 0.895
PWY-6317~D-galactose degradation I (Leloir pathway) 0.75 0.97 1 0.46 0.91 1 0.022 0.022 0.022 0.022 0.023 0.0054 0.022 0.022 0.0081 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6387~UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) 0.84 0.97 1 0.71 0.97 1 0.017 0.017 0.017 0.017 0.017 0.0032 0.017 0.017 0.0054 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6964~ammonia assimilation cycle II 0.48 0.97 1 0.28 0.91 1 0.044 0.044 0.045 0.045 0.045 0.0074 0.043 0.045 0.012 -0.066 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6619~adenine and adenosine salvage VI 0.52 0.97 1 0.36 0.91 1 0.00029 0.00011 0 1e-04 0 0.00021 0.00011 0 0.00016 0.14 14 / 38 (37%) 7 / 19 (37%) 7 / 19 (37%) 0.368 0.368
PWY-7663~gondoate biosynthesis (anaerobic) 0.09 0.97 1 0.18 0.91 1 0.0049 0.0049 0.0035 0.0053 0.0042 0.0043 0.0044 0.003 0.0046 -0.27 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6828~linezolid resistance 0.58 0.97 1 0.64 0.96 1 0.00024 1e-04 0 8.8e-05 0 0.00017 0.00012 0 0.00024 0.45 16 / 38 (42%) 7 / 19 (37%) 9 / 19 (47%) 0.368 0.474
PWY0-1296~purine ribonucleosides degradation 0.52 0.97 1 0.8 0.99 1 0.01 0.01 0.01 0.0099 0.01 0.003 0.01 0.0098 0.0031 0.014 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6578~8-amino-7-oxononanoate biosynthesis III 0.21 0.97 1 0.21 0.91 1 0.00032 0.00016 1.4e-05 0.00013 0 0.00021 2e-04 0.00016 0.00023 0.62 19 / 38 (50%) 8 / 19 (42%) 11 / 19 (58%) 0.421 0.579
PWY0-1182~trehalose degradation II (cytosolic) 0.86 0.97 1 0.79 0.99 1 0.002 0.0013 0.00056 0.0015 5e-04 0.0026 0.0011 6e-04 0.0013 -0.45 25 / 38 (66%) 12 / 19 (63%) 13 / 19 (68%) 0.632 0.684
ASPARAGINE-DEG1-PWY-1~L-asparagine degradation III (mammalian) 0.92 0.98 1 0.9 0.99 1 0.00038 0.00021 7.7e-05 2e-04 7.7e-05 0.00027 0.00022 7.6e-05 0.00036 0.14 21 / 38 (55%) 11 / 19 (58%) 10 / 19 (53%) 0.579 0.526
PWY-6282~palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) 0.089 0.97 1 0.18 0.91 1 0.0048 0.0048 0.0035 0.0053 0.0042 0.0043 0.0044 0.003 0.0046 -0.27 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-46~putrescine biosynthesis III 0.84 0.97 1 0.85 0.99 1 0.0014 0.0012 0.00075 0.0013 0.00062 0.0014 0.0011 0.00087 0.0012 -0.24 33 / 38 (87%) 16 / 19 (84%) 17 / 19 (89%) 0.842 0.895
PWY-2941~L-lysine biosynthesis II 0.76 0.97 1 0.75 0.98 1 0.0017 0.0015 0.00083 0.0016 0.00084 0.0018 0.0014 0.00081 0.0013 -0.19 33 / 38 (87%) 17 / 19 (89%) 16 / 19 (84%) 0.895 0.842
PWY-7509~cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas) 0.1 0.97 1 0.082 0.91 1 0.0029 0.0029 0.0029 0.0032 0.0033 0.0014 0.0026 0.0027 0.0012 -0.3 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6759~hydrogen production III 0.76 0.97 1 0.9 0.99 1 0.03 0.03 0.03 0.03 0.03 0.009 0.03 0.031 0.008 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLYSYN-THR-PWY~glycine biosynthesis IV 0.76 0.97 1 0.79 0.99 1 0.011 0.011 0.0098 0.011 0.0098 0.0035 0.012 0.0098 0.0055 0.13 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6839~2-aminoethylphosphonate biosynthesis 0.9 0.98 1 0.84 0.99 1 0.00042 0.00013 0 0.00013 0 0.00025 0.00013 0 0.00031 0 12 / 38 (32%) 6 / 19 (32%) 6 / 19 (32%) 0.316 0.316
PWY-7965~2-methyladeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP 0.59 0.97 1 0.39 0.91 1 0.0049 0.0049 0.0047 0.005 0.0047 0.0018 0.0047 0.0046 0.0014 -0.089 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1535~D-serine degradation 0.77 0.97 1 0.82 0.99 1 0.00018 0.00011 8.4e-05 0.00011 7.5e-05 0.00016 0.00011 8.7e-05 0.00016 0 23 / 38 (61%) 11 / 19 (58%) 12 / 19 (63%) 0.579 0.632
PWY-6543~4-aminobenzoate biosynthesis 0.55 0.97 1 0.63 0.96 1 0.0023 0.0021 0.0014 0.0022 0.0015 0.0021 0.0021 0.0012 0.0033 -0.067 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
PWY0-1546~muropeptide degradation 0.67 0.97 1 0.39 0.91 1 0.00045 9.5e-05 0 9.3e-05 0 0.00022 9.7e-05 0 0.00029 0.061 8 / 38 (21%) 5 / 19 (26%) 3 / 19 (16%) 0.263 0.158
PWY-5989~stearate biosynthesis II (bacteria and plants) 0.062 0.97 1 0.041 0.91 1 0.005 0.0044 0.0029 0.0047 0.0029 0.0043 0.004 0.0029 0.0046 -0.23 33 / 38 (87%) 16 / 19 (84%) 17 / 19 (89%) 0.842 0.895
PWY-6788~cellulose degradation II (fungi) 0.63 0.97 1 0.084 0.91 1 0.0079 0.0056 0.0039 0.0054 0.0041 0.0055 0.0059 0.0018 0.007 0.13 27 / 38 (71%) 15 / 19 (79%) 12 / 19 (63%) 0.789 0.632
PWYQT-4429~CO2 fixation into oxaloacetate (anaplerotic) 0.45 0.97 1 0.51 0.93 1 0.0035 0.0031 0.0018 0.0026 0.0019 0.0026 0.0036 0.0018 0.0062 0.47 34 / 38 (89%) 16 / 19 (84%) 18 / 19 (95%) 0.842 0.947
GALACT-GLUCUROCAT-PWY~superpathway of hexuronide and hexuronate degradation 0.67 0.97 1 0.51 0.93 1 0.0029 0.0028 0.0026 0.0031 0.0027 0.0026 0.0024 0.0025 0.0018 -0.37 36 / 38 (95%) 17 / 19 (89%) 19 / 19 (100%) 0.895 1
PWY-5122~geranyl diphosphate biosynthesis 0.81 0.97 1 0.52 0.93 1 0.0012 0.0011 0.00077 0.0011 0.00084 0.0012 0.0011 0.00076 0.00091 0 33 / 38 (87%) 16 / 19 (84%) 17 / 19 (89%) 0.842 0.895
PWY-5891~menaquinol-11 biosynthesis 0.24 0.97 1 0.48 0.91 1 0.0015 0.00073 6.1e-05 0.00093 0.00012 0.0015 0.00052 0 0.00089 -0.84 19 / 38 (50%) 10 / 19 (53%) 9 / 19 (47%) 0.526 0.474
PWY-5493~reductive monocarboxylic acid cycle 0.36 0.97 1 0.19 0.91 1 0.034 0.034 0.034 0.035 0.034 0.0081 0.032 0.034 0.0083 -0.13 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
XYLCAT-PWY~D-xylose degradation I 0.81 0.97 1 0.8 0.99 1 0.0053 0.0053 0.0039 0.005 0.004 0.0038 0.0055 0.0034 0.0067 0.14 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1295~pyrimidine ribonucleosides degradation 0.2 0.97 1 0.089 0.91 1 0.0065 0.0065 0.0062 0.0068 0.0064 0.0021 0.0062 0.006 0.0021 -0.13 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLNSYN-PWY~L-glutamine biosynthesis I 0.38 0.97 1 0.26 0.91 1 0.047 0.047 0.048 0.048 0.05 0.0066 0.046 0.046 0.011 -0.061 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7219~adenosine ribonucleotides de novo biosynthesis 0.87 0.97 1 0.71 0.97 1 0.016 0.016 0.016 0.016 0.017 0.0035 0.016 0.015 0.0042 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5382~hydrogen oxidation II (aerobic NAD) 0.42 0.97 1 0.52 0.93 1 6e-04 0.00019 0 0.00024 0 0.00057 0.00013 0 3e-04 -0.88 12 / 38 (32%) 6 / 19 (32%) 6 / 19 (32%) 0.316 0.316
PWY-5970~fatty acids biosynthesis (yeast) 0.21 0.97 1 0.081 0.91 1 0.0041 0.0035 0.0028 0.0036 0.0031 0.0032 0.0034 0.0022 0.0044 -0.082 32 / 38 (84%) 16 / 19 (84%) 16 / 19 (84%) 0.842 0.842
PWY-7971~adenosylcobinamide-GDP salvage from cobinamide I 0.51 0.97 1 0.48 0.91 1 0.0026 0.0026 0.0022 0.0027 0.0023 0.0014 0.0025 0.0021 0.0012 -0.11 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6758~hydrogen production II 0.42 0.97 1 0.52 0.93 1 6e-04 0.00019 0 0.00024 0 0.00057 0.00013 0 3e-04 -0.88 12 / 38 (32%) 6 / 19 (32%) 6 / 19 (32%) 0.316 0.316
PWY-6197~chlorinated phenols degradation 0.26 0.97 1 0.17 0.91 1 0.0014 0.0014 0.0012 0.0015 0.0012 0.001 0.0013 0.0011 0.00086 -0.21 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7909~formaldehyde oxidation VII (THF pathway) 0.33 0.97 1 0.48 0.91 1 0.00087 0.00039 0 5e-04 0 0.001 0.00027 0 0.00045 -0.89 17 / 38 (45%) 9 / 19 (47%) 8 / 19 (42%) 0.474 0.421
PWY-4861~UDP-α-D-galacturonate biosynthesis I (from UDP-D-glucuronate) 0.18 0.97 1 0.23 0.91 1 0.00015 1.6e-05 0 1.8e-05 0 5.7e-05 1.4e-05 0 4.6e-05 -0.36 4 / 38 (11%) 2 / 19 (11%) 2 / 19 (11%) 0.105 0.105
PWY-7195~pyrimidine ribonucleosides salvage III 0.92 0.98 1 0.93 0.99 1 0.0021 0.0014 0.00079 0.0012 0.00076 0.0013 0.0017 0.00081 0.0026 0.5 26 / 38 (68%) 12 / 19 (63%) 14 / 19 (74%) 0.632 0.737
OANTIGEN-PWY~O-antigen building blocks biosynthesis (E. coli) 0.5 0.97 1 0.87 0.99 1 0.0036 0.0035 0.0031 0.0036 0.0032 0.0024 0.0034 0.0027 0.0028 -0.082 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-5154~L-arginine biosynthesis III (via N-acetyl-L-citrulline) 0.04 0.97 1 0.0078 0.62 1 0.0014 0.00088 0.00043 0.00083 0 0.0017 0.00093 0.00085 0.00081 0.16 24 / 38 (63%) 9 / 19 (47%) 15 / 19 (79%) 0.474 0.789
PWY-6122~5-aminoimidazole ribonucleotide biosynthesis II 0.82 0.97 1 0.44 0.91 1 0.021 0.021 0.02 0.021 0.021 0.0046 0.021 0.02 0.0083 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLUTSYN-PWY~L-glutamate biosynthesis I 0.8 0.97 1 0.48 0.91 1 0.091 0.091 0.093 0.091 0.092 0.014 0.09 0.094 0.021 -0.016 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-2301~myo-inositol biosynthesis 0.32 0.97 1 0.27 0.91 1 0.002 0.0018 0.001 0.0014 0.0011 0.0017 0.0022 0.00097 0.004 0.65 34 / 38 (89%) 17 / 19 (89%) 17 / 19 (89%) 0.895 0.895
PWY-6898~thiamine salvage III 0.33 0.97 1 0.2 0.91 1 0.0079 0.0079 0.0076 0.008 0.0077 0.002 0.0077 0.0073 0.0031 -0.055 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1241~ADP-L-glycero-β-D-manno-heptose biosynthesis 0.31 0.97 1 0.47 0.91 1 0.00067 0.00023 0 0.00016 0 0.00036 3e-04 0 0.00058 0.91 13 / 38 (34%) 6 / 19 (32%) 7 / 19 (37%) 0.316 0.368
PWY-7964~adeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP 0.59 0.97 1 0.39 0.91 1 0.0049 0.0049 0.0047 0.005 0.0047 0.0018 0.0047 0.0046 0.0014 -0.089 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
NONMEVIPP-PWY~methylerythritol phosphate pathway I 0.92 0.98 1 0.65 0.96 1 0.014 0.014 0.014 0.014 0.014 0.0034 0.014 0.013 0.0046 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
OXIDATIVEPENT-PWY~pentose phosphate pathway (oxidative branch) I 0.7 0.97 1 0.56 0.93 1 0.0033 0.0029 0.0017 0.0029 0.0024 0.0027 0.003 0.0016 0.0051 0.049 34 / 38 (89%) 16 / 19 (84%) 18 / 19 (95%) 0.842 0.947
PWY-5384~sucrose degradation IV (sucrose phosphorylase) 0.9 0.98 1 0.68 0.96 1 0.0063 0.0061 0.0058 0.0058 0.0072 0.0036 0.0064 0.0057 0.0066 0.14 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY0-1586~peptidoglycan maturation (meso-diaminopimelate containing) 0.095 0.97 1 0.051 0.91 1 0.0033 0.0026 0.0014 0.0028 0.0016 0.0029 0.0024 0.00082 0.0034 -0.22 30 / 38 (79%) 17 / 19 (89%) 13 / 19 (68%) 0.895 0.684
PWY-5785~di-transpoly-cis-undecaprenyl phosphate biosynthesis 0.74 0.97 1 0.63 0.96 1 0.0017 0.0017 0.001 0.0015 0.0012 0.0014 0.0019 0.00097 0.0032 0.34 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
TRESYN-PWY~trehalose biosynthesis I 0.51 0.97 1 0.91 0.99 1 0.00097 0.00049 1.6e-05 0.00064 0 0.0016 0.00034 3.1e-05 0.00067 -0.91 19 / 38 (50%) 9 / 19 (47%) 10 / 19 (53%) 0.474 0.526
PWY0-881~superpathway of fatty acid biosynthesis I (E. coli) 0.91 0.98 1 0.96 0.99 1 0.0026 0.0015 0.00025 0.0015 0.00021 0.0026 0.0015 0.00029 0.0032 0 21 / 38 (55%) 10 / 19 (53%) 11 / 19 (58%) 0.526 0.579
PWY-6587~pyruvate fermentation to ethanol III 0.19 0.97 1 0.55 0.93 1 0.0016 0.0011 0.00076 9e-04 0.00049 0.0011 0.0013 0.001 0.0015 0.53 26 / 38 (68%) 13 / 19 (68%) 13 / 19 (68%) 0.684 0.684
PWY-2622~trehalose biosynthesis IV 0.059 0.97 1 0.1 0.91 1 0.0038 0.0038 0.0031 0.0035 0.0031 0.0019 0.004 0.0029 0.0022 0.19 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
COA-PWY-1~superpathway of coenzyme A biosynthesis III (mammals) 0.7 0.97 1 0.45 0.91 1 0.0083 0.0083 0.0072 0.0084 0.0082 0.0029 0.0082 0.0071 0.0043 -0.035 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
MET-SAM-PWY~superpathway of S-adenosyl-L-methionine biosynthesis 0.82 0.97 1 0.92 0.99 1 0.00087 0.00037 0 0.00035 0 0.00073 0.00038 0 0.00071 0.12 16 / 38 (42%) 8 / 19 (42%) 8 / 19 (42%) 0.421 0.421
PWY-6124~inosine-5-phosphate biosynthesis II 0.85 0.97 1 0.59 0.94 1 0.012 0.012 0.01 0.012 0.012 0.0035 0.012 0.01 0.0048 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1325~superpathway of L-asparagine biosynthesis 0.84 0.97 1 0.77 0.99 1 0.01 0.01 0.01 0.01 0.01 0.0027 0.01 0.011 0.0028 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
P21-PWY~pentose phosphate pathway (partial) 0.63 0.97 1 0.36 0.91 1 0.021 0.021 0.021 0.021 0.021 0.0057 0.021 0.018 0.0062 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
FASYN-ELONG-PWY~fatty acid elongation -- saturated 0.39 0.97 1 0.18 0.91 1 0.0059 0.0059 0.0044 0.0059 0.0049 0.0046 0.006 0.0041 0.008 0.024 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6608~guanosine nucleotides degradation III 0.19 0.97 1 0.096 0.91 1 0.0039 0.0039 0.0039 0.0037 0.0039 0.0024 0.0041 0.0039 0.0015 0.15 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLUTSYNIII-PWY~L-glutamate biosynthesis III 0.63 0.97 1 0.91 0.99 1 0.002 0.0013 0.00033 0.0016 3e-04 0.0032 0.001 0.00038 0.0016 -0.68 25 / 38 (66%) 12 / 19 (63%) 13 / 19 (68%) 0.632 0.684
PWY-7211~superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis 0.69 0.97 1 0.78 0.99 1 0.0014 0.00085 0.00023 0.00094 0.00012 0.0016 0.00076 3e-04 0.0012 -0.31 23 / 38 (61%) 12 / 19 (63%) 11 / 19 (58%) 0.632 0.579
PWY0-1319~CDP-diacylglycerol biosynthesis II 0.91 0.98 1 0.54 0.93 1 0.00093 0.00083 0.00068 0.00084 0.00071 0.00069 0.00082 0.00055 0.00073 -0.035 34 / 38 (89%) 16 / 19 (84%) 18 / 19 (95%) 0.842 0.947
PENTOSE-P-PWY~pentose phosphate pathway 0.73 0.97 1 0.95 0.99 1 0.0031 0.0029 0.0023 0.0028 0.0024 0.0025 0.003 0.0018 0.0044 0.1 35 / 38 (92%) 17 / 19 (89%) 18 / 19 (95%) 0.895 0.947
PWY-5966~fatty acid biosynthesis initiation II 0.61 0.97 1 0.19 0.91 1 0.0063 0.0054 0.0034 0.005 0.0037 0.0047 0.0059 0.0031 0.009 0.24 33 / 38 (87%) 17 / 19 (89%) 16 / 19 (84%) 0.895 0.842
PWY-5938~pyruvate fermentation to (R)-acetoin I 0.93 0.98 1 0.99 1 1 0.00048 0.00013 0 0.00013 0 0.00034 0.00013 0 0.00026 0 10 / 38 (26%) 5 / 19 (26%) 5 / 19 (26%) 0.263 0.263
PWY-6125~superpathway of guanosine nucleotides de novo biosynthesis II 0.62 0.97 1 0.3 0.91 1 0.0015 0.001 4e-04 0.001 0.00023 0.0018 0.00097 4e-04 0.0014 -0.044 25 / 38 (66%) 11 / 19 (58%) 14 / 19 (74%) 0.579 0.737
POLYISOPRENSYN-PWY~polyisoprenoid biosynthesis (E. coli) 0.71 0.97 1 0.1 0.91 1 0.0012 0.00087 0.00052 0.00091 0.00067 0.0012 0.00083 0.00048 0.00083 -0.13 27 / 38 (71%) 11 / 19 (58%) 16 / 19 (84%) 0.579 0.842
PWY-6549~L-glutamine biosynthesis III 0.51 0.97 1 0.91 0.99 1 0.0011 0.00042 0 0.00027 0 0.00043 0.00057 0 0.0013 1.1 14 / 38 (37%) 7 / 19 (37%) 7 / 19 (37%) 0.368 0.368
ASPARAGINE-DEG1-PWY~L-asparagine degradation I 0.73 0.97 1 0.67 0.96 1 0.0086 0.0086 0.0078 0.0087 0.0079 0.0039 0.0085 0.0072 0.0048 -0.034 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5807~heptaprenyl diphosphate biosynthesis 0.62 0.97 1 0.83 0.99 1 0.00093 0.00088 0.00071 8e-04 0.00074 0.00064 0.00096 0.00052 9e-04 0.26 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
PWY0-501~lipoate biosynthesis and incorporation I 0.72 0.97 1 0.96 0.99 1 0.0011 0.00053 3.5e-05 6e-04 0 0.0011 0.00045 7.1e-05 0.00074 -0.42 19 / 38 (50%) 9 / 19 (47%) 10 / 19 (53%) 0.474 0.526
PWY-4341~L-glutamate biosynthesis V 0.75 0.97 1 0.46 0.91 1 0.045 0.045 0.046 0.046 0.047 0.0085 0.045 0.044 0.012 -0.032 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
HOMOSER-THRESYN-PWY~L-threonine biosynthesis 0.98 0.99 1 0.53 0.93 1 0.0081 0.0081 0.008 0.008 0.0079 0.0025 0.0083 0.008 0.0046 0.053 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5030~L-histidine degradation III 0.56 0.97 1 0.91 0.99 1 0.0014 0.00075 0.00014 0.00093 0.00013 0.0018 0.00057 0.00015 0.001 -0.71 20 / 38 (53%) 10 / 19 (53%) 10 / 19 (53%) 0.526 0.526
PWY-5097~L-lysine biosynthesis VI 0.63 0.97 1 0.33 0.91 1 0.018 0.018 0.018 0.018 0.018 0.003 0.017 0.017 0.0044 -0.082 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
ANAEROFRUCAT-PWY~homolactic fermentation 0.75 0.97 1 0.36 0.91 1 0.014 0.014 0.014 0.014 0.014 0.0033 0.014 0.014 0.0048 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7494~choline degradation IV 0.65 0.97 1 0.21 0.91 1 0.00077 0.00051 0.00027 0.00055 0.00015 8e-04 0.00046 0.00029 5e-04 -0.26 25 / 38 (66%) 10 / 19 (53%) 15 / 19 (79%) 0.526 0.789
PWY-5347~superpathway of L-methionine biosynthesis (transsulfuration) 0.74 0.97 1 0.74 0.98 1 0.00098 0.00039 0 0.00038 0 0.00084 4e-04 0 0.00078 0.074 15 / 38 (39%) 7 / 19 (37%) 8 / 19 (42%) 0.368 0.421
PWY-7459~kojibiose degradation 0.47 0.97 1 0.22 0.91 1 8e-04 0.00078 0.00057 8e-04 5e-04 0.00091 0.00076 0.00065 0.00053 -0.074 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
ASPARTATE-DEG1-PWY~L-aspartate degradation I 0.57 0.97 1 0.27 0.91 1 0.02 0.02 0.019 0.02 0.02 0.0063 0.02 0.017 0.012 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6700~queuosine biosynthesis 0.1 0.97 1 0.13 0.91 1 0.0026 0.0026 0.0023 0.0031 0.0025 0.0019 0.0022 0.002 0.0012 -0.49 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6922~L-Nδ-acetylornithine biosynthesis 0.67 0.97 1 0.96 0.99 1 0.0012 0.00035 0 0.00044 0 0.001 0.00026 0 0.00056 -0.76 11 / 38 (29%) 5 / 19 (26%) 6 / 19 (32%) 0.263 0.316
GOLPDLCAT-PWY~superpathway of glycerol degradation to 13-propanediol 0.98 0.99 1 0.83 0.99 1 0.00048 0.00011 0 0.00011 0 0.00023 0.00012 0 0.00028 0.13 9 / 38 (24%) 5 / 19 (26%) 4 / 19 (21%) 0.263 0.211
GLUTDEG-PWY~L-glutamate degradation II 0.37 0.97 1 0.38 0.91 1 0.0087 0.0087 0.0082 0.009 0.0086 0.0043 0.0083 0.008 0.003 -0.12 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6284~superpathway of unsaturated fatty acids biosynthesis (E. coli) 0.086 0.97 1 0.14 0.91 1 0.0047 0.0047 0.0034 0.0052 0.0042 0.0042 0.0043 0.003 0.0045 -0.27 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
P142-PWY~pyruvate fermentation to acetate I 0.23 0.97 1 0.16 0.91 1 0.016 0.016 0.017 0.017 0.018 0.0043 0.016 0.016 0.0038 -0.087 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
FASYN-INITIAL-PWY~superpathway of fatty acid biosynthesis initiation (E. coli) 0.57 0.97 1 0.2 0.91 1 0.0013 0.00063 0 0.00068 0 0.0015 0.00058 0.00022 0.00091 -0.23 18 / 38 (47%) 7 / 19 (37%) 11 / 19 (58%) 0.368 0.579
PWY0-461~L-lysine degradation I 0.24 0.97 1 0.26 0.91 1 0.005 0.0049 0.0049 0.0048 0.0049 0.0024 0.0051 0.0051 0.0027 0.087 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-5890~menaquinol-10 biosynthesis 0.24 0.97 1 0.48 0.91 1 0.0015 0.00073 6.1e-05 0.00093 0.00012 0.0015 0.00052 0 0.00089 -0.84 19 / 38 (50%) 10 / 19 (53%) 9 / 19 (47%) 0.526 0.474
PWY-6744~hydrogen production I 0.76 0.97 1 0.97 0.99 1 0.00011 1.8e-05 0 1.3e-05 0 3.3e-05 2.2e-05 0 6.2e-05 0.76 6 / 38 (16%) 3 / 19 (16%) 3 / 19 (16%) 0.158 0.158
COA-PWY~coenzyme A biosynthesis I (prokaryotic) 0.76 0.97 1 0.51 0.93 1 0.0081 0.0081 0.0075 0.0082 0.0077 0.0029 0.0081 0.0068 0.0041 -0.018 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1312~acetate and ATP formation from acetyl-CoA I 0.99 0.99 1 0.62 0.96 1 0.013 0.013 0.013 0.013 0.013 0.0031 0.013 0.013 0.0051 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
METSYN-PWY~superpathway of L-homoserine and L-methionine biosynthesis 0.86 0.97 1 0.93 0.99 1 0.00087 0.00037 0 0.00036 0 0.00075 0.00038 0 0.00071 0.078 16 / 38 (42%) 8 / 19 (42%) 8 / 19 (42%) 0.421 0.421
PWY4FS-8~phosphatidylglycerol biosynthesis II (non-plastidic) 0.92 0.98 1 0.52 0.93 1 0.00092 0.00078 0.00073 0.00081 0.00091 0.00069 0.00074 0.00054 0.00066 -0.13 32 / 38 (84%) 15 / 19 (79%) 17 / 19 (89%) 0.789 0.895
PWY0-1314~fructose degradation 0.21 0.97 1 0.22 0.91 1 0.00042 0.00027 0.00013 2e-04 0.00011 0.00026 0.00034 0.00014 0.00052 0.77 25 / 38 (66%) 11 / 19 (58%) 14 / 19 (74%) 0.579 0.737
METHFORM-PWY~methyl-coenzyme M reduction to methane 0.69 0.97 1 0.96 0.99 1 0.00068 7.2e-05 0 5.2e-05 0 0.00015 9.2e-05 0 0.00032 0.82 4 / 38 (11%) 2 / 19 (11%) 2 / 19 (11%) 0.105 0.105
GLUTAMATE-SYN2-PWY~L-glutamate biosynthesis II 0.29 0.97 1 0.98 0.99 1 0.00091 0.00048 5.2e-05 0.00068 0 0.0014 0.00028 8e-05 0.00046 -1.3 20 / 38 (53%) 9 / 19 (47%) 11 / 19 (58%) 0.474 0.579
PWY-7198~pyrimidine deoxyribonucleotides de novo biosynthesis IV 0.32 0.97 1 0.29 0.91 1 0.00093 0.00034 0 0.00028 0 0.00081 4e-04 0 0.001 0.51 14 / 38 (37%) 5 / 19 (26%) 9 / 19 (47%) 0.263 0.474
PWY-5951~(RR)-butanediol biosynthesis 0.62 0.97 1 0.79 0.99 1 0.00014 2.9e-05 0 2.1e-05 0 5.4e-05 3.7e-05 0 9.4e-05 0.82 8 / 38 (21%) 4 / 19 (21%) 4 / 19 (21%) 0.211 0.211
ORN-AMINOPENTANOATE-CAT-PWY~L-ornithine degradation I (L-proline biosynthesis) 0.98 0.99 1 0.66 0.96 1 0.0011 0.00084 0.00057 0.00078 0.00057 0.00073 0.00091 0.00048 0.001 0.22 29 / 38 (76%) 15 / 19 (79%) 14 / 19 (74%) 0.789 0.737
PWY-6293~superpathway of L-cysteine biosynthesis (fungi) 0.87 0.97 1 0.3 0.91 1 0.0038 0.0026 0.00097 0.0022 0.0011 0.0029 0.0031 0.00085 0.0072 0.49 26 / 38 (68%) 14 / 19 (74%) 12 / 19 (63%) 0.737 0.632
PWY-5418~phenol degradation I (aerobic) 0.26 0.97 1 0.17 0.91 1 0.0014 0.0014 0.0012 0.0015 0.0012 0.001 0.0013 0.0011 0.00086 -0.21 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5483~pyruvate fermentation to acetate III 0.68 0.97 1 0.92 0.99 1 0.0036 0.0027 0.0025 0.0027 0.0022 0.0024 0.0028 0.0025 0.0026 0.052 29 / 38 (76%) 15 / 19 (79%) 14 / 19 (74%) 0.789 0.737
ARGSYN-PWY~L-arginine biosynthesis I (via L-ornithine) 0.62 0.97 1 0.57 0.93 1 0.019 0.019 0.019 0.019 0.02 0.0056 0.019 0.018 0.0062 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7858~(5Z)-dodecenoate biosynthesis II 0.26 0.97 1 0.37 0.91 1 0.00036 7.5e-05 0 3e-05 0 8e-05 0.00012 0 0.00033 2 8 / 38 (21%) 3 / 19 (16%) 5 / 19 (26%) 0.158 0.263
COMPLETE-ARO-PWY~superpathway of aromatic amino acid biosynthesis 0.44 0.97 1 0.35 0.91 1 0.0018 0.001 0.00055 0.00084 0 0.001 0.0012 0.00063 0.0015 0.51 21 / 38 (55%) 9 / 19 (47%) 12 / 19 (63%) 0.474 0.632
PWY-4985~mimosine biosynthesis 0.53 0.97 1 0.44 0.91 1 0.0017 0.0011 0.00027 0.00078 0.00045 0.0011 0.0013 0.00026 0.0032 0.74 24 / 38 (63%) 11 / 19 (58%) 13 / 19 (68%) 0.579 0.684
PWY0-1305~L-glutamate degradation IX (via 4-aminobutanoate) 0.88 0.98 1 0.78 0.99 1 0.0027 0.0026 0.0017 0.0025 0.0018 0.0024 0.0027 0.0017 0.005 0.11 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
GLUTAMINDEG-PWY~L-glutamine degradation I 0.08 0.97 1 0.065 0.91 1 0.014 0.014 0.014 0.015 0.015 0.0034 0.014 0.013 0.0034 -0.1 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
BRANCHED-CHAIN-AA-SYN-PWY~superpathway of branched chain amino acid biosynthesis 0.79 0.97 1 0.82 0.99 1 0.022 0.022 0.021 0.022 0.022 0.0051 0.022 0.021 0.0067 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7309~acrylonitrile degradation II 0.72 0.97 1 0.94 0.99 1 0.00034 0.00023 0.00012 0.00021 0.00014 0.00025 0.00025 0.00011 0.00039 0.25 26 / 38 (68%) 13 / 19 (68%) 13 / 19 (68%) 0.684 0.684
PWY-6510~methanol oxidation to formaldehyde II 0.15 0.97 1 0.22 0.91 1 0.00094 0.00089 0.00087 0.00074 0.00067 0.00051 0.001 0.00097 0.00075 0.43 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
PWY-6163~chorismate biosynthesis from 3-dehydroquinate 0.79 0.97 1 0.59 0.94 1 0.011 0.011 0.011 0.011 0.012 0.003 0.011 0.0097 0.004 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5939~pyruvate fermentation to (R)-acetoin II 0.95 0.99 1 0.68 0.96 1 0.00092 0.00039 0 0.00035 0 0.00065 0.00042 0 0.00089 0.26 16 / 38 (42%) 9 / 19 (47%) 7 / 19 (37%) 0.474 0.368
PWY-7400~L-arginine biosynthesis IV (archaebacteria) 0.69 0.97 1 0.59 0.95 1 0.019 0.019 0.018 0.019 0.02 0.0054 0.018 0.018 0.0063 -0.078 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1315~L-lactaldehyde degradation (anaerobic) 0.79 0.97 1 0.48 0.91 1 0.014 0.014 0.013 0.015 0.014 0.0039 0.014 0.013 0.0048 -0.1 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PRPP-PWY~superpathway of histidine purine and pyrimidine biosynthesis 0.79 0.97 1 0.92 0.99 1 0.003 0.0024 0.0011 0.002 0.00085 0.0022 0.0027 0.0013 0.0053 0.43 30 / 38 (79%) 15 / 19 (79%) 15 / 19 (79%) 0.789 0.789
ILEUSYN-PWY~L-isoleucine biosynthesis I (from threonine) 0.79 0.97 1 0.82 0.99 1 0.023 0.023 0.023 0.023 0.023 0.0053 0.023 0.023 0.0069 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-66~GDP-L-fucose biosynthesis I (from GDP-D-mannose) 0.15 0.97 1 0.12 0.91 1 0.0032 0.0032 0.0029 0.0035 0.0038 0.002 0.0028 0.0026 0.0016 -0.32 37 / 38 (97%) 19 / 19 (100%) 18 / 19 (95%) 1 0.947
PWY-922~mevalonate pathway I 0.79 0.97 1 1 1 1 0.00034 8.9e-05 0 6.6e-05 0 0.00013 0.00011 0 0.00031 0.74 10 / 38 (26%) 5 / 19 (26%) 5 / 19 (26%) 0.263 0.263
PWY-6630~superpathway of L-tyrosine biosynthesis 0.23 0.97 1 0.1 0.91 1 0.0034 0.0034 0.0026 0.0033 0.0027 0.0021 0.0034 0.0025 0.0047 0.043 37 / 38 (97%) 19 / 19 (100%) 18 / 19 (95%) 1 0.947
PWY-5108~L-isoleucine biosynthesis V 0.68 0.97 1 0.67 0.96 1 0.0012 0.00058 6.2e-05 0.00075 0 0.0014 0.00042 0.00019 0.00067 -0.84 19 / 38 (50%) 8 / 19 (42%) 11 / 19 (58%) 0.421 0.579
THREONINE-DEG2-PWY~L-threonine degradation II 0.27 0.97 1 0.17 0.91 1 0.0022 0.0022 0.0015 0.002 0.0012 0.0021 0.0023 0.0015 0.0016 0.2 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1597~prenylated FMNH2 biosynthesis 0.36 0.97 1 0.37 0.91 1 0.0013 0.0013 0.0012 0.0014 0.0014 0.00095 0.0012 0.0012 0.00053 -0.22 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7392~taxadiene biosynthesis (engineered) 0.66 0.97 1 0.092 0.91 1 0.0012 0.00094 0.00056 0.00099 0.00052 0.0014 0.00088 0.00064 0.00083 -0.17 29 / 38 (76%) 12 / 19 (63%) 17 / 19 (89%) 0.632 0.895
PWY-6753~S-methyl-5-thioadenosine degradation III 0.38 0.97 1 0.55 0.93 1 0.00016 2.5e-05 0 1.5e-05 0 3.8e-05 3.5e-05 0 9.5e-05 1.2 6 / 38 (16%) 3 / 19 (16%) 3 / 19 (16%) 0.158 0.158
PWY-5783~octaprenyl diphosphate biosynthesis 0.84 0.97 1 0.42 0.91 1 0.0033 0.0033 0.0021 0.0032 0.0026 0.0026 0.0035 0.0021 0.0053 0.13 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-8015~glycine degradation (Stickland reaction) 0.0018 0.33 0.99 0.00081 0.45 0.45 0.0017 0.0016 0.0012 0.0012 0.00093 0.0012 0.0021 0.002 0.0013 0.81 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-7806~glyphosate degradation II 0.41 0.97 1 0.92 0.99 1 0.00081 0.00051 0.00019 4e-04 0.00014 0.00054 0.00062 0.00042 0.00075 0.63 24 / 38 (63%) 12 / 19 (63%) 12 / 19 (63%) 0.632 0.632
PWY-6173~histamine biosynthesis 0.91 0.98 1 0.48 0.91 1 0.00038 0.00013 0 0.00016 0 0.00044 9.5e-05 0 0.00017 -0.75 13 / 38 (34%) 5 / 19 (26%) 8 / 19 (42%) 0.263 0.421
PWY-6970~acetyl-CoA biosynthesis II (NADP-dependent pyruvate dehydrogenase) 0.82 0.97 1 0.68 0.96 1 0.0017 0.00065 0 0.00066 0 0.0014 0.00065 0 0.0012 -0.022 15 / 38 (39%) 7 / 19 (37%) 8 / 19 (42%) 0.368 0.421
PWY-5123~trans trans-farnesyl diphosphate biosynthesis 0.52 0.97 1 0.73 0.97 1 0.00085 0.00036 0 0.00045 0 0.00095 0.00027 0 0.00048 -0.74 16 / 38 (42%) 8 / 19 (42%) 8 / 19 (42%) 0.421 0.421
PWY-7790~UMP biosynthesis II 0.079 0.97 1 0.074 0.91 1 0.024 0.024 0.025 0.025 0.025 0.0044 0.023 0.021 0.0071 -0.12 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5005~biotin biosynthesis II 0.37 0.97 1 0.39 0.91 1 0.00038 0.00016 0 0.00013 0 0.00022 0.00018 0 0.00023 0.47 16 / 38 (42%) 7 / 19 (37%) 9 / 19 (47%) 0.368 0.474
PWY-6901~superpathway of glucose and xylose degradation 0.67 0.97 1 0.95 0.99 1 0.0031 0.0028 0.0022 0.0028 0.0024 0.0026 0.0028 0.002 0.0044 0 35 / 38 (92%) 17 / 19 (89%) 18 / 19 (95%) 0.895 0.947
METHANOGENESIS-PWY~methanogenesis from H2 and CO2 0.16 0.97 1 0.26 0.91 1 0.00037 2.9e-05 0 8.8e-06 0 3.8e-05 5e-05 0 0.00015 2.5 3 / 38 (7.9%) 1 / 19 (5.3%) 2 / 19 (11%) 0.0526 0.105
PWY0-781~aspartate superpathway 0.64 0.97 1 0.91 0.99 1 0.0021 0.0018 0.001 0.0015 0.00091 0.0013 0.002 0.0012 0.0023 0.42 32 / 38 (84%) 16 / 19 (84%) 16 / 19 (84%) 0.842 0.842
GLUCUROCAT-PWY~superpathway of β-D-glucuronosides degradation 0.37 0.97 1 0.9 0.99 1 0.0038 0.0037 0.0038 0.0043 0.0045 0.003 0.0032 0.0032 0.0023 -0.43 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-5676~acetyl-CoA fermentation to butanoate II 0.099 0.97 1 0.12 0.91 1 0.0015 0.0014 0.001 0.0016 0.0013 0.0012 0.0012 9e-04 0.00095 -0.42 37 / 38 (97%) 19 / 19 (100%) 18 / 19 (95%) 1 0.947
PWY-3821~D-galactose detoxification 0.79 0.97 1 0.86 0.99 1 0.0013 0.00081 0.00055 0.00078 0.00062 0.00088 0.00085 0.00048 0.0012 0.12 24 / 38 (63%) 11 / 19 (58%) 13 / 19 (68%) 0.579 0.684
ARGSYNBSUB-PWY~L-arginine biosynthesis II (acetyl cycle) 0.86 0.97 1 0.59 0.94 1 0.021 0.021 0.021 0.021 0.022 0.0048 0.021 0.02 0.0057 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-4121~glutathionylspermidine biosynthesis 0.97 0.99 1 0.55 0.93 1 0.00081 0.00028 0 0.00033 0 0.00071 0.00022 0 0.00043 -0.58 13 / 38 (34%) 5 / 19 (26%) 8 / 19 (42%) 0.263 0.421
BSUBPOLYAMSYN-PWY~spermidine biosynthesis I 0.6 0.97 1 0.76 0.98 1 0.00069 0.00058 0.00053 0.00055 0.00048 0.00051 0.00062 0.00054 0.00045 0.17 32 / 38 (84%) 16 / 19 (84%) 16 / 19 (84%) 0.842 0.842
PWY-5686~UMP biosynthesis I 0.088 0.97 1 0.088 0.91 1 0.024 0.024 0.025 0.025 0.026 0.0043 0.023 0.021 0.0071 -0.12 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
P124-PWY~Bifidobacterium shunt 0.95 0.99 1 0.48 0.91 1 0.011 0.011 0.011 0.01 0.011 0.0025 0.011 0.011 0.0054 0.14 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-1001~cellulose biosynthesis 0.21 0.97 1 0.73 0.97 1 0.0021 0.0013 0.00012 0.00088 0.00011 0.0013 0.0017 0.00012 0.0023 0.95 23 / 38 (61%) 11 / 19 (58%) 12 / 19 (63%) 0.579 0.632
PWY-7968~5-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP 0.59 0.97 1 0.39 0.91 1 0.0049 0.0049 0.0047 0.005 0.0047 0.0018 0.0047 0.0046 0.0014 -0.089 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7197~pyrimidine deoxyribonucleotide phosphorylation 0.26 0.97 1 0.29 0.91 1 0.00044 3e-04 2e-04 0.00024 9.4e-05 0.00028 0.00036 0.00026 0.00038 0.58 26 / 38 (68%) 12 / 19 (63%) 14 / 19 (74%) 0.632 0.737
DENOVOPURINE2-PWY~superpathway of purine nucleotides de novo biosynthesis II 0.81 0.97 1 0.97 0.99 1 0.0015 0.001 0.00048 0.0011 0.00045 0.0019 0.00087 5e-04 0.0012 -0.34 26 / 38 (68%) 13 / 19 (68%) 13 / 19 (68%) 0.684 0.684
PWY0-823~L-arginine degradation III (arginine decarboxylase/agmatinase pathway) 0.78 0.97 1 0.5 0.93 1 0.0058 0.0057 0.0046 0.0056 0.0045 0.0034 0.0057 0.0048 0.0038 0.026 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-7111~pyruvate fermentation to isobutanol (engineered) 0.67 0.97 1 0.93 0.99 1 0.024 0.024 0.024 0.023 0.025 0.0067 0.024 0.024 0.0083 0.061 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1298~superpathway of pyrimidine deoxyribonucleosides degradation 0.051 0.97 1 0.12 0.91 1 0.0028 0.0027 0.0025 0.0031 0.0028 0.0015 0.0023 0.002 0.0013 -0.43 37 / 38 (97%) 19 / 19 (100%) 18 / 19 (95%) 1 0.947
HISTSYN-PWY~L-histidine biosynthesis 0.084 0.97 1 0.039 0.91 1 0.0095 0.0095 0.0092 0.01 0.0099 0.0024 0.009 0.0089 0.0033 -0.15 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
ALANINE-DEG3-PWY~L-alanine degradation III 0.67 0.97 1 0.19 0.91 1 0.0072 0.0072 0.0064 0.007 0.0069 0.0034 0.0075 0.005 0.008 0.1 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
MALTOSECAT-PWY~maltose degradation 0.72 0.97 1 0.93 0.99 1 0.00048 0.00017 0 0.00019 0 0.00031 0.00014 0 0.00026 -0.44 13 / 38 (34%) 6 / 19 (32%) 7 / 19 (37%) 0.316 0.368
PWY-4261~glycerol degradation I 0.26 0.97 1 0.45 0.91 1 0.0014 0.0011 0.00064 0.00087 0.00044 0.0011 0.0013 0.00098 0.0013 0.58 29 / 38 (76%) 14 / 19 (74%) 15 / 19 (79%) 0.737 0.789
PWY-6470~peptidoglycan biosynthesis V (β-lactam resistance) 0.45 0.97 1 0.26 0.91 1 0.006 0.0057 0.0036 0.0052 0.0035 0.0049 0.0062 0.0036 0.0097 0.25 36 / 38 (95%) 17 / 19 (89%) 19 / 19 (100%) 0.895 1
PWY-6376~desferrioxamine B biosynthesis 0.24 0.97 1 0.26 0.91 1 0.005 0.0049 0.0049 0.0048 0.0049 0.0024 0.0051 0.0051 0.0027 0.087 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-7388~octanoyl-[acyl-carrier protein] biosynthesis (mitochondria yeast) 0.61 0.97 1 0.71 0.97 1 0.013 0.013 0.012 0.012 0.014 0.005 0.013 0.011 0.0084 0.12 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7221~guanosine ribonucleotides de novo biosynthesis 0.15 0.97 1 0.092 0.91 1 0.0012 0.00096 0.00075 0.00089 0.00063 0.0011 0.001 0.00085 0.00093 0.17 31 / 38 (82%) 14 / 19 (74%) 17 / 19 (89%) 0.737 0.895
PWY-7003~glycerol degradation to butanol 0.49 0.97 1 0.63 0.96 1 0.0014 0.00056 0 0.00068 0 0.001 0.00044 0 0.00068 -0.63 15 / 38 (39%) 8 / 19 (42%) 7 / 19 (37%) 0.421 0.368
ASPARAGINESYN-PWY~L-asparagine biosynthesis II 0.84 0.97 1 0.77 0.99 1 0.01 0.01 0.01 0.01 0.01 0.0027 0.01 0.011 0.0028 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6527~stachyose degradation 0.62 0.97 1 0.9 0.99 1 0.0019 0.0012 0.00068 0.0011 0.00066 0.0013 0.0012 0.00083 0.0018 0.13 23 / 38 (61%) 11 / 19 (58%) 12 / 19 (63%) 0.579 0.632
PWY-7176~UTP and CTP de novo biosynthesis 0.15 0.97 1 0.06 0.91 1 0.00098 0.00082 0.00064 0.00078 0.00048 0.00098 0.00087 0.00065 0.00073 0.16 32 / 38 (84%) 14 / 19 (74%) 18 / 19 (95%) 0.737 0.947
PWY-6012-1~acyl carrier protein activation 0.92 0.98 1 0.95 0.99 1 0.003 0.003 0.0026 0.0029 0.0027 0.0015 0.0031 0.0022 0.0025 0.096 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7356~thiamine salvage IV (yeast) 0.99 0.99 1 0.45 0.91 1 0.0044 0.0041 0.0036 0.0038 0.004 0.0025 0.0044 0.0031 0.0046 0.21 35 / 38 (92%) 18 / 19 (95%) 17 / 19 (89%) 0.947 0.895
PWY-4821~UDP-α-D-xylose biosynthesis 0.55 0.97 1 0.62 0.96 1 0.0015 0.00039 0 2e-04 0 6e-04 0.00058 0 0.0023 1.5 10 / 38 (26%) 4 / 19 (21%) 6 / 19 (32%) 0.211 0.316
LARABITOLUTIL-PWY~xylitol degradation 0.75 0.97 1 0.48 0.91 1 0.0036 0.003 0.0015 0.0027 0.0015 0.0028 0.0034 0.001 0.0059 0.33 32 / 38 (84%) 16 / 19 (84%) 16 / 19 (84%) 0.842 0.842
GLUTATHIONESYN-PWY~glutathione biosynthesis 0.65 0.97 1 0.67 0.96 1 0.0015 0.00093 0.00015 0.0014 0.00012 0.0052 0.00044 0.00019 0.00065 -1.7 23 / 38 (61%) 11 / 19 (58%) 12 / 19 (63%) 0.579 0.632
RHAMCAT-PWY~L-rhamnose degradation I 0.29 0.97 1 0.79 0.99 1 0.0012 0.00083 0.00032 0.0012 0.00066 0.0017 0.00048 0.00028 0.00051 -1.3 27 / 38 (71%) 12 / 19 (63%) 15 / 19 (79%) 0.632 0.789
PWY3O-355~stearate biosynthesis III (fungi) 0.48 0.97 1 0.19 0.91 1 0.0058 0.0049 0.0034 0.0046 0.0035 0.0042 0.0051 0.0027 0.0076 0.15 32 / 38 (84%) 16 / 19 (84%) 16 / 19 (84%) 0.842 0.842
P121-PWY~adenine and adenosine salvage I 0.72 0.97 1 0.4 0.91 1 0.007 0.007 0.0071 0.0071 0.0071 0.0015 0.0069 0.007 0.0021 -0.041 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
ASPARTATESYN-PWY~L-aspartate biosynthesis 0.57 0.97 1 0.27 0.91 1 0.02 0.02 0.019 0.02 0.02 0.0063 0.02 0.017 0.012 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY66-409~superpathway of purine nucleotide salvage 0.87 0.97 1 0.85 0.99 1 0.0012 0.00085 0.00043 0.00098 0.00046 0.0016 0.00072 4e-04 0.00074 -0.44 26 / 38 (68%) 13 / 19 (68%) 13 / 19 (68%) 0.684 0.684
PWY-6628~superpathway of L-phenylalanine biosynthesis 0.7 0.97 1 0.37 0.91 1 0.01 0.01 0.01 0.01 0.011 0.0038 0.011 0.0086 0.006 0.14 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7208~superpathway of pyrimidine nucleobases salvage 0.19 0.97 1 0.07 0.91 1 0.001 0.00079 0.00056 0.00074 0.00051 0.00093 0.00083 6e-04 0.00079 0.17 30 / 38 (79%) 13 / 19 (68%) 17 / 19 (89%) 0.684 0.895
PWY-6277~superpathway of 5-aminoimidazole ribonucleotide biosynthesis 0.54 0.97 1 0.26 0.91 1 0.014 0.014 0.013 0.014 0.015 0.0027 0.014 0.013 0.0036 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
ETOH-ACETYLCOA-ANA-PWY~ethanol degradation I 0.57 0.97 1 0.72 0.97 1 0.0034 0.0034 0.0021 0.003 0.0017 0.0025 0.0037 0.0024 0.0048 0.3 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PROSYN-PWY~L-proline biosynthesis I 0.77 0.97 1 0.64 0.96 1 0.011 0.011 0.01 0.011 0.011 0.0028 0.011 0.0099 0.0035 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLUCONEO-PWY~gluconeogenesis I 0.12 0.97 1 0.036 0.91 1 0.0074 0.0074 0.0074 0.0081 0.0085 0.0028 0.0068 0.0068 0.0025 -0.25 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7199~pyrimidine deoxyribonucleosides salvage 0.81 0.97 1 0.43 0.91 1 0.0011 0.00093 6e-04 0.001 6e-04 0.0012 0.00086 0.00059 0.00082 -0.22 31 / 38 (82%) 14 / 19 (74%) 17 / 19 (89%) 0.737 0.895
RIBOKIN-PWY~ribose phosphorylation 0.52 0.97 1 0.48 0.91 1 0.00064 0.00055 0.00036 0.00055 0.00033 0.00075 0.00055 0.00037 0.00067 0 33 / 38 (87%) 16 / 19 (84%) 17 / 19 (89%) 0.842 0.895
GLUTAMATE-DEG1-PWY~L-glutamate degradation I 0.2 0.97 1 0.39 0.91 1 0.0026 0.0026 0.0023 0.0031 0.0029 0.0022 0.0021 0.0017 0.0012 -0.56 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
FOLSYN-PWY~superpathway of tetrahydrofolate biosynthesis and salvage 0.28 0.97 1 0.27 0.91 1 0.00084 2e-04 0 0.00026 0 0.00065 0.00014 0 0.00032 -0.89 9 / 38 (24%) 5 / 19 (26%) 4 / 19 (21%) 0.263 0.211
PWY-4101~D-sorbitol degradation I 0.93 0.98 1 0.92 0.99 1 0.013 0.013 0.013 0.014 0.013 0.0052 0.013 0.012 0.0041 -0.11 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5831~CDP-abequose biosynthesis 0.73 0.97 1 0.93 0.99 1 0.00028 4.4e-05 0 6.8e-05 0 0.00028 2e-05 0 5.6e-05 -1.8 6 / 38 (16%) 3 / 19 (16%) 3 / 19 (16%) 0.158 0.158
PWY-5344~L-homocysteine biosynthesis 0.4 0.97 1 0.28 0.91 1 0.023 0.023 0.023 0.023 0.024 0.0051 0.022 0.022 0.0065 -0.064 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7247~β-D-glucuronide and D-glucuronate degradation 0.22 0.97 1 0.34 0.91 1 0.0073 0.0073 0.0068 0.0081 0.0089 0.004 0.0065 0.006 0.0029 -0.32 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1477~ethanolamine utilization 0.31 0.97 1 0.24 0.91 1 0.0032 0.0031 0.0022 0.0027 0.0024 0.0022 0.0036 0.002 0.0047 0.42 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-5490~paraoxon degradation 0.59 0.97 1 0.75 0.98 1 0.00045 8.3e-05 0 1e-04 0 4e-04 6.2e-05 0 0.00022 -0.69 7 / 38 (18%) 4 / 19 (21%) 3 / 19 (16%) 0.211 0.158
PWY-7229~superpathway of adenosine nucleotides de novo biosynthesis I 0.94 0.99 1 0.71 0.97 1 0.0074 0.0074 0.0063 0.0072 0.0066 0.0029 0.0077 0.006 0.0046 0.097 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
LACTOSECAT-PWY~lactose and galactose degradation I 0.21 0.97 1 0.19 0.91 1 0.00086 5e-04 0.00028 0.00038 0.00018 0.00049 0.00061 0.00033 0.00099 0.68 22 / 38 (58%) 10 / 19 (53%) 12 / 19 (63%) 0.526 0.632
PWY-6827~gellan degradation 0.35 0.97 1 0.44 0.91 1 0.00016 1.3e-05 0 4.1e-06 0 1.8e-05 2.2e-05 0 8.3e-05 2.4 3 / 38 (7.9%) 1 / 19 (5.3%) 2 / 19 (11%) 0.0526 0.105
PWY-6057~dimethyl sulfide degradation III (oxidation) 0.5 0.97 1 0.52 0.93 1 0.00021 1.7e-05 0 1.3e-05 0 5.5e-05 2.1e-05 0 6.8e-05 0.69 3 / 38 (7.9%) 1 / 19 (5.3%) 2 / 19 (11%) 0.0526 0.105
PWY0-662~PRPP biosynthesis 0.3 0.97 1 0.68 0.96 1 0.025 0.025 0.025 0.024 0.026 0.0058 0.026 0.025 0.0081 0.12 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY4LZ-257~superpathway of fermentation (Chlamydomonas reinhardtii) 0.84 0.97 1 0.78 0.99 1 0.0017 0.00031 0 0.00027 0 0.00081 0.00035 0 0.0012 0.37 7 / 38 (18%) 4 / 19 (21%) 3 / 19 (16%) 0.211 0.158
PWY-7581~N-acetylneuraminate and N-acetylmannosamine degradation II 0.39 0.97 1 0.78 0.99 1 0.00064 0.00015 0 0.00025 0 0.00067 5.6e-05 0 1e-04 -2.2 9 / 38 (24%) 4 / 19 (21%) 5 / 19 (26%) 0.211 0.263
PWY-7686~L-malate degradation II 0.92 0.98 1 0.65 0.96 1 0.0069 0.0069 0.0068 0.0069 0.0068 0.002 0.0068 0.007 0.0019 -0.021 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7179-1~purine deoxyribonucleosides degradation II 0.12 0.97 1 0.069 0.91 1 0.0035 0.0035 0.0032 0.0033 0.0031 0.0017 0.0038 0.0032 0.0021 0.2 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1309~chitobiose degradation 0.57 0.97 1 0.77 0.99 1 0.0069 0.002 0 0.0015 0 0.003 0.0025 0 0.005 0.74 11 / 38 (29%) 5 / 19 (26%) 6 / 19 (32%) 0.263 0.316
PWY-5853~demethylmenaquinol-6 biosynthesis I 0.46 0.97 1 0.4 0.91 1 0.0029 0.0027 0.0018 0.0028 0.0028 0.0022 0.0027 0.00097 0.0041 -0.052 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
DTDPRHAMSYN-PWY~dTDP-L-rhamnose biosynthesis 0.085 0.97 1 0.054 0.91 1 0.01 0.01 0.01 0.011 0.011 0.003 0.0093 0.009 0.0028 -0.24 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
ACETATEUTIL-PWY~superpathway of acetate utilization and formation 0.43 0.97 1 0.9 0.99 1 0.0019 0.0013 0.00056 0.0016 0.00047 0.0023 0.00097 0.00064 0.0012 -0.72 25 / 38 (66%) 12 / 19 (63%) 13 / 19 (68%) 0.632 0.684
PWY-7167~choline degradation III 0.61 0.97 1 0.88 0.99 1 0.0011 0.00022 0 2e-04 0 0.00067 0.00025 0 0.00086 0.32 8 / 38 (21%) 4 / 19 (21%) 4 / 19 (21%) 0.211 0.211
N2FIX-PWY~nitrogen fixation I (ferredoxin) 0.21 0.97 1 0.29 0.91 1 0.009 0.009 0.0088 0.0085 0.0089 0.0034 0.0094 0.0088 0.0029 0.15 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-541~cyclopropane fatty acid (CFA) biosynthesis 0.4 0.97 1 0.45 0.91 1 0.0037 0.0037 0.0032 0.0034 0.0029 0.0019 0.0039 0.0035 0.002 0.2 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7761~NAD salvage pathway II (PNC IV cycle) 0.086 0.97 1 0.033 0.91 1 0.001 0.00049 0 0.00041 0 0.00078 0.00057 0.00041 0.00065 0.48 18 / 38 (47%) 7 / 19 (37%) 11 / 19 (58%) 0.368 0.579
PWY-1042~glycolysis IV (plant cytosol) 0.17 0.97 1 0.044 0.91 1 0.015 0.015 0.014 0.015 0.016 0.0026 0.014 0.014 0.0038 -0.1 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLYCOLYSIS-E-D~superpathway of glycolysis and the Entner-Doudoroff pathway 0.38 0.97 1 0.94 0.99 1 0.0021 0.00062 0 0.00084 0 0.0019 0.00039 0 0.00078 -1.1 11 / 38 (29%) 5 / 19 (26%) 6 / 19 (32%) 0.263 0.316
HSERMETANA-PWY~L-methionine biosynthesis III 0.67 0.97 1 0.47 0.91 1 0.011 0.011 0.012 0.012 0.012 0.0044 0.011 0.011 0.005 -0.13 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLYCOCAT-PWY~glycogen degradation I 0.37 0.97 1 0.22 0.91 1 0.014 0.014 0.014 0.015 0.014 0.0072 0.014 0.014 0.0055 -0.1 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PYRIDOXSYN-PWY~pyridoxal 5-phosphate biosynthesis I 0.15 0.97 1 0.19 0.91 1 0.0026 0.00062 0 0.00086 0 0.002 0.00038 0 0.00078 -1.2 9 / 38 (24%) 5 / 19 (26%) 4 / 19 (21%) 0.263 0.211
PHOSPHONOTASE-PWY~2-aminoethylphosphonate degradation I 0.06 0.97 1 0.077 0.91 1 0.00034 5.4e-05 0 6.7e-05 0 0.00017 4.2e-05 0 0.00013 -0.67 6 / 38 (16%) 4 / 19 (21%) 2 / 19 (11%) 0.211 0.105
PWY-5838~superpathway of menaquinol-8 biosynthesis I 0.47 0.97 1 0.31 0.91 1 0.00075 5.9e-05 0 6.5e-05 0 0.00019 5.4e-05 0 0.00023 -0.27 3 / 38 (7.9%) 2 / 19 (11%) 1 / 19 (5.3%) 0.105 0.0526
PWY-5100~pyruvate fermentation to acetate and lactate II 0.62 0.97 1 0.64 0.96 1 0.011 0.011 0.011 0.01 0.011 0.0035 0.011 0.011 0.0034 0.14 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6285~superpathway of fatty acids biosynthesis (E. coli) 0.1 0.97 1 0.2 0.91 1 0.0047 0.0047 0.0035 0.0051 0.0042 0.0041 0.0043 0.003 0.0045 -0.25 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6019~pseudouridine degradation 0.31 0.97 1 0.63 0.96 1 0.0014 0.00018 0 0.00013 0 0.00055 0.00023 0 0.00088 0.82 5 / 38 (13%) 2 / 19 (11%) 3 / 19 (16%) 0.105 0.158
MALATE-ASPARTATE-SHUTTLE-PWY~L-aspartate degradation II 0.51 0.97 1 0.86 0.99 1 0.0027 0.0027 0.002 0.0031 0.0019 0.0034 0.0024 0.0021 0.0015 -0.37 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6807~xyloglucan degradation II (exoglucanase) 0.15 0.97 1 0.15 0.91 1 0.008 0.00063 0 0.0011 0 0.004 0.00017 0 0.00072 -2.7 3 / 38 (7.9%) 2 / 19 (11%) 1 / 19 (5.3%) 0.105 0.0526
FUC-RHAMCAT-PWY~superpathway of fucose and rhamnose degradation 0.41 0.97 1 0.41 0.91 1 0.001 0.00019 0 0.00022 0 0.00049 0.00016 0 0.00042 -0.46 7 / 38 (18%) 4 / 19 (21%) 3 / 19 (16%) 0.211 0.158
PHOSLIPSYN-PWY~superpathway of phospholipid biosynthesis I (bacteria) 0.37 0.97 1 0.27 0.91 1 9e-04 7.1e-05 0 8.4e-05 0 0.00026 5.8e-05 0 0.00025 -0.53 3 / 38 (7.9%) 2 / 19 (11%) 1 / 19 (5.3%) 0.105 0.0526
GALACTUROCAT-PWY~D-galacturonate degradation I 0.6 0.97 1 0.79 0.99 1 0.0033 0.0033 0.0029 0.0036 0.0028 0.0025 0.0031 0.003 0.0019 -0.22 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5659~GDP-mannose biosynthesis 0.79 0.97 1 0.87 0.99 1 0.0028 0.0025 0.0019 0.0025 0.0015 0.0023 0.0024 0.0021 0.0019 -0.059 33 / 38 (87%) 17 / 19 (89%) 16 / 19 (84%) 0.895 0.842
PWY-5194~siroheme biosynthesis 0.17 0.97 1 0.38 0.91 1 0.00048 0.00043 3e-04 0.00035 3e-04 3e-04 5e-04 0.00036 0.00043 0.51 34 / 38 (89%) 17 / 19 (89%) 17 / 19 (89%) 0.895 0.895
PWY0-1313~acetate conversion to acetyl-CoA 0.55 0.97 1 0.8 0.99 1 0.0034 0.0032 0.003 0.0034 0.0045 0.0023 0.003 0.0026 0.002 -0.18 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
PWY-5669~phosphatidylethanolamine biosynthesis I 0.1 0.97 1 0.082 0.91 1 0.0029 0.0029 0.0029 0.0032 0.0033 0.0014 0.0026 0.0027 0.0012 -0.3 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5156~superpathway of fatty acid biosynthesis II (plant) 0.16 0.97 1 0.94 0.99 1 0.0048 0.0044 0.003 0.0047 0.0031 0.0041 0.0042 0.0029 0.0044 -0.16 35 / 38 (92%) 17 / 19 (89%) 18 / 19 (95%) 0.895 0.947
PWY-7970~benzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP 0.59 0.97 1 0.39 0.91 1 0.0049 0.0049 0.0047 0.005 0.0047 0.0018 0.0047 0.0046 0.0014 -0.089 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7205~CMP phosphorylation 0.47 0.97 1 0.35 0.91 1 0.00064 0.00057 0.00044 0.00057 0.00046 0.00065 0.00058 0.00044 0.00046 0.025 34 / 38 (89%) 16 / 19 (84%) 18 / 19 (95%) 0.842 0.947
GLUGLNSYN-PWY~L-glutamate biosynthesis IV 0.58 0.97 1 0.42 0.91 1 0.039 0.039 0.039 0.039 0.039 0.014 0.038 0.04 0.011 -0.037 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6617~adenosine nucleotides degradation III 0.94 0.99 1 0.67 0.96 1 0.001 0.00044 0 0.00049 0 0.00092 0.00038 0 0.00069 -0.37 16 / 38 (42%) 7 / 19 (37%) 9 / 19 (47%) 0.368 0.474
PWY-5148~acyl-CoA hydrolysis 0.42 0.97 1 0.43 0.91 1 0.00027 7.8e-05 0 9.5e-05 0 0.00015 6.1e-05 0 0.00013 -0.64 11 / 38 (29%) 6 / 19 (32%) 5 / 19 (26%) 0.316 0.263
GDPRHAMSYN-PWY~GDP-D-rhamnose biosynthesis 0.61 0.97 1 0.29 0.91 1 0.0011 0.00034 0 0.00037 0 0.00084 0.00031 0 0.00054 -0.26 12 / 38 (32%) 4 / 19 (21%) 8 / 19 (42%) 0.211 0.421
PWY-6406~salicylate biosynthesis I 0.15 0.97 1 0.3 0.91 1 8e-04 6.3e-05 0 3.9e-05 0 0.00017 8.7e-05 0 0.00035 1.2 3 / 38 (7.9%) 1 / 19 (5.3%) 2 / 19 (11%) 0.0526 0.105
PLPSAL-PWY~pyridoxal 5-phosphate salvage I 0.089 0.97 1 0.29 0.91 1 0.0011 0.00075 0.00047 0.00089 0.00066 0.00098 0.00062 0.00045 0.00068 -0.52 26 / 38 (68%) 13 / 19 (68%) 13 / 19 (68%) 0.684 0.684
PWY-7242~D-fructuronate degradation 0.24 0.97 1 0.57 0.93 1 0.0024 0.002 0.0013 0.0024 0.0021 0.0022 0.0016 0.0012 0.0017 -0.58 32 / 38 (84%) 16 / 19 (84%) 16 / 19 (84%) 0.842 0.842
PWY-6164~3-dehydroquinate biosynthesis I 0.67 0.97 1 0.86 0.99 1 0.019 0.019 0.018 0.018 0.019 0.0052 0.019 0.018 0.0089 0.078 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-724~superpathway of L-lysine L-threonine and L-methionine biosynthesis II 0.97 0.99 1 0.95 0.99 1 0.0094 0.0094 0.0097 0.0092 0.01 0.0037 0.0096 0.0088 0.0062 0.061 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7346~UDP-α-D-glucuronate biosynthesis (from UDP-glucose) 0.6 0.97 1 0.63 0.96 1 0.011 0.011 0.01 0.011 0.011 0.0043 0.01 0.0097 0.0038 -0.14 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
DAPLYSINESYN-PWY~L-lysine biosynthesis I 0.95 0.99 1 0.47 0.91 1 0.0033 0.0028 0.0016 0.0024 0.0017 0.0023 0.0033 0.0016 0.0061 0.46 33 / 38 (87%) 17 / 19 (89%) 16 / 19 (84%) 0.895 0.842
HISDEG-PWY~L-histidine degradation I 0.15 0.97 1 0.1 0.91 1 0.00023 5.4e-05 0 7.4e-05 0 0.00015 3.3e-05 0 8.5e-05 -1.2 9 / 38 (24%) 6 / 19 (32%) 3 / 19 (16%) 0.316 0.158
PWY-7518~atromentin biosynthesis 0.28 0.97 1 0.26 0.91 1 0.00082 0.00065 0.00046 0.00053 0.00045 0.00056 0.00077 0.00053 0.00089 0.54 30 / 38 (79%) 14 / 19 (74%) 16 / 19 (84%) 0.737 0.842
PWY-2161~folate polyglutamylation 0.74 0.97 1 0.81 0.99 1 0.013 0.013 0.012 0.013 0.013 0.0041 0.013 0.012 0.0061 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7432~L-phenylalanine biosynthesis III (cytosolic plants) 0.26 0.97 1 0.27 0.91 1 0.001 0.00076 0.00052 0.00061 0.00044 0.00063 0.00091 0.00057 0.0011 0.58 28 / 38 (74%) 13 / 19 (68%) 15 / 19 (79%) 0.684 0.789
PWY66-162~ethanol degradation IV 0.16 0.97 1 0.36 0.91 1 0.0015 0.00012 0 1e-04 0 0.00045 0.00014 0 0.00058 0.49 3 / 38 (7.9%) 1 / 19 (5.3%) 2 / 19 (11%) 0.0526 0.105
PWY-622~starch biosynthesis 0.97 0.99 1 0.56 0.93 1 0.0083 0.0064 0.0025 0.0053 0.0021 0.0065 0.0075 0.0038 0.017 0.5 29 / 38 (76%) 15 / 19 (79%) 14 / 19 (74%) 0.789 0.737
PWY0-1545~cardiolipin biosynthesis III 0.26 0.97 1 0.28 0.91 1 0.00033 0.00012 0 0.00016 0 0.00032 8.4e-05 0 0.00016 -0.93 14 / 38 (37%) 8 / 19 (42%) 6 / 19 (32%) 0.421 0.316
PWY-7685~L-malate degradation I 0.15 0.97 1 0.19 0.91 1 0.00013 9.9e-06 0 1.5e-05 0 5.3e-05 5.1e-06 0 2.2e-05 -1.6 3 / 38 (7.9%) 2 / 19 (11%) 1 / 19 (5.3%) 0.105 0.0526
PWY-6612~superpathway of tetrahydrofolate biosynthesis 0.18 0.97 1 0.15 0.91 1 0.00075 2e-04 0 0.00026 0 0.00062 0.00013 0 0.00031 -1 10 / 38 (26%) 6 / 19 (32%) 4 / 19 (21%) 0.316 0.211
PWY-621~sucrose degradation III (sucrose invertase) 0.97 0.99 1 0.53 0.93 1 0.015 0.015 0.015 0.014 0.015 0.0055 0.015 0.014 0.0095 0.1 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-2781~cis-zeatin biosynthesis 0.41 0.97 1 0.86 0.99 1 0.012 0.012 0.012 0.012 0.012 0.0025 0.013 0.012 0.0036 0.12 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-283~benzoate degradation II (aerobic and anaerobic) 0.21 0.97 1 0.42 0.91 1 0.0036 0.00047 0 0.00085 0 0.0023 8.8e-05 0 0.00026 -3.3 5 / 38 (13%) 3 / 19 (16%) 2 / 19 (11%) 0.158 0.105
PWY-6910~hydroxymethylpyrimidine salvage 0.48 0.97 1 0.96 0.99 1 0.011 0.011 0.011 0.011 0.01 0.0029 0.011 0.011 0.0036 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLYSYN-PWY~glycine biosynthesis I 0.24 0.97 1 0.74 0.98 1 0.014 0.014 0.014 0.014 0.013 0.0027 0.014 0.014 0.004 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLUAMCAT-PWY~N-acetylglucosamine degradation I 0.57 0.97 1 0.31 0.91 1 0.013 0.013 0.012 0.013 0.013 0.0038 0.012 0.011 0.0026 -0.12 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5895~menaquinol-13 biosynthesis 0.24 0.97 1 0.48 0.91 1 0.0015 0.00073 6.1e-05 0.00093 0.00012 0.0015 0.00052 0 0.00089 -0.84 19 / 38 (50%) 10 / 19 (53%) 9 / 19 (47%) 0.526 0.474
PWY-6050~dimethyl sulfoxide degradation 0.2 0.97 1 0.28 0.91 1 0.00081 4e-04 4.7e-05 0.00032 0 0.00075 0.00049 0.00012 0.00086 0.61 19 / 38 (50%) 8 / 19 (42%) 11 / 19 (58%) 0.421 0.579
PWY-6130~glycerol degradation III 0.0029 0.41 1 0.055 0.91 1 0.0019 0.0018 0.0017 0.0015 0.0012 0.0011 0.0021 0.0021 0.0012 0.49 35 / 38 (92%) 17 / 19 (89%) 18 / 19 (95%) 0.895 0.947
PWY-6535~4-aminobutanoate degradation I 0.8 0.97 1 0.38 0.91 1 0.00044 3.5e-05 0 3e-05 0 0.00012 4e-05 0 0.00018 0.42 3 / 38 (7.9%) 2 / 19 (11%) 1 / 19 (5.3%) 0.105 0.0526
PWY18C3-24~methylsalicylate degradation 0.14 0.97 1 0.14 0.91 1 0.0019 0.0018 0.0016 0.0019 0.0016 0.0013 0.0017 0.0017 0.0014 -0.16 37 / 38 (97%) 19 / 19 (100%) 18 / 19 (95%) 1 0.947
GLYCLEAV-PWY~glycine cleavage 0.69 0.97 1 0.45 0.91 1 0.0021 0.0019 0.00089 0.0021 0.00082 0.0028 0.0018 0.00097 0.0022 -0.22 35 / 38 (92%) 18 / 19 (95%) 17 / 19 (89%) 0.947 0.895
PWY-6139~CMP-N-acetylneuraminate biosynthesis II (bacteria) 0.29 0.97 1 0.022 0.91 1 0.00074 0.00023 0 0.00027 0 9e-04 2e-04 0 0.00034 -0.43 12 / 38 (32%) 3 / 19 (16%) 9 / 19 (47%) 0.158 0.474
PWY-7184~pyrimidine deoxyribonucleotides de novo biosynthesis I 0.56 0.97 1 0.71 0.97 1 0.00091 0.00043 0 0.00034 0 0.00075 0.00052 0 0.0011 0.61 18 / 38 (47%) 9 / 19 (47%) 9 / 19 (47%) 0.474 0.474
PWY-8004~Entner-Doudoroff pathway I 0.16 0.97 1 0.19 0.91 1 0.0018 0.00024 0 4e-04 0 0.0011 7.4e-05 0 0.00025 -2.4 5 / 38 (13%) 3 / 19 (16%) 2 / 19 (11%) 0.158 0.105
PWY-3801~sucrose degradation II (sucrose synthase) 0.57 0.97 1 0.9 0.99 1 0.0051 0.0051 0.0038 0.0047 0.0043 0.0028 0.0054 0.0037 0.0056 0.2 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6519~8-amino-7-oxononanoate biosynthesis I 0.25 0.97 1 0.38 0.91 1 0.0028 0.0011 0 0.0013 0 0.0027 0.00084 0 0.0018 -0.63 15 / 38 (39%) 8 / 19 (42%) 7 / 19 (37%) 0.421 0.368
PWY4FS-7~phosphatidylglycerol biosynthesis I (plastidic) 0.92 0.98 1 0.52 0.93 1 0.00092 0.00078 0.00073 0.00081 0.00091 0.00069 0.00074 0.00054 0.00066 -0.13 32 / 38 (84%) 15 / 19 (79%) 17 / 19 (89%) 0.789 0.895
PWY0-162~superpathway of pyrimidine ribonucleotides de novo biosynthesis 0.78 0.97 1 0.59 0.94 1 0.0041 0.0038 0.0026 0.0035 0.0024 0.0033 0.0042 0.003 0.0073 0.26 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
PWY-5674~nitrate reduction IV (dissimilatory) 0.37 0.97 1 0.55 0.93 1 0.00055 0.00016 0 0.00014 0 0.00043 0.00017 0 0.00045 0.28 11 / 38 (29%) 5 / 19 (26%) 6 / 19 (32%) 0.263 0.316
PWY-3282~superpathway of ammonia assimilation (plants) 0.57 0.97 1 0.33 0.91 1 0.033 0.033 0.032 0.033 0.033 0.0096 0.032 0.032 0.01 -0.044 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6545~pyrimidine deoxyribonucleotides de novo biosynthesis III 0.17 0.97 1 0.14 0.91 1 0.0013 0.00027 0 2e-04 0 7e-04 0.00034 0 0.00088 0.77 8 / 38 (21%) 2 / 19 (11%) 6 / 19 (32%) 0.105 0.316
PWY-6610~adenine salvage 0.062 0.97 1 0.081 0.91 1 0.0056 0.0056 0.0058 0.0053 0.0054 0.0019 0.0058 0.006 0.0015 0.13 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6590~superpathway of Clostridium acetobutylicum acidogenic fermentation 0.61 0.97 1 0.52 0.93 1 6e-04 0.00035 0.00022 0.00036 0.00034 0.00039 0.00033 0.00014 0.00053 -0.13 22 / 38 (58%) 12 / 19 (63%) 10 / 19 (53%) 0.632 0.526
PWY-6348~phosphate acquisition 0.28 0.97 1 0.2 0.91 1 0.0026 0.0024 0.0017 0.0026 0.0014 0.0028 0.0022 0.0018 0.0037 -0.24 35 / 38 (92%) 18 / 19 (95%) 17 / 19 (89%) 0.947 0.895
PWY-6389~pyruvate fermentation to (S)-acetoin 0.31 0.97 1 0.22 0.91 1 0.0022 0.0018 0.001 0.0015 0.00081 0.0026 0.002 0.0011 0.0028 0.42 30 / 38 (79%) 14 / 19 (74%) 16 / 19 (84%) 0.737 0.842
P23-PWY~reductive TCA cycle I 0.36 0.97 1 0.25 0.91 1 0.0013 0.00021 0 0.00026 0 0.00066 0.00017 0 0.00052 -0.61 6 / 38 (16%) 3 / 19 (16%) 3 / 19 (16%) 0.158 0.158
PWY-5297~siroheme amide biosynthesis 0.6 0.97 1 0.48 0.91 1 0.00026 4e-05 0 4e-05 0 0.00015 4.1e-05 0 8.6e-05 0.036 6 / 38 (16%) 2 / 19 (11%) 4 / 19 (21%) 0.105 0.211
PWY3O-4106~NAD salvage pathway IV (from nicotinamide riboside) 0.69 0.97 1 0.93 0.99 1 0.00052 0.00022 0 0.00017 0 0.00039 0.00026 0 0.00065 0.61 16 / 38 (42%) 8 / 19 (42%) 8 / 19 (42%) 0.421 0.421
PWY66-366~flavin biosynthesis IV (mammalian) 0.6 0.97 1 0.34 0.91 1 0.011 0.011 0.011 0.011 0.011 0.0017 0.011 0.011 0.0019 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5981~CDP-diacylglycerol biosynthesis III 0.87 0.97 1 0.74 0.98 1 0.0097 0.0097 0.0094 0.0098 0.011 0.0027 0.0096 0.009 0.0021 -0.03 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1587~N6-L-threonylcarbamoyladenosine37-modified tRNA biosynthesis 0.31 0.97 1 0.048 0.91 1 0.0098 0.0098 0.01 0.01 0.0098 0.0019 0.0095 0.01 0.0024 -0.074 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
MANNCAT-PWY~D-mannose degradation 0.52 0.97 1 0.61 0.96 1 0.007 0.007 0.0065 0.0074 0.0066 0.0034 0.0066 0.0064 0.0027 -0.17 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7335~UDP-N-acetyl-α-D-mannosaminouronate biosynthesis 0.52 0.97 1 0.5 0.93 1 0.0015 0.00044 0 0.00054 0 0.0011 0.00035 0 0.00081 -0.63 11 / 38 (29%) 6 / 19 (32%) 5 / 19 (26%) 0.316 0.263
UDPNAGSYN-PWY~UDP-N-acetyl-D-glucosamine biosynthesis I 0.69 0.97 1 0.86 0.99 1 0.0071 0.0071 0.0059 0.0067 0.0065 0.0035 0.0074 0.0051 0.0056 0.14 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7204~pyridoxal 5-phosphate salvage II (plants) 0.6 0.97 1 0.98 0.99 1 0.00083 0.00044 0.00019 0.00043 0 0.00058 0.00044 0.00026 0.00071 0.033 20 / 38 (53%) 9 / 19 (47%) 11 / 19 (58%) 0.474 0.579
GLYCOGENSYNTH-PWY~glycogen biosynthesis I (from ADP-D-Glucose) 0.55 0.97 1 0.92 0.99 1 0.036 0.036 0.037 0.035 0.039 0.01 0.037 0.037 0.015 0.08 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1391~S-methyl-5-thioadenosine degradation IV 0.4 0.97 1 0.34 0.91 1 0.00024 5.7e-05 0 5.5e-05 0 0.00015 5.9e-05 0 0.00014 0.1 9 / 38 (24%) 3 / 19 (16%) 6 / 19 (32%) 0.158 0.316
PWY-6381~bisucaberin biosynthesis 0.24 0.97 1 0.26 0.91 1 0.005 0.0049 0.0049 0.0048 0.0049 0.0024 0.0051 0.0051 0.0027 0.087 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-5910~superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 0.64 0.97 1 0.54 0.93 1 0.00025 3.3e-05 0 3.9e-05 0 0.00011 2.7e-05 0 9.6e-05 -0.53 5 / 38 (13%) 3 / 19 (16%) 2 / 19 (11%) 0.158 0.105
PWY-4381~fatty acid biosynthesis initiation I 0.52 0.97 1 0.48 0.91 1 0.009 0.009 0.0084 0.0092 0.0088 0.0029 0.0087 0.0073 0.0026 -0.081 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7664~oleate biosynthesis IV (anaerobic) 0.095 0.97 1 0.2 0.91 1 0.0048 0.0048 0.0034 0.0052 0.0042 0.0042 0.0043 0.003 0.0045 -0.27 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY66-426~hydrogen sulfide biosynthesis II (mammalian) 0.26 0.97 1 0.32 0.91 1 0.0023 0.00018 0 0.00013 0 0.00056 0.00024 0 0.00074 0.88 3 / 38 (7.9%) 1 / 19 (5.3%) 2 / 19 (11%) 0.0526 0.105
PWY-6595~superpathway of guanosine nucleotides degradation (plants) 0.27 0.97 1 0.46 0.91 1 0.0014 0.00046 0 0.00035 0 0.00066 0.00058 0 0.00091 0.73 13 / 38 (34%) 6 / 19 (32%) 7 / 19 (37%) 0.316 0.368
SAM-PWY~S-adenosyl-L-methionine biosynthesis 0.92 0.98 1 0.6 0.95 1 0.024 0.024 0.023 0.024 0.024 0.0052 0.023 0.023 0.0059 -0.061 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7179~purine deoxyribonucleosides degradation I 0.13 0.97 1 0.069 0.91 1 0.0036 0.0036 0.0032 0.0034 0.0031 0.0018 0.0039 0.0032 0.0022 0.2 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1275~lipoate biosynthesis and incorporation II 0.33 0.97 1 0.33 0.91 1 0.00039 8.1e-05 0 4.3e-05 0 0.00012 0.00012 0 0.00036 1.5 8 / 38 (21%) 3 / 19 (16%) 5 / 19 (26%) 0.158 0.263
PANTO-PWY~phosphopantothenate biosynthesis I 0.05 0.97 1 0.03 0.91 1 0.0029 0.0029 0.0027 0.0033 0.0028 0.0016 0.0024 0.0018 0.0014 -0.46 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7996~menaquinol-4 biosynthesis I 0.83 0.97 1 0.96 0.99 1 0.0057 0.0057 0.0056 0.0056 0.0056 0.0021 0.0057 0.0055 0.0018 0.026 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLYCOLYSIS~glycolysis I (from glucose 6-phosphate) 0.077 0.97 1 0.011 0.75 1 0.011 0.011 0.012 0.012 0.013 0.0031 0.01 0.01 0.003 -0.26 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-3001~superpathway of L-isoleucine biosynthesis I 0.49 0.97 1 0.2 0.91 1 0.017 0.017 0.017 0.018 0.018 0.0048 0.017 0.016 0.0071 -0.082 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5695~inosine 5-phosphate degradation 0.97 0.99 1 0.82 0.99 1 0.0064 0.0064 0.0061 0.0064 0.0057 0.0026 0.0064 0.0064 0.0023 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLCMANNANAUT-PWY~superpathway of N-acetylglucosamine N-acetylmannosamine and N-acetylneuraminate degradation 0.96 0.99 1 0.83 0.99 1 0.0045 0.0045 0.0045 0.0045 0.0037 0.0022 0.0044 0.0046 0.0018 -0.032 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5849~menaquinol-6 biosynthesis 0.83 0.97 1 0.96 0.99 1 0.0057 0.0057 0.0056 0.0056 0.0056 0.0021 0.0057 0.0055 0.0018 0.026 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5516~D-xylose degradation II 0.04 0.97 1 0.032 0.91 1 0.00084 0.00084 0.00082 0.00074 0.00076 0.00032 0.00094 0.00097 0.00042 0.35 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1317~L-lactaldehyde degradation (aerobic) 0.81 0.97 1 0.56 0.93 1 0.0012 0.00042 0 0.00046 0 0.0011 0.00039 0 0.00071 -0.24 14 / 38 (37%) 6 / 19 (32%) 8 / 19 (42%) 0.316 0.421
BIOTIN-BIOSYNTHESIS-PWY~biotin biosynthesis I 0.27 0.97 1 0.58 0.94 1 0.0026 0.00096 0 0.0012 0 0.0024 7e-04 0 0.0015 -0.78 14 / 38 (37%) 7 / 19 (37%) 7 / 19 (37%) 0.368 0.368
P41-PWY~pyruvate fermentation to acetate and (S)-lactate I 0.32 0.97 1 0.3 0.91 1 0.0028 0.0028 0.0017 0.0023 0.0016 0.0021 0.0033 0.002 0.0047 0.52 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-5482~pyruvate fermentation to acetate II 0.33 0.97 1 0.32 0.91 1 0.0029 0.0029 0.0018 0.0024 0.0015 0.0021 0.0034 0.0022 0.0048 0.5 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-5886~4-hydroxyphenylpyruvate biosynthesis 0.28 0.97 1 0.26 0.91 1 0.00082 0.00065 0.00046 0.00053 0.00045 0.00056 0.00077 0.00053 0.00089 0.54 30 / 38 (79%) 14 / 19 (74%) 16 / 19 (84%) 0.737 0.842
PWY-723~alkylnitronates degradation 0.08 0.97 1 0.59 0.94 1 0.00026 4.1e-05 0 3.6e-05 0 0.00011 4.6e-05 0 0.00014 0.35 6 / 38 (16%) 3 / 19 (16%) 3 / 19 (16%) 0.158 0.158
PWY-5851~demethylmenaquinol-9 biosynthesis 0.46 0.97 1 0.4 0.91 1 0.0029 0.0027 0.0018 0.0028 0.0028 0.0022 0.0027 0.00097 0.0041 -0.052 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
PWY-6028~acetoin degradation 0.95 0.99 1 0.8 0.99 1 0.00036 8.5e-05 0 7.8e-05 0 0.00023 9.1e-05 0 0.00023 0.22 9 / 38 (24%) 5 / 19 (26%) 4 / 19 (21%) 0.263 0.211
PWY-6536~4-aminobutanoate degradation III 0.76 0.97 1 0.35 0.91 1 0.00092 7.3e-05 0 6.5e-05 0 0.00027 8.1e-05 0 0.00035 0.32 3 / 38 (7.9%) 2 / 19 (11%) 1 / 19 (5.3%) 0.105 0.0526
PWY0-845~superpathway of pyridoxal 5-phosphate biosynthesis and salvage 0.13 0.97 1 0.14 0.91 1 0.0022 0.00047 0 7e-04 0 0.0016 0.00024 0 0.00058 -1.5 8 / 38 (21%) 5 / 19 (26%) 3 / 19 (16%) 0.263 0.158
PWY-6353~purine nucleotides degradation II (aerobic) 0.66 0.97 1 0.9 0.99 1 0.0058 0.0058 0.0057 0.0057 0.0052 0.0022 0.0059 0.0065 0.002 0.05 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
P4-PWY~superpathway of L-lysine L-threonine and L-methionine biosynthesis I 0.9 0.98 1 0.73 0.97 1 0.0038 0.0028 0.0014 0.0024 0.0012 0.0027 0.0032 0.0016 0.0066 0.42 28 / 38 (74%) 14 / 19 (74%) 14 / 19 (74%) 0.737 0.737
ARGDEG-III-PWY~L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) 0.85 0.97 1 0.68 0.96 1 0.0067 0.0067 0.0062 0.0067 0.0059 0.0026 0.0068 0.0066 0.0026 0.021 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-701~L-methionine degradation II 0.77 0.97 1 0.82 0.99 1 0.00018 0.00011 8.4e-05 0.00011 7.5e-05 0.00016 0.00011 8.7e-05 0.00016 0 23 / 38 (61%) 11 / 19 (58%) 12 / 19 (63%) 0.579 0.632
ALACAT2-PWY~L-alanine degradation II (to D-lactate) 0.77 0.97 1 0.61 0.96 1 0.0012 0.00043 0 0.00055 0 0.0012 0.00031 0 0.00057 -0.83 14 / 38 (37%) 6 / 19 (32%) 8 / 19 (42%) 0.316 0.421
PWY0-1466~trehalose degradation VI (periplasmic) 0.88 0.98 1 0.76 0.99 1 0.0028 0.0018 0.00094 0.0022 0.00086 0.0043 0.0015 0.001 0.0019 -0.55 25 / 38 (66%) 12 / 19 (63%) 13 / 19 (68%) 0.632 0.684
PWY-6897~thiamine salvage II 0.84 0.97 1 0.36 0.91 1 0.01 0.01 0.01 0.01 0.011 0.0028 0.01 0.0094 0.0045 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5964~guanylyl molybdenum cofactor biosynthesis 0.032 0.97 1 0.018 0.91 1 0.0016 0.0016 0.0015 0.0014 0.001 0.0011 0.0018 0.0016 0.00074 0.36 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5345~superpathway of L-methionine biosynthesis (by sulfhydrylation) 0.76 0.97 1 0.47 0.91 1 0.0053 0.0049 0.0043 0.0051 0.0043 0.0031 0.0048 0.0043 0.0025 -0.087 35 / 38 (92%) 18 / 19 (95%) 17 / 19 (89%) 0.947 0.895
PWY-6892~thiazole biosynthesis I (facultative anaerobic bacteria) 0.0096 0.76 1 0.0063 0.62 1 0.00058 0.00034 0.00019 0.00025 0 0.00043 0.00043 0.00045 0.00037 0.78 22 / 38 (58%) 8 / 19 (42%) 14 / 19 (74%) 0.421 0.737
PWY-5489~methyl parathion degradation 0.59 0.97 1 0.75 0.98 1 0.00045 8.3e-05 0 1e-04 0 4e-04 6.2e-05 0 0.00022 -0.69 7 / 38 (18%) 4 / 19 (21%) 3 / 19 (16%) 0.211 0.158
PWY-6333~acetaldehyde biosynthesis I 1 1 1 0.72 0.97 1 0.027 0.027 0.026 0.027 0.027 0.0081 0.027 0.026 0.0078 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7622~UDP-α-D-galactofuranose biosynthesis 0.74 0.97 1 0.9 0.99 1 0.022 0.022 0.02 0.022 0.02 0.0072 0.023 0.021 0.0089 0.064 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-1881~formate oxidation to CO2 0.19 0.97 1 0.57 0.93 1 0.00079 0.00058 2e-04 0.00044 0.00019 0.00069 0.00072 0.00024 0.0011 0.71 28 / 38 (74%) 14 / 19 (74%) 14 / 19 (74%) 0.737 0.737
PWY-6893~thiamine diphosphate biosynthesis II (Bacillus) 0.072 0.97 1 0.19 0.91 1 0.0015 0.0012 0.00073 0.0015 0.001 0.0017 0.00083 0.00048 0.001 -0.85 30 / 38 (79%) 16 / 19 (84%) 14 / 19 (74%) 0.842 0.737
RIBOSYN2-PWY~flavin biosynthesis I (bacteria and plants) 0.15 0.97 1 0.11 0.91 1 0.0054 0.0054 0.0055 0.0058 0.0059 0.002 0.005 0.005 0.0017 -0.21 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
ARGDEGRAD-PWY~L-arginine degradation V (arginine deiminase pathway) 0.036 0.97 1 0.15 0.91 1 0.0015 0.0013 0.0011 0.00094 0.00082 0.00076 0.0017 0.0019 0.0013 0.85 33 / 38 (87%) 16 / 19 (84%) 17 / 19 (89%) 0.842 0.895
PWY-6126~superpathway of adenosine nucleotides de novo biosynthesis II 0.87 0.97 1 0.68 0.96 1 0.0016 0.0011 0.00061 0.0012 4e-04 0.0019 0.0011 0.00062 0.0013 -0.13 27 / 38 (71%) 13 / 19 (68%) 14 / 19 (74%) 0.684 0.737
P185-PWY~formaldehyde assimilation III (dihydroxyacetone cycle) 0.95 0.99 1 0.84 0.99 1 0.0073 0.0073 0.0075 0.0073 0.0073 0.0026 0.0073 0.0077 0.0027 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5852~demethylmenaquinol-8 biosynthesis I 0.46 0.97 1 0.4 0.91 1 0.0029 0.0027 0.0018 0.0028 0.0028 0.0022 0.0027 0.00097 0.0041 -0.052 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
PWY-7796~pentose phosphate pathway (oxidative branch) II 0.034 0.97 1 0.034 0.91 1 0.00051 0.00043 0.00035 0.00057 0.00048 0.00054 0.00029 0.00027 0.00027 -0.97 32 / 38 (84%) 18 / 19 (95%) 14 / 19 (74%) 0.947 0.737
HOMOSERSYN-PWY~L-homoserine biosynthesis 0.32 0.97 1 0.24 0.91 1 0.02 0.02 0.02 0.021 0.02 0.0036 0.02 0.019 0.0051 -0.07 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6894~thiamine diphosphate biosynthesis I (E. coli) 0.072 0.97 1 0.19 0.91 1 0.0015 0.0012 0.00073 0.0015 0.001 0.0017 0.00083 0.00048 0.001 -0.85 30 / 38 (79%) 16 / 19 (84%) 14 / 19 (74%) 0.842 0.737
P441-PWY~superpathway of N-acetylneuraminate degradation 0.51 0.97 1 0.64 0.96 1 0.0058 0.0058 0.0056 0.0056 0.0045 0.0035 0.006 0.0066 0.003 0.1 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7181~pyrimidine deoxyribonucleosides degradation 0.03 0.97 1 0.11 0.91 1 0.0029 0.0029 0.0028 0.0034 0.0028 0.0016 0.0024 0.0021 0.0012 -0.5 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7210~pyrimidine deoxyribonucleotides biosynthesis from CTP 0.12 0.97 1 0.093 0.91 1 0.00067 5.3e-05 0 0 0 0 0.00011 0 0.00038 Inf 3 / 38 (7.9%) 0 / 19 (0%) 3 / 19 (16%) 0 0.158
PWY-6349~CDP-archaeol biosynthesis 0.17 0.97 1 0.26 0.91 1 0.00019 1.5e-05 0 3.9e-06 0 1.7e-05 2.6e-05 0 7.7e-05 2.7 3 / 38 (7.9%) 1 / 19 (5.3%) 2 / 19 (11%) 0.0526 0.105
SER-GLYSYN-PWY~superpathway of L-serine and glycine biosynthesis I 0.55 0.97 1 0.97 0.99 1 0.0087 0.0087 0.008 0.0082 0.0082 0.0031 0.0092 0.0078 0.0059 0.17 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLYCINE-SYN2-PWY~glycine biosynthesis II 0.69 0.97 1 0.45 0.91 1 0.0021 0.0019 0.00089 0.0021 0.00082 0.0028 0.0018 0.00097 0.0022 -0.22 35 / 38 (92%) 18 / 19 (95%) 17 / 19 (89%) 0.947 0.895
PWY-7997~demethylmenaquinol-4 biosynthesis 0.46 0.97 1 0.4 0.91 1 0.0029 0.0027 0.0018 0.0028 0.0028 0.0022 0.0027 0.00097 0.0041 -0.052 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
ASPASN-PWY~superpathway of L-aspartate and L-asparagine biosynthesis 0.57 0.97 1 0.62 0.96 1 0.0029 0.0028 0.0024 0.0031 0.0023 0.0024 0.0026 0.0026 0.0016 -0.25 37 / 38 (97%) 19 / 19 (100%) 18 / 19 (95%) 1 0.947
PWY-6053~dimethylsulfoniopropanoate biosynthesis III (algae) 0.41 0.97 1 0.32 0.91 1 0.00044 9.3e-05 0 9e-05 0 0.00026 9.7e-05 0 3e-04 0.11 8 / 38 (21%) 3 / 19 (16%) 5 / 19 (26%) 0.158 0.263
PWY-6507~4-deoxy-L-threo-hex-4-enopyranuronate degradation 0.85 0.97 1 0.55 0.93 1 0.00096 2e-04 0 0.00018 0 0.00041 0.00022 0 0.00055 0.29 8 / 38 (21%) 5 / 19 (26%) 3 / 19 (16%) 0.263 0.158
PWY-7228~superpathway of guanosine nucleotides de novo biosynthesis I 0.21 0.97 1 0.056 0.91 1 0.0014 0.0012 0.00084 0.0012 0.001 0.0015 0.0013 0.00072 0.0011 0.12 34 / 38 (89%) 15 / 19 (79%) 19 / 19 (100%) 0.789 1
PWY-7194~pyrimidine nucleobases salvage II 0.64 0.97 1 0.52 0.93 1 0.0013 0.0011 0.00064 0.001 0.00066 0.0011 0.0012 0.00059 0.0015 0.26 33 / 38 (87%) 16 / 19 (84%) 17 / 19 (89%) 0.842 0.895
PWY-5731~atrazine degradation III 0.67 0.97 1 0.85 0.99 1 0.00055 0.00025 0 0.00031 0 0.00051 0.00019 0 0.00026 -0.71 17 / 38 (45%) 8 / 19 (42%) 9 / 19 (47%) 0.421 0.474
PWY-7791~UMP biosynthesis III 0.056 0.97 1 0.063 0.91 1 0.024 0.024 0.024 0.025 0.025 0.0045 0.023 0.021 0.0071 -0.12 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6131~glycerol degradation II 0.018 0.97 1 0.023 0.91 1 0.0022 0.0022 0.0019 0.0026 0.0022 0.0017 0.0017 0.0016 0.00095 -0.61 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
TYRSYN~L-tyrosine biosynthesis I 0.43 0.97 1 0.48 0.91 1 0.00095 6e-04 0.00031 0.00049 0.00018 0.00057 7e-04 0.00036 0.00082 0.51 24 / 38 (63%) 11 / 19 (58%) 13 / 19 (68%) 0.579 0.684
PWY-6609~adenine and adenosine salvage III 0.2 0.97 1 0.25 0.91 1 0.0031 0.0031 0.0027 0.0029 0.0028 0.0016 0.0032 0.0027 0.0019 0.14 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-7227~adenosine deoxyribonucleotides de novo biosynthesis 0.53 0.97 1 0.25 0.91 1 0.0017 0.0014 0.00066 0.0014 0.00053 0.0022 0.0013 0.00067 0.0016 -0.11 31 / 38 (82%) 14 / 19 (74%) 17 / 19 (89%) 0.737 0.895
NAD-BIOSYNTHESIS-II~NAD salvage pathway III (to nicotinamide riboside) 0.049 0.97 1 0.044 0.91 1 0.0043 0.0041 0.0032 0.0046 0.0045 0.0035 0.0036 0.0021 0.0049 -0.35 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
ARGININE-SYN4-PWY~L-ornithine biosynthesis II 0.43 0.97 1 0.68 0.96 1 0.0011 0.00018 0 0.00026 0 0.00078 0.00011 0 0.00029 -1.2 6 / 38 (16%) 3 / 19 (16%) 3 / 19 (16%) 0.158 0.158
PWY-7639~bis(guanylyl molybdenum cofactor) biosynthesis 0.032 0.97 1 0.018 0.91 1 0.0016 0.0016 0.0015 0.0014 0.001 0.0011 0.0018 0.0016 0.00074 0.36 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5142~acyl-[acyl-carrier protein] thioesterase pathway 0.98 0.99 1 0.56 0.93 1 0.0017 0.0016 0.0015 0.0017 0.0015 0.0012 0.0016 0.0016 0.0012 -0.087 36 / 38 (95%) 17 / 19 (89%) 19 / 19 (100%) 0.895 1
PWY-1722~formate assimilation into 510-methylenetetrahydrofolate 0.88 0.98 1 0.72 0.97 1 0.016 0.016 0.016 0.016 0.015 0.0025 0.016 0.016 0.0037 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY3O-4107~NAD salvage pathway V (PNC V cycle) 0.84 0.97 1 0.71 0.97 1 0.0023 0.0018 0.00093 0.0014 0.00093 0.0017 0.0021 0.00093 0.005 0.58 29 / 38 (76%) 15 / 19 (79%) 14 / 19 (74%) 0.789 0.737
SALVADEHYPOX-PWY~adenosine nucleotides degradation II 0.38 0.97 1 0.5 0.93 1 0.0078 0.0078 0.0076 0.0076 0.0061 0.0028 0.008 0.0084 0.0025 0.074 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5994~palmitate biosynthesis I (animals and fungi) 0.21 0.97 1 0.091 0.91 1 0.0049 0.0043 0.0033 0.0043 0.0034 0.0038 0.0043 0.0025 0.0057 0 33 / 38 (87%) 17 / 19 (89%) 16 / 19 (84%) 0.895 0.842
CITRULBIO-PWY~L-citrulline biosynthesis 0.67 0.97 1 0.96 0.99 1 0.0013 0.00038 0 0.00047 0 0.0011 0.00029 0 0.00061 -0.7 11 / 38 (29%) 5 / 19 (26%) 6 / 19 (32%) 0.263 0.316
PWY0-1301~melibiose degradation 0.57 0.97 1 0.44 0.91 1 0.057 0.057 0.054 0.058 0.055 0.02 0.056 0.054 0.021 -0.051 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PROUT-PWY~L-proline degradation 0.99 0.99 1 0.6 0.95 1 0.0019 0.00069 0 8e-04 0 0.0018 0.00058 0 0.001 -0.46 14 / 38 (37%) 6 / 19 (32%) 8 / 19 (42%) 0.316 0.421
PWY-6614~tetrahydrofolate biosynthesis 0.17 0.97 1 0.95 0.99 1 0.0017 0.0016 0.0013 0.0017 0.0014 0.0011 0.0015 0.0012 9e-04 -0.18 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-6646~fluoroacetate degradation 0.86 0.97 1 0.81 0.99 1 0.0018 0.0016 0.0012 0.0016 0.0011 0.0017 0.0016 0.0014 0.0013 0 34 / 38 (89%) 17 / 19 (89%) 17 / 19 (89%) 0.895 0.895
PWY-6121~5-aminoimidazole ribonucleotide biosynthesis I 0.83 0.97 1 0.66 0.96 1 0.023 0.023 0.023 0.023 0.023 0.0044 0.024 0.023 0.008 0.061 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PANTOSYN-PWY~superpathway of coenzyme A biosynthesis I (bacteria) 0.16 0.97 1 0.11 0.91 1 0.004 0.004 0.0042 0.0043 0.0043 0.0015 0.0037 0.0039 0.0014 -0.22 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1582~glycerol-3-phosphate to fumarate electron transfer 0.87 0.97 1 0.79 0.99 1 0.0012 0.00049 0 0.00049 0 0.00085 5e-04 0 0.00089 0.029 15 / 38 (39%) 7 / 19 (37%) 8 / 19 (42%) 0.368 0.421
GLUCONSUPER-PWY~D-gluconate degradation 0.31 0.97 1 0.026 0.91 1 0.0014 0.0011 0.00039 0.0011 0.00049 0.0012 0.0012 0.00028 0.0031 0.13 32 / 38 (84%) 17 / 19 (89%) 15 / 19 (79%) 0.895 0.789
PWY-5892~menaquinol-12 biosynthesis 0.24 0.97 1 0.48 0.91 1 0.0015 0.00073 6.1e-05 0.00093 0.00012 0.0015 0.00052 0 0.00089 -0.84 19 / 38 (50%) 10 / 19 (53%) 9 / 19 (47%) 0.526 0.474
ARG%2bPOLYAMINE-SYN~superpathway of arginine and polyamine biosynthesis 0.44 0.97 1 0.3 0.91 1 0.0014 0.00072 0.00014 0.00069 0 0.0013 0.00075 6e-04 0.00083 0.12 19 / 38 (50%) 8 / 19 (42%) 11 / 19 (58%) 0.421 0.579
PWY0-1264~biotin-carboxyl carrier protein assembly 0.78 0.97 1 0.95 0.99 1 0.0085 0.0085 0.0075 0.0084 0.0075 0.0033 0.0085 0.0074 0.0028 0.017 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
GLYCEROLMETAB-PWY~glycerol degradation V 0.059 0.97 1 0.1 0.91 1 0.0027 0.0027 0.0023 0.0032 0.0025 0.0023 0.0022 0.0019 0.0013 -0.54 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1280~ethylene glycol degradation 0.86 0.97 1 0.43 0.91 1 0.001 0.00035 0 0.00041 0 0.00093 0.00029 0 0.00049 -0.5 13 / 38 (34%) 5 / 19 (26%) 8 / 19 (42%) 0.263 0.421
PWY-3841~folate transformations II 0.67 0.97 1 0.32 0.91 1 0.0096 0.0096 0.0094 0.0096 0.0099 0.0019 0.0095 0.0092 0.0041 -0.015 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-4981~L-proline biosynthesis II (from arginine) 0.66 0.97 1 0.29 0.91 1 0.00097 7.6e-05 0 6.9e-05 0 0.00028 8.4e-05 0 0.00036 0.28 3 / 38 (7.9%) 2 / 19 (11%) 1 / 19 (5.3%) 0.105 0.0526
PWY0-1300~2-O-α-mannosyl-D-glycerate degradation 0.25 0.97 1 0.29 0.91 1 0.00021 4.4e-05 0 2.6e-05 0 7.9e-05 6.2e-05 0 0.00013 1.3 8 / 38 (21%) 3 / 19 (16%) 5 / 19 (26%) 0.158 0.263
PWY-7200~superpathway of pyrimidine deoxyribonucleoside salvage 0.1 0.97 1 0.1 0.91 1 0.00044 5.8e-05 0 3.1e-05 0 0.00014 8.5e-05 0 0.00022 1.5 5 / 38 (13%) 1 / 19 (5.3%) 4 / 19 (21%) 0.0526 0.211
ALANINE-SYN2-PWY~L-alanine biosynthesis II 0.67 0.97 1 0.19 0.91 1 0.0072 0.0072 0.0064 0.007 0.0069 0.0034 0.0075 0.005 0.008 0.1 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7625~phosphatidylinositol biosynthesis II (eukaryotes) 0.75 0.97 1 0.3 0.91 1 0.0012 0.001 0.00058 0.00094 6e-04 0.00097 0.0011 0.00042 0.0026 0.23 32 / 38 (84%) 16 / 19 (84%) 16 / 19 (84%) 0.842 0.842
P122-PWY~heterolactic fermentation 0.91 0.98 1 0.65 0.96 1 0.003 0.0022 0.0011 0.0019 0.0012 0.002 0.0025 0.00088 0.0049 0.4 28 / 38 (74%) 14 / 19 (74%) 14 / 19 (74%) 0.737 0.737
TREDEGLOW-PWY~trehalose degradation I (low osmolarity) 0.5 0.97 1 0.57 0.93 1 0.0035 0.0035 0.0024 0.0034 0.0024 0.0025 0.0036 0.0023 0.0037 0.082 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5512~UDP-N-acetyl-D-galactosamine biosynthesis I 0.75 0.97 1 0.85 0.99 1 0.00041 9.8e-05 0 0.00012 0 0.00031 7.7e-05 0 2e-04 -0.64 9 / 38 (24%) 4 / 19 (21%) 5 / 19 (26%) 0.211 0.263
PWY-6151~S-adenosyl-L-methionine cycle I 0.7 0.97 1 0.88 0.99 1 0.0087 0.0087 0.0085 0.0082 0.0085 0.0029 0.0091 0.008 0.0059 0.15 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5350~thiosulfate disproportionation IV (rhodanese) 0.61 0.97 1 0.9 0.99 1 0.0095 0.0095 0.0088 0.0092 0.0085 0.0035 0.0097 0.0091 0.0039 0.076 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
VALSYN-PWY~L-valine biosynthesis 0.74 0.97 1 0.87 0.99 1 0.023 0.023 0.023 0.023 0.023 0.0053 0.023 0.023 0.0069 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
THIOREDOX-PWY~thioredoxin pathway 0.73 0.97 1 0.85 0.99 1 0.028 0.028 0.029 0.027 0.029 0.007 0.028 0.028 0.0086 0.052 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7842~UDP-yelosamine biosynthesis 0.021 0.97 1 0.0072 0.62 1 0.00057 7.5e-05 0 0.00015 0 0.00031 0 0 0 -Inf 5 / 38 (13%) 5 / 19 (26%) 0 / 19 (0%) 0.263 0
PWY-6698~oxalate degradation V 0.49 0.97 1 0.36 0.91 1 0.00075 0.00075 0.00058 0.00078 0.00062 0.00059 0.00071 0.00052 0.00061 -0.14 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
ARO-PWY~chorismate biosynthesis I 0.75 0.97 1 0.85 0.99 1 0.011 0.011 0.011 0.011 0.011 0.0036 0.012 0.0098 0.0052 0.13 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6143~CMP-pseudaminate biosynthesis 0.21 0.97 1 0.2 0.91 1 0.00083 0.00015 0 0.00019 0 0.00047 0.00011 0 0.00029 -0.79 7 / 38 (18%) 4 / 19 (21%) 3 / 19 (16%) 0.211 0.158
ANAGLYCOLYSIS-PWY~glycolysis III (from glucose) 0.43 0.97 1 0.22 0.91 1 0.015 0.015 0.015 0.016 0.015 0.003 0.015 0.015 0.0047 -0.093 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-381~glycerol and glycerophosphodiester degradation 0.5 0.97 1 0.31 0.91 1 0.00096 0.00038 0 4e-04 0 0.00076 0.00036 0 0.00073 -0.15 15 / 38 (39%) 9 / 19 (47%) 6 / 19 (32%) 0.474 0.316
GLYSYN-ALA-PWY~glycine biosynthesis III 0.16 0.97 1 0.31 0.91 1 0.00077 0.00042 0.00012 0.00027 5.4e-05 0.00043 0.00058 0.00035 0.00076 1.1 21 / 38 (55%) 10 / 19 (53%) 11 / 19 (58%) 0.526 0.579
PWY-6613~tetrahydrofolate salvage from 510-methenyltetrahydrofolate 0.67 0.97 1 0.88 0.99 1 0.0093 0.0093 0.0094 0.0091 0.0092 0.0014 0.0094 0.0099 0.0021 0.047 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6785~hydrogen production VIII 0.76 0.97 1 0.9 0.99 1 0.03 0.03 0.03 0.03 0.03 0.009 0.03 0.031 0.008 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6588~pyruvate fermentation to acetone 0.0015 0.33 0.84 0.0035 0.62 1 0.0014 0.0011 0.0011 0.0016 0.0015 0.0011 0.00068 5e-04 0.00072 -1.2 31 / 38 (82%) 18 / 19 (95%) 13 / 19 (68%) 0.947 0.684
PWY-6512~hydrogen oxidation III (anaerobic NADP) 0.63 0.97 1 0.28 0.91 1 0.0012 0.00062 1.6e-05 0.00066 0 0.0013 0.00057 0.00017 9e-04 -0.21 19 / 38 (50%) 8 / 19 (42%) 11 / 19 (58%) 0.421 0.579
PWY-43~putrescine biosynthesis II 0.85 0.97 1 0.68 0.96 1 0.0067 0.0067 0.0062 0.0067 0.0059 0.0026 0.0068 0.0066 0.0026 0.021 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5965~fatty acid biosynthesis initiation III 0.68 0.97 1 0.47 0.91 1 0.0044 0.0041 0.0024 0.004 0.0024 0.0038 0.0043 0.0025 0.0087 0.1 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
PROPIONMET-PWY~propanoyl CoA degradation I 0.82 0.97 1 0.52 0.93 1 0.0022 0.0011 0 0.0012 0 0.0027 0.00094 0.00038 0.0016 -0.35 18 / 38 (47%) 8 / 19 (42%) 10 / 19 (53%) 0.421 0.526
PWY-5121~superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) 0.53 0.97 1 0.81 0.99 1 0.0077 0.0077 0.008 0.0081 0.0085 0.0035 0.0073 0.0076 0.0026 -0.15 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5278~sulfite oxidation III 0.67 0.97 1 0.87 0.99 1 0.012 0.012 0.011 0.012 0.011 0.0039 0.012 0.012 0.0052 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5436~L-threonine degradation IV 0.56 0.97 1 0.77 0.99 1 0.0025 0.0025 0.0015 0.0021 0.0014 0.002 0.0029 0.0016 0.0047 0.47 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY66-428~L-threonine degradation V 0.72 0.97 1 0.35 0.91 1 0.00089 0.00054 0.00013 0.00058 0 9e-04 0.00049 0.00019 0.00059 -0.24 23 / 38 (61%) 9 / 19 (47%) 14 / 19 (74%) 0.474 0.737
PWY-5703~urea degradation I 0.76 0.97 1 0.71 0.97 1 0.0034 0.0026 0.00057 0.0031 0.00057 0.0047 0.0021 0.00058 0.0045 -0.56 29 / 38 (76%) 14 / 19 (74%) 15 / 19 (79%) 0.737 0.789
PWY-7345~superpathway of anaerobic sucrose degradation 0.56 0.97 1 0.99 1 1 0.0014 0.00037 0 0.00024 0 0.00047 5e-04 0 0.001 1.1 10 / 38 (26%) 5 / 19 (26%) 5 / 19 (26%) 0.263 0.263
PWY0-1324~N-acetylneuraminate and N-acetylmannosamine degradation I 0.25 0.97 1 0.23 0.91 1 0.00084 4e-04 0 0.00033 0 0.00057 0.00046 9.4e-05 0.00065 0.48 18 / 38 (47%) 8 / 19 (42%) 10 / 19 (53%) 0.421 0.526
PYRIDNUCSAL-PWY~NAD salvage pathway I (PNC VI cycle) 0.78 0.97 1 0.95 0.99 1 0.0025 0.0017 9e-04 0.0014 0.00088 0.0018 0.002 0.00092 0.0049 0.51 26 / 38 (68%) 13 / 19 (68%) 13 / 19 (68%) 0.684 0.684
PWY-2722~trehalose degradation IV 0.27 0.97 1 0.12 0.91 1 0.0011 0.00017 0 0.00019 0 0.00049 0.00016 0 0.00062 -0.25 6 / 38 (16%) 4 / 19 (21%) 2 / 19 (11%) 0.211 0.105
GLUTORN-PWY~L-ornithine biosynthesis I 0.55 0.97 1 0.43 0.91 1 0.015 0.015 0.015 0.015 0.017 0.0038 0.015 0.014 0.0043 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PEPTIDOGLYCANSYN-PWY~peptidoglycan biosynthesis I (meso-diaminopimelate containing) 0.52 0.97 1 1 1 1 0.018 0.018 0.017 0.018 0.018 0.0034 0.018 0.017 0.0054 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY1-2~L-alanine degradation IV 0.69 0.97 1 0.65 0.96 1 0.0014 0.0014 9e-04 0.0017 0.00074 0.0018 0.0011 9e-04 0.00078 -0.63 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-7560~methylerythritol phosphate pathway II 0.49 0.97 1 0.22 0.91 1 0.0073 0.0073 0.0078 0.0075 0.0079 0.0027 0.0072 0.0072 0.0029 -0.059 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5973~cis-vaccenate biosynthesis 0.1 0.97 1 0.19 0.91 1 0.0044 0.0042 0.0039 0.0048 0.0048 0.0031 0.0036 0.0033 0.0022 -0.42 37 / 38 (97%) 19 / 19 (100%) 18 / 19 (95%) 1 0.947
PWY-7234~inosine-5-phosphate biosynthesis III 0.44 0.97 1 0.33 0.91 1 0.0021 0.0019 0.0011 0.0016 0.0011 0.0016 0.0023 0.0011 0.0042 0.52 34 / 38 (89%) 16 / 19 (84%) 18 / 19 (95%) 0.842 0.947
PWY-2942~L-lysine biosynthesis III 0.41 0.97 1 0.37 0.91 1 0.0062 0.0062 0.0058 0.0066 0.0058 0.003 0.0058 0.0055 0.0025 -0.19 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
P283-PWY~hydrogen oxidation I (aerobic) 0.35 0.97 1 0.38 0.91 1 0.0013 0.00051 0 0.00044 0 0.0012 0.00058 0 0.0017 0.4 15 / 38 (39%) 7 / 19 (37%) 8 / 19 (42%) 0.368 0.421
PWY-7328~superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis 0.79 0.97 1 0.89 0.99 1 0.0052 0.005 0.0038 0.0045 0.0044 0.0029 0.0054 0.0034 0.0073 0.26 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
PWY-5805~nonaprenyl diphosphate biosynthesis I 0.45 0.97 1 0.56 0.93 1 0.00041 7.6e-05 0 5.2e-05 0 0.00013 1e-04 0 0.00028 0.94 7 / 38 (18%) 3 / 19 (16%) 4 / 19 (21%) 0.158 0.211
PWY-1269~CMP-3-deoxy-D-manno-octulosonate biosynthesis 0.27 0.97 1 0.37 0.91 1 0.0013 0.00038 0 0.00049 0 0.00089 0.00026 0 0.00052 -0.91 11 / 38 (29%) 6 / 19 (32%) 5 / 19 (26%) 0.316 0.263
PWY-5941~glycogen degradation II 0.79 0.97 1 0.71 0.97 1 0.036 0.036 0.036 0.035 0.036 0.0092 0.037 0.036 0.013 0.08 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6765~hydrogen production IV 0.63 0.97 1 0.28 0.91 1 0.0012 0.00062 1.6e-05 0.00066 0 0.0013 0.00057 0.00017 9e-04 -0.21 19 / 38 (50%) 8 / 19 (42%) 11 / 19 (58%) 0.421 0.579
PWY-6606~guanosine nucleotides degradation II 0.27 0.97 1 0.46 0.91 1 0.0016 0.00056 0 0.00042 0 0.00079 7e-04 0 0.0011 0.74 13 / 38 (34%) 6 / 19 (32%) 7 / 19 (37%) 0.316 0.368
PWY-5535~acetate and ATP formation from acetyl-CoA II 0.2 0.97 1 0.3 0.91 1 0.00093 0.00071 0.00033 0.00061 0.00022 0.001 8e-04 0.00038 0.00095 0.39 29 / 38 (76%) 15 / 19 (79%) 14 / 19 (74%) 0.789 0.737
PWY-5704~urea degradation II 0.7 0.97 1 0.62 0.96 1 0.0039 0.0039 0.0035 0.0038 0.0028 0.0022 0.0039 0.0037 0.0018 0.037 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
1CMET2-PWY~N10-formyl-tetrahydrofolate biosynthesis 0.52 0.97 1 0.45 0.91 1 0.0051 0.0051 0.0054 0.0053 0.0055 0.0019 0.0049 0.0049 0.0016 -0.11 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6717~(14)-β-D-xylan degradation 0.63 0.97 1 0.26 0.91 1 0.026 0.026 0.023 0.025 0.024 0.014 0.026 0.02 0.022 0.057 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6890~4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis 0.78 0.97 1 0.73 0.97 1 0.012 0.012 0.013 0.012 0.013 0.0031 0.013 0.013 0.0046 0.12 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
LEUSYN-PWY~L-leucine biosynthesis 0.74 0.97 1 0.81 0.99 1 0.02 0.02 0.019 0.019 0.019 0.0044 0.02 0.018 0.0062 0.074 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-1299~arginine dependent acid resistance 0.98 0.99 1 0.57 0.93 1 0.025 0.025 0.025 0.025 0.025 0.005 0.025 0.026 0.0068 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5364~sulfur reduction II (via polysulfide) 0.47 0.97 1 0.35 0.91 1 0.0012 0.00078 0.00029 0.00063 0.00012 0.00093 0.00094 0.00041 0.0024 0.58 24 / 38 (63%) 11 / 19 (58%) 13 / 19 (68%) 0.579 0.684
TRYPDEG-PWY~L-tryptophan degradation II (via pyruvate) 0.77 0.97 1 0.82 0.99 1 0.00018 0.00011 8.4e-05 0.00011 7.5e-05 0.00016 0.00011 8.7e-05 0.00016 0 23 / 38 (61%) 11 / 19 (58%) 12 / 19 (63%) 0.579 0.632
PWY-6466~pyridoxal 5-phosphate biosynthesis II 0.73 0.97 1 0.61 0.96 1 0.01 0.01 0.01 0.01 0.011 0.0039 0.01 0.01 0.0058 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5332~sulfur reduction I 0.47 0.97 1 0.35 0.91 1 0.0012 0.00078 0.00029 0.00063 0.00012 0.00093 0.00094 0.00041 0.0024 0.58 24 / 38 (63%) 11 / 19 (58%) 13 / 19 (68%) 0.579 0.684
SULFATE-CYS-PWY~superpathway of sulfate assimilation and cysteine biosynthesis 0.084 0.97 1 0.085 0.91 1 0.00086 0.00011 0 9.6e-05 0 0.00042 0.00013 0 4e-04 0.44 5 / 38 (13%) 1 / 19 (5.3%) 4 / 19 (21%) 0.0526 0.211
PWY-7013~(S)-propane-12-diol degradation 0.037 0.97 1 0.037 0.91 1 0.0017 0.0016 0.0013 0.0014 0.0011 0.0011 0.0018 0.002 8e-04 0.36 36 / 38 (95%) 17 / 19 (89%) 19 / 19 (100%) 0.895 1
NONOXIPENT-PWY~pentose phosphate pathway (non-oxidative branch) 0.68 0.97 1 0.37 0.91 1 0.017 0.017 0.017 0.017 0.018 0.0042 0.017 0.015 0.0048 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5723~Rubisco shunt 0.7 0.97 1 0.41 0.91 1 0.01 0.01 0.01 0.011 0.01 0.0032 0.01 0.011 0.0033 -0.14 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6386~UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) 0.95 0.99 1 0.63 0.96 1 0.015 0.015 0.014 0.015 0.014 0.0036 0.015 0.013 0.0054 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
P125-PWY~superpathway of (RR)-butanediol biosynthesis 0.58 0.97 1 0.67 0.96 1 0.00032 3.4e-05 0 5.3e-05 0 2e-04 1.5e-05 0 4.9e-05 -1.8 4 / 38 (11%) 2 / 19 (11%) 2 / 19 (11%) 0.105 0.105
PWY-6780~hydrogen production VI 0.18 0.97 1 0.23 0.91 1 0.008 0.008 0.007 0.0075 0.0068 0.0044 0.0085 0.0079 0.0039 0.18 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7344~UDP-α-D-galactose biosynthesis 0.75 0.97 1 0.71 0.97 1 0.033 0.033 0.031 0.033 0.031 0.008 0.034 0.031 0.01 0.043 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
CYANCAT-PWY~cyanate degradation 0.9 0.98 1 0.53 0.93 1 0.0034 0.0034 0.0027 0.0033 0.0029 0.002 0.0035 0.0027 0.0039 0.085 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
HOMOSER-METSYN-PWY~L-methionine biosynthesis I 0.93 0.98 1 0.95 0.99 1 0.00062 0.00029 0 3e-04 0 0.00056 0.00029 0 0.00049 -0.049 18 / 38 (47%) 9 / 19 (47%) 9 / 19 (47%) 0.474 0.474
ACETOACETATE-DEG-PWY~acetoacetate degradation (to acetyl CoA) 0.0055 0.5 1 0.0059 0.62 1 7e-04 0.00057 0.00059 0.00075 0.00066 0.00053 0.00038 0.00037 0.00036 -0.98 31 / 38 (82%) 18 / 19 (95%) 13 / 19 (68%) 0.947 0.684
PWY-6629~superpathway of L-tryptophan biosynthesis 0.072 0.97 1 0.14 0.91 1 0.0022 0.002 0.002 0.0023 0.0021 0.0013 0.0017 0.0016 0.0011 -0.44 34 / 38 (89%) 18 / 19 (95%) 16 / 19 (84%) 0.947 0.842
PWY0-1507~biotin biosynthesis from 8-amino-7-oxononanoate I 0.91 0.98 1 0.47 0.91 1 0.0027 0.0026 0.0022 0.0027 0.0026 0.0018 0.0025 0.0021 0.0013 -0.11 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PPGPPMET-PWY~ppGpp biosynthesis 0.32 0.97 1 0.96 0.99 1 0.0031 0.0029 0.0016 0.0032 0.0023 0.0037 0.0026 0.0015 0.0024 -0.3 35 / 38 (92%) 17 / 19 (89%) 18 / 19 (95%) 0.895 0.947
PWY-7196~superpathway of pyrimidine ribonucleosides salvage 0.4 0.97 1 0.68 0.96 1 0.00075 0.00028 0 0.00038 0 9e-04 0.00018 0 0.00033 -1.1 14 / 38 (37%) 7 / 19 (37%) 7 / 19 (37%) 0.368 0.368
PWY0-1297~superpathway of purine deoxyribonucleosides degradation 0.25 0.97 1 0.23 0.91 1 0.003 0.003 0.0024 0.0028 0.0022 0.0016 0.0032 0.0024 0.0019 0.19 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY66-422~D-galactose degradation V (Leloir pathway) 0.75 0.97 1 0.46 0.91 1 0.022 0.022 0.022 0.022 0.023 0.0054 0.022 0.022 0.0081 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
ASPARAGINE-BIOSYNTHESIS~L-asparagine biosynthesis I 0.85 0.97 1 0.63 0.96 1 0.019 0.019 0.019 0.018 0.019 0.0046 0.019 0.018 0.0079 0.078 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
P461-PWY~hexitol fermentation to lactate formate ethanol and acetate 0.029 0.97 1 0.083 0.91 1 0.0026 0.002 0.0018 0.0025 0.0022 0.002 0.0014 0.0014 0.0012 -0.84 29 / 38 (76%) 16 / 19 (84%) 13 / 19 (68%) 0.842 0.684
PWY-7966~5-methoxy-6-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP 0.59 0.97 1 0.39 0.91 1 0.0049 0.0049 0.0047 0.005 0.0047 0.0018 0.0047 0.0046 0.0014 -0.089 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5816~all trans undecaprenyl diphosphate biosynthesis 0.81 0.97 1 0.52 0.93 1 0.0012 0.0011 0.00077 0.0011 0.00084 0.0012 0.0011 0.00076 0.00091 0 33 / 38 (87%) 16 / 19 (84%) 17 / 19 (89%) 0.842 0.895
PWY-5120~geranylgeranyl diphosphate biosynthesis 0.63 0.97 1 0.75 0.98 1 0.0028 0.0028 0.002 0.0028 0.0023 0.0023 0.0028 0.002 0.0044 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5485~pyruvate fermentation to acetate IV 0.96 0.99 1 0.72 0.97 1 0.018 0.018 0.018 0.018 0.018 0.0049 0.018 0.017 0.0063 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6270~isoprene biosynthesis I 0.92 0.98 1 0.65 0.96 1 0.014 0.014 0.014 0.014 0.014 0.0034 0.014 0.013 0.0046 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-7343~UDP-α-D-glucose biosynthesis I 0.24 0.97 1 0.55 0.93 1 0.0088 0.0088 0.0079 0.008 0.0076 0.0038 0.0096 0.0084 0.0071 0.26 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
ARGASEDEG-PWY~L-arginine degradation I (arginase pathway) 0.76 0.97 1 0.82 0.99 1 0.0014 0.00033 0 0.00042 0 0.0012 0.00024 0 0.00062 -0.81 9 / 38 (24%) 4 / 19 (21%) 5 / 19 (26%) 0.211 0.263
PHENOLDEG-PWY~phenol degradation II (anaerobic) 0.14 0.97 1 0.05 0.91 1 0.00065 0.00021 0 0.00024 0 0.00053 0.00017 0 5e-04 -0.5 12 / 38 (32%) 9 / 19 (47%) 3 / 19 (16%) 0.474 0.158
PWY3O-246~(RR)-butanediol degradation 0.62 0.97 1 0.79 0.99 1 0.00014 2.9e-05 0 2.1e-05 0 5.4e-05 3.7e-05 0 9.4e-05 0.82 8 / 38 (21%) 4 / 19 (21%) 4 / 19 (21%) 0.211 0.211
PYRIDNUCSYN-PWY~NAD de novo biosynthesis I (from aspartate) 0.38 0.97 1 0.25 0.91 1 0.01 0.01 0.01 0.011 0.01 0.0026 0.01 0.01 0.0026 -0.14 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6963~ammonia assimilation cycle I 0.44 0.97 1 0.25 0.91 1 0.034 0.034 0.035 0.035 0.035 0.0098 0.033 0.034 0.01 -0.085 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5096~pyruvate fermentation to acetate and alanine 0.83 0.97 1 0.55 0.93 1 0.0025 0.0012 0 0.0012 0.00046 0.0016 0.0012 0 0.0019 0 18 / 38 (47%) 10 / 19 (53%) 8 / 19 (42%) 0.526 0.421
ALANINE-VALINESYN-PWY~L-alanine biosynthesis I 0.31 0.97 1 0.4 0.91 1 0.00078 0.00018 0 0.00015 0 0.00051 0.00022 0 0.00055 0.55 9 / 38 (24%) 4 / 19 (21%) 5 / 19 (26%) 0.211 0.263
PWY-7967~5-methoxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP 0.59 0.97 1 0.39 0.91 1 0.0049 0.0049 0.0047 0.005 0.0047 0.0018 0.0047 0.0046 0.0014 -0.089 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6707~gallate biosynthesis 0.96 0.99 1 0.88 0.99 1 0.012 0.012 0.012 0.012 0.012 0.0025 0.012 0.012 0.0019 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
P42-PWY~incomplete reductive TCA cycle 0.71 0.97 1 0.54 0.93 1 0.0028 0.0012 0 0.0016 0 0.0033 0.00085 0.00039 0.0014 -0.91 17 / 38 (45%) 7 / 19 (37%) 10 / 19 (53%) 0.368 0.526
MENAQUINONESYN-PWY~menaquinol-8 biosynthesis 0.83 0.97 1 0.96 0.99 1 0.0057 0.0057 0.0056 0.0056 0.0056 0.0021 0.0057 0.0055 0.0018 0.026 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
SERDEG-PWY~L-serine degradation 0.77 0.97 1 0.82 0.99 1 0.00018 0.00011 8.4e-05 0.00011 7.5e-05 0.00016 0.00011 8.7e-05 0.00016 0 23 / 38 (61%) 11 / 19 (58%) 12 / 19 (63%) 0.579 0.632
PWY-6751~superpathway of hydrogen production 0.76 0.97 1 0.9 0.99 1 0.03 0.03 0.03 0.03 0.03 0.009 0.03 0.031 0.008 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5600~pyruvate fermentation to acetate VII 0.23 0.97 1 0.16 0.91 1 0.016 0.016 0.017 0.017 0.018 0.0043 0.016 0.016 0.0038 -0.087 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6517~N-acetylglucosamine degradation II 0.41 0.97 1 0.55 0.93 1 0.0015 0.0015 0.0014 0.0017 0.0015 0.0012 0.0014 0.0014 0.00075 -0.28 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
SALVPURINE2-PWY~xanthine and xanthosine salvage 0.96 0.99 1 0.73 0.97 1 0.0086 0.0086 0.0086 0.0086 0.0084 0.0021 0.0086 0.0086 0.0021 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5143~long-chain fatty acid activation 0.41 0.97 1 0.21 0.91 1 0.031 0.031 0.024 0.031 0.029 0.016 0.031 0.023 0.026 0 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
CYSTSYN-PWY~L-cysteine biosynthesis I 0.13 0.97 1 0.055 0.91 1 0.013 0.013 0.012 0.013 0.014 0.0027 0.012 0.011 0.0038 -0.12 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
COLANSYN-PWY~colanic acid building blocks biosynthesis 0.66 0.97 1 0.76 0.98 1 0.0028 0.0021 0.0017 0.0024 0.0015 0.0028 0.0019 0.0019 0.0017 -0.34 29 / 38 (76%) 15 / 19 (79%) 14 / 19 (74%) 0.789 0.737
P161-PWY~acetylene degradation 0.29 0.97 1 0.25 0.91 1 0.0031 0.003 0.002 0.0025 0.0018 0.0022 0.0035 0.002 0.0047 0.49 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PWY-7675~Kdo transfer to lipid IVA II 0.85 0.97 1 0.36 0.91 1 0.00074 0.00018 0 0.00022 0 0.00064 0.00013 0 0.00026 -0.76 9 / 38 (24%) 3 / 19 (16%) 6 / 19 (32%) 0.158 0.316
PWY-5667~CDP-diacylglycerol biosynthesis I 0.91 0.98 1 0.54 0.93 1 0.00093 0.00083 0.00068 0.00084 0.00071 0.00069 0.00082 0.00055 0.00073 -0.035 34 / 38 (89%) 16 / 19 (84%) 18 / 19 (95%) 0.842 0.947
PWY-6123~inosine-5-phosphate biosynthesis I 0.43 0.97 1 0.27 0.91 1 0.0099 0.0099 0.0095 0.01 0.01 0.0031 0.0097 0.0087 0.0047 -0.044 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-1861~formaldehyde assimilation II (assimilatory RuMP Cycle) 0.0046 0.5 1 0.0061 0.62 1 0.0028 0.0027 0.0021 0.0033 0.0029 0.0023 0.0021 0.0015 0.0017 -0.65 36 / 38 (95%) 18 / 19 (95%) 18 / 19 (95%) 0.947 0.947
PWY-I9~L-cysteine biosynthesis VI (from L-methionine) 0.99 0.99 1 0.39 0.91 1 0.003 0.002 0.00084 0.0017 0.0011 0.0022 0.0024 8e-04 0.0053 0.5 26 / 38 (68%) 14 / 19 (74%) 12 / 19 (63%) 0.737 0.632
PWY-7645~hyaluronan degradation 0.63 0.97 1 0.4 0.91 1 0.00031 5.8e-05 0 5.4e-05 0 0.00013 6.2e-05 0 2e-04 0.2 7 / 38 (18%) 4 / 19 (21%) 3 / 19 (16%) 0.211 0.158
DETOX1-PWY~superoxide radicals degradation 0.97 0.99 1 0.96 0.99 1 0.0011 0.00046 0 0.00048 0 0.00099 0.00045 0 0.00091 -0.093 16 / 38 (42%) 8 / 19 (42%) 8 / 19 (42%) 0.421 0.421
PWY-6952~glycerophosphodiester degradation 0.42 0.97 1 0.39 0.91 1 0.0011 5e-04 0 0.00056 0.00013 0.00091 0.00044 0 8e-04 -0.35 18 / 38 (47%) 10 / 19 (53%) 8 / 19 (42%) 0.526 0.421
THRESYN-PWY~superpathway of L-threonine biosynthesis 0.22 0.97 1 0.11 0.91 1 0.017 0.017 0.016 0.017 0.018 0.0038 0.016 0.016 0.0065 -0.087 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY66-380~estradiol biosynthesis I (via estrone) 0.56 0.97 1 0.61 0.96 1 0.0015 0.00085 0.00012 6e-04 0.00022 0.00087 0.0011 0 0.0029 0.87 21 / 38 (55%) 12 / 19 (63%) 9 / 19 (47%) 0.632 0.474
AMMASSIM-PWY~ammonia assimilation cycle III 0.58 0.97 1 0.35 0.91 1 0.067 0.067 0.067 0.068 0.066 0.01 0.066 0.069 0.016 -0.043 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-6754~S-methyl-5-thioadenosine degradation I 0.42 0.97 1 0.34 0.91 1 0.00065 5.1e-05 0 5.9e-05 0 0.00018 4.3e-05 0 0.00019 -0.46 3 / 38 (7.9%) 2 / 19 (11%) 1 / 19 (5.3%) 0.105 0.0526
PWY-5480~pyruvate fermentation to ethanol I 0.62 0.97 1 0.83 0.99 1 0.0038 0.0038 0.0023 0.0033 0.0023 0.0026 0.0042 0.0023 0.0057 0.35 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5004~superpathway of L-citrulline metabolism 0.47 0.97 1 0.71 0.97 1 0.0016 0.00026 0 0.00035 0 0.001 0.00016 0 0.00045 -1.1 6 / 38 (16%) 3 / 19 (16%) 3 / 19 (16%) 0.158 0.158
PWY-7586~β-14-D-mannosyl-N-acetyl-D-glucosamine degradation 0.46 0.97 1 0.62 0.96 1 0.0012 0.00018 0 0.00024 0 0.00064 0.00013 0 0.00035 -0.88 6 / 38 (16%) 3 / 19 (16%) 3 / 19 (16%) 0.158 0.158
PWY-4983~nitric oxide biosynthesis II (mammals) 0.15 0.97 1 0.17 0.91 1 0.00052 0.00026 3.9e-05 0.00019 0 0.00031 0.00033 0.00016 0.00044 0.8 19 / 38 (50%) 8 / 19 (42%) 11 / 19 (58%) 0.421 0.579
CENTFERM-PWY~pyruvate fermentation to butanoate 0.62 0.97 1 0.42 0.91 1 0.00064 0.00039 0.00033 0.00039 0.00034 0.00038 0.00038 3e-04 0.00052 -0.037 23 / 38 (61%) 13 / 19 (68%) 10 / 19 (53%) 0.684 0.526
PWY-5509~adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I 0.59 0.97 1 0.39 0.91 1 0.0049 0.0049 0.0047 0.005 0.0047 0.0018 0.0047 0.0046 0.0014 -0.089 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
MANNIDEG-PWY~mannitol degradation I 0.046 0.97 1 0.18 0.91 1 0.0025 0.0025 0.0022 0.003 0.0025 0.0019 0.0021 0.002 0.001 -0.51 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5340~sulfate activation for sulfonation 0.8 0.97 1 0.39 0.91 1 0.0082 0.0082 0.0077 0.0082 0.0078 0.0031 0.0081 0.0077 0.0037 -0.018 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5155~β-alanine biosynthesis III 0.2 0.97 1 0.39 0.91 1 0.0031 0.0031 0.003 0.0034 0.0034 0.0015 0.0028 0.0027 0.00094 -0.28 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5971~palmitate biosynthesis II (bacteria and plants) 0.1 0.97 1 0.2 0.91 1 0.0047 0.0047 0.0035 0.0051 0.0042 0.0041 0.0043 0.0029 0.0045 -0.25 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-3341~L-proline biosynthesis III 0.99 0.99 1 0.61 0.96 1 0.00083 0.00026 0 0.00031 0 0.00077 0.00021 0 0.00041 -0.56 12 / 38 (32%) 5 / 19 (26%) 7 / 19 (37%) 0.263 0.368
PWY-7180~2-deoxy-α-D-ribose 1-phosphate degradation 0.18 0.97 1 0.24 0.91 1 0.00059 0.00017 0 1e-04 0 0.00025 0.00024 0 0.00037 1.3 11 / 38 (29%) 4 / 19 (21%) 7 / 19 (37%) 0.211 0.368
GLUTAMINEFUM-PWY~L-glutamine degradation II 0.8 0.97 1 0.48 0.91 1 0.091 0.091 0.093 0.091 0.092 0.014 0.09 0.094 0.021 -0.016 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY0-862~(5Z)-dodecenoate biosynthesis I 0.092 0.97 1 0.16 0.91 1 0.0046 0.0046 0.0033 0.0051 0.0041 0.004 0.0042 0.0029 0.0044 -0.28 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-4984~urea cycle 0.12 0.97 1 0.24 0.91 1 0.002 0.0011 0.00029 0.0014 0.00072 0.0018 0.00066 0 0.00097 -1.1 20 / 38 (53%) 11 / 19 (58%) 9 / 19 (47%) 0.579 0.474
LCYSDEG-PWY~L-cysteine degradation II 0.77 0.97 1 0.82 0.99 1 0.00018 0.00011 8.4e-05 0.00011 7.5e-05 0.00016 0.00011 8.7e-05 0.00016 0 23 / 38 (61%) 11 / 19 (58%) 12 / 19 (63%) 0.579 0.632
PWY-5839~menaquinol-7 biosynthesis 0.24 0.97 1 0.48 0.91 1 0.0015 0.00073 6.1e-05 0.00093 0.00012 0.0015 0.00052 0 0.00089 -0.84 19 / 38 (50%) 10 / 19 (53%) 9 / 19 (47%) 0.526 0.474
NAGLIPASYN-PWY~lipid IVA biosynthesis 0.086 0.97 1 0.24 0.91 1 0.0016 0.00078 0 0.0012 9.7e-05 0.0019 0.00037 0 0.00057 -1.7 18 / 38 (47%) 10 / 19 (53%) 8 / 19 (42%) 0.526 0.421
HEMESYN2-PWY~heme b biosynthesis II (anaerobic) 0.61 0.97 1 0.98 0.99 1 0.00051 5.4e-05 0 4.5e-05 0 0.00018 6.3e-05 0 0.00026 0.49 4 / 38 (11%) 2 / 19 (11%) 2 / 19 (11%) 0.105 0.105
PWY-5844~menaquinol-9 biosynthesis 0.83 0.97 1 0.96 0.99 1 0.0057 0.0057 0.0056 0.0056 0.0056 0.0021 0.0057 0.0055 0.0018 0.026 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5484~glycolysis II (from fructose 6-phosphate) 0.12 0.97 1 0.019 0.91 1 0.011 0.011 0.012 0.012 0.013 0.0031 0.011 0.011 0.0029 -0.13 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5766~L-glutamate degradation X 0.29 0.97 1 0.98 0.99 1 0.00091 0.00048 5.2e-05 0.00068 0 0.0014 0.00028 8e-05 0.00046 -1.3 20 / 38 (53%) 9 / 19 (47%) 11 / 19 (58%) 0.474 0.579
PWY-6599~guanine and guanosine salvage II 0.86 0.97 1 0.46 0.91 1 0.0018 0.0017 0.0014 0.0015 0.0017 0.0011 0.0019 0.0012 0.002 0.34 35 / 38 (92%) 17 / 19 (89%) 18 / 19 (95%) 0.895 0.947
PWY-841~superpathway of purine nucleotides de novo biosynthesis I 0.7 0.97 1 0.72 0.97 1 0.0041 0.004 0.0034 0.0042 0.0032 0.003 0.0038 0.0038 0.0023 -0.14 37 / 38 (97%) 18 / 19 (95%) 19 / 19 (100%) 0.947 1
PHESYN~L-phenylalanine biosynthesis I 0.94 0.99 1 0.7 0.97 1 0.0046 0.0046 0.0029 0.0042 0.0047 0.0032 0.005 0.0025 0.0069 0.25 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5897~superpathway of menaquinol-11 biosynthesis 0.27 0.97 1 0.14 0.91 1 0.00069 7.3e-05 0 9.2e-05 0 0.00026 5.4e-05 0 0.00023 -0.77 4 / 38 (11%) 3 / 19 (16%) 1 / 19 (5.3%) 0.158 0.0526
PWY-6471~peptidoglycan biosynthesis IV (Enterococcus faecium) 0.64 0.97 1 0.73 0.97 1 0.0053 0.0035 0.0011 0.0028 0.00085 0.0036 0.0041 0.0012 0.0094 0.55 25 / 38 (66%) 13 / 19 (68%) 12 / 19 (63%) 0.684 0.632
PWY-1263~taurine degradation I 0.65 0.97 1 0.98 0.99 1 0.00081 0.00057 0.00027 0.00053 0.00023 0.00058 0.00061 0.00048 0.00069 0.2 27 / 38 (71%) 14 / 19 (74%) 13 / 19 (68%) 0.737 0.684
PWY-5505~L-glutamate and L-glutamine biosynthesis 0.38 0.97 1 0.26 0.91 1 0.047 0.047 0.048 0.048 0.05 0.0066 0.046 0.046 0.011 -0.061 38 / 38 (100%) 19 / 19 (100%) 19 / 19 (100%) 1 1
PWY-5274~sulfide oxidation II (sulfide dehydrogenase) 0.59 0.97 1 0.56 0.93 1 9.5e-05 7.5e-06 0 1.2e-05 0 5.4e-05 2.6e-06 0 8.2e-06 -2.2 3 / 38 (7.9%) 1 / 19 (5.3%) 2 / 19 (11%) 0.0526 0.105
PWY66-423~fructose 26-bisphosphate biosynthesis 0.78 0.97 1 0.93 0.99 1 0.0016 0.0013 6e-04 0.0012 0.00072 0.0015 0.0015 0.00059 0.0033 0.32 32 / 38 (84%) 15 / 19 (79%) 17 / 19 (89%) 0.789 0.895
ARG-PRO-PWY~L-arginine degradation VI (arginase 2 pathway) 0.82 0.97 1 0.67 0.96 1 0.001 0.00022 0 0.00028 0 0.00081 0.00016 0 0.00044 -0.81 8 / 38 (21%) 3 / 19 (16%) 5 / 19 (26%) 0.158 0.263

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Methods:

P lmer condition effect (sqrt): Differentially abundant functions were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Treatment. Effect tested: Treatment.

P lmer condition effect (clr): Differentially abundant functions were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Treatment. Effect tested: Treatment.

Glossary:

clr: Centered log-ratio transformation. P Welch's ANOVA (sqrt): Welch's ANOVA p-values (Anova was run on sqrt transformed abundances). It is an alternative to the classic ANOVA and can be used even if the samples have unequal variances and/or unequal sample sizes. P Welch's t-test (sqrt): Welch's T-test p-values (run on sqrt transformed abundances). It is an alternative to the classic Student's t-test and is more reliable if the data violates the assumption of homogeneity of variances and/or if the study conditions have unequal sample sizes. P Welch's ANOVA (clr): Welch's ANOVA p-values (Anova was run on clr transformed abundances). It is an alternative to the classic ANOVA and can be used even if the samples have unequal variances and/or unequal sample sizes. P Welch's t-test (clr): Welch's T-test p-values (run on clr transformed abundances). It is an alternative to the classic Student's t-test and is more reliable if the data violates the assumption of homogeneity of variances and/or if the study conditions have unequal sample sizes. P lmer XXX (clr): P-value of Linear Mixed-Effects Regression on clr transformed abundances, testing significance of XXX effect. Varying intercepts per subjects are used to control for repeated measures. Pbonf: Bonferroni corrected p-value. FDR: False Discovery Rate q-value. Mean Pos: Mean abundance in positive samples. Positive samples: The number and percentage of samples in which each function has been detected. Positive XXX: The number and percentage of positive samples in study group XXX. Positive_XXX_percent: Percentage of positive samples in study group XXX. P Welch's t-test (Aldex2): Expected P value of Welch’s t-test computed by Aldex2. FDR Welch's t-test (Aldex2): Expected Benjamini-Hochberg corrected P value for Welch’s t-test. P Wilcoxon rank test (Aldex2): Expected P value of Wilcoxon rank test computed by Aldex2. FDR Wilcoxon rank test (Aldex2): Expected Benjamini-Hochberg corrected P value of Wilcoxon test. P Kruskal-Wallace test (Aldex2): Expected P value of Kruskal-Wallace test. FDR Kruskal-Wallace test (Aldex2): Expected Benjamini-Hochberg corrected P value of Kruskal-Wallace test. P GLM test (Aldex2): Expected P value of generalized linear model. FDR GLM test (Aldex2): Expected Benjamini-Hochberg corrected P value of generalized linear model.

Differentially Abundant Microbial Functions

The following plots present the distribution of the top most differentially abundant microbial functions across all applied statistical analysis. Plots are ordered alphabetically.

Glossary:

"Rel. Abundance": Relative abundance data; "Rel. Abundance (sqrt)": sqrt (Hellinger) transformed relative abundances; "Rel. Abundance (clr)": centered log-ratio (clr) transformed read counts.
ACETOACETATE DEG PWY acetoacetate degradation to acetyl CoA
GLUCONSUPER PWY D gluconate degradation
GLYCOLYSIS glycolysis I from glucose 6 phosphate
P461 PWY hexitol fermentation to lactate formate ethanol and acetate
PANTO PWY phosphopantothenate biosynthesis I
PWY 1861 formaldehyde assimilation II assimilatory RuMP Cycle
PWY 5154 L arginine biosynthesis III via N acetyl L citrulline
PWY 5484 glycolysis II from fructose 6 phosphate
PWY 5516 D xylose degradation II
PWY 5964 guanylyl molybdenum cofactor biosynthesis
PWY 6130 glycerol degradation III
PWY 6131 glycerol degradation II
PWY 6139 CMP N acetylneuraminate biosynthesis II bacteria
PWY 6588 pyruvate fermentation to acetone
PWY 6892 thiazole biosynthesis I facultative anaerobic bacteria
PWY 7181 pyrimidine deoxyribonucleosides degradation
PWY 7639 bis guanylyl molybdenum cofactor biosynthesis
PWY 7842 UDP yelosamine biosynthesis
PWY 8015 glycine degradation Stickland reaction
SORBDEG PWY D sorbitol degradation II