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Microba Research Discovery Report

Analysis: Aim 2 Longitudinal Fibre Intake Effect

Taxonomic Profiles (Species)

The charts below show the taxonomic composition of the analysed samples using different quantitative visualization techniques. Only the top most abundant species are shown.

Areachart

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Barchart clustered within each group

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All features barchart clustered within each group

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Scaled heatmap of most abundant features ordered by study group

Features were filtered by mean abundance. Samples were first ordered by study group and then clustered within each study group. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

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Heatmap of most abundant features ordered by study group

Features were filtered by mean abundance. Samples were first ordered by study group and then clustered within each study group. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

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Scaled heatmap of all features

Profiles were clustered by hierarchical clustering. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

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Heatmap of all features

Profiles were clustered by hierarchical clustering. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

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Scaled heatmap of top most abundant features filtered by mean abundance

Profiles were clustered by hierarchical clustering. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Heatmap of top most abundant features filtered by mean abundance

Profiles were clustered by hierarchical clustering. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Scaled heatmap of top most abundant features filtered by max abundance

Profiles were clustered by hierarchical clustering. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Heatmap of top most abundant features filtered by max abundance

Profiles were clustered by hierarchical clustering. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Scaled heatmap of top most variable features

Profiles were clustered by hierarchical clustering. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

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Hierarchically clustered barchart

Profiles were clustered by hierarchical clustering.

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Interactive Barchart

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Microbial alpha diversity (species)

This page provides an overview of the microbial alpha diversity of the analysed samples. Alpha diversity is measured by the Shannon index and species richnes. Richness simply quantifies the total number of species present in each sample. Shannon index additionally accounts for relative abundance and evenness of the species present and quantifies the entropy of microbial communties. Barcharts and boxplots present the mean diversity in each study group.

Methods:

Shannon diversity was compared using linear mixed effect regression, including Participant as a random effect (intercept), and Fibre_Intake, Treatment, and Fibre_Intake vs Treatment as fixed effects. Effect tested: Fibre_Intake vs Treatment. Richness was compared using linear mixed effect regression, including Participant as a random effect (intercept), and Fibre_Intake, Treatment, and Fibre_Intake vs Treatment as fixed effects. Effect tested: Fibre_Intake vs Treatment. Data was rarefied to 702268 reads.

Index: Richness

Index: Shannon index

Summary Table

Index rarefiedTo P lmer treatment effect (interaction) Mean Pos Mean Abundance Median Abundance Mean Fibre_Intakelow:Treatmentpre_treatment Median Fibre_Intakelow:Treatmentpre_treatment SD Fibre_Intakelow:Treatmentpre_treatment Mean Fibre_Intakelow:Treatmentpost_treatment Median Fibre_Intakelow:Treatmentpost_treatment SD Fibre_Intakelow:Treatmentpost_treatment Fold Change Log2(Fibre_Intakelow:Treatmentpost_treatment/Fibre_Intakelow:Treatmentpre_treatment) Positive samples Positive Fibre_Intakelow:Treatmentpre_treatment Positive Fibre_Intakelow:Treatmentpost_treatment Positive_Fibre_Intakelow:Treatmentpre_treatment_percent Positive_Fibre_Intakelow:Treatmentpost_treatment_percent Mean Fibre_Intakehigh:Treatmentpre_treatment Median Fibre_Intakehigh:Treatmentpre_treatment SD Fibre_Intakehigh:Treatmentpre_treatment Mean Fibre_Intakehigh:Treatmentpost_treatment Median Fibre_Intakehigh:Treatmentpost_treatment SD Fibre_Intakehigh:Treatmentpost_treatment Fold Change Log2(Fibre_Intakehigh:Treatmentpost_treatment/Fibre_Intakehigh:Treatmentpre_treatment) Positive Fibre_Intakehigh:Treatmentpre_treatment Positive Fibre_Intakehigh:Treatmentpost_treatment Positive_Fibre_Intakehigh:Treatmentpre_treatment_percent Positive_Fibre_Intakehigh:Treatmentpost_treatment_percent
Shannon 702268 0.52 3.1 3.1 3 3.1 2.9 0.47 2.9 2.8 0.51 -0.096 36 / 36 (100%) 7 / 7 (100%) 7 / 7 (100%) 1 1 3.2 3.1 0.52 3 3 0.2 -0.093 11 / 11 (100%) 11 / 11 (100%) 1 1
Richness 702268 0.84 45 45 36 49 32 32 43 34 25 -0.19 36 / 36 (100%) 7 / 7 (100%) 7 / 7 (100%) 1 1 49 42 21 41 41 10 -0.26 11 / 11 (100%) 11 / 11 (100%) 1 1
Download diversity values in csv format . On some platforms (including Windows) you may need to change the suffix from .txt or .html to .csv before opening the file in a spreadsheet program, like Excel.

Clustering and ordination (species)

Taxonomic profiles were analyzed using supervised and unsupervised multivariate methods. Profiles were ordinated using the unsupervised methods Principal Coordinates Analysis (PCoA), Non-Metric Multidimensional Scaling (NMDS) and Principal Component Analysis (PCA). PCoA and NMDS are related to PCA, but take dissimlarity matrices as input. PCoA and NMDS both attempt to represent the pairwise dissimlarities between samples in low dimensional space as close as possible. NMDS is a rank-based approach and therefore less effected by outliers.

The supervised methods Adonis and Redundancy analysis (RDA) were used to assess if variance in microbial community composition can be attributed to the study condition. NMDS, PCoA and Adonis were run on Bray-Curtis dissimilarities. A short introduction of the used methods can be found at the GUide to STatistical Analysis in Microbial Ecology (GUSTA ME). Sparse Partial Least Square Discriminant Analysis (sPLS-DA) from the MixMc package was additionaly used to extract features associated with the study condition.

Unsupervised ordination

Interactive PCA (clr transformed)

Please click here to view an interactive 3D PCA.

Univariate analysis of species abundance

Differentially abundant species were identified by ANOVA or LMER (linear mixed effect regression) of clr transformed relative abudances, Fisher's exact test and/or ALDEx2 (on species read counts). Fisher's exact test is used to test for differences in the detection rate, i.e. number of samples in which each species has been detected.

LMER is used for repeated measures data, using random effects to control for correlation between samples from the same subject. Fixed effects are included for treatment groups, time, and treatment over time, where appropriate. The LMER P values correspond to a nested model test of the significance of including the corresponding fixed effect.

ALDEx2 uses subsampling (Bayesian sampling) to estimate the underlying technical variation. For each subsample instance, center log-ratio transformed data is statistically compared across study groups and computed P values are corrected for multiple testing using the Benjamini–Hochberg procedure. The expected P value (mean P value) is reported, which are those that would likely have been observed if the same samples had been run multiple times. The expected values are reported for both the distribution of P values and for the distribution of Benjamini–Hochberg corrected values.

Taxon GTDB taxonomy P lmer study group effect (sqrt) FDR lmer study group effect (sqrt) Pbonf lmer study group effect (sqrt) P lmer time effect (sqrt) FDR lmer time effect (sqrt) Pbonf lmer time effect (sqrt) P lmer treatment effect (interaction) (sqrt) FDR lmer treatment effect (interaction) (sqrt) Pbonf lmer treatment effect (interaction) (sqrt) P lmer study group effect (clr) FDR lmer study group effect (clr) Pbonf lmer study group effect (clr) P lmer time effect (clr) FDR lmer time effect (clr) Pbonf lmer time effect (clr) P lmer treatment effect (interaction) (clr) FDR lmer treatment effect (interaction) (clr) Pbonf lmer treatment effect (interaction) (clr) Mean Pos Mean Abundance Median Abundance Mean Fibre_Intakelow:Treatmentpre_treatment Median Fibre_Intakelow:Treatmentpre_treatment SD Fibre_Intakelow:Treatmentpre_treatment Mean Fibre_Intakelow:Treatmentpost_treatment Median Fibre_Intakelow:Treatmentpost_treatment SD Fibre_Intakelow:Treatmentpost_treatment Fold Change Log2(Fibre_Intakelow:Treatmentpost_treatment/Fibre_Intakelow:Treatmentpre_treatment) Positive samples Positive Fibre_Intakelow:Treatmentpre_treatment Positive Fibre_Intakelow:Treatmentpost_treatment Positive_Fibre_Intakelow:Treatmentpre_treatment_percent Positive_Fibre_Intakelow:Treatmentpost_treatment_percent Mean Fibre_Intakehigh:Treatmentpre_treatment Median Fibre_Intakehigh:Treatmentpre_treatment SD Fibre_Intakehigh:Treatmentpre_treatment Mean Fibre_Intakehigh:Treatmentpost_treatment Median Fibre_Intakehigh:Treatmentpost_treatment SD Fibre_Intakehigh:Treatmentpost_treatment Fold Change Log2(Fibre_Intakehigh:Treatmentpost_treatment/Fibre_Intakehigh:Treatmentpre_treatment) Positive Fibre_Intakehigh:Treatmentpre_treatment Positive Fibre_Intakehigh:Treatmentpost_treatment Positive_Fibre_Intakehigh:Treatmentpre_treatment_percent Positive_Fibre_Intakehigh:Treatmentpost_treatment_percent
s__Acetatifactor sp900066365 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Acetatifactor 0.98 0.99 1 0.56 1 1 0.55 0.86 1 0.82 0.9 1 0.46 1 1 0.46 0.71 1 0.29 0.024 0 0.015 0 0.04 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.026 0 0.087 0.043 0 0.14 0.73 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__Acetatifactor sp900066565 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Acetatifactor 0.054 0.51 1 0.089 0.99 1 0.18 0.79 1 0.012 0.31 1 0.47 1 1 0.66 0.78 1 0.69 0.12 0 0.18 0 0.31 0.42 0 0.64 1.2 6 / 36 (17%) 3 / 7 (43%) 3 / 7 (43%) 0.429 0.429 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
s__Adlercreutzia equolifaciens d__Bacteria; p__Actinobacteriota; c__Coriobacteriia; o__Coriobacteriales; f__Eggerthellaceae; g__Adlercreutzia 0.27 0.63 1 1 1 1 0.74 0.87 1 0.19 0.53 1 0.78 1 1 0.48 0.71 1 0.25 0.021 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.03 0 0.07 0.038 0 0.12 0.34 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Agathobacter faecis d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Agathobacter 0.81 0.93 1 0.069 0.99 1 0.085 0.79 1 0.58 0.85 1 0.091 1 1 0.073 0.71 1 2.8 1.5 0.49 2.2 0 3.1 0.51 0 1.4 -2.1 19 / 36 (53%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 1.5 0.51 2.3 1.6 0.67 2 0.093 7 / 11 (64%) 8 / 11 (73%) 0.636 0.727
s__Agathobacter rectale d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Agathobacter 0.043 0.5 1 0.42 1 1 0.77 0.87 1 0.0066 0.27 1 0.68 1 1 0.97 0.99 1 9.5 8 6.2 4.4 1 6.4 6.2 3.8 8 0.49 30 / 36 (83%) 4 / 7 (57%) 4 / 7 (57%) 0.571 0.571 9.4 11 6.9 9.9 8.7 6.8 0.075 11 / 11 (100%) 11 / 11 (100%) 1 1
s__Agathobaculum butyriciproducens d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Butyricicoccaceae; g__Agathobaculum 0.32 0.67 1 0.61 1 1 0.33 0.79 1 0.32 0.62 1 0.47 1 1 0.37 0.71 1 0.65 0.16 0 0 0 0 0.051 0 0.13 Inf 9 / 36 (25%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 0.12 0 0.29 0.38 0.36 0.44 1.7 2 / 11 (18%) 6 / 11 (55%) 0.182 0.545
s__Akkermansia muciniphila d__Bacteria; p__Verrucomicrobiota; c__Verrucomicrobiae; o__Verrucomicrobiales; f__Akkermansiaceae; g__Akkermansia 0.98 0.99 1 0.89 1 1 0.75 0.87 1 0.87 0.9 1 0.95 1 1 0.9 0.96 1 1.8 0.3 0 0.43 0 1.1 0.33 0 0.88 -0.38 6 / 36 (17%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.37 0 0.91 0.13 0 0.37 -1.5 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
s__Alistipes finegoldii d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Rikenellaceae; g__Alistipes 0.12 0.58 1 0.086 0.99 1 0.43 0.84 1 0.12 0.5 1 0.24 1 1 0.66 0.78 1 0.61 0.067 0 0.21 0 0.47 0.092 0 0.24 -1.2 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.027 0 0.089 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
s__Alistipes onderdonkii d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Rikenellaceae; g__Alistipes 0.33 0.67 1 0.71 1 1 0.27 0.79 1 0.24 0.55 1 0.98 1 1 0.35 0.71 1 0.94 0.079 0 0.11 0 0.29 0.045 0 0.12 -1.3 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 0.16 0 0.53 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__Alistipes putredinis d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Rikenellaceae; g__Alistipes 0.62 0.84 1 0.47 1 1 0.66 0.87 1 0.11 0.5 1 0.12 1 1 0.39 0.71 1 1.3 0.32 0 0.22 0.3 0.21 0.23 0 0.51 0.064 9 / 36 (25%) 4 / 7 (57%) 2 / 7 (29%) 0.571 0.286 0.3 0 0.69 0.46 0 1.5 0.62 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Anaerostipes hadrus d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Anaerostipes 0.51 0.78 1 0.21 0.99 1 0.6 0.87 1 0.29 0.62 1 0.62 1 1 0.11 0.71 1 3.5 2.9 1.9 1.7 1.1 1.8 4 1.4 5.6 1.2 30 / 36 (83%) 5 / 7 (71%) 4 / 7 (57%) 0.714 0.571 2.2 1.6 2 3.8 4 2.2 0.79 10 / 11 (91%) 11 / 11 (100%) 0.909 1
s__Anaerostipes hadrus_A d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Anaerostipes 0.7 0.88 1 0.48 1 1 0.47 0.86 1 0.4 0.74 1 0.7 1 1 0.4 0.71 1 2.2 0.55 0 0.44 0 1.2 0.82 0 2.2 0.9 9 / 36 (25%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.51 0 1.2 0.5 0 1.1 -0.029 4 / 11 (36%) 3 / 11 (27%) 0.364 0.273
s__Bacteroides caccae d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Bacteroidaceae; g__Bacteroides 0.78 0.92 1 0.28 1 1 0.64 0.87 1 0.78 0.89 1 0.11 1 1 0.38 0.71 1 0.88 0.12 0 0.077 0 0.17 0 0 0 -Inf 5 / 36 (14%) 2 / 7 (29%) 0 / 7 (0%) 0.286 0 0.19 0 0.46 0.16 0 0.53 -0.25 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Bacteroides ovatus d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Bacteroidaceae; g__Bacteroides 0.96 0.99 1 0.57 1 1 0.072 0.79 1 0.82 0.9 1 0.4 1 1 0.05 0.71 1 0.99 0.14 0 0.033 0 0.087 0 0 0 -Inf 5 / 36 (14%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.041 0 0.14 0.39 0 1 3.2 1 / 11 (9.1%) 3 / 11 (27%) 0.0909 0.273
s__Bacteroides stercoris d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Bacteroidaceae; g__Bacteroides 0.18 0.6 1 0.41 1 1 0.29 0.79 1 0.11 0.5 1 0.44 1 1 0.27 0.71 1 1.7 0.38 0 0.65 0 1.2 0.35 0 0.77 -0.89 8 / 36 (22%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 0.21 0 0.71 0.4 0 0.89 0.93 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
s__Bacteroides uniformis d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Bacteroidaceae; g__Bacteroides 0.036 0.5 1 0.2 0.99 1 0.54 0.86 1 0.0092 0.27 1 0.39 1 1 0.93 0.97 1 4.5 1.5 0 1.9 1.8 2 5.2 0.81 10 1.5 12 / 36 (33%) 4 / 7 (57%) 5 / 7 (71%) 0.571 0.714 0.05 0 0.16 0.33 0 0.74 2.7 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
s__Bacteroides_B massiliensis d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Bacteroidaceae; g__Bacteroides_B 0.48 0.77 1 0.16 0.99 1 0.3 0.79 1 0.5 0.82 1 0.13 1 1 0.33 0.71 1 0.44 0.062 0 0.12 0 0.27 0 0 0 -Inf 5 / 36 (14%) 2 / 7 (29%) 0 / 7 (0%) 0.286 0 0.049 0 0.11 0.077 0 0.25 0.65 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Bacteroides_B vulgatus d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Bacteroidaceae; g__Bacteroides_B 0.72 0.88 1 0.33 1 1 0.65 0.87 1 0.38 0.73 1 0.22 1 1 0.65 0.78 1 2.7 0.88 0 0.99 0.7 1.5 0.33 0 0.79 -1.6 12 / 36 (33%) 4 / 7 (57%) 2 / 7 (29%) 0.571 0.286 1.1 0 2.3 0.98 0 2.8 -0.17 4 / 11 (36%) 2 / 11 (18%) 0.364 0.182
s__Barnesiella intestinihominis d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Barnesiellaceae; g__Barnesiella 0.95 0.99 1 0.82 1 1 0.52 0.86 1 0.78 0.89 1 0.95 1 1 0.48 0.71 1 0.31 0.026 0 0.03 0 0.081 0.018 0 0.047 -0.74 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.055 0 0.18 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
s__Bifidobacterium MIC6680 d__Bacteria; p__Actinobacteriota; c__Actinobacteria; o__Actinomycetales; f__Bifidobacteriaceae; g__Bifidobacterium 0.43 0.73 1 1 1 1 0.68 0.87 1 0.47 0.8 1 0.86 1 1 0.48 0.71 1 1.2 0.1 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.14 0 0.47 0.19 0 0.48 0.44 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
s__Bifidobacterium MIC7686 d__Bacteria; p__Actinobacteriota; c__Actinobacteria; o__Actinomycetales; f__Bifidobacteriaceae; g__Bifidobacterium 0.42 0.73 1 1 1 1 0.69 0.87 1 0.47 0.8 1 0.85 1 1 0.49 0.71 1 0.64 0.053 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.077 0 0.26 0.097 0 0.25 0.33 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
s__Bifidobacterium adolescentis d__Bacteria; p__Actinobacteriota; c__Actinobacteria; o__Actinomycetales; f__Bifidobacteriaceae; g__Bifidobacterium 0.021 0.5 1 0.44 1 1 0.73 0.87 1 0.0051 0.27 0.86 0.18 1 1 0.67 0.78 1 6.9 3.8 0.74 0.14 0 0.36 0.74 0 1.5 2.4 20 / 36 (56%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 6.5 3 14 5.6 2.8 6.7 -0.22 8 / 11 (73%) 9 / 11 (82%) 0.727 0.818
s__Bifidobacterium angulatum d__Bacteria; p__Actinobacteriota; c__Actinobacteria; o__Actinomycetales; f__Bifidobacteriaceae; g__Bifidobacterium 0.18 0.6 1 1 1 1 0.93 0.96 1 0.11 0.5 1 0.83 1 1 0.52 0.71 1 1.1 0.15 0 0 0 0 0 0 0 NA 5 / 36 (14%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.23 0 0.51 0.28 0 0.62 0.28 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
s__Bifidobacterium bifidum d__Bacteria; p__Actinobacteriota; c__Actinobacteria; o__Actinomycetales; f__Bifidobacteriaceae; g__Bifidobacterium 0.26 0.63 1 0.38 1 1 0.49 0.86 1 0.28 0.6 1 0.32 1 1 0.5 0.71 1 0.43 0.059 0 0 0 0 0.042 0 0.11 Inf 5 / 36 (14%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 0.085 0 0.21 0.082 0 0.18 -0.052 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
s__Bifidobacterium longum d__Bacteria; p__Actinobacteriota; c__Actinobacteria; o__Actinomycetales; f__Bifidobacteriaceae; g__Bifidobacterium 0.49 0.77 1 0.37 1 1 0.46 0.86 1 0.16 0.5 1 0.3 1 1 0.53 0.71 1 2.8 2.2 1.7 1.7 2.1 1.7 2.2 2.3 2.5 0.37 28 / 36 (78%) 4 / 7 (57%) 4 / 7 (57%) 0.571 0.571 1.9 1.4 2 2.8 2.8 1.9 0.56 10 / 11 (91%) 10 / 11 (91%) 0.909 0.909
s__Bifidobacterium pseudocatenulatum d__Bacteria; p__Actinobacteriota; c__Actinobacteria; o__Actinomycetales; f__Bifidobacteriaceae; g__Bifidobacterium 0.68 0.87 1 0.3 1 1 0.42 0.83 1 0.89 0.92 1 0.91 1 1 0.4 0.71 1 2.5 0.9 0 1.5 0 2.6 0.99 0 2 -0.6 13 / 36 (36%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0.76 0 1.2 0.58 0 0.8 -0.39 4 / 11 (36%) 5 / 11 (45%) 0.364 0.455
s__Blautia sp000436935 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia 0.16 0.59 1 0.4 1 1 0.9 0.95 1 0.095 0.5 1 0.75 1 1 0.48 0.71 1 1.8 0.25 0 0.32 0 0.54 0.8 0 1.9 1.3 5 / 36 (14%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0 0 0 0.1 0 0.33 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__Blautia_A MIC7077 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.16 0.59 1 1 1 1 0.39 0.81 1 0.14 0.5 1 0.81 1 1 0.38 0.71 1 0.28 0.023 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.052 0 0.12 0.025 0 0.082 -1.1 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Blautia_A MIC8050 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.58 0.84 1 0.79 1 1 0.36 0.8 1 0.69 0.85 1 0.88 1 1 0.39 0.71 1 1 0.14 0 0.23 0 0.61 0.19 0 0.51 -0.28 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.084 0 0.28 0.12 0 0.27 0.51 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
s__Blautia_A MIC8343 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.88 0.95 1 0.11 0.99 1 0.33 0.79 1 0.64 0.85 1 0.073 1 1 0.27 0.71 1 0.18 0.024 0 0.025 0 0.045 0 0 0 -Inf 5 / 36 (14%) 2 / 7 (29%) 0 / 7 (0%) 0.286 0 0.03 0 0.068 0.033 0 0.11 0.14 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Blautia_A MIC9663 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.3 0.65 1 0.95 1 1 0.38 0.81 1 0.31 0.62 1 0.86 1 1 0.39 0.71 1 0.42 0.035 0 0.055 0 0.15 0.051 0 0.13 -0.11 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 0.047 0 0.16 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__Blautia_A massiliensis d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.27 0.63 1 0.56 1 1 0.59 0.87 1 0.41 0.74 1 0.98 1 1 0.35 0.71 1 2.2 1.4 0.64 1.1 0.16 1.5 0.63 0.5 0.78 -0.8 23 / 36 (64%) 4 / 7 (57%) 4 / 7 (57%) 0.571 0.571 2.2 1.7 3 1.3 0.84 1.6 -0.76 8 / 11 (73%) 7 / 11 (64%) 0.727 0.636
s__Blautia_A obeum d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.33 0.67 1 0.56 1 1 0.69 0.87 1 0.49 0.82 1 0.77 1 1 0.67 0.78 1 1.9 1 0.38 0.33 0 0.5 0.69 0 1.3 1.1 19 / 36 (53%) 3 / 7 (43%) 3 / 7 (43%) 0.429 0.429 1 0.48 1.4 1.6 0.58 1.9 0.68 6 / 11 (55%) 7 / 11 (64%) 0.545 0.636
s__Blautia_A sp000285855 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.85 0.94 1 0.98 1 1 0.64 0.87 1 0.96 0.97 1 0.87 1 1 0.85 0.94 1 0.28 0.046 0 0.052 0 0.14 0.053 0 0.14 0.027 6 / 36 (17%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.026 0 0.063 0.058 0 0.13 1.2 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
s__Blautia_A sp000436615 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.17 0.59 1 0.41 1 1 0.72 0.87 1 0.19 0.53 1 0.38 1 1 0.88 0.95 1 1.1 0.18 0 0.4 0 0.78 0.32 0 0.54 -0.32 6 / 36 (17%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0.068 0 0.23 0.048 0 0.16 -0.5 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__Blautia_A sp900066145 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.14 0.58 1 0.25 1 1 0.14 0.79 1 0.24 0.55 1 0.99 1 1 0.28 0.71 1 0.84 0.07 0 0.23 0 0.6 0.11 0 0.29 -1.1 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 0.015 0 0.051 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__Blautia_A sp900066165 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.42 0.73 1 0.53 1 1 0.35 0.8 1 0.61 0.85 1 0.42 1 1 0.41 0.71 1 1.5 0.99 0.74 1.2 1 0.98 1.2 0.49 1.4 0 23 / 36 (64%) 5 / 7 (71%) 4 / 7 (57%) 0.714 0.571 0.71 0.68 0.68 1 0.7 1.1 0.49 7 / 11 (64%) 7 / 11 (64%) 0.636 0.636
s__Blautia_A sp900066205 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.22 0.62 1 0.74 1 1 0.68 0.87 1 0.24 0.55 1 0.52 1 1 0.66 0.78 1 1.3 0.18 0 0.014 0 0.037 0 0 0 -Inf 5 / 36 (14%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.29 0 0.55 0.28 0 0.94 -0.051 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
s__Blautia_A sp900066335 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.13 0.58 1 1 1 1 0.69 0.87 1 0.097 0.5 1 0.83 1 1 0.5 0.71 1 0.4 0.055 0 0 0 0 0 0 0 NA 5 / 36 (14%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.087 0 0.15 0.094 0 0.23 0.11 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
s__Blautia_A sp900066355 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.53 0.79 1 0.92 1 1 0.58 0.86 1 0.67 0.85 1 0.85 1 1 0.61 0.78 1 0.23 0.031 0 0.016 0 0.043 0.022 0 0.059 0.46 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.052 0 0.12 0.026 0 0.086 -1 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Blautia_A sp900120195 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.47 0.76 1 0.11 0.99 1 0.14 0.79 1 0.49 0.82 1 0.07 1 1 0.18 0.71 1 0.21 0.018 0 0 0 0 0.04 0 0.11 Inf 3 / 36 (8.3%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 0.021 0 0.071 0.011 0 0.038 -0.93 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__Blautia_A wexlerae d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Blautia_A 0.035 0.5 1 0.93 1 1 0.58 0.86 1 0.14 0.5 1 0.78 1 1 0.58 0.76 1 9.9 9.9 8.7 14 11 8 15 13 10 0.1 36 / 36 (100%) 7 / 7 (100%) 7 / 7 (100%) 1 1 7.1 6.1 3.8 6.6 4 5.4 -0.11 11 / 11 (100%) 11 / 11 (100%) 1 1
s__CAG-103 MIC7540 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__CAG-103 0.13 0.58 1 0.17 0.99 1 0.32 0.79 1 0.18 0.52 1 0.34 1 1 0.41 0.71 1 0.56 0.078 0 0.21 0 0.4 0.097 0 0.26 -1.1 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.034 0 0.11 0.022 0 0.073 -0.63 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__CAG-103 sp000432375 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__CAG-103 0.37 0.72 1 0.7 1 1 0.69 0.87 1 0.32 0.62 1 0.12 1 1 0.71 0.81 1 0.73 0.12 0 0.16 0 0.27 0.18 0 0.32 0.17 6 / 36 (17%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0.067 0 0.22 0.11 0 0.38 0.72 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__CAG-110 sp000435995 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__CAG-110 0.5 0.78 1 0.83 1 1 0.51 0.86 1 0.31 0.62 1 0.74 1 1 0.49 0.71 1 0.18 0.015 0 0.01 0 0.027 0.017 0 0.044 0.77 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 0.033 0 0.11 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__CAG-110 sp003525905 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__CAG-110 0.25 0.62 1 1 1 1 0.41 0.82 1 0.21 0.54 1 0.83 1 1 0.42 0.71 1 0.37 0.031 0 0.06 0 0.16 0.06 0 0.16 0 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 0.024 0 0.08 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__CAG-127 sp900319515 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__CAG-127 0.95 0.99 1 0.84 1 1 0.83 0.91 1 0.85 0.9 1 0.99 1 1 0.82 0.92 1 0.54 0.075 0 0.059 0 0.16 0.031 0 0.083 -0.93 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.056 0 0.12 0.13 0 0.44 1.2 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__CAG-138 MIC9630 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Christensenellales; f__CAG-138; g__CAG-138 MIC9630 0.74 0.88 1 0.54 1 1 0.31 0.79 1 0.46 0.79 1 0.96 1 1 0.13 0.71 1 1.3 0.18 0 0.34 0 0.91 0.12 0 0.32 -1.5 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.29 0 0.5 0 0 0 -Inf 3 / 11 (27%) 0 / 11 (0%) 0.273 0
s__CAG-1427 sp000435675 d__Bacteria; p__Actinobacteriota; c__Coriobacteriia; o__Coriobacteriales; f__Eggerthellaceae; g__CAG-1427 0.87 0.95 1 0.99 1 1 0.9 0.95 1 0.77 0.89 1 0.89 1 1 0.95 0.98 1 0.21 0.023 0 0.02 0 0.053 0.02 0 0.052 0 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.02 0 0.066 0.03 0 0.099 0.58 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__CAG-1427 sp000436075 d__Bacteria; p__Actinobacteriota; c__Coriobacteriia; o__Coriobacteriales; f__Eggerthellaceae; g__CAG-1427 0.065 0.51 1 1 1 1 0.26 0.79 1 0.046 0.49 1 0.87 1 1 0.21 0.71 1 0.46 0.051 0 0 0 0 0 0 0 NA 4 / 36 (11%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.12 0 0.22 0.044 0 0.15 -1.4 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
s__CAG-170 sp000432135 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__CAG-170 0.55 0.81 1 0.57 1 1 0.73 0.87 1 0.91 0.93 1 0.2 1 1 0.45 0.71 1 1.5 0.12 0 0.05 0 0.13 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.36 0 1.2 0.011 0 0.036 -5 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__CAG-177 sp003514385 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Acutalibacteraceae; g__CAG-177 0.21 0.62 1 1 1 1 0.65 0.87 1 0.26 0.59 1 0.85 1 1 0.43 0.71 1 1.3 0.17 0 0 0 0 0 0 0 NA 5 / 36 (14%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.29 0 0.71 0.28 0 0.49 -0.051 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
s__CAG-217 sp000436335 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Acutalibacteraceae; g__CAG-217 0.099 0.58 1 0.5 1 1 0.5 0.86 1 0.093 0.5 1 0.95 1 1 0.4 0.71 1 1.7 0.42 0 0.83 0 1.1 0.67 0 1 -0.31 9 / 36 (25%) 3 / 7 (43%) 3 / 7 (43%) 0.429 0.429 0.25 0 0.84 0.16 0 0.36 -0.64 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
s__CAG-245 sp000435175 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__TANB77; f__CAG-508; g__CAG-245 0.63 0.85 1 0.21 0.99 1 0.47 0.86 1 0.98 0.98 1 0.37 1 1 0.67 0.78 1 0.48 0.053 0 0.14 0 0.38 0 0 0 -Inf 4 / 36 (11%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.048 0 0.11 0.034 0 0.11 -0.5 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__CAG-274 MIC6942 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__CAG-274; g__CAG-274 0.72 0.88 1 1 1 1 0.23 0.79 1 0.57 0.85 1 0.82 1 1 0.27 0.71 1 0.33 0.028 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.008 0 0.026 0.082 0 0.22 3.4 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
s__CAG-274 sp000432155 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__CAG-274; g__CAG-274 0.6 0.84 1 0.57 1 1 0.77 0.87 1 0.69 0.85 1 0.71 1 1 0.49 0.71 1 0.6 0.084 0 0.086 0 0.23 0.17 0 0.46 0.98 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.02 0 0.067 0.088 0 0.24 2.1 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
s__CAG-302 sp001916775 d__Bacteria; p__Firmicutes; c__Bacilli; o__RF39; f__CAG-302; g__CAG-302 0.6 0.84 1 0.2 0.99 1 0.44 0.84 1 0.76 0.89 1 0.14 1 1 0.19 0.71 1 0.83 0.12 0 0.07 0 0.18 0 0 0 -Inf 5 / 36 (14%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.2 0 0.55 0.13 0 0.3 -0.62 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
s__CAG-313 sp000433035 d__Bacteria; p__Firmicutes; c__Bacilli; o__ML615J-28; f__CAG-313; g__CAG-313 0.33 0.67 1 0.46 1 1 0.87 0.94 1 0.52 0.82 1 0.94 1 1 0.48 0.71 1 0.46 0.039 0 0.11 0 0.29 0.063 0 0.17 -0.8 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.017 0 0.055 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
s__CAG-354 sp001915925 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__TANB77; f__CAG-508; g__CAG-354 0.4 0.73 1 0.47 1 1 0.32 0.79 1 0.55 0.84 1 0.62 1 1 0.44 0.71 1 0.41 0.057 0 0.0078 0 0.021 0.092 0 0.24 3.6 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.084 0 0.19 0.039 0 0.13 -1.1 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__CAG-41 sp900066215 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Monoglobales; f__UBA1381; g__CAG-41 0.2 0.6 1 0.8 1 1 0.024 0.79 1 0.21 0.54 1 0.56 1 1 0.0087 0.71 1 0.79 0.4 0.053 0.51 0.11 0.72 0.58 0 1.1 0.19 18 / 36 (50%) 4 / 7 (57%) 3 / 7 (43%) 0.571 0.429 0.16 0 0.28 0.44 0.48 0.35 1.5 3 / 11 (27%) 8 / 11 (73%) 0.273 0.727
s__CAG-417 sp000432835 d__Bacteria; p__Firmicutes; c__Bacilli; o__RF39; f__CAG-611; g__CAG-417 0.18 0.6 1 0.43 1 1 0.18 0.79 1 0.23 0.55 1 0.94 1 1 0.32 0.71 1 1.2 0.098 0 0.25 0 0.67 0.083 0 0.22 -1.6 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 0.11 0 0.35 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__CAG-452 sp000434035 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__TANB77; f__CAG-508; g__CAG-452 0.14 0.58 1 1 1 1 0.33 0.79 1 0.14 0.5 1 0.81 1 1 0.35 0.71 1 0.29 0.024 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.058 0 0.13 0.02 0 0.067 -1.5 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__CAG-460 MIC6729 d__Bacteria; p__Firmicutes; c__Bacilli; o__RF39; f__CAG-1000; g__CAG-460 0.13 0.58 1 1 1 1 0.29 0.79 1 0.14 0.5 1 0.86 1 1 0.35 0.71 1 2 0.17 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.44 0 0.98 0.12 0 0.39 -1.9 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__CAG-485 MIC8260 d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Muribaculaceae; g__CAG-485 0.26 0.63 1 1 1 1 0.76 0.87 1 0.17 0.51 1 0.82 1 1 0.47 0.71 1 0.49 0.041 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.06 0 0.13 0.074 0 0.25 0.3 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__CAG-533 sp000434495 d__Bacteria; p__Firmicutes; c__Bacilli; o__RF39; f__CAG-1000; g__CAG-533 0.12 0.58 1 1 1 1 0.27 0.79 1 0.13 0.5 1 0.86 1 1 0.34 0.71 1 2 0.16 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.44 0 0.97 0.095 0 0.31 -2.2 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__CAG-557 sp000435275 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Acutalibacteraceae; g__CAG-557 0.2 0.6 1 1 1 1 0.55 0.86 1 0.16 0.5 1 0.83 1 1 0.43 0.71 1 0.63 0.052 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.096 0 0.21 0.074 0 0.25 -0.38 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__CAG-56 sp900066615 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__CAG-56 0.96 0.99 1 0.52 1 1 0.22 0.79 1 0.67 0.85 1 0.59 1 1 0.15 0.71 1 0.99 0.55 0.26 0.72 0 1.3 0.5 0 0.91 -0.53 20 / 36 (56%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 0.45 0.22 0.53 0.56 0.48 0.44 0.32 6 / 11 (55%) 9 / 11 (82%) 0.545 0.818
s__CAG-628 sp003524085 d__Bacteria; p__Firmicutes; c__Bacilli; o__RF39; f__CAG-1000; g__CAG-628 0.14 0.58 1 1 1 1 0.32 0.79 1 0.14 0.5 1 0.83 1 1 0.35 0.71 1 0.47 0.039 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.097 0 0.22 0.032 0 0.11 -1.6 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__CAG-83 sp000431575 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__CAG-83 0.32 0.67 1 0.86 1 1 0.34 0.79 1 0.24 0.55 1 0.91 1 1 0.39 0.71 1 0.53 0.044 0 0.063 0 0.17 0.046 0 0.12 -0.45 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 0.075 0 0.25 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__CAG-83 sp000435555 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__CAG-83 0.13 0.58 1 1 1 1 0.31 0.79 1 0.14 0.5 1 0.85 1 1 0.35 0.71 1 1 0.087 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.22 0 0.5 0.061 0 0.2 -1.9 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__CAG-83 sp003487665 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__CAG-83 0.14 0.58 1 1 1 1 0.33 0.79 1 0.14 0.5 1 0.83 1 1 0.36 0.71 1 0.45 0.037 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.091 0 0.2 0.031 0 0.1 -1.6 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__CAG-877 sp000433455 d__Bacteria; p__Firmicutes; c__Bacilli; o__RF39; f__CAG-611; g__CAG-877 0.33 0.67 1 0.096 0.99 1 0.18 0.79 1 0.56 0.85 1 0.89 1 1 0.24 0.71 1 0.41 0.045 0 0.13 0 0.33 0.053 0 0.14 -1.3 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.017 0 0.058 0.018 0 0.059 0.082 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__Clostridium MIC8163 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Clostridiales; f__Clostridiaceae; g__Clostridium 0.99 0.99 1 0.47 1 1 0.58 0.86 1 0.45 0.79 1 0.39 1 1 0.15 0.71 1 0.71 0.14 0 0.11 0 0.25 0.012 0 0.032 -3.2 7 / 36 (19%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.28 0 0.93 0.095 0 0.18 -1.6 1 / 11 (9.1%) 3 / 11 (27%) 0.0909 0.273
s__Collinsella MIC7086 d__Bacteria; p__Actinobacteriota; c__Coriobacteriia; o__Coriobacteriales; f__Coriobacteriaceae; g__Collinsella 0.18 0.6 1 1 1 1 0.48 0.86 1 0.15 0.5 1 0.84 1 1 0.41 0.71 1 0.7 0.058 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.12 0 0.26 0.074 0 0.24 -0.7 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Collinsella MIC7241 d__Bacteria; p__Actinobacteriota; c__Coriobacteriia; o__Coriobacteriales; f__Coriobacteriaceae; g__Collinsella 0.076 0.54 1 1 1 1 0.27 0.79 1 0.065 0.5 1 0.89 1 1 0.23 0.71 1 1.3 0.15 0 0 0 0 0 0 0 NA 4 / 36 (11%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.41 0 1 0.066 0 0.22 -2.6 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
s__Collinsella MIC7504 d__Bacteria; p__Actinobacteriota; c__Coriobacteriia; o__Coriobacteriales; f__Coriobacteriaceae; g__Collinsella 0.094 0.58 1 1 1 1 0.19 0.79 1 0.072 0.5 1 0.87 1 1 0.22 0.71 1 0.75 0.083 0 0 0 0 0 0 0 NA 4 / 36 (11%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.19 0 0.39 0.084 0 0.28 -1.2 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
s__Collinsella aerofaciens_F d__Bacteria; p__Actinobacteriota; c__Coriobacteriia; o__Coriobacteriales; f__Coriobacteriaceae; g__Collinsella 0.47 0.76 1 0.59 1 1 0.71 0.87 1 0.3 0.62 1 0.71 1 1 0.53 0.71 1 0.81 0.068 0 0.052 0 0.14 0.13 0 0.35 1.3 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 0.1 0 0.34 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__Collinsella sp002232035 d__Bacteria; p__Actinobacteriota; c__Coriobacteriia; o__Coriobacteriales; f__Coriobacteriaceae; g__Collinsella 0.82 0.93 1 0.6 1 1 0.23 0.79 1 0.84 0.9 1 0.29 1 1 0.36 0.71 1 3.4 0.38 0 0.24 0 0.62 0.45 0 1.2 0.91 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.68 0 2.2 0.14 0 0.46 -2.3 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__Collinsella sp003487125 d__Bacteria; p__Actinobacteriota; c__Coriobacteriia; o__Coriobacteriales; f__Coriobacteriaceae; g__Collinsella 0.53 0.79 1 0.65 1 1 0.62 0.87 1 0.68 0.85 1 0.53 1 1 0.53 0.71 1 0.58 0.081 0 0.024 0 0.063 0 0 0 -Inf 5 / 36 (14%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.1 0 0.24 0.15 0 0.37 0.58 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
s__Coprococcus eutactus_A d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Coprococcus 0.81 0.93 1 0.67 1 1 0.52 0.86 1 0.66 0.85 1 0.4 1 1 0.44 0.71 1 1.9 0.43 0 0.37 0 0.84 0.49 0 1.2 0.41 8 / 36 (22%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0.31 0 0.83 0.54 0 1.2 0.8 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
s__Coprococcus sp900066115 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Coprococcus 0.095 0.58 1 0.8 1 1 0.42 0.83 1 0.08 0.5 1 0.84 1 1 0.46 0.71 1 2.5 0.35 0 0.88 0 2.1 0.54 0 0.96 -0.7 5 / 36 (14%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0 0 0 0.25 0 0.84 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__Coprococcus_A catus d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Coprococcus_A 0.45 0.76 1 0.31 1 1 0.34 0.79 1 0.64 0.85 1 0.26 1 1 0.41 0.71 1 0.42 0.082 0 0.018 0 0.048 0.078 0 0.14 2.1 7 / 36 (19%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0.12 0 0.26 0.091 0 0.22 -0.4 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
s__Coprococcus_B comes d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Coprococcus_B 0.019 0.5 1 0.54 1 1 0.024 0.79 1 0.0068 0.27 1 0.31 1 1 0.025 0.71 1 0.78 0.56 0.6 0.45 0 0.66 0.47 0.56 0.55 0.063 26 / 36 (72%) 3 / 7 (43%) 4 / 7 (57%) 0.429 0.571 0.81 0.72 0.34 0.45 0.48 0.36 -0.85 11 / 11 (100%) 8 / 11 (73%) 1 0.727
s__Dialister invisus d__Bacteria; p__Firmicutes_C; c__Negativicutes; o__Veillonellales; f__Dialisteraceae; g__Dialister 0.01 0.5 1 0.23 1 1 0.12 0.79 1 0.018 0.35 1 0.72 1 1 0.25 0.71 1 2 0.39 0 1.1 0 1.5 0.57 0 1 -0.95 7 / 36 (19%) 3 / 7 (43%) 3 / 7 (43%) 0.429 0.429 0 0 0 0.22 0 0.74 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__Dialister sp900343095 d__Bacteria; p__Firmicutes_C; c__Negativicutes; o__Veillonellales; f__Dialisteraceae; g__Dialister 0.098 0.58 1 1 1 1 0.75 0.87 1 0.1 0.5 1 0.89 1 1 0.92 0.96 1 1.1 0.18 0 0 0 0 0 0 0 NA 6 / 36 (17%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.34 0 0.59 0.25 0 0.52 -0.44 3 / 11 (27%) 3 / 11 (27%) 0.273 0.273
s__Dorea formicigenerans d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Dorea 0.71 0.88 1 0.2 0.99 1 0.37 0.81 1 0.75 0.89 1 0.27 1 1 0.65 0.78 1 0.63 0.28 0 0.3 0 0.42 0.46 0.41 0.47 0.62 16 / 36 (44%) 3 / 7 (43%) 4 / 7 (57%) 0.429 0.571 0.22 0 0.36 0.21 0 0.31 -0.067 4 / 11 (36%) 5 / 11 (45%) 0.364 0.455
s__Dorea longicatena d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Dorea 0.03 0.5 1 0.73 1 1 0.54 0.86 1 0.03 0.43 1 0.96 1 1 0.91 0.96 1 1.2 0.54 0 0.21 0 0.55 0.12 0 0.33 -0.81 16 / 36 (44%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.94 0.5 1.1 0.61 0.5 0.67 -0.62 7 / 11 (64%) 7 / 11 (64%) 0.636 0.636
s__Dorea longicatena_B d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Dorea 0.49 0.77 1 0.49 1 1 0.39 0.81 1 0.69 0.85 1 0.38 1 1 0.66 0.78 1 1.1 0.49 0 0.73 0 1 0.82 0.73 0.97 0.17 16 / 36 (44%) 3 / 7 (43%) 4 / 7 (57%) 0.429 0.571 0.4 0 0.61 0.21 0 0.27 -0.93 4 / 11 (36%) 5 / 11 (45%) 0.364 0.455
s__Dorea sp000433215 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Dorea 0.042 0.5 1 1 1 1 0.13 0.79 1 0.046 0.49 1 0.84 1 1 0.15 0.71 1 0.2 0.022 0 0 0 0 0 0 0 NA 4 / 36 (11%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.065 0 0.12 0.0085 0 0.028 -2.9 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
s__Dorea sp900066555 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Dorea 0.55 0.81 1 0.63 1 1 0.13 0.79 1 0.65 0.85 1 0.69 1 1 0.18 0.71 1 0.18 0.02 0 0.013 0 0.033 0.032 0 0.085 1.3 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.036 0 0.086 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
s__Duncaniella MIC6738 d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Muribaculaceae; g__Duncaniella 0.25 0.62 1 1 1 1 0.72 0.87 1 0.17 0.51 1 0.82 1 1 0.47 0.71 1 0.49 0.041 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.062 0 0.14 0.071 0 0.24 0.2 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__ER4 sp900317525 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__ER4 0.037 0.5 1 0.19 0.99 1 0.09 0.79 1 0.036 0.48 1 0.77 1 1 0.25 0.71 1 0.51 0.071 0 0.21 0 0.37 0.086 0 0.16 -1.3 5 / 36 (14%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0 0 0 0.044 0 0.14 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__Eisenbergiella sp900066775 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Eisenbergiella 0.035 0.5 1 0.022 0.99 1 0.067 0.79 1 0.028 0.43 1 0.059 1 1 0.093 0.71 1 2 0.16 0 0.71 0 1.7 0.13 0 0.35 -2.4 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
s__Erysipelatoclostridium ramosum d__Bacteria; p__Firmicutes; c__Bacilli; o__Erysipelotrichales; f__Erysipelatoclostridiaceae; g__Erysipelatoclostridium 0.25 0.62 1 0.21 0.99 1 0.66 0.87 1 0.5 0.82 1 0.87 1 1 0.63 0.78 1 0.37 0.031 0 0.11 0 0.29 0.032 0 0.084 -1.8 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.011 0 0.038 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
s__Erysipelatoclostridium sp000752095 d__Bacteria; p__Firmicutes; c__Bacilli; o__Erysipelotrichales; f__Erysipelatoclostridiaceae; g__Erysipelatoclostridium 0.51 0.78 1 0.08 0.99 1 0.56 0.86 1 0.99 0.99 1 0.094 1 1 0.83 0.92 1 0.94 0.71 0.46 1.1 0.7 1.5 0.69 0.25 1 -0.67 27 / 36 (75%) 6 / 7 (86%) 4 / 7 (57%) 0.857 0.571 0.67 0.46 0.9 0.48 0.46 0.49 -0.48 10 / 11 (91%) 7 / 11 (64%) 0.909 0.636
s__Eubacterium_E hallii d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Eubacterium_E 0.22 0.62 1 0.81 1 1 0.56 0.86 1 0.27 0.6 1 0.98 1 1 0.28 0.71 1 2 1.8 1.7 1.5 1.2 1.2 1.4 1.5 1 -0.1 32 / 36 (89%) 6 / 7 (86%) 6 / 7 (86%) 0.857 0.857 2.1 2.1 1 1.9 2.1 1.3 -0.14 11 / 11 (100%) 9 / 11 (82%) 1 0.818
s__Eubacterium_E hallii_A d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Eubacterium_E 0.045 0.5 1 0.4 1 1 0.73 0.87 1 0.026 0.43 1 0.66 1 1 0.32 0.71 1 0.69 0.15 0 0.24 0 0.33 0.39 0 0.57 0.7 8 / 36 (22%) 3 / 7 (43%) 3 / 7 (43%) 0.429 0.429 0 0 0 0.098 0 0.22 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
s__Eubacterium_F MIC7104 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Eubacterium_F 0.47 0.76 1 0.28 1 1 0.81 0.9 1 0.4 0.74 1 0.33 1 1 0.83 0.92 1 0.44 0.061 0 0.075 0 0.2 0 0 0 -Inf 5 / 36 (14%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.12 0 0.23 0.026 0 0.087 -2.2 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
s__Eubacterium_G ventriosum d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Eubacterium_G 0.065 0.51 1 0.44 1 1 0.22 0.79 1 0.071 0.5 1 0.46 1 1 0.27 0.71 1 0.65 0.13 0 0.053 0 0.14 0 0 0 -Inf 7 / 36 (19%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.29 0 0.4 0.09 0 0.3 -1.7 5 / 11 (45%) 1 / 11 (9.1%) 0.455 0.0909
s__Eubacterium_I ramulus d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Eubacterium_I 0.35 0.7 1 0.22 0.99 1 0.98 0.98 1 0.3 0.62 1 0.33 1 1 0.94 0.97 1 0.62 0.12 0 0.11 0 0.28 0 0 0 -Inf 7 / 36 (19%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.22 0 0.42 0.11 0 0.25 -1 4 / 11 (36%) 2 / 11 (18%) 0.364 0.182
s__Eubacterium_I ramulus_A d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Eubacterium_I 0.0056 0.5 0.96 0.15 0.99 1 0.26 0.79 1 0.0093 0.27 1 0.17 1 1 0.22 0.71 1 0.82 0.11 0 0.39 0 0.64 0.19 0 0.36 -1 5 / 36 (14%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
s__Eubacterium_R sp000434995 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Acutalibacteraceae; g__Eubacterium_R 0.93 0.98 1 0.76 1 1 0.24 0.79 1 0.83 0.9 1 0.79 1 1 0.34 0.71 1 1.5 0.21 0 0.24 0 0.64 0.33 0 0.86 0.46 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.23 0 0.51 0.083 0 0.27 -1.5 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__F23-B02 sp002472405 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__F23-B02 0.049 0.5 1 1 1 1 0.2 0.79 1 0.041 0.49 1 0.88 1 1 0.19 0.71 1 0.73 0.082 0 0 0 0 0 0 0 NA 4 / 36 (11%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.22 0 0.41 0.042 0 0.14 -2.4 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
s__Faecalibacterium MIC7145 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Faecalibacterium 0.78 0.92 1 0.052 0.99 1 0.31 0.79 1 0.84 0.9 1 0.073 1 1 0.47 0.71 1 0.66 0.15 0 0.3 0 0.55 0 0 0 -Inf 8 / 36 (22%) 2 / 7 (29%) 0 / 7 (0%) 0.286 0 0.17 0 0.26 0.11 0 0.26 -0.63 4 / 11 (36%) 2 / 11 (18%) 0.364 0.182
s__Faecalibacterium MIC7301 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Faecalibacterium 0.2 0.6 1 1 1 1 0.56 0.86 1 0.16 0.5 1 0.8 1 1 0.44 0.71 1 0.23 0.019 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.036 0 0.079 0.028 0 0.093 -0.36 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Faecalibacterium MIC8666 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Faecalibacterium 0.19 0.6 1 1 1 1 0.22 0.79 1 0.17 0.51 1 0.82 1 1 0.33 0.71 1 1.7 0.14 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.33 0 0.98 0.12 0 0.39 -1.5 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Faecalibacterium MIC9210 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Faecalibacterium 0.37 0.72 1 0.2 0.99 1 0.56 0.86 1 0.6 0.85 1 0.69 1 1 0.45 0.71 1 3 0.42 0 0.77 0 2 1.2 0 3.2 0.64 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.054 0 0.18 0.064 0 0.15 0.25 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
s__Faecalibacterium prausnitzii_A d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Faecalibacterium 0.47 0.76 1 1 1 1 0.69 0.87 1 0.22 0.54 1 0.81 1 1 0.6 0.78 1 1.2 0.098 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.063 0 0.16 0.26 0 0.85 2 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Faecalibacterium prausnitzii_C d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Faecalibacterium 0.59 0.84 1 0.32 1 1 0.18 0.79 1 0.12 0.5 1 0.39 1 1 0.55 0.73 1 4 2.5 0.76 2.5 0 5 1.5 0 3.8 -0.74 22 / 36 (61%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 2 1.3 2.3 3.5 1.4 4.1 0.81 9 / 11 (82%) 8 / 11 (73%) 0.818 0.727
s__Faecalibacterium prausnitzii_D d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Faecalibacterium 0.058 0.51 1 0.22 0.99 1 0.19 0.79 1 0.05 0.5 1 0.78 1 1 0.25 0.71 1 2.2 1 0 1.9 0.95 2 1.2 1.1 1.3 -0.66 17 / 36 (47%) 5 / 7 (71%) 5 / 7 (71%) 0.714 0.714 0.68 0 1.4 0.75 0 1.5 0.14 3 / 11 (27%) 4 / 11 (36%) 0.273 0.364
s__Faecalibacterium prausnitzii_G d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Faecalibacterium 0.069 0.51 1 0.98 1 1 0.34 0.79 1 0.13 0.5 1 0.39 1 1 0.62 0.78 1 1.6 0.75 0 1.3 1 1.4 1.1 0.83 1.3 -0.24 17 / 36 (47%) 4 / 7 (57%) 5 / 7 (71%) 0.571 0.714 0.34 0 0.67 0.58 0 0.8 0.77 3 / 11 (27%) 5 / 11 (45%) 0.273 0.455
s__Faecalibacterium prausnitzii_I d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Faecalibacterium 0.27 0.63 1 0.66 1 1 0.76 0.87 1 0.36 0.69 1 0.59 1 1 0.63 0.78 1 0.47 0.091 0 0.019 0 0.05 0 0 0 -Inf 7 / 36 (19%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.14 0 0.27 0.14 0 0.29 0 3 / 11 (27%) 3 / 11 (27%) 0.273 0.273
s__Faecalibacterium prausnitzii_J d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Faecalibacterium 0.24 0.62 1 0.2 0.99 1 0.42 0.83 1 0.22 0.54 1 0.28 1 1 0.66 0.78 1 0.8 0.18 0 0.38 0 0.78 0.16 0 0.27 -1.2 8 / 36 (22%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 0.11 0 0.24 0.13 0 0.44 0.24 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Faecalibacterium prausnitzii_K d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Faecalibacterium 0.16 0.59 1 0.56 1 1 0.31 0.79 1 0.12 0.5 1 0.48 1 1 0.31 0.71 1 1.8 0.59 0 0.094 0 0.25 0 0 0 -Inf 12 / 36 (33%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.66 0 0.89 1.2 0.29 2.6 0.86 5 / 11 (45%) 6 / 11 (55%) 0.455 0.545
s__Faecalicatena faecis d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Faecalicatena 0.81 0.93 1 0.53 1 1 0.068 0.79 1 0.76 0.89 1 0.47 1 1 0.032 0.71 1 1.4 0.63 0 1.1 0 1.6 0.7 0.21 0.97 -0.65 16 / 36 (44%) 3 / 7 (43%) 4 / 7 (57%) 0.429 0.571 0.73 0.47 0.91 0.16 0 0.3 -2.2 6 / 11 (55%) 3 / 11 (27%) 0.545 0.273
s__Faecalicatena gnavus d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Faecalicatena 0.05 0.5 1 0.025 0.99 1 0.14 0.79 1 0.13 0.5 1 0.17 1 1 0.49 0.71 1 1.3 0.14 0 0.58 0 1.3 0.12 0 0.31 -2.3 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.023 0 0.075 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
s__Faecalicatena lactaris d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Faecalicatena 0.2 0.6 1 0.2 0.99 1 0.93 0.96 1 0.66 0.85 1 0.94 1 1 0.32 0.71 1 0.93 0.21 0 0.57 0 1.1 0.31 0 0.55 -0.88 8 / 36 (22%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0.081 0 0.14 0.036 0 0.12 -1.2 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
s__Faecalicatena torques d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Faecalicatena 0.4 0.73 1 0.5 1 1 0.34 0.79 1 0.6 0.85 1 0.49 1 1 0.45 0.71 1 0.42 0.093 0 0.092 0 0.17 0.046 0 0.12 -1 8 / 36 (22%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.2 0 0.3 0.018 0 0.059 -3.5 4 / 11 (36%) 1 / 11 (9.1%) 0.364 0.0909
s__Fusicatenibacter saccharivorans d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Fusicatenibacter 0.71 0.88 1 0.88 1 1 0.58 0.86 1 0.85 0.9 1 0.52 1 1 0.61 0.78 1 4.6 4.1 2.8 4.8 2 6.1 4.7 3.8 5 -0.03 32 / 36 (89%) 6 / 7 (86%) 6 / 7 (86%) 0.857 0.857 3.3 2.6 2.6 4.1 3 3.2 0.31 10 / 11 (91%) 10 / 11 (91%) 0.909 0.909
s__GCA-900066135 MIC6659 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__GCA-900066135 0.13 0.58 1 0.85 1 1 0.055 0.79 1 0.13 0.5 1 0.88 1 1 0.061 0.71 1 0.32 0.072 0 0.13 0 0.29 0.092 0 0.18 -0.5 8 / 36 (22%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0 0 0 0.097 0 0.15 Inf 0 / 11 (0%) 4 / 11 (36%) 0 0.364
s__Gemmiger MIC9530 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Gemmiger 0.24 0.62 1 0.4 1 1 0.57 0.86 1 0.22 0.54 1 0.24 1 1 0.29 0.71 1 0.38 0.053 0 0.1 0 0.18 0.093 0 0.25 -0.1 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.027 0 0.091 0.02 0 0.065 -0.43 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__Gemmiger formicilis d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Gemmiger 1 1 1 0.096 0.99 1 0.55 0.86 1 0.66 0.85 1 0.31 1 1 0.78 0.88 1 2.3 0.78 0 0.6 0 1.6 1.9 0 3.8 1.7 12 / 36 (33%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0.34 0 0.71 0.58 0.33 0.79 0.77 3 / 11 (27%) 6 / 11 (55%) 0.273 0.545
s__Gemmiger sp003476825 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Gemmiger 0.5 0.78 1 0.69 1 1 0.72 0.87 1 0.61 0.85 1 0.86 1 1 0.98 0.99 1 1.8 1.4 1 1 1.1 0.86 1.3 0.73 1.5 0.38 28 / 36 (78%) 5 / 7 (71%) 5 / 7 (71%) 0.714 0.714 1.7 0.88 2.1 1.5 1.1 1.4 -0.18 9 / 11 (82%) 9 / 11 (82%) 0.818 0.818
s__Holdemanella sp002299315 d__Bacteria; p__Firmicutes; c__Bacilli; o__Erysipelotrichales; f__Erysipelotrichaceae; g__Holdemanella 0.97 0.99 1 0.66 1 1 0.26 0.79 1 0.8 0.9 1 0.21 1 1 0.47 0.71 1 2.5 0.27 0 0.23 0 0.6 0.31 0 0.81 0.43 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.39 0 1.3 0.16 0 0.55 -1.3 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__Intestinibacter bartlettii d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Peptostreptococcales; f__Peptostreptococcaceae; g__Intestinibacter 0.037 0.5 1 0.1 0.99 1 0.054 0.79 1 0.057 0.5 1 0.15 1 1 0.089 0.71 1 0.27 0.052 0 0.13 0 0.18 0.037 0 0.097 -1.8 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0.0064 0 0.021 0.061 0 0.14 3.3 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
s__KLE1615 sp900066985 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__KLE1615 0.15 0.59 1 0.56 1 1 0.99 0.99 1 0.12 0.5 1 0.47 1 1 0.86 0.94 1 1.3 0.56 0 0.32 0 0.55 0.28 0 0.73 -0.19 16 / 36 (44%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.79 0.72 0.83 0.67 0.22 0.81 -0.24 7 / 11 (64%) 6 / 11 (55%) 0.636 0.545
s__Lachnospira eligens_B d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Lachnospira 0.91 0.97 1 0.22 0.99 1 0.93 0.96 1 0.86 0.9 1 0.33 1 1 0.91 0.96 1 0.43 0.036 0 0.09 0 0.24 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.059 0 0.13 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
s__Lachnospira rogosae d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Lachnospira 0.27 0.63 1 1 1 1 0.95 0.97 1 0.08 0.5 1 0.91 1 1 0.5 0.71 1 0.66 0.074 0 0 0 0 0 0 0 NA 4 / 36 (11%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.07 0 0.13 0.17 0 0.57 1.3 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
s__Lachnospira sp000437735 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Lachnospira 0.4 0.73 1 0.033 0.99 1 0.088 0.79 1 0.28 0.61 1 0.034 1 1 0.13 0.71 1 0.49 0.041 0 0.035 0 0.094 0.18 0 0.3 2.4 3 / 36 (8.3%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
s__Lachnospira sp003451515 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Lachnospira 0.73 0.88 1 0.68 1 1 0.65 0.87 1 0.81 0.9 1 0.97 1 1 0.49 0.71 1 1.2 0.22 0 0.18 0 0.47 0.066 0 0.18 -1.4 7 / 36 (19%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.31 0 0.74 0.28 0 0.61 -0.15 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
s__Lactobacillus_B salivarius d__Bacteria; p__Firmicutes; c__Bacilli; o__Lactobacillales; f__Lactobacillaceae; g__Lactobacillus_B 0.61 0.84 1 1 1 1 0.23 0.79 1 0.53 0.82 1 0.83 1 1 0.29 0.71 1 0.81 0.067 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.039 0 0.13 0.18 0 0.44 2.2 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
s__Megamonas funiformis d__Bacteria; p__Firmicutes_C; c__Negativicutes; o__Selenomonadales; f__Selenomonadaceae; g__Megamonas 0.34 0.68 1 0.17 0.99 1 0.12 0.79 1 0.51 0.82 1 0.15 1 1 0.12 0.71 1 0.44 0.037 0 0.083 0 0.22 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.007 0 0.023 0.06 0 0.2 3.1 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__Methanobrevibacter_A smithii d__Archaea; p__Euryarchaeota; c__Methanobacteria; o__Methanobacteriales; f__Methanobacteriaceae; g__Methanobrevibacter_A 0.66 0.87 1 0.53 1 1 0.77 0.87 1 0.67 0.85 1 0.95 1 1 0.53 0.71 1 1 0.087 0 0.19 0 0.5 0.067 0 0.18 -1.5 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.12 0 0.4 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
s__Monoglobus pectinilyticus d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Monoglobales; f__Monoglobaceae; g__Monoglobus 0.72 0.88 1 0.18 0.99 1 0.86 0.93 1 0.85 0.9 1 0.3 1 1 0.99 1 1 0.2 0.04 0 0.086 0 0.17 0.011 0 0.029 -3 7 / 36 (19%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.06 0 0.12 0.0088 0 0.029 -2.8 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
s__NK3B98 sp003150485 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__NK3B98 0.73 0.88 1 0.8 1 1 0.31 0.79 1 0.66 0.85 1 0.72 1 1 0.36 0.71 1 0.2 0.017 0 0.025 0 0.065 0.033 0 0.088 0.4 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.017 0 0.057 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
s__Oxalobacter formigenes_A d__Bacteria; p__Proteobacteria; c__Gammaproteobacteria; o__Burkholderiales; f__Burkholderiaceae; g__Oxalobacter 0.3 0.65 1 0.73 1 1 0.58 0.86 1 0.22 0.54 1 0.7 1 1 0.49 0.71 1 0.11 0.0088 0 0.014 0 0.037 0.02 0 0.052 0.51 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 0.0073 0 0.024 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__Parabacteroides distasonis d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Tannerellaceae; g__Parabacteroides 0.39 0.73 1 0.45 1 1 0.92 0.96 1 0.52 0.82 1 0.4 1 1 0.88 0.95 1 0.6 0.067 0 0.0089 0 0.024 0 0 0 -Inf 4 / 36 (11%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.11 0 0.31 0.098 0 0.32 -0.17 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Parabacteroides merdae d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Tannerellaceae; g__Parabacteroides 0.85 0.94 1 0.71 1 1 0.82 0.91 1 0.64 0.85 1 1 1 1 0.59 0.77 1 0.27 0.053 0 0.059 0 0.11 0.037 0 0.062 -0.67 7 / 36 (19%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0.068 0 0.16 0.045 0 0.15 -0.6 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Parasutterella excrementihominis d__Bacteria; p__Proteobacteria; c__Gammaproteobacteria; o__Burkholderiales; f__Burkholderiaceae; g__Parasutterella 0.61 0.84 1 0.098 0.99 1 0.22 0.79 1 0.52 0.82 1 0.057 1 1 0.19 0.71 1 0.46 0.038 0 0 0 0 0.11 0 0.29 Inf 3 / 36 (8.3%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 0.022 0 0.073 0.032 0 0.11 0.54 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__Phascolarctobacterium faecium d__Bacteria; p__Firmicutes_C; c__Negativicutes; o__Acidaminococcales; f__Acidaminococcaceae; g__Phascolarctobacterium 0.68 0.87 1 0.28 1 1 0.65 0.87 1 0.95 0.96 1 0.83 1 1 0.53 0.71 1 0.82 0.2 0 0.13 0 0.22 0.06 0 0.1 -1.1 9 / 36 (25%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0.33 0 0.79 0.22 0 0.64 -0.58 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
s__Prevotella copri d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Bacteroidaceae; g__Prevotella 0.68 0.87 1 0.39 1 1 0.17 0.79 1 0.66 0.85 1 0.15 1 1 0.13 0.71 1 4.2 0.35 0 0.26 0 0.69 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.073 0 0.24 0.89 0 3 3.6 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__Prevotella sp000436915 d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Bacteroidaceae; g__Prevotella 0.23 0.62 1 1 1 1 0.66 0.87 1 0.17 0.51 1 0.82 1 1 0.46 0.71 1 0.45 0.037 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.06 0 0.13 0.062 0 0.2 0.047 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Prevotella sp900313215 d__Bacteria; p__Bacteroidota; c__Bacteroidia; o__Bacteroidales; f__Bacteroidaceae; g__Prevotella 0.32 0.67 1 1 1 1 0.97 0.98 1 0.18 0.51 1 0.86 1 1 0.5 0.71 1 3.4 0.29 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.33 0 0.73 0.61 0 2 0.89 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__QAMH01 MIC6543 d__Bacteria; p__Actinobacteriota; c__Coriobacteriia; o__Coriobacteriales; f__QAMH01; g__QAMH01 0.15 0.59 1 1 1 1 0.37 0.81 1 0.14 0.5 1 0.83 1 1 0.37 0.71 1 0.5 0.041 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.098 0 0.22 0.037 0 0.12 -1.4 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Romboutsia timonensis d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Peptostreptococcales; f__Peptostreptococcaceae; g__Romboutsia 0.84 0.93 1 0.43 1 1 0.4 0.82 1 0.6 0.85 1 0.5 1 1 0.33 0.71 1 0.73 0.24 0 0.27 0 0.51 0.11 0 0.21 -1.3 12 / 36 (33%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 0.28 0 0.54 0.28 0 0.42 0 3 / 11 (27%) 4 / 11 (36%) 0.273 0.364
s__Roseburia hominis d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Roseburia 0.61 0.84 1 0.32 1 1 0.72 0.87 1 0.57 0.85 1 0.41 1 1 0.73 0.84 1 0.84 0.12 0 0.25 0 0.6 0.11 0 0.3 -1.2 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.15 0 0.33 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
s__Roseburia intestinalis d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Roseburia 0.83 0.93 1 0.2 0.99 1 0.96 0.98 1 0.83 0.9 1 0.36 1 1 0.65 0.78 1 0.57 0.13 0 0.27 0 0.5 0.068 0 0.18 -2 8 / 36 (22%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.16 0 0.23 0.04 0 0.13 -2 4 / 11 (36%) 1 / 11 (9.1%) 0.364 0.0909
s__Ruminiclostridium_C MIC9168 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__Ruminiclostridium_C 0.3 0.65 1 0.54 1 1 0.77 0.87 1 0.22 0.54 1 0.69 1 1 0.51 0.71 1 0.3 0.025 0 0.039 0 0.1 0.066 0 0.17 0.76 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 0.014 0 0.047 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
s__Ruminiclostridium_C sp000435295 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__Ruminiclostridium_C 0.41 0.73 1 0.75 1 1 0.1 0.79 1 0.41 0.74 1 0.99 1 1 0.074 0.71 1 0.22 0.06 0 0.066 0 0.13 0.048 0 0.1 -0.46 10 / 36 (28%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0.11 0 0.14 0.018 0 0.06 -2.6 5 / 11 (45%) 1 / 11 (9.1%) 0.455 0.0909
s__Ruminiclostridium_E MIC9645 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Ruminiclostridium_E 0.12 0.58 1 1 1 1 0.28 0.79 1 0.13 0.5 1 0.86 1 1 0.33 0.71 1 1.5 0.12 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.34 0 0.75 0.071 0 0.23 -2.3 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Ruminococcus_A sp003011855 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__Ruminococcus_A 0.28 0.63 1 0.22 0.99 1 0.077 0.79 1 0.4 0.74 1 0.15 1 1 0.11 0.71 1 0.98 0.38 0 0.14 0 0.24 0.19 0 0.27 0.44 14 / 36 (39%) 2 / 7 (29%) 3 / 7 (43%) 0.286 0.429 0.57 0 1 0.47 0 0.81 -0.28 5 / 11 (45%) 4 / 11 (36%) 0.455 0.364
s__Ruminococcus_C sp000433635 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Ruminococcus_C 0.17 0.6 1 0.49 1 1 0.53 0.86 1 0.37 0.7 1 0.94 1 1 0.9 0.96 1 0.77 0.15 0 0.35 0 0.63 0.19 0 0.36 -0.88 7 / 36 (19%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0.039 0 0.087 0.11 0 0.35 1.5 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__Ruminococcus_D bicirculans d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__Ruminococcus_D 0.97 0.99 1 0.37 1 1 0.12 0.79 1 0.74 0.88 1 0.19 1 1 0.1 0.71 1 2.8 1.3 0 0.93 0.22 1.3 0.48 0 0.93 -0.95 17 / 36 (47%) 4 / 7 (57%) 2 / 7 (29%) 0.571 0.286 1.1 0 1.7 2.3 0.82 3.2 1.1 5 / 11 (45%) 6 / 11 (55%) 0.455 0.545
s__Ruminococcus_E bromii d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Acutalibacteraceae; g__Ruminococcus_E 0.23 0.62 1 1 1 1 0.9 0.95 1 0.21 0.54 1 0.17 1 1 0.9 0.96 1 3.7 0.42 0 0 0 0 0 0 0 NA 4 / 36 (11%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.67 0 1.5 0.69 0 1.8 0.042 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
s__Ruminococcus_E bromii_B d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Acutalibacteraceae; g__Ruminococcus_E 0.6 0.84 1 0.82 1 1 0.32 0.79 1 0.72 0.87 1 0.33 1 1 1 1 1 4.6 2.6 0.57 2.1 0.39 2.9 2.3 0 3.5 0.13 20 / 36 (56%) 4 / 7 (57%) 3 / 7 (43%) 0.571 0.429 3.3 0.73 4.5 2.3 0.43 3.7 -0.52 7 / 11 (64%) 6 / 11 (55%) 0.636 0.545
s__Ruminococcus_E sp900314705 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Acutalibacteraceae; g__Ruminococcus_E 0.73 0.88 1 0.37 1 1 0.17 0.79 1 0.68 0.85 1 0.15 1 1 0.11 0.71 1 1.6 0.13 0 0.094 0 0.25 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 0.037 0 0.12 0.34 0 1.1 3.2 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__Senegalimassilia anaerobia d__Bacteria; p__Actinobacteriota; c__Coriobacteriia; o__Coriobacteriales; f__Eggerthellaceae; g__Senegalimassilia 0.73 0.88 1 0.83 1 1 0.33 0.79 1 0.68 0.85 1 0.78 1 1 0.42 0.71 1 0.31 0.026 0 0.04 0 0.11 0.051 0 0.14 0.35 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.028 0 0.091 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
s__Streptococcus salivarius d__Bacteria; p__Firmicutes; c__Bacilli; o__Lactobacillales; f__Streptococcaceae; g__Streptococcus 0.38 0.72 1 0.0061 0.99 1 0.12 0.79 1 0.46 0.79 1 0.0032 0.55 0.55 0.066 0.71 1 0.65 0.22 0 0.022 0 0.057 0.28 0.15 0.31 3.7 12 / 36 (33%) 1 / 7 (14%) 4 / 7 (57%) 0.143 0.571 0.18 0 0.36 0.33 0 0.62 0.87 3 / 11 (27%) 4 / 11 (36%) 0.273 0.364
s__Streptococcus thermophilus d__Bacteria; p__Firmicutes; c__Bacilli; o__Lactobacillales; f__Streptococcaceae; g__Streptococcus 0.066 0.51 1 0.19 0.99 1 0.032 0.79 1 0.057 0.5 1 0.067 1 1 0.018 0.71 1 1.1 0.25 0 0 0 0 0.3 0 0.73 Inf 8 / 36 (22%) 0 / 7 (0%) 2 / 7 (29%) 0 0.286 0.56 0 1.3 0.056 0 0.16 -3.3 4 / 11 (36%) 2 / 11 (18%) 0.364 0.182
s__TF01-11 sp003149875 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__TF01-11 0.12 0.58 1 0.46 1 1 0.094 0.79 1 0.1 0.5 1 0.25 1 1 0.058 0.71 1 0.17 0.014 0 0 0 0 0.013 0 0.034 Inf 3 / 36 (8.3%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 0.038 0 0.084 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
s__TF01-11 sp003524945 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__TF01-11 0.42 0.73 1 0.071 0.99 1 0.15 0.79 1 0.29 0.62 1 0.043 1 1 0.15 0.71 1 0.19 0.016 0 0.013 0 0.034 0.069 0 0.14 2.4 3 / 36 (8.3%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
s__Turicibacter sp001543345 d__Bacteria; p__Firmicutes; c__Bacilli; o__Haloplasmatales; f__Turicibacteraceae; g__Turicibacter 0.023 0.5 1 0.15 0.99 1 0.25 0.79 1 0.016 0.35 1 0.19 1 1 0.23 0.71 1 0.22 0.018 0 0.073 0 0.15 0.021 0 0.057 -1.8 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
s__UBA11524 sp000437595 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Christensenellales; f__CAG-74; g__UBA11524 0.46 0.76 1 0.76 1 1 0.56 0.86 1 0.59 0.85 1 0.9 1 1 0.45 0.71 1 1.5 0.12 0 0.29 0 0.77 0.22 0 0.59 -0.4 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.079 0 0.26 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
s__UBA11774 sp003507655 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__UBA11774 0.67 0.87 1 0.98 1 1 0.87 0.94 1 0.89 0.92 1 0.13 1 1 0.28 0.71 1 1.3 0.39 0 0.7 0 1.7 0.4 0 0.68 -0.81 11 / 36 (31%) 2 / 7 (29%) 3 / 7 (43%) 0.286 0.429 0.32 0 0.64 0.27 0 0.6 -0.25 3 / 11 (27%) 3 / 11 (27%) 0.273 0.273
s__UBA1191 MIC6696 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Peptostreptococcales; f__Anaerovoracaceae; g__UBA1191 0.42 0.73 1 0.53 1 1 0.21 0.79 1 0.5 0.82 1 0.69 1 1 0.35 0.71 1 0.58 0.048 0 0.093 0 0.25 0.13 0 0.35 0.48 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.014 0 0.045 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
s__UBA1394 sp900066845 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Ruminococcaceae; g__UBA1394 0.83 0.93 1 0.42 1 1 0.51 0.86 1 0.82 0.9 1 0.56 1 1 0.37 0.71 1 0.46 0.064 0 0.031 0 0.083 0.085 0 0.22 1.5 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.048 0 0.12 0.087 0 0.29 0.86 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__UBA1417 sp003531055 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Acutalibacteraceae; g__UBA1417 0.0064 0.5 1 1 1 1 0.033 0.79 1 0.0043 0.27 0.73 0.9 1 1 0.039 0.71 1 0.62 0.1 0 0 0 0 0 0 0 NA 6 / 36 (17%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.3 0 0.43 0.041 0 0.13 -2.9 5 / 11 (45%) 1 / 11 (9.1%) 0.455 0.0909
s__UBA1691 MIC9213 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Acutalibacteraceae; g__UBA1691 0.91 0.97 1 0.11 0.99 1 0.28 0.79 1 0.78 0.89 1 0.77 1 1 0.39 0.71 1 1 0.11 0 0.12 0 0.32 0.043 0 0.11 -1.5 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.14 0 0.48 0.12 0 0.4 -0.22 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
s__UBA1777 MIC6732 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Oscillospirales; f__Oscillospiraceae; g__UBA1777 0.14 0.58 1 1 1 1 0.34 0.79 1 0.14 0.5 1 0.85 1 1 0.37 0.71 1 1.2 0.098 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 0.24 0 0.53 0.081 0 0.27 -1.6 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
s__UBA7160 MIC6745 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__UBA7160 0.65 0.87 1 0.62 1 1 0.66 0.87 1 0.66 0.85 1 0.58 1 1 0.41 0.71 1 0.57 0.13 0 0.2 0 0.51 0.17 0 0.46 -0.23 8 / 36 (22%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.097 0 0.22 0.077 0 0.15 -0.33 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
s__UBA7160 MIC9207 d__Bacteria; p__Firmicutes_A; c__Clostridia; o__Lachnospirales; f__Lachnospiraceae; g__UBA7160 0.83 0.93 1 0.96 1 1 0.38 0.81 1 0.72 0.87 1 0.79 1 1 0.43 0.71 1 0.12 0.01 0 0.015 0 0.038 0.016 0 0.042 0.093 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0.014 0 0.046 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0

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Methods:

P lmer study group effect (sqrt): Differentially abundant species were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Fibre_Intake, Treatment, Fibre_Intake vs Treatment. Effect tested: Fibre_Intake.

P lmer study group effect (clr): Differentially abundant species were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Fibre_Intake, Treatment, Fibre_Intake vs Treatment. Effect tested: Fibre_Intake.

P lmer time effect (sqrt): Differentially abundant species were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Fibre_Intake, Treatment, Fibre_Intake vs Treatment. Effect tested: Treatment.

P lmer time effect (clr): Differentially abundant species were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Fibre_Intake, Treatment, Fibre_Intake vs Treatment. Effect tested: Treatment.

P lmer treatment effect (interaction) (sqrt): Differentially abundant species were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Fibre_Intake, Treatment, Fibre_Intake vs Treatment. Effect tested: Fibre_Intake vs Treatment.

P lmer treatment effect (interaction) (clr): Differentially abundant species were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Fibre_Intake, Treatment, Fibre_Intake vs Treatment. Effect tested: Fibre_Intake vs Treatment.

Glossary:

clr: Centered log-ratio transformation. P Welch's ANOVA (sqrt): Welch's ANOVA p-values (Anova was run on sqrt transformed abundances). It is an alternative to the classic ANOVA and can be used even if the samples have unequal variances and/or unequal sample sizes. P Welch's t-test (sqrt): Welch's T-test p-values (run on sqrt transformed abundances). It is an alternative to the classic Student's t-test and is more reliable if the data violates the assumption of homogeneity of variances and/or if the study conditions have unequal sample sizes. P Welch's ANOVA (clr): Welch's ANOVA p-values (Anova was run on clr transformed abundances). It is an alternative to the classic ANOVA and can be used even if the samples have unequal variances and/or unequal sample sizes. P Welch's t-test (clr): Welch's T-test p-values (run on clr transformed abundances). It is an alternative to the classic Student's t-test and is more reliable if the data violates the assumption of homogeneity of variances and/or if the study conditions have unequal sample sizes. P lmer XXX (clr): P-value of Linear Mixed-Effects Regression on clr transformed abundances, testing significance of XXX effect. Varying intercepts per subjects are used to control for repeated measures. Pbonf: Bonferroni corrected p-value. FDR: False Discovery Rate q-value. Mean Pos: Mean abundance in positive samples. Positive samples: The number and percentage of samples in which each species has been detected. Positive XXX: The number and percentage of positive samples in study group XXX. Positive_XXX_percent: Percentage of positive samples in study group XXX. P Welch's t-test (Aldex2): Expected P value of Welch’s t-test computed by Aldex2. FDR Welch's t-test (Aldex2): Expected Benjamini-Hochberg corrected P value for Welch’s t-test. P Wilcoxon rank test (Aldex2): Expected P value of Wilcoxon rank test computed by Aldex2. FDR Wilcoxon rank test (Aldex2): Expected Benjamini-Hochberg corrected P value of Wilcoxon test. P Kruskal-Wallace test (Aldex2): Expected P value of Kruskal-Wallace test. FDR Kruskal-Wallace test (Aldex2): Expected Benjamini-Hochberg corrected P value of Kruskal-Wallace test. P GLM test (Aldex2): Expected P value of generalized linear model. FDR GLM test (Aldex2): Expected Benjamini-Hochberg corrected P value of generalized linear model.

Differentially abundant taxa (species)

The following plots present the distribution of the top most differentially abundant species across all applied statistical analysis. Plots are ordered alphabetically.

Glossary:

"Rel. Abundance": Relative abundance data; "Rel. Abundance (sqrt)": sqrt (Hellinger) transformed relative abundances; "Rel. Abundance (clr)": centered log-ratio (clr) transformed read counts.
s__Agathobacter faecis
s__Anaerostipes hadrus
s__Bacteroides ovatus
s__CAG 41 sp900066215
s__Coprococcus_B comes
s__Dialister invisus
s__Eisenbergiella sp900066775
s__ER4 sp900317525
s__Faecalicatena faecis
s__GCA 900066135 MIC6659
s__Intestinibacter bartlettii
s__Lachnospira sp000437735
s__Ruminiclostridium_C sp000435295
s__Ruminococcus_A sp003011855
s__Ruminococcus_D bicirculans
s__Ruminococcus_E sp900314705
s__Streptococcus salivarius
s__Streptococcus thermophilus
s__TF01 11 sp003149875
s__UBA1417 sp003531055