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Microba Research Discovery Report

Analysis: Aim 2 Longitudinal Fibre Intake Effect

Functional profiles: Membrane Transport Proteins (TCDB)

Quantitative visualisation of the top most abundant microbial functions identified in the analysed samples.

Scaled heatmap of most abundant features ordered by study group

Features were filtered by mean abundance. Samples were first ordered by study group and then clustered within each study group. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Heatmap of most abundant features ordered by study group

Features were filtered by mean abundance. Samples were first ordered by study group and then clustered within each study group. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Scaled heatmap of all features

Profiles were clustered by hierarchical clustering. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Heatmap of all features

Profiles were clustered by hierarchical clustering. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Scaled heatmap of top most abundant features filtered by mean abundance

Profiles were clustered by hierarchical clustering. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Heatmap of top most abundant features filtered by mean abundance

Profiles were clustered by hierarchical clustering. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Scaled heatmap of top most abundant features filtered by max abundance

Profiles were clustered by hierarchical clustering. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Heatmap of top most abundant features filtered by max abundance

Profiles were clustered by hierarchical clustering. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Scaled heatmap of top most variable features

Profiles were clustered by hierarchical clustering. Abundances were scaled to a max value of 1. Color scale shows not-detected (white), and abundance ranging from low (blue) to high (yellow).

Click here to open full-sized image in new window.

Membrane Transport Proteins (TCDB)

Functional Alpha Diversity

This page provides an overview of the functional alpha diversity of the analysed sample. Alpha diversity was measured using the Shannon index and functional richnes. Richness measures the total number of gene functions present in each sample. Shannon index combines richness and evenness.

Methods:

Shannon diversity was compared using linear mixed effect regression, including Participant as a random effect (intercept), and Fibre_Intake, Treatment, and Fibre_Intake vs Treatment as fixed effects. Effect tested: Fibre_Intake vs Treatment. Richness was compared using linear mixed effect regression, including Participant as a random effect (intercept), and Fibre_Intake, Treatment, and Fibre_Intake vs Treatment as fixed effects. Effect tested: Fibre_Intake vs Treatment. Data was rarefied to 74 reads.

Index: Richness

Index: Shannon index

Summary Table

Index rarefiedTo P lmer treatment effect (interaction) Mean Pos Mean Abundance Median Abundance Mean Fibre_Intakelow:Treatmentpre_treatment Median Fibre_Intakelow:Treatmentpre_treatment SD Fibre_Intakelow:Treatmentpre_treatment Mean Fibre_Intakelow:Treatmentpost_treatment Median Fibre_Intakelow:Treatmentpost_treatment SD Fibre_Intakelow:Treatmentpost_treatment Fold Change Log2(Fibre_Intakelow:Treatmentpost_treatment/Fibre_Intakelow:Treatmentpre_treatment) Positive samples Positive Fibre_Intakelow:Treatmentpre_treatment Positive Fibre_Intakelow:Treatmentpost_treatment Positive_Fibre_Intakelow:Treatmentpre_treatment_percent Positive_Fibre_Intakelow:Treatmentpost_treatment_percent Mean Fibre_Intakehigh:Treatmentpre_treatment Median Fibre_Intakehigh:Treatmentpre_treatment SD Fibre_Intakehigh:Treatmentpre_treatment Mean Fibre_Intakehigh:Treatmentpost_treatment Median Fibre_Intakehigh:Treatmentpost_treatment SD Fibre_Intakehigh:Treatmentpost_treatment Fold Change Log2(Fibre_Intakehigh:Treatmentpost_treatment/Fibre_Intakehigh:Treatmentpre_treatment) Positive Fibre_Intakehigh:Treatmentpre_treatment Positive Fibre_Intakehigh:Treatmentpost_treatment Positive_Fibre_Intakehigh:Treatmentpre_treatment_percent Positive_Fibre_Intakehigh:Treatmentpost_treatment_percent
Shannon 74 0.0028 3.2 3.2 3 3.6 3.8 0.54 3.1 2.8 0.57 -0.22 36 / 36 (100%) 7 / 7 (100%) 7 / 7 (100%) 1 1 3.1 3 0.46 3 3 0.39 -0.047 11 / 11 (100%) 11 / 11 (100%) 1 1
Richness 74 0.00058 34 34 28 47 52 16 34 24 16 -0.47 36 / 36 (100%) 7 / 7 (100%) 7 / 7 (100%) 1 1 30 26 12 30 26 12 0 11 / 11 (100%) 11 / 11 (100%) 1 1
Download diversity values in csv format . On some platforms (including Windows) you may need to change the suffix from .txt or .html to .csv before opening the file in a spreadsheet program, like Excel.

Functional clustering and ordination

Microbial functions were analyzed using supervised and unsupervised multivariate techniques. Functional profiles were ordinated using the unsupervised methods Principal Coordinates Analysis (PCoA), Non-Metric Multidimensional Scaling (NMDS) and Principal Component Analysis (PCA). The supervised methods Adonis and Redundancy analysis (RDA) were used to assess if variance in the functional profiles was significantly associated with the study condition. A guide explaining these methods can be found here. Sparse Partial Least Square Discriminant Analysis (sPLS-DA) from the MixMc package was additionaly used to extract features associated with the condition of interest.

Unsupervised ordination

Interactive PCA (clr transformed)

Please click here to view an interactive 3D PCA.

Membrane Transport Proteins (TCDB)

Univariate analysis of microbial functions

Differentially abundant microbial functions were identified using the univariate methods ANOVA or LMER (linear mixed effect regression) on clr transformed relative abundance data, Fisher's exact test, and Aldex2 (ANOVA-like Differential Expression). Aldex2 was run on read count data. Fisher's exact test was used to test for diffrerences in the presence and absence (detection rate) of microbial functions across study groups.

LMER is used for repeated measures data, using random effects to control for correlation between samples from the same subject. Fixed effects are included for treatment groups, time, and treatment over time, where appropriate. The LMER P values correspond to a nested model test of the significance of including the corresponding fixed effect.

ALDEx2 uses subsampling (Bayesian sampling) to estimate the underlying technical variation. For each subsample instance, center log-ratio transformed data is statistically compared across study groups and computed P values are corrected for multiple testing using the Benjamini–Hochberg procedure. The expected P value (mean P value) is reported, which are those that would likely have been observed if the same samples had been run multiple times. The expected values are reported for both the distribution of P values and for the distribution of Benjamini–Hochberg corrected values.

Function Annotation P lmer study group effect (sqrt) FDR lmer study group effect (sqrt) Pbonf lmer study group effect (sqrt) P lmer time effect (sqrt) FDR lmer time effect (sqrt) Pbonf lmer time effect (sqrt) P lmer treatment effect (interaction) (sqrt) FDR lmer treatment effect (interaction) (sqrt) Pbonf lmer treatment effect (interaction) (sqrt) P lmer study group effect (clr) FDR lmer study group effect (clr) Pbonf lmer study group effect (clr) P lmer time effect (clr) FDR lmer time effect (clr) Pbonf lmer time effect (clr) P lmer treatment effect (interaction) (clr) FDR lmer treatment effect (interaction) (clr) Pbonf lmer treatment effect (interaction) (clr) Mean Pos Mean Abundance Median Abundance Mean Fibre_Intakelow:Treatmentpre_treatment Median Fibre_Intakelow:Treatmentpre_treatment SD Fibre_Intakelow:Treatmentpre_treatment Mean Fibre_Intakelow:Treatmentpost_treatment Median Fibre_Intakelow:Treatmentpost_treatment SD Fibre_Intakelow:Treatmentpost_treatment Fold Change Log2(Fibre_Intakelow:Treatmentpost_treatment/Fibre_Intakelow:Treatmentpre_treatment) Positive samples Positive Fibre_Intakelow:Treatmentpre_treatment Positive Fibre_Intakelow:Treatmentpost_treatment Positive_Fibre_Intakelow:Treatmentpre_treatment_percent Positive_Fibre_Intakelow:Treatmentpost_treatment_percent Mean Fibre_Intakehigh:Treatmentpre_treatment Median Fibre_Intakehigh:Treatmentpre_treatment SD Fibre_Intakehigh:Treatmentpre_treatment Mean Fibre_Intakehigh:Treatmentpost_treatment Median Fibre_Intakehigh:Treatmentpost_treatment SD Fibre_Intakehigh:Treatmentpost_treatment Fold Change Log2(Fibre_Intakehigh:Treatmentpost_treatment/Fibre_Intakehigh:Treatmentpre_treatment) Positive Fibre_Intakehigh:Treatmentpre_treatment Positive Fibre_Intakehigh:Treatmentpost_treatment Positive_Fibre_Intakehigh:Treatmentpre_treatment_percent Positive_Fibre_Intakehigh:Treatmentpost_treatment_percent
3.A.1.140.6 The ATP-binding Cassette (ABC) Superfamily 0.12 0.34 1 0.56 0.76 1 0.35 0.6 1 0.048 0.27 1 0.32 0.83 1 0.2 0.69 1 0.00022 3.6e-05 0 0 0 0 1.7e-05 0 4.5e-05 Inf 6 / 36 (17%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 7e-05 0 0.00016 3.8e-05 0 1e-04 -0.88 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
2.A.1.1.92 The Major Facilitator Superfamily (MFS) 0.022 0.34 1 0.0092 0.22 1 0.015 0.37 1 0.0059 0.16 1 0.055 0.62 1 0.062 0.58 1 0.00049 6.8e-05 0 0.00021 0 0.00043 0.00013 0 0.00033 -0.69 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 6.5e-06 0 2.1e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
5.A.1.1.1 The Disulfide Bond Oxidoreductase D (DsbD) Family 0.0076 0.34 1 0.0014 0.16 0.77 0.0066 0.37 1 0.0022 0.15 1 0.012 0.5 1 0.038 0.58 1 0.00042 8.2e-05 0 0.00031 1.6e-05 6e-04 9.7e-05 0 0.00026 -1.7 7 / 36 (19%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 2.6e-06 0 8.5e-06 6.8e-06 0 2.3e-05 1.4 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.2.1 The ATP-binding Cassette (ABC) Superfamily 0.058 0.34 1 0.14 0.44 1 0.083 0.39 1 0.04 0.27 1 0.13 0.66 1 0.076 0.6 1 0.00036 7.1e-05 0 0.00016 0 3e-04 0.00016 0 0.00044 0 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 3e-06 0 9.9e-06 2.1e-05 0 4.7e-05 2.8 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
3.A.1.1.46 The ATP-binding Cassette (ABC) Superfamily 0.16 0.34 1 0.11 0.4 1 0.73 0.88 1 0.26 0.58 1 0.25 0.77 1 0.99 1 1 0.00062 1e-04 0 0.00027 0 0.00066 0.00022 0 0.00059 -0.3 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.5e-05 0 7.2e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
4.A.6.1.11 The PTS Mannose-Fructose-Sorbose (Man) Family 0.25 0.36 1 0.13 0.42 1 0.69 0.86 1 0.99 0.99 1 0.27 0.78 1 1 1 1 0.00011 1.8e-05 0 4.8e-05 0 8.8e-05 7.7e-06 0 2e-05 -2.6 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.3e-05 0 5.1e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
1.B.23.1.22 The Cyanobacterial Porin (CBP) Family 0.46 0.53 1 0.32 0.61 1 0.71 0.87 1 0.86 0.95 1 0.55 0.91 1 0.94 0.99 1 7e-04 0.00015 0 0.00035 0 0.00084 0.00017 0 0.00046 -1 8 / 36 (22%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.00012 0 0.00034 4.9e-05 0 0.00013 -1.3 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
1.A.23.2.1 The Small Conductance Mechanosensitive Ion Channel (MscS) Family 0.18 0.34 1 0.59 0.78 1 0.14 0.43 1 0.52 0.76 1 0.75 0.94 1 0.33 0.73 1 0.00041 4.6e-05 0 0.00012 0 0.00031 7.7e-05 0 2e-04 -0.64 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.6e-05 0 6.9e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
1.E.34.2.1 The Putative Actinobacterial Holin-X (Hol-X) Family 0.56 0.61 1 0.49 0.75 1 0.81 0.92 1 0.31 0.62 1 0.28 0.78 1 0.52 0.82 1 0.00013 1.5e-05 0 1.7e-05 0 4.5e-05 3.9e-05 0 1e-04 1.2 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 1e-05 0 3.4e-05 1.7 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.B.1.1.2 The Na+-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family 0.84 0.88 1 0.81 0.91 1 0.69 0.86 1 0.61 0.82 1 0.91 0.98 1 0.98 1 1 0.00016 3.6e-05 0 2.8e-05 0 5e-05 2.3e-05 0 5.1e-05 -0.28 8 / 36 (22%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 3.4e-05 0 9.7e-05 5.2e-05 0 0.00015 0.61 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
1.E.24.1.5 The Bacterophage Dp-1 Holin (Dp-1 Holin) Family 0.29 0.39 1 0.22 0.51 1 0.2 0.48 1 0.8 0.91 1 0.44 0.86 1 0.41 0.76 1 0.00014 1.2e-05 0 3.2e-05 0 8.5e-05 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 2.6e-06 0 8.5e-06 1.6e-05 0 5.3e-05 2.6 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
4.A.2.1.10 The PTS Fructose-Mannitol (Fru) Family 0.18 0.34 1 0.61 0.79 1 0.24 0.52 1 0.34 0.63 1 0.37 0.84 1 0.89 0.97 1 0.00075 6.3e-05 0 0.00017 0 0.00045 0.00015 0 0.00038 -0.18 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.A.23.4.3 The Small Conductance Mechanosensitive Ion Channel (MscS) Family 0.031 0.34 1 0.0067 0.22 1 0.061 0.37 1 0.038 0.27 1 0.051 0.62 1 0.32 0.73 1 0.00016 2.2e-05 0 8.1e-05 0 0.00017 2.9e-05 0 7.7e-05 -1.5 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
9.B.102.1.1 The YedE/YeeE (YedE/YeeE) Family 0.28 0.38 1 0.35 0.63 1 0.6 0.82 1 0.62 0.82 1 0.88 0.97 1 0.64 0.86 1 2e-04 2.2e-05 0 6.7e-05 0 0.00018 2.9e-05 0 7.7e-05 -1.2 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 7.3e-06 0 2.4e-05 2.7e-06 0 8.9e-06 -1.4 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.8.1.2 The Gluconate:H+ Symporter (GntP) Family 0.17 0.34 1 0.096 0.39 1 0.19 0.48 1 0.66 0.85 1 0.63 0.91 1 0.49 0.82 1 0.00049 5.5e-05 0 0.00019 0 0.00049 8.7e-05 0 0.00023 -1.1 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 2.7e-06 0 8.9e-06 -0.15 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.98.1.3 The Putative Sulfate Exporter (PSE) Family 0.16 0.34 1 0.45 0.72 1 0.19 0.48 1 0.47 0.72 1 0.68 0.92 1 0.69 0.88 1 0.00049 4.1e-05 0 0.00012 0 0.00031 7.7e-05 0 2e-04 -0.64 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.85.1.3 The Aromatic Acid Exporter (ArAE) Family 0.076 0.34 1 0.038 0.28 1 0.042 0.37 1 0.045 0.27 1 0.29 0.78 1 0.17 0.68 1 0.00097 0.00011 0 0.00037 0 0.00093 0.00017 0 0.00046 -1.1 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 8.1e-06 0 2.7e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
9.B.14.1.3 The Putative Heme Handling Protein (HHP) Family 0.097 0.34 1 0.026 0.25 1 0.11 0.42 1 0.23 0.54 1 0.19 0.72 1 0.5 0.82 1 0.00036 5.9e-05 0 0.00019 0 0.00044 9.7e-05 0 0.00026 -0.97 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 5.5e-06 0 1.2e-05 5.4e-06 0 1.8e-05 -0.026 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.3.1.14 The Amino Acid-Polyamine-Organocation (APC) Family 0.33 0.42 1 0.6 0.78 1 0.74 0.89 1 0.86 0.95 1 0.6 0.91 1 0.7 0.88 1 0.00037 6.1e-05 0 0.00012 0 0.00026 0.00015 0 0.00038 0.32 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.8e-05 0 7.3e-05 2.7e-06 0 8.9e-06 -3.4 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.1.46.6 The Major Facilitator Superfamily (MFS) 0.13 0.34 1 0.36 0.64 1 0.47 0.72 1 0.14 0.4 1 0.87 0.97 1 0.72 0.88 1 0.00034 2.9e-05 0 7e-05 0 0.00018 7.7e-05 0 2e-04 0.14 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
3.A.1.106.3 The ATP-binding Cassette (ABC) Superfamily 0.12 0.34 1 0.12 0.41 1 0.44 0.69 1 0.043 0.27 1 0.39 0.84 1 0.53 0.82 1 0.0011 0.00089 0.00044 0.00032 0.00023 0.00038 0.00088 0.00036 0.001 1.5 29 / 36 (81%) 5 / 7 (71%) 4 / 7 (57%) 0.714 0.571 0.00095 0.00077 0.001 0.0012 0.00098 0.0011 0.34 10 / 11 (91%) 10 / 11 (91%) 0.909 0.909
3.A.1.135.1 The ATP-binding Cassette (ABC) Superfamily 0.59 0.65 1 0.39 0.67 1 0.89 0.96 1 0.21 0.52 1 0.28 0.78 1 0.66 0.87 1 0.00017 1.8e-05 0 0 0 0 2.3e-05 0 6.1e-05 Inf 4 / 36 (11%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 1.2e-05 0 3.9e-05 3.4e-05 0 7.8e-05 1.5 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.103.1.1 The Bacterial Murein Precursor Exporter (MPE) Family 0.18 0.34 1 0.13 0.43 1 0.23 0.52 1 0.6 0.82 1 0.051 0.62 1 0.1 0.65 1 0.00042 3.5e-05 0 8.4e-05 0 0.00022 9.5e-05 0 2e-04 0.18 3 / 36 (8.3%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
1.S.2.1.1 The Bacterial Microcompartment Shell/Pore-forming Protein-2 (BMC-SP2) Family 0.44 0.52 1 0.93 0.97 1 0.43 0.69 1 0.4 0.67 1 0.57 0.91 1 0.19 0.68 1 0.00031 4.4e-05 0 1e-04 0 0.00027 9.7e-05 0 0.00026 -0.044 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.4e-05 0 3.7e-05 2.7e-06 0 8.9e-06 -2.4 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
1.A.35.4.1 The CorA Metal Ion Transporter (MIT) Family 0.046 0.34 1 0.024 0.24 1 0.03 0.37 1 0.036 0.27 1 0.11 0.65 1 0.083 0.61 1 0.00034 6.6e-05 0 0.00024 0 0.00057 7.7e-05 0 2e-04 -1.6 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 1.3e-05 0 3.5e-05 2.3 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
3.A.1.107.3 The ATP-binding Cassette (ABC) Superfamily 0.2 0.34 1 0.35 0.64 1 0.33 0.59 1 0.67 0.86 1 0.68 0.92 1 0.9 0.97 1 0.00056 6.2e-05 0 0.00019 0 0.00049 0.00012 0 0.00031 -0.66 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 8.1e-06 0 2.7e-05 1.6 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.55.3.1 The Metal Ion (Mn2+-iron) Transporter (Nramp) Family 0.47 0.54 1 0.58 0.77 1 0.96 0.99 1 0.66 0.85 1 0.63 0.91 1 0.98 1 1 0.00016 3e-05 0 3.6e-05 0 8.8e-05 8.7e-05 0 0.00023 1.3 7 / 36 (19%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 5.5e-06 0 1.2e-05 1.6e-05 0 3.7e-05 1.5 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
9.B.143.4.2 The 6 TMS DUF1275/Pf06912 (DUF1275) Family 0.59 0.65 1 0.64 0.8 1 0.97 0.99 1 0.16 0.43 1 0.34 0.83 1 0.55 0.83 1 0.00013 1.1e-05 0 0 0 0 4.4e-06 0 1.2e-05 Inf 3 / 36 (8.3%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 7.3e-06 0 2.4e-05 2.6e-05 0 8.6e-05 1.8 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
9.B.154.1.1 The Putative Holin-2 (PH-2) Family 0.52 0.58 1 0.38 0.65 1 0.045 0.37 1 0.85 0.94 1 0.75 0.94 1 0.067 0.58 1 0.0013 0.00028 0 0.00037 0 0.00098 4e-05 0 0.00011 -3.2 8 / 36 (22%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5e-05 0 0.00016 0.00061 0 0.0014 3.6 2 / 11 (18%) 4 / 11 (36%) 0.182 0.364
2.A.6.2.13 The Resistance-Nodulation-Cell Division (RND) Superfamily 0.067 0.34 1 0.016 0.23 1 0.083 0.39 1 0.03 0.27 1 0.088 0.62 1 0.28 0.73 1 0.00094 0.00016 0 0.00047 0 0.0011 0.00032 0 0.00084 -0.55 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 1.1e-05 0 3.6e-05 2.7e-06 0 8.9e-06 -2 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.3.6.2 The P-type ATPase (P-ATPase) Superfamily 0.094 0.34 1 0.14 0.44 1 0.13 0.43 1 0.036 0.27 1 0.3 0.8 1 0.24 0.7 1 0.00075 8.3e-05 0 0.00022 0 0.00053 2e-04 0 0.00054 -0.14 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.76.1.3 The Resistance to Homoserine/Threonine (RhtB) Family 0.45 0.52 1 0.66 0.81 1 0.72 0.88 1 0.82 0.93 1 0.64 0.92 1 0.72 0.88 1 0.00014 2.3e-05 0 1.9e-05 0 4.4e-05 5.8e-05 0 0.00015 1.6 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 3e-06 0 9.9e-06 2.3e-05 0 5.2e-05 2.9 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.B.14.2.14 The Outer Membrane Receptor (OMR) Family 0.08 0.34 1 0.17 0.46 1 0.11 0.43 1 0.05 0.28 1 0.37 0.84 1 0.23 0.7 1 0.00058 6.4e-05 0 0.00017 0 4e-04 0.00015 0 0.00038 -0.18 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 8.1e-06 0 2.7e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.A.12.3.1 The Intracellular Chloride Channel (CLIC) Family 0.33 0.42 1 0.54 0.76 1 0.69 0.86 1 0.68 0.86 1 0.8 0.94 1 0.72 0.88 1 0.00028 3.2e-05 0 8.4e-05 0 0.00022 4.8e-05 0 0.00013 -0.81 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.1e-05 0 3.6e-05 8.1e-06 0 2.7e-05 -0.44 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
1.B.38.4.1 The Treponema Porin Major Surface Protein (TP-MSP) Family 0.21 0.35 1 0.27 0.55 1 0.35 0.6 1 0.92 0.97 1 0.52 0.87 1 0.62 0.85 1 1e-04 1.4e-05 0 3.2e-05 0 5.7e-05 8.8e-06 0 2.3e-05 -1.9 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 8.9e-06 0 3e-05 1.2e-05 0 4e-05 0.43 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.2.3.1 The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family 0.28 0.38 1 0.76 0.88 1 0.28 0.54 1 0.91 0.97 1 0.5 0.87 1 0.84 0.93 1 2e-04 2.8e-05 0 6.7e-05 0 0.00018 5.8e-05 0 0.00015 -0.21 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 9.5e-06 0 2.3e-05 1.9 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.A.34.1.2 The Bacillus Gap Junction-like Channel-forming Complex (GJ-CC) Family 0.31 0.4 1 0.7 0.85 1 0.27 0.53 1 0.88 0.96 1 0.46 0.87 1 0.18 0.68 1 0.00053 4.4e-05 0 1e-04 0 0.00027 0.00012 0 0.00031 0.26 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 6e-06 0 2e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.1.17.3 The Major Facilitator Superfamily (MFS) 0.18 0.34 1 0.68 0.83 1 0.26 0.53 1 0.48 0.73 1 0.58 0.91 1 0.77 0.9 1 0.00054 4.5e-05 0 0.00012 0 0.00031 9.7e-05 0 0.00026 -0.31 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.C.1.1.1 The TonB-ExbB-ExbD/TolA-TolQ-TolR Outer Membrane Receptor Energizers and Stabilizers (TonB/TolA) Family 0.16 0.34 1 0.87 0.95 1 0.68 0.86 1 0.25 0.56 1 0.61 0.91 1 0.86 0.94 1 0.00017 1.9e-05 0 3.6e-05 0 8.8e-05 5.8e-05 0 0.00015 0.69 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.2.4 The ATP-binding Cassette (ABC) Superfamily 0.022 0.34 1 0.00083 0.16 0.47 0.01 0.37 1 0.0012 0.15 0.69 0.0047 0.36 1 0.049 0.58 1 0.00068 0.00017 0 0.00054 8.1e-05 0.0012 3e-04 0 0.00079 -0.85 9 / 36 (25%) 5 / 7 (71%) 1 / 7 (14%) 0.714 0.143 1.4e-05 0 3.7e-05 8.1e-06 0 2.7e-05 -0.79 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.7.3.6 The Drug/Metabolite Transporter (DMT) Superfamily 0.27 0.38 1 0.6 0.78 1 0.24 0.52 1 0.99 0.99 1 0.1 0.64 1 0.015 0.46 1 0.00043 3.6e-05 0 8.4e-05 0 0.00022 9.7e-05 0 0.00026 0.21 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
1.B.21.1.1 The OmpG Porin (OmpG) Family 0.26 0.37 1 0.66 0.82 1 0.64 0.84 1 0.83 0.93 1 0.48 0.87 1 0.2 0.69 1 3e-04 2.5e-05 0 6.7e-05 0 0.00018 5.8e-05 0 0.00015 -0.21 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.49.5.3 The Chloride Carrier/Channel (ClC) Family 0.057 0.34 1 0.13 0.42 1 0.24 0.52 1 0.045 0.27 1 0.12 0.66 1 0.26 0.72 1 0.00024 4.1e-05 0 1e-04 0 0.00018 9.7e-05 0 0.00026 -0.044 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 3e-06 0 9.9e-06 2.7e-06 0 8.9e-06 -0.15 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.122.15 The ATP-binding Cassette (ABC) Superfamily 0.063 0.34 1 0.0091 0.22 1 0.036 0.37 1 0.019 0.26 1 0.05 0.62 1 0.14 0.65 1 0.00049 8.2e-05 0 0.00023 0 0.00053 0.00018 0 0.00049 -0.35 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 3e-06 0 9.9e-06 2.7e-06 0 8.9e-06 -0.15 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
9.B.146.1.7 The Putative Undecaprenyl-phosphate N-Acetylglucosaminyl Transferase (MurG) Family 0.054 0.34 1 0.16 0.46 1 0.19 0.48 1 0.029 0.27 1 0.24 0.77 1 0.24 0.7 1 6e-04 6.7e-05 0 0.00019 0 0.00036 0.00015 0 0.00041 -0.34 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
4.A.1.1.2 The PTS Glucose-Glucoside (Glc) Family 0.14 0.34 1 0.51 0.75 1 0.76 0.9 1 0.46 0.72 1 0.087 0.62 1 0.23 0.7 1 0.00035 6.8e-05 0 0.00019 0 0.00049 0.00014 0 0.00027 -0.44 7 / 36 (19%) 2 / 7 (29%) 3 / 7 (43%) 0.286 0.429 2.6e-06 0 8.5e-06 1.1e-05 0 3.6e-05 2.1 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.1.20.2 The Major Facilitator Superfamily (MFS) 0.16 0.34 1 0.38 0.65 1 0.17 0.46 1 0.47 0.73 1 0.68 0.92 1 0.63 0.85 1 0.00034 2.8e-05 0 8.4e-05 0 0.00022 4.8e-05 0 0.00013 -0.81 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 8.1e-06 0 2.7e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.4.1 The ATP-binding Cassette (ABC) Superfamily 0.19 0.34 1 0.6 0.78 1 0.52 0.75 1 0.65 0.85 1 0.65 0.92 1 0.84 0.93 1 0.0011 0.00025 0 0.00073 0 0.0019 0.00048 0 0.0012 -0.6 8 / 36 (22%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 1.5e-05 0 3.3e-05 3.4e-05 0 7.8e-05 1.2 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
9.B.126.1.1 The Putative Lipid IV Exporter (YhjD) Family 0.16 0.34 1 0.038 0.28 1 0.23 0.51 1 0.47 0.73 1 0.34 0.83 1 0.98 1 1 0.00025 4.2e-05 0 0.00012 0 0.00031 7.7e-05 0 2e-04 -0.64 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 5.5e-06 0 1.2e-05 2.7e-06 0 8.9e-06 -1 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
8.A.46.1.1 The Glycan-binding Protein (SusD) Family 0.89 0.92 1 0.76 0.88 1 0.61 0.82 1 0.36 0.64 1 0.5 0.87 1 0.45 0.79 1 7.5e-05 1e-05 0 8.1e-06 0 2.1e-05 8.3e-06 0 1.4e-05 0.035 5 / 36 (14%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 1.8e-05 0 5.9e-05 6e-06 0 2e-05 -1.6 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
1.B.46.1.1 The Outer Membrane LolAB Lipoprotein Insertion Apparatus (LolAB) Family 0.47 0.54 1 0.76 0.88 1 0.56 0.78 1 0.43 0.69 1 0.66 0.92 1 0.21 0.69 1 0.00026 2.2e-05 0 5e-05 0 0.00013 3.9e-05 0 1e-04 -0.36 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.5e-05 0 4.9e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
1.B.14.1.9 The Outer Membrane Receptor (OMR) Family 0.28 0.38 1 0.87 0.94 1 0.65 0.84 1 0.88 0.96 1 0.58 0.91 1 0.9 0.97 1 0.00054 7.5e-05 0 0.00017 0 0.00045 0.00018 0 0.00049 0.082 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.1e-06 0 1.7e-05 1.6e-05 0 3.7e-05 1.6 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
4.A.1.2.7 The PTS Glucose-Glucoside (Glc) Family 0.15 0.34 1 0.82 0.91 1 0.92 0.97 1 0.079 0.32 1 0.77 0.94 1 0.56 0.83 1 0.00042 4.6e-05 0 7.9e-05 0 0.00018 0.00015 0 0.00041 0.93 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.139.2 The ATP-binding Cassette (ABC) Superfamily 0.73 0.79 1 0.55 0.76 1 0.45 0.7 1 0.29 0.61 1 0.54 0.89 1 0.37 0.74 1 0.00027 3.8e-05 0 5e-05 0 0.00013 9.7e-05 0 0.00026 0.96 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.7e-05 0 4e-05 1.3e-05 0 4.3e-05 -0.39 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.1.21.22 The Major Facilitator Superfamily (MFS) 0.87 0.9 1 0.26 0.55 1 0.97 0.99 1 0.62 0.82 1 0.077 0.62 1 0.56 0.83 1 0.00019 7.5e-05 0 5.8e-05 0 0.00013 8.9e-05 2.7e-05 0.00013 0.62 14 / 36 (39%) 2 / 7 (29%) 4 / 7 (57%) 0.286 0.571 3.8e-05 0 7.2e-05 0.00011 0 0.00027 1.5 3 / 11 (27%) 5 / 11 (45%) 0.273 0.455
2.A.17.1.5 The Proton-dependent Oligopeptide Transporter (POT/PTR) Family 0.22 0.35 1 0.37 0.65 1 0.47 0.72 1 0.67 0.85 1 0.25 0.77 1 0.32 0.73 1 0.00021 3.6e-05 0 7.2e-05 0 0.00018 9.4e-05 0 2e-04 0.38 6 / 36 (17%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 6e-06 0 2e-05 5.4e-06 0 1.8e-05 -0.15 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.1.25.2 The Major Facilitator Superfamily (MFS) 0.084 0.34 1 0.27 0.56 1 0.18 0.48 1 0.017 0.25 1 0.23 0.76 1 0.16 0.67 1 0.00046 6.4e-05 0 0.00015 0 0.00035 0.00017 0 0.00046 0.18 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.6.4.1 The Resistance-Nodulation-Cell Division (RND) Superfamily 0.13 0.34 1 0.65 0.81 1 0.6 0.82 1 0.19 0.5 1 0.65 0.92 1 0.69 0.88 1 0.00043 0.00011 0 0.00022 0 0.00048 0.00025 0 0.00061 0.18 9 / 36 (25%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 1.7e-05 0 4.9e-05 3.4e-05 0 1e-04 1 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
9.B.1.1.6 The Integral Membrane CAAX Protease (CAAX Protease) Family 0.028 0.34 1 0.021 0.23 1 0.021 0.37 1 0.012 0.22 1 0.087 0.62 1 0.056 0.58 1 0.00026 3.6e-05 0 0.00013 0 0.00031 3.9e-05 0 1e-04 -1.7 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 1.1e-05 0 3.6e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.1.14.33 The Major Facilitator Superfamily (MFS) 0.16 0.34 1 0.24 0.53 1 0.14 0.43 1 0.3 0.62 1 0.34 0.83 1 0.99 1 1 0.00061 5.1e-05 0 0.00015 0 4e-04 0.00011 0 0.00028 -0.45 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.A.35.1.1 The CorA Metal Ion Transporter (MIT) Family 0.74 0.79 1 0.59 0.78 1 0.31 0.58 1 0.34 0.63 1 0.65 0.92 1 0.25 0.7 1 2e-04 3.4e-05 0 3.6e-05 0 8.8e-05 9.7e-05 0 0.00026 1.4 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.5e-05 0 7.2e-05 2.7e-06 0 8.9e-06 -3.2 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.21.3.19 The Solute:Sodium Symporter (SSS) Family 0.066 0.34 1 0.94 0.98 1 0.24 0.52 1 0.12 0.38 1 0.83 0.95 1 0.55 0.83 1 0.00076 0.00038 1.6e-05 6e-04 0.00022 0.00092 0.00055 0.00012 0.00079 -0.13 18 / 36 (50%) 5 / 7 (71%) 5 / 7 (71%) 0.714 0.714 7.7e-05 0 0.00017 0.00044 0 0.00077 2.5 3 / 11 (27%) 5 / 11 (45%) 0.273 0.455
2.A.1.1.42 The Major Facilitator Superfamily (MFS) 0.25 0.36 1 0.18 0.48 1 0.86 0.94 1 0.11 0.36 1 0.18 0.72 1 0.97 1 1 0.0011 0.00084 0.00068 0.00033 0.00034 0.00035 0.00085 0.00072 0.00087 1.4 27 / 36 (75%) 4 / 7 (57%) 4 / 7 (57%) 0.571 0.571 0.00086 0.00042 0.0013 0.0011 0.00091 0.00096 0.36 9 / 11 (82%) 10 / 11 (91%) 0.818 0.909
3.A.1.11.7 The ATP-binding Cassette (ABC) Superfamily 0.3 0.4 1 0.19 0.49 1 0.39 0.64 1 0.15 0.42 1 0.12 0.66 1 0.37 0.75 1 0.00027 6e-05 0 0 0 0 8.2e-05 0 0.00015 Inf 8 / 36 (22%) 0 / 7 (0%) 2 / 7 (29%) 0 0.286 8.8e-05 0 0.00027 5.6e-05 0 1e-04 -0.65 2 / 11 (18%) 4 / 11 (36%) 0.182 0.364
3.A.10.1.5 The H+. Na+-translocating Pyrophosphatase (M+-PPase) Family 0.29 0.38 1 0.28 0.57 1 0.83 0.92 1 0.53 0.76 1 0.92 0.98 1 0.35 0.74 1 0.00019 1.6e-05 0 5e-05 0 0.00013 1.9e-05 0 5.1e-05 -1.4 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 6.6e-06 0 2.2e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.23.1.8 The Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family 0.14 0.34 1 0.36 0.64 1 0.8 0.91 1 0.32 0.63 1 0.42 0.86 1 0.97 1 1 0.00056 6.3e-05 0 0.00015 0 0.00026 0.00014 0 0.00036 -0.1 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.2e-05 0 7.3e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
8.A.1.1.3 The Membrane Fusion Protein (MFP) Family 0.14 0.34 1 0.92 0.96 1 0.91 0.96 1 0.45 0.71 1 0.43 0.86 1 0.62 0.85 1 0.00021 3.5e-05 0 8.9e-05 0 0.00022 7.5e-05 0 0.00015 -0.25 6 / 36 (17%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 2.6e-06 0 8.5e-06 8.1e-06 0 2.7e-05 1.6 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.53.3.11 The Sulfate Permease (SulP) Family 0.3 0.4 1 0.99 1 1 0.75 0.9 1 0.88 0.95 1 0.58 0.91 1 0.8 0.92 1 0.00027 3e-05 0 6.7e-05 0 0.00018 6.8e-05 0 0.00018 0.021 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 1e-05 0 3.4e-05 1.7 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
8.A.42.1.6 The small hydrophilic YodL domain/protein (YodL) Family 0.94 0.95 1 0.63 0.8 1 0.99 0.99 1 0.9 0.97 1 0.36 0.84 1 0.59 0.85 1 0.00059 0.00031 0.00019 0.00023 0.00027 0.00024 0.00028 0.00025 0.00029 0.28 19 / 36 (53%) 4 / 7 (57%) 5 / 7 (71%) 0.571 0.714 3e-04 0 0.00053 4e-04 0 0.00057 0.42 5 / 11 (45%) 5 / 11 (45%) 0.455 0.455
9.B.307.1.2 The FtsH AAA(+) Zinc Metaloprotease (FtsH) Family 0.16 0.34 1 0.66 0.82 1 0.14 0.43 1 0.19 0.5 1 0.99 1 1 0.23 0.7 1 0.00052 7.2e-05 0 0.00017 0 0.00044 0.00017 0 0.00046 0 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.6e-05 0 3.7e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.1.15.13 The Major Facilitator Superfamily (MFS) 0.0073 0.34 1 0.0029 0.22 1 0.0056 0.35 1 0.00038 0.11 0.22 0.0098 0.46 1 0.015 0.46 1 0.00022 3.6e-05 0 0.00012 1.6e-05 0.00021 5.8e-05 0 0.00015 -1 6 / 36 (17%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.3.25 The ATP-binding Cassette (ABC) Superfamily 0.19 0.34 1 0.79 0.9 1 0.79 0.91 1 0.07 0.3 1 1 1 1 0.69 0.88 1 0.00013 2.1e-05 0 2.3e-06 0 6.1e-06 0 0 0 -Inf 6 / 36 (17%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 4.7e-05 0 0.00012 2e-05 0 4.9e-05 -1.2 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
3.A.1.2.27 The ATP-binding Cassette (ABC) Superfamily 0.14 0.34 1 0.092 0.39 1 0.25 0.52 1 0.47 0.73 1 0.23 0.76 1 0.53 0.82 1 0.00047 0.00012 0 0.00032 0 0.00066 0.00019 0 0.00051 -0.75 9 / 36 (25%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.9e-05 0 5.9e-05 2.6e-05 0 6.9e-05 -0.16 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
2.A.33.1.5 The NhaA Na+:H+ Antiporter (NhaA) Family 0.11 0.34 1 0.023 0.24 1 0.032 0.37 1 0.024 0.27 1 0.096 0.64 1 0.063 0.58 1 0.00059 0.00044 0.00042 0.00022 0.00011 0.00025 0.00063 0.00024 0.00076 1.5 27 / 36 (75%) 4 / 7 (57%) 4 / 7 (57%) 0.571 0.571 0.00047 0.00048 0.00032 0.00044 0.00044 0.00034 -0.095 10 / 11 (91%) 9 / 11 (82%) 0.909 0.818
2.C.1.1.3 The TonB-ExbB-ExbD/TolA-TolQ-TolR Outer Membrane Receptor Energizers and Stabilizers (TonB/TolA) Family 0.15 0.34 1 0.62 0.79 1 0.47 0.72 1 0.35 0.64 1 0.3 0.8 1 0.21 0.69 1 4e-04 5.5e-05 0 0.00014 0 0.00035 0.00014 0 0.00033 0 5 / 36 (14%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.3.1.4 The Amino Acid-Polyamine-Organocation (APC) Family 0.23 0.35 1 0.047 0.29 1 0.44 0.69 1 0.5 0.75 1 0.051 0.62 1 0.48 0.81 1 0.00021 4.2e-05 0 5.3e-05 0 0.00013 0.00014 0 3e-04 1.4 7 / 36 (19%) 2 / 7 (29%) 3 / 7 (43%) 0.286 0.429 0 0 0 1.5e-05 0 3.3e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
3.A.1.13.1 The ATP-binding Cassette (ABC) Superfamily 0.077 0.34 1 0.023 0.24 1 0.068 0.37 1 0.038 0.27 1 0.28 0.78 1 0.47 0.81 1 0.00065 5.4e-05 0 0.00016 0 4e-04 0.00012 0 0.00031 -0.42 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
3.A.1.5.1 The ATP-binding Cassette (ABC) Superfamily 0.16 0.34 1 0.037 0.28 1 0.13 0.43 1 0.27 0.6 1 0.06 0.62 1 0.17 0.68 1 0.00033 7.2e-05 0 0.00016 0 0.00035 0.00015 0 0.00038 -0.093 8 / 36 (22%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.5e-05 0 7.2e-05 1.6e-05 0 3.7e-05 -0.64 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
2.A.85.7.1 The Aromatic Acid Exporter (ArAE) Family 0.12 0.34 1 0.084 0.39 1 0.42 0.67 1 0.26 0.59 1 0.38 0.84 1 0.99 1 1 0.00056 6.2e-05 0 0.00019 0 0.00044 0.00012 0 0.00031 -0.66 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.1e-05 0 3.6e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.40.1.1 The Nucleobase/Ascorbate Transporter (NAT) or Nucleobase:Cation Symporter-2 (NCS2) Family 0.051 0.34 1 0.027 0.25 1 0.057 0.37 1 0.081 0.32 1 0.095 0.64 1 0.16 0.67 1 0.00031 7e-05 0 0.00022 0 0.00048 9.7e-05 0 0.00026 -1.2 8 / 36 (22%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 9.9e-06 0 2.5e-05 1.6e-05 0 3.7e-05 0.69 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
1.A.30.2.2 The H+- or Na+-translocating Bacterial Flagellar Motor/ExbBD Outer Membrane Transport Energizer (Mot/Exb) Superfamily 0.046 0.34 1 0.16 0.46 1 0.27 0.53 1 0.0083 0.19 1 0.13 0.66 1 0.27 0.72 1 0.00042 4.6e-05 0 0.00011 0 0.00022 0.00013 0 0.00033 0.24 4 / 36 (11%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.4.1.4 The Cation Diffusion Facilitator (CDF) Family 0.053 0.34 1 0.066 0.36 1 0.27 0.53 1 0.036 0.27 1 0.14 0.66 1 0.49 0.82 1 0.00024 3.3e-05 0 8.8e-05 0 0.00017 7.7e-05 0 2e-04 -0.19 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 3e-06 0 9.9e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
9.B.62.1.4 The Copper Resistance (CopD) Family 0.34 0.43 1 0.95 0.98 1 0.9 0.96 1 0.5 0.75 1 0.41 0.85 1 0.32 0.73 1 0.00019 2.2e-05 0 5e-05 0 0.00013 4.8e-05 0 0.00013 -0.059 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.1e-06 0 1.7e-05 2.7e-06 0 8.9e-06 -0.92 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
1.B.11.2.1 The Outer Membrane Fimbrial Usher Porin (FUP) Family 0.064 0.34 1 0.055 0.31 1 0.13 0.43 1 0.03 0.27 1 0.23 0.76 1 0.39 0.75 1 0.001 8.7e-05 0 0.00025 0 0.00057 0.00019 0 0.00051 -0.4 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.28.3.4 The Bile Acid:Na+ Symporter (BASS) Family 0.26 0.37 1 0.55 0.76 1 0.56 0.78 1 0.92 0.97 1 0.68 0.92 1 0.76 0.9 1 0.00033 3.7e-05 0 1e-04 0 0.00027 6.8e-05 0 0.00018 -0.56 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.1e-06 0 1.7e-05 8.1e-06 0 2.7e-05 0.67 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.3.13.1 The Amino Acid-Polyamine-Organocation (APC) Family 0.06 0.34 1 0.13 0.42 1 0.1 0.42 1 0.047 0.27 1 0.33 0.83 1 0.23 0.7 1 0.00033 3.7e-05 0 1e-04 0 0.00022 7.7e-05 0 2e-04 -0.38 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.42.2.3 The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family 0.18 0.34 1 0.76 0.88 1 0.3 0.57 1 0.39 0.67 1 0.35 0.84 1 0.92 0.98 1 0.00054 4.5e-05 0 0.00012 0 0.00031 0.00011 0 0.00028 -0.13 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.66.2.3 The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily 0.32 0.41 1 0.41 0.69 1 0.18 0.48 1 0.68 0.86 1 0.069 0.62 1 0.011 0.46 1 0.00029 2.4e-05 0 5e-05 0 0.00013 6.8e-05 0 0.00018 0.44 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
1.B.48.2.5 The Curli Fiber Subunit Porin. CgsA. CsgG (CsgG) Family 0.84 0.88 1 0.89 0.96 1 0.098 0.42 1 0.34 0.63 1 0.84 0.96 1 0.2 0.69 1 0.00018 4e-05 0 8.1e-06 0 2.1e-05 4.4e-06 0 1.2e-05 -0.88 8 / 36 (22%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.4e-05 0 3.1e-05 0.00011 0 0.00021 3 2 / 11 (18%) 4 / 11 (36%) 0.182 0.364
8.A.1.6.1 The Membrane Fusion Protein (MFP) Family 0.12 0.34 1 0.55 0.76 1 0.64 0.83 1 0.055 0.29 1 0.49 0.87 1 0.67 0.88 1 0.00085 7.1e-05 0 0.00016 0 4e-04 2e-04 0 0.00054 0.32 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
9.B.65.1.1 The Putative Transporter (YhgE) Family 0.19 0.34 1 0.11 0.4 1 0.45 0.71 1 0.75 0.89 1 0.59 0.91 1 0.72 0.88 1 0.00056 9.4e-05 0 0.00031 0 8e-04 0.00015 0 0.00038 -1 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.6e-05 0 3.9e-05 2.7e-06 0 8.9e-06 -2.6 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
1.A.62.2.3 The Homotrimeric Cation Channel (TRIC) Family 0.11 0.34 1 0.14 0.44 1 0.12 0.43 1 0.41 0.68 1 0.91 0.98 1 0.5 0.82 1 0.00021 1.8e-05 0 6.7e-05 0 0.00018 1.9e-05 0 5.1e-05 -1.8 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.1.2.9 The Major Facilitator Superfamily (MFS) 0.13 0.34 1 0.52 0.75 1 0.2 0.48 1 0.33 0.63 1 0.97 0.99 1 0.48 0.81 1 0.00021 2.3e-05 0 5.3e-05 0 0.00013 4.8e-05 0 0.00013 -0.14 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
9.A.47.2.2 The Tight Adherence (Pilus) Biogenesis Apparatus (TABA) Family 0.2 0.34 1 0.25 0.53 1 0.54 0.77 1 0.028 0.27 1 0.29 0.78 1 0.19 0.68 1 0.0021 0.0017 0.0013 0.00099 0.0013 0.00099 0.0016 0.0017 0.0017 0.69 29 / 36 (81%) 4 / 7 (57%) 4 / 7 (57%) 0.571 0.571 0.0018 0.0013 0.0022 0.002 0.0013 0.0015 0.15 11 / 11 (100%) 10 / 11 (91%) 1 0.909
3.A.10.1.10 The H+. Na+-translocating Pyrophosphatase (M+-PPase) Family 0.94 0.95 1 0.61 0.79 1 0.49 0.73 1 0.53 0.76 1 0.89 0.98 1 0.86 0.94 1 0.00084 0.00052 1e-04 0.00043 0.00028 0.00073 0.00023 0.00011 0.00035 -0.9 22 / 36 (61%) 4 / 7 (57%) 4 / 7 (57%) 0.571 0.571 0.00041 9.7e-05 0.00069 0.00085 2.9e-05 0.0017 1.1 8 / 11 (73%) 6 / 11 (55%) 0.727 0.545
2.A.13.1.1 The C4-Dicarboxylate Uptake (Dcu) Family 0.17 0.34 1 0.094 0.39 1 0.3 0.57 1 0.53 0.76 1 0.29 0.78 1 0.61 0.85 1 0.00029 6.5e-05 0 2e-04 0 0.00048 7.7e-05 0 2e-04 -1.4 8 / 36 (22%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.7e-05 0 7.3e-05 9.5e-06 0 2.3e-05 -1.5 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
2.A.37.1.1 The Monovalent Cation:Proton Antiporter-2 (CPA2) Family 0.073 0.34 1 0.091 0.39 1 0.16 0.46 1 0.12 0.38 1 0.37 0.84 1 0.4 0.75 1 0.00047 1e-04 0 0.00032 0 0.00075 0.00015 0 0.00038 -1.1 8 / 36 (22%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 2.2e-05 0 7.3e-05 1.5e-05 0 3.3e-05 -0.55 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
3.A.1.7.1 The ATP-binding Cassette (ABC) Superfamily 0.2 0.34 1 0.64 0.8 1 0.99 0.99 1 0.51 0.75 1 0.4 0.85 1 0.69 0.88 1 6e-04 0.00013 0 0.00032 0 0.00084 0.00033 0 0.00084 0.044 8 / 36 (22%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 5.5e-06 0 1.2e-05 1.5e-05 0 3.3e-05 1.4 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
1.A.14.2.2 The Calcium Transporter A (CaTA) (formerly the Testis-Enhanced Gene Transfer (TEGT) Family 0.37 0.45 1 0.95 0.98 1 0.38 0.63 1 0.67 0.85 1 0.54 0.89 1 0.19 0.68 1 0.00044 3.7e-05 0 8.4e-05 0 0.00022 8.7e-05 0 0.00023 0.051 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.1e-05 0 3.6e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
1.A.43.3.3 The Camphor Resistance or Fluoride Exporter (Fluc) Family 0.23 0.35 1 0.76 0.88 1 0.89 0.96 1 0.069 0.3 1 0.76 0.94 1 0.9 0.97 1 0.00044 3e-04 0.00018 0.00019 0.00011 0.00021 0.00019 0 0.00025 0 25 / 36 (69%) 4 / 7 (57%) 3 / 7 (43%) 0.571 0.429 0.00037 0.00028 0.00042 0.00039 0.00022 0.00038 0.076 10 / 11 (91%) 8 / 11 (73%) 0.909 0.727
2.A.3.1.7 The Amino Acid-Polyamine-Organocation (APC) Family 0.23 0.36 1 0.43 0.7 1 1 1 1 0.76 0.89 1 0.8 0.94 1 0.35 0.74 1 0.00044 8.6e-05 0 0.00025 0 0.00062 0.00013 0 3e-04 -0.94 7 / 36 (19%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 3.6e-05 0 0.00011 5.4e-06 0 1.8e-05 -2.7 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
3.A.1.147.4 The ATP-binding Cassette (ABC) Superfamily 0.5 0.56 1 0.029 0.25 1 0.0044 0.35 1 0.19 0.49 1 0.048 0.62 1 0.0049 0.46 1 0.00019 6.5e-05 0 3.9e-05 0 9.1e-05 0.00018 0 0.00032 2.2 12 / 36 (33%) 2 / 7 (29%) 3 / 7 (43%) 0.286 0.429 6.2e-05 0 8.9e-05 9.5e-06 0 2.3e-05 -2.7 5 / 11 (45%) 2 / 11 (18%) 0.455 0.182
4.A.2.1.24 The PTS Fructose-Mannitol (Fru) Family 0.092 0.34 1 0.081 0.38 1 0.066 0.37 1 0.11 0.36 1 0.56 0.91 1 0.24 0.7 1 0.00053 5.9e-05 0 2e-04 0 0.00053 8.7e-05 0 0.00023 -1.2 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 8.1e-06 0 2.7e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.45.2.5 The Arsenite-Antimonite (ArsB) Efflux Family 0.33 0.42 1 0.45 0.72 1 0.97 0.99 1 0.72 0.87 1 0.91 0.98 1 0.5 0.82 1 0.00021 3.5e-05 0 8.6e-05 0 0.00022 6.8e-05 0 0.00018 -0.34 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.4e-05 0 3.7e-05 2.7e-06 0 8.9e-06 -2.4 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.3.7.4 The Amino Acid-Polyamine-Organocation (APC) Family 0.26 0.37 1 0.87 0.94 1 0.94 0.98 1 0.83 0.94 1 0.37 0.84 1 0.54 0.83 1 0.00045 5e-05 0 0.00012 0 0.00031 0.00013 0 0.00033 0.12 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 5.4e-06 0 1.8e-05 1.1 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.122.30 The ATP-binding Cassette (ABC) Superfamily 0.39 0.47 1 0.42 0.69 1 0.84 0.92 1 0.075 0.31 1 0.2 0.74 1 0.51 0.82 1 0.0022 0.0017 0.0013 0.0012 0.00094 0.0013 0.0017 0.0019 0.0019 0.5 28 / 36 (78%) 4 / 7 (57%) 4 / 7 (57%) 0.571 0.571 0.0018 0.0013 0.0027 0.002 0.0014 0.0017 0.15 10 / 11 (91%) 10 / 11 (91%) 0.909 0.909
2.A.47.4.8 The Divalent Anion:Na+ Symporter (DASS) Family 0.093 0.34 1 0.074 0.37 1 0.17 0.47 1 0.096 0.34 1 0.21 0.74 1 0.39 0.75 1 0.00044 7.4e-05 0 2e-04 0 0.00048 0.00015 0 0.00041 -0.42 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 7.3e-06 0 2.4e-05 5.4e-06 0 1.8e-05 -0.43 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.66.2.16 The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily 0.14 0.34 1 0.22 0.51 1 0.054 0.37 1 0.044 0.27 1 0.14 0.66 1 0.026 0.57 1 3e-04 4.2e-05 0 0 0 0 8.9e-05 0 0.00023 Inf 5 / 36 (14%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 7.9e-05 0 0.00019 2.7e-06 0 8.8e-06 -4.9 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
3.A.1.6.1 The ATP-binding Cassette (ABC) Superfamily 0.19 0.34 1 0.2 0.49 1 0.66 0.84 1 0.38 0.65 1 0.07 0.62 1 0.35 0.74 1 0.0011 0.00012 0 0.00029 0 0.00076 0.00031 0 0.00076 0.096 4 / 36 (11%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0 0 0 8.1e-06 0 2.7e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.A.43.3.1 The Camphor Resistance or Fluoride Exporter (Fluc) Family 0.5 0.56 1 0.82 0.91 1 0.82 0.92 1 0.13 0.39 1 0.52 0.87 1 0.72 0.88 1 0.00059 0.00044 0.00041 0.00043 0.00014 0.00052 0.00044 0.00059 0.00044 0.033 27 / 36 (75%) 4 / 7 (57%) 4 / 7 (57%) 0.571 0.571 0.00048 0.00042 0.00044 0.00042 4e-04 0.00032 -0.19 9 / 11 (82%) 10 / 11 (91%) 0.818 0.909
2.A.2.3.4 The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family 0.12 0.34 1 0.18 0.47 1 0.1 0.42 1 0.27 0.6 1 0.48 0.87 1 0.23 0.7 1 0.00037 7.2e-05 0 2e-04 0 0.00048 0.00013 0 0.00033 -0.62 7 / 36 (19%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 7.7e-06 0 2.6e-05 2e-05 0 3.9e-05 1.4 1 / 11 (9.1%) 3 / 11 (27%) 0.0909 0.273
2.A.23.1.7 The Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family 0.068 0.34 1 0.72 0.86 1 0.78 0.91 1 0.035 0.27 1 0.82 0.95 1 0.7 0.88 1 0.00039 5.4e-05 0 0.00011 0 0.00022 0.00017 0 4e-04 0.63 5 / 36 (14%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
3.D.4.3.2 The Proton-translocating Cytochrome Oxidase (COX) Superfamily 0.22 0.35 1 0.49 0.75 1 0.56 0.78 1 0.62 0.82 1 0.94 0.98 1 0.98 1 1 0.00062 8.6e-05 0 0.00022 0 0.00058 0.00018 0 0.00049 -0.29 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.1e-05 0 3.6e-05 1.3e-05 0 4.5e-05 0.24 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.17.1.6 The Proton-dependent Oligopeptide Transporter (POT/PTR) Family 0.065 0.34 1 0.047 0.29 1 0.022 0.37 1 0.02 0.26 1 0.0023 0.31 1 0.0033 0.46 1 3e-04 0.00011 0 0 0 0 0.00014 6.8e-05 0.00018 Inf 13 / 36 (36%) 0 / 7 (0%) 4 / 7 (57%) 0 0.571 0.00023 0 0.00058 2.8e-05 0 3.9e-05 -3 4 / 11 (36%) 5 / 11 (45%) 0.364 0.455
3.D.4.5.1 The Proton-translocating Cytochrome Oxidase (COX) Superfamily 0.1 0.34 1 0.027 0.25 1 0.11 0.42 1 0.23 0.54 1 0.23 0.76 1 0.62 0.85 1 0.00056 0.00015 0 0.00048 0 0.0012 0.00026 0 0.00063 -0.88 10 / 36 (28%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 1.7e-05 0 3.7e-05 1.6e-05 0 3.7e-05 -0.087 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
2.A.1.7.17 The Major Facilitator Superfamily (MFS) 0.077 0.34 1 0.032 0.27 1 0.054 0.37 1 0.24 0.56 1 0.074 0.62 1 0.14 0.65 1 0.00028 1e-04 0 0.00019 0.00014 0.00022 3.3e-05 0 5.6e-05 -2.5 13 / 36 (36%) 5 / 7 (71%) 2 / 7 (29%) 0.714 0.286 6.4e-05 0 0.00013 0.00012 0 0.00032 0.91 3 / 11 (27%) 3 / 11 (27%) 0.273 0.273
9.B.211.1.2 The 10 TMS Putative Permease (10PP) Family 0.12 0.34 1 0.45 0.72 1 0.34 0.6 1 0.059 0.29 1 0.63 0.91 1 0.21 0.69 1 0.00024 0.00019 0.00018 0.00017 0.00014 0.00018 0.00013 6.2e-05 0.00017 -0.39 28 / 36 (78%) 5 / 7 (71%) 4 / 7 (57%) 0.714 0.571 0.00026 0.00024 0.00013 0.00016 7.5e-05 2e-04 -0.7 11 / 11 (100%) 8 / 11 (73%) 1 0.727
2.A.42.2.5 The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family 0.091 0.34 1 0.1 0.39 1 0.19 0.48 1 0.045 0.27 1 0.37 0.84 1 0.56 0.83 1 0.00066 5.5e-05 0 0.00015 0 0.00035 0.00014 0 0.00036 -0.1 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
9.B.209.1.1 The DUF2633 (DUF2633) Family 0.15 0.34 1 0.9 0.96 1 0.92 0.97 1 0.18 0.49 1 0.62 0.91 1 0.54 0.83 1 3e-04 2.5e-05 0 5.3e-05 0 0.00013 7.7e-05 0 2e-04 0.54 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
9.B.160.1.16 The Colicin V Production (CvpA) Family 0.11 0.34 1 0.27 0.56 1 0.13 0.43 1 0.13 0.39 1 0.95 0.98 1 0.51 0.82 1 0.00018 2e-05 0 5.3e-05 0 0.00013 4.8e-05 0 0.00013 -0.14 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
5.A.3.4.1 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO) Family 0.09 0.34 1 0.29 0.58 1 0.16 0.46 1 0.091 0.34 1 0.58 0.91 1 0.35 0.74 1 0.00059 0.00013 0 0.00033 0 0.00079 0.00029 0 0.00071 -0.19 8 / 36 (22%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 8.9e-06 0 3e-05 2.6e-05 0 6.9e-05 1.5 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
5.A.3.4.3 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO) Family 0.6 0.66 1 0.34 0.63 1 0.69 0.86 1 0.62 0.82 1 0.58 0.91 1 0.96 1 1 0.00026 5.9e-05 0 5.3e-05 0 0.00013 0.00019 0 0.00051 1.8 8 / 36 (22%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.2e-05 0 2.8e-05 2.3e-05 0 4.1e-05 0.94 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
4.A.6.1.4 The PTS Mannose-Fructose-Sorbose (Man) Family 0.071 0.34 1 0.9 0.96 1 0.36 0.6 1 0.14 0.4 1 0.5 0.87 1 0.75 0.89 1 0.00026 3.7e-05 0 8.7e-05 0 0.00018 8.5e-05 0 0.00018 -0.034 5 / 36 (14%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0 0 0 1.1e-05 0 3.6e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
8.A.3.3.2 The Cytoplasmic Membrane-Periplasmic Auxiliary-1 (MPA1) Protein with Cytoplasmic (C) Domain (MPA1-C or MPA1+C) Family 0.49 0.56 1 0.59 0.78 1 0.51 0.75 1 0.44 0.71 1 0.81 0.95 1 0.16 0.67 1 0.00083 9.2e-05 0 0.00024 0 0.00062 0.00015 0 0.00041 -0.68 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.2e-05 0 0.00015 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
2.A.3.1.1 The Amino Acid-Polyamine-Organocation (APC) Family 0.043 0.34 1 0.0066 0.22 1 0.063 0.37 1 0.026 0.27 1 0.035 0.62 1 0.29 0.73 1 0.00039 5.4e-05 0 0.00019 0 0.00044 7.7e-05 0 2e-04 -1.3 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 5.1e-06 0 1.7e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
3.D.1.9.1 The H+ or Na+-translocating NADH Dehydrogenase (NDH) Family 0.94 0.95 1 0.73 0.87 1 0.58 0.79 1 0.46 0.72 1 0.59 0.91 1 0.42 0.77 1 0.00013 2.5e-05 0 1.6e-05 0 3.1e-05 3.4e-05 0 7.9e-05 1.1 7 / 36 (19%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 2.9e-05 0 7.4e-05 2.2e-05 0 7.1e-05 -0.4 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
8.A.5.1.5 The Voltage-gated K+ Channel β-subunit (Kvβ) Family 0.038 0.34 1 0.076 0.38 1 0.036 0.37 1 0.0069 0.17 1 0.11 0.64 1 0.045 0.58 1 0.00034 5.7e-05 0 0.00015 0 3e-04 0.00013 0 0.00033 -0.21 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 1.3e-05 0 3.5e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.121.1.1 The Sulfate Transporter (CysZ) Family 0.12 0.34 1 0.71 0.86 1 0.26 0.52 1 0.15 0.42 1 0.64 0.92 1 0.2 0.69 1 0.00032 4.4e-05 0 8.4e-05 0 0.00018 0.00012 0 0.00031 0.51 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.7e-05 0 3.9e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
8.A.2.1.3 The Secretin Auxiliary Lipoprotein (SAL) Family 0.21 0.35 1 0.19 0.49 1 0.61 0.82 1 0.6 0.82 1 0.89 0.98 1 0.35 0.74 1 0.00017 1.4e-05 0 5e-05 0 0.00013 1.9e-05 0 5.1e-05 -1.4 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
1.B.33.2.4 The Outer Membrane Protein Insertion Porin (Bam Complex) (OmpIP) Family 0.036 0.34 1 0.04 0.28 1 0.039 0.37 1 0.043 0.27 1 0.19 0.72 1 0.12 0.65 1 0.00034 3.8e-05 0 0.00014 0 0.00031 3.9e-05 0 1e-04 -1.8 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.1e-05 0 3.6e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.3.1.24 The Amino Acid-Polyamine-Organocation (APC) Family 0.22 0.35 1 0.079 0.38 1 0.056 0.37 1 0.71 0.87 1 0.45 0.86 1 0.24 0.7 1 0.00021 3.5e-05 0 8.9e-05 0 0.00022 4.8e-05 0 0.00013 -0.89 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.1e-05 0 3.6e-05 1.6e-05 0 3.7e-05 0.54 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
3.A.1.120.6 The ATP-binding Cassette (ABC) Superfamily 0.32 0.41 1 0.89 0.96 1 0.66 0.84 1 0.8 0.92 1 0.59 0.91 1 0.82 0.93 1 0.00034 5.6e-05 0 0.00013 0 0.00036 0.00013 0 0.00033 0 6 / 36 (17%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.5e-06 0 1.2e-05 1.3e-05 0 3.3e-05 1.2 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
9.B.34.1.2 The Kinase/Phosphatase/Cyclic-GMP Synthase/Cyclic di-GMP Hydrolase (KPSH) Family 0.37 0.45 1 0.16 0.46 1 0.65 0.84 1 0.79 0.9 1 0.18 0.72 1 1 1 1 4e-04 4.5e-05 0 5e-05 0 0.00013 0.00016 0 0.00044 1.7 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 9.5e-06 0 2.3e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.19.1.1 The Ca2+:Cation Antiporter (CaCA) Family 0.14 0.34 1 0.53 0.76 1 0.46 0.71 1 0.28 0.6 1 0.58 0.91 1 0.54 0.83 1 0.00023 3.2e-05 0 6.8e-05 0 0.00013 7.7e-05 0 2e-04 0.18 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 1e-05 0 3.4e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
8.A.46.2.1 The Glycan-binding Protein (SusD) Family 0.49 0.56 1 0.34 0.63 1 0.46 0.71 1 0.13 0.39 1 0.23 0.76 1 0.31 0.73 1 6.5e-05 5.4e-06 0 0 0 0 8.8e-06 0 2.3e-05 Inf 3 / 36 (8.3%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 6e-06 0 2e-05 6e-06 0 2e-05 0 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
1.B.17.3.10 The Outer Membrane Factor (OMF) Family 0.068 0.34 1 0.14 0.44 1 0.055 0.37 1 0.062 0.3 1 0.38 0.84 1 0.13 0.65 1 0.00036 5e-05 0 0.00014 0 0.00031 9.7e-05 0 0.00026 -0.53 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.3e-05 0 3.5e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.1.2.65 The Major Facilitator Superfamily (MFS) 0.21 0.35 1 0.86 0.94 1 0.78 0.91 1 0.9 0.97 1 0.19 0.72 1 0.53 0.82 1 0.00025 4.1e-05 0 0.00012 0 0.00031 7.3e-05 0 0.00015 -0.72 6 / 36 (17%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 3e-06 0 9.9e-06 9.5e-06 0 2.3e-05 1.7 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.1.2.15 The Major Facilitator Superfamily (MFS) 0.2 0.34 1 0.096 0.39 1 0.2 0.48 1 0.93 0.97 1 0.6 0.91 1 0.47 0.81 1 0.00028 3.1e-05 0 1e-04 0 0.00027 4.8e-05 0 0.00013 -1.1 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 2.7e-06 0 8.9e-06 -0.15 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.1.1.2 The Major Facilitator Superfamily (MFS) 0.041 0.34 1 0.016 0.23 1 0.052 0.37 1 0.021 0.26 1 0.11 0.64 1 0.24 0.7 1 0.00078 6.5e-05 0 0.00026 0 0.00062 7.7e-05 0 2e-04 -1.8 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
1.E.14.1.4 The CidA/LrgA Holin (CidA/LrgA Holin) Family 0.91 0.93 1 0.23 0.51 1 0.05 0.37 1 0.02 0.26 1 0.19 0.72 1 0.013 0.46 1 0.00015 2e-05 0 1.7e-05 0 4.5e-05 6.8e-05 0 0.00018 2 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.2e-05 0 2.3e-05 0 0 0 -Inf 3 / 11 (27%) 0 / 11 (0%) 0.273 0
3.A.1.105.15 The ATP-binding Cassette (ABC) Superfamily 0.17 0.34 1 0.15 0.44 1 0.83 0.92 1 0.71 0.87 1 0.77 0.94 1 0.33 0.73 1 0.00034 8.5e-05 0 0.00026 0 0.00062 0.00013 0 3e-04 -1 9 / 36 (25%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 2.4e-05 0 4.3e-05 5.4e-06 0 1.8e-05 -2.2 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
1.B.6.2.1 The OmpA-OmpF Porin (OOP) Family 0.055 0.34 1 0.15 0.45 1 0.26 0.52 1 0.085 0.33 1 0.42 0.86 1 0.61 0.85 1 2e-04 1.6e-05 0 4.5e-05 0 8.9e-05 3.9e-05 0 1e-04 -0.21 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
4.A.6.1.3 The PTS Mannose-Fructose-Sorbose (Man) Family 0.078 0.34 1 0.47 0.73 1 0.57 0.79 1 0.065 0.3 1 0.47 0.87 1 0.64 0.86 1 0.00037 3.1e-05 0 7e-05 0 0.00014 8.7e-05 0 0.00023 0.31 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.40.7.7 The Nucleobase/Ascorbate Transporter (NAT) or Nucleobase:Cation Symporter-2 (NCS2) Family 0.26 0.37 1 0.45 0.72 1 0.56 0.78 1 0.45 0.71 1 0.61 0.91 1 0.6 0.85 1 0.00043 5.9e-05 0 1e-04 0 0.00027 0.00019 0 0.00051 0.93 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 2.7e-06 0 8.9e-06 0.054 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
1.A.30.2.1 The H+- or Na+-translocating Bacterial Flagellar Motor/ExbBD Outer Membrane Transport Energizer (Mot/Exb) Superfamily 0.018 0.34 1 0.0094 0.22 1 0.021 0.37 1 0.0053 0.16 1 0.054 0.62 1 0.074 0.6 1 0.00035 4.8e-05 0 0.00018 0 0.00035 6.8e-05 0 0.00018 -1.4 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.86.1.4 The Autoinducer-2 Exporter (AI-2E) Family (Formerly the PerM Family. TC #9.B.22) 0.27 0.37 1 0.98 1 1 0.4 0.65 1 0.87 0.95 1 0.14 0.66 1 0.021 0.52 1 0.00032 2.7e-05 0 6.7e-05 0 0.00018 6.8e-05 0 0.00018 0.021 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
1.B.17.3.5 The Outer Membrane Factor (OMF) Family 0.022 0.34 1 0.091 0.39 1 0.25 0.52 1 0.015 0.23 1 0.065 0.62 1 0.27 0.72 1 0.00028 3.9e-05 0 0.00011 0 0.00015 8.7e-05 0 0.00023 -0.34 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
5.A.3.4.2 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO) Family 0.13 0.34 1 0.17 0.47 1 0.062 0.37 1 0.17 0.45 1 0.4 0.84 1 0.14 0.65 1 0.00059 9.8e-05 0 0.00025 0 0.00062 0.00021 0 0.00056 -0.25 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 3e-06 0 9.9e-06 2.1e-05 0 4.7e-05 2.8 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
4.A.1.1.3 The PTS Glucose-Glucoside (Glc) Family 0.5 0.56 1 0.44 0.72 1 0.32 0.59 1 0.7 0.87 1 0.95 0.98 1 0.79 0.91 1 0.00026 5e-05 0 8.6e-05 0 0.00022 7.7e-05 0 2e-04 -0.16 7 / 36 (19%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.5e-05 0 7.2e-05 3.6e-05 0 1e-04 0.53 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
3.A.1.21.1 The ATP-binding Cassette (ABC) Superfamily 0.19 0.34 1 0.72 0.87 1 0.51 0.75 1 0.22 0.52 1 0.82 0.95 1 0.35 0.74 1 5e-04 7e-05 0 0.00014 0 0.00036 2e-04 0 0.00054 0.51 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.3e-05 0 3.5e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
9.B.55.1.1 The 4 TMS DUF307/YccF (DUF307) Family 0.16 0.34 1 0.13 0.42 1 0.37 0.63 1 0.87 0.95 1 0.9 0.98 1 0.44 0.79 1 0.00031 2.6e-05 0 1e-04 0 0.00027 2.9e-05 0 7.7e-05 -1.8 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.1.1.1 The Major Facilitator Superfamily (MFS) 0.32 0.41 1 0.76 0.88 1 0.96 0.99 1 0.94 0.98 1 0.61 0.91 1 0.74 0.89 1 0.00093 1e-04 0 0.00022 0 0.00058 0.00026 0 0.00069 0.24 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1e-05 0 3.4e-05 2.1e-05 0 6.8e-05 1.1 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.1.3.17 The Major Facilitator Superfamily (MFS) 0.15 0.34 1 0.33 0.62 1 0.21 0.49 1 0.3 0.62 1 0.58 0.91 1 0.37 0.74 1 0.00031 5.2e-05 0 0.00013 0 0.00031 0.00011 0 0.00028 -0.24 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 5.1e-06 0 1.7e-05 1.6e-05 0 3.7e-05 1.6 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.7.22.1 The Drug/Metabolite Transporter (DMT) Superfamily 0.11 0.34 1 0.22 0.51 1 0.1 0.42 1 0.22 0.52 1 0.75 0.94 1 0.34 0.73 1 0.00046 5.1e-05 0 0.00015 0 4e-04 7.7e-05 0 2e-04 -0.96 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.1e-05 0 6.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
8.A.1.6.2 The Membrane Fusion Protein (MFP) Family 0.8 0.84 1 0.18 0.48 1 0.082 0.39 1 0.11 0.37 1 0.053 0.62 1 0.011 0.46 1 0.00023 3.2e-05 0 1.7e-05 0 4.5e-05 7.7e-05 0 2e-04 2.2 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3.5e-05 0 0.00011 1e-05 0 3.4e-05 -1.8 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
1.A.16.3.1 The Formate-Nitrite Transporter (FNT) Family 0.15 0.34 1 0.29 0.58 1 0.091 0.41 1 0.39 0.66 1 0.8 0.94 1 0.33 0.73 1 0.00044 4.8e-05 0 0.00015 0 4e-04 7.7e-05 0 2e-04 -0.96 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 1.3e-05 0 3.5e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.20.1.1 The Inorganic Phosphate Transporter (PiT) Family 0.23 0.35 1 0.51 0.75 1 0.73 0.88 1 0.82 0.93 1 0.51 0.87 1 0.39 0.75 1 6e-04 6.7e-05 0 0.00019 0 0.00049 0.00015 0 0.00038 -0.34 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.1e-06 0 1.7e-05 2.7e-06 0 8.9e-06 -0.92 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
1.B.1.1.1 The General Bacterial Porin (GBP) Family 0.22 0.35 1 0.43 0.7 1 0.18 0.48 1 0.86 0.95 1 0.86 0.96 1 0.49 0.82 1 3e-04 4.1e-05 0 0.00012 0 0.00031 5.8e-05 0 0.00015 -1 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 2.1e-05 0 4.7e-05 3 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.A.77.3.11 The Mg2+/Ca2+ Uniporter (MCU) Family 0.18 0.34 1 0.6 0.78 1 0.24 0.52 1 0.45 0.71 1 0.41 0.85 1 0.85 0.94 1 0.00037 3.1e-05 0 8.4e-05 0 0.00022 6.8e-05 0 0.00018 -0.3 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.2.2 The ATP-binding Cassette (ABC) Superfamily 0.11 0.34 1 0.18 0.47 1 0.044 0.37 1 0.11 0.37 1 0.59 0.91 1 0.12 0.65 1 0.00081 0.00011 0 0.00033 0 0.00084 2e-04 0 0.00054 -0.72 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.9e-05 0 6.8e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
3.A.2.1.1 The H+- or Na+-translocating F-type. V-type and A-type ATPase (F-ATPase) Superfamily 0.058 0.34 1 0.04 0.28 1 0.059 0.37 1 0.01 0.22 1 0.016 0.5 1 0.034 0.58 1 6e-04 0.00023 0 0.00054 8.1e-05 0.0012 0.00058 0 0.0015 0.1 14 / 36 (39%) 6 / 7 (86%) 2 / 7 (29%) 0.857 0.286 1.9e-05 0 3.6e-05 3.1e-05 0 5.5e-05 0.71 3 / 11 (27%) 3 / 11 (27%) 0.273 0.273
3.A.1.3.26 The ATP-binding Cassette (ABC) Superfamily 0.11 0.34 1 0.32 0.61 1 0.39 0.64 1 0.14 0.4 1 0.98 0.99 1 0.99 1 1 0.00076 0.00015 0 0.00042 0 0.0011 0.00032 0 0.00079 -0.39 7 / 36 (19%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 7.7e-06 0 2.6e-05 1.1e-05 0 3.6e-05 0.51 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
1.B.14.1.1 The Outer Membrane Receptor (OMR) Family 0.14 0.34 1 0.63 0.8 1 0.99 0.99 1 0.094 0.34 1 0.34 0.83 1 0.82 0.93 1 0.00057 7.9e-05 0 0.00016 0 0.00035 0.00024 0 0.00064 0.58 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 6e-06 0 2e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.7.26.1 The Drug/Metabolite Transporter (DMT) Superfamily 0.27 0.38 1 0.56 0.77 1 0.43 0.69 1 0.76 0.89 1 0.75 0.94 1 1 1 1 0.00017 1.9e-05 0 5e-05 0 0.00013 2.9e-05 0 7.7e-05 -0.79 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 1e-05 0 3.4e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.1.33.2 The Major Facilitator Superfamily (MFS) 0.85 0.88 1 0.66 0.82 1 0.94 0.98 1 0.76 0.89 1 0.62 0.91 1 0.97 1 1 0.00035 8.9e-05 0 6.4e-05 0 0.00013 0.00012 0 0.00028 0.91 9 / 36 (25%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 6.2e-05 0 0.00015 0.00011 0 0.00029 0.83 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
1.A.23.4.5 The Small Conductance Mechanosensitive Ion Channel (MscS) Family 0.033 0.34 1 0.067 0.36 1 0.069 0.37 1 0.031 0.27 1 0.18 0.72 1 0.16 0.67 1 0.00023 5.8e-05 0 0.00017 1.6e-05 0.00035 9.1e-05 0 0.00023 -0.9 9 / 36 (25%) 4 / 7 (57%) 2 / 7 (29%) 0.571 0.286 7.7e-06 0 2.6e-05 1.8e-05 0 4.5e-05 1.2 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.B.25.1.5 The Outer Membrane Porin (Opr) Family 0.18 0.34 1 0.45 0.72 1 0.99 0.99 1 0.41 0.68 1 0.57 0.91 1 0.76 0.9 1 0.00031 3.5e-05 0 7.9e-05 0 0.00018 8.7e-05 0 0.00023 0.14 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 7.7e-06 0 2.6e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
3.A.1.25.6 The ATP-binding Cassette (ABC) Superfamily 0.21 0.35 1 0.55 0.76 1 0.21 0.48 1 0.25 0.56 1 0.62 0.91 1 0.39 0.75 1 0.00068 0.00044 2e-04 2e-04 8.1e-05 0.00034 0.00046 0.00024 8e-04 1.2 23 / 36 (64%) 5 / 7 (71%) 4 / 7 (57%) 0.714 0.571 0.00079 0.00053 0.0016 0.00022 0.00022 0.00022 -1.8 7 / 11 (64%) 7 / 11 (64%) 0.636 0.636
3.A.1.129.1 The ATP-binding Cassette (ABC) Superfamily 0.25 0.36 1 0.77 0.88 1 0.39 0.64 1 0.71 0.87 1 0.44 0.86 1 0.83 0.93 1 0.00056 0.00012 0 0.00031 0 8e-04 0.00027 0 0.00069 -0.2 8 / 36 (22%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 2.2e-05 0 7.3e-05 2e-05 0 3.9e-05 -0.14 1 / 11 (9.1%) 3 / 11 (27%) 0.0909 0.273
2.A.1.2.60 The Major Facilitator Superfamily (MFS) 0.08 0.34 1 0.079 0.38 1 0.33 0.59 1 0.19 0.5 1 0.68 0.92 1 0.55 0.83 1 0.00021 4.8e-05 0 0.00015 0 0.00035 8.3e-05 0 0.00018 -0.85 8 / 36 (22%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 5.5e-06 0 1.2e-05 2.7e-06 0 8.9e-06 -1 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
1.B.14.14.1 The Outer Membrane Receptor (OMR) Family 0.41 0.49 1 0.57 0.77 1 0.72 0.88 1 0.15 0.41 1 0.77 0.94 1 0.64 0.86 1 0.00013 1.4e-05 0 8.1e-06 0 2.1e-05 0 0 0 -Inf 4 / 36 (11%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 3.9e-05 0 0.00011 3e-06 0 1e-05 -3.7 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
9.B.226.1.8 The Uncharacterized 9 or 10 TMS Protein (U-TMP) Family 0.46 0.53 1 0.51 0.75 1 0.85 0.93 1 0.19 0.49 1 0.79 0.94 1 0.96 1 1 0.00089 0.00071 0.00044 0.00044 0.00023 0.00054 0.00068 0.00096 0.00065 0.63 29 / 36 (81%) 5 / 7 (71%) 4 / 7 (57%) 0.714 0.571 0.00081 0.00049 0.0015 0.00082 0.00044 0.00079 0.018 10 / 11 (91%) 10 / 11 (91%) 0.909 0.909
9.B.22.1.8 The Leukotoxin Secretion Morphogenesis Protein C (MorC) Family 0.017 0.34 1 0.2 0.49 1 0.1 0.42 1 0.093 0.34 1 0.59 0.91 1 0.25 0.71 1 0.0013 0.00033 0 0.00087 0 0.0011 0.00049 0 0.00089 -0.83 9 / 36 (25%) 3 / 7 (43%) 3 / 7 (43%) 0.429 0.429 2.2e-05 0 7.3e-05 0.00019 0 0.00053 3.1 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.B.75.1.3 The DUF481 Putative Beta Barrel Porin (DUF481) Family 0.26 0.37 1 0.22 0.51 1 0.34 0.6 1 0.99 0.99 1 0.062 0.62 1 0.12 0.65 1 0.00026 3.6e-05 0 8.4e-05 0 0.00022 9.4e-05 0 2e-04 0.16 5 / 36 (14%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 2.6e-06 0 8.5e-06 2.7e-06 0 8.9e-06 0.054 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.40.4.3 The Nucleobase/Ascorbate Transporter (NAT) or Nucleobase:Cation Symporter-2 (NCS2) Family 0.12 0.34 1 0.58 0.77 1 0.98 0.99 1 0.29 0.6 1 0.34 0.83 1 0.75 0.89 1 0.00028 3.9e-05 0 8.9e-05 0 0.00022 9.8e-05 0 0.00018 0.14 5 / 36 (14%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.1.4.3 The Major Facilitator Superfamily (MFS) 0.25 0.36 1 0.83 0.92 1 0.53 0.76 1 0.61 0.82 1 0.79 0.94 1 0.54 0.82 1 0.00027 4.6e-05 0 8.6e-05 0 0.00022 0.00013 0 0.00033 0.6 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 3e-06 0 9.9e-06 1.2e-05 0 2.6e-05 2 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
5.A.3.1.1 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO) Family 0.24 0.36 1 0.61 0.79 1 0.34 0.6 1 0.54 0.77 1 0.78 0.94 1 0.4 0.75 1 0.00036 8e-05 0 0.00015 0 0.00035 0.00023 0 0.00056 0.62 8 / 36 (22%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 1.6e-05 0 3.6e-05 2.7e-06 0 8.9e-06 -2.6 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
9.B.174.1.2 The Two Tunnel Gated C-terminal Processing Protease (CTP) Family 0.33 0.42 1 0.39 0.67 1 0.72 0.88 1 0.92 0.97 1 0.38 0.84 1 0.65 0.86 1 5e-04 5.6e-05 0 1e-04 0 0.00027 0.00016 0 0.00044 0.68 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 1e-05 0 3.4e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.17.1.2 The Proton-dependent Oligopeptide Transporter (POT/PTR) Family 0.16 0.34 1 0.37 0.65 1 0.092 0.41 1 0.54 0.77 1 0.85 0.96 1 0.27 0.72 1 0.00026 2.9e-05 0 8.4e-05 0 0.00022 3.9e-05 0 1e-04 -1.1 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 1.6e-05 0 3.7e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
3.A.1.125.1 The ATP-binding Cassette (ABC) Superfamily 0.041 0.34 1 0.0052 0.22 1 0.031 0.37 1 0.073 0.31 1 0.035 0.62 1 0.15 0.66 1 0.00043 0.00012 0 0.00042 1.6e-05 0.00091 0.00014 0 0.00036 -1.6 10 / 36 (28%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 1.9e-05 0 3.8e-05 1.7e-05 0 4e-05 -0.16 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
3.A.1.5.42 The ATP-binding Cassette (ABC) Superfamily 0.4 0.47 1 0.82 0.91 1 0.4 0.65 1 0.68 0.86 1 0.63 0.91 1 0.24 0.7 1 0.00033 7.4e-05 0 0.00016 0 4e-04 0.00018 0 0.00046 0.17 8 / 36 (22%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 1.9e-05 0 3.8e-05 1.1e-05 0 3.6e-05 -0.79 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
9.B.186.1.1 The Putative Lipoprotein Supressor of a ts bamD mutant. YiaD (YiaD) Family 0.26 0.37 1 0.2 0.49 1 0.68 0.85 1 0.97 0.99 1 0.077 0.62 1 0.39 0.75 1 0.00018 2e-05 0 3.4e-05 0 8.9e-05 5.4e-05 0 1e-04 0.67 4 / 36 (11%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.109.1.7 The Tellurium Ion Resistance (TerC) Family 0.53 0.6 1 0.2 0.49 1 0.087 0.4 1 0.46 0.72 1 0.31 0.8 1 0.052 0.58 1 0.00062 6.9e-05 0 1e-04 0 0.00027 0.00023 0 0.00061 1.2 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.4e-05 0 3.7e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
1.B.11.2.2 The Outer Membrane Fimbrial Usher Porin (FUP) Family 0.09 0.34 1 0.12 0.42 1 0.037 0.37 1 0.86 0.95 1 0.22 0.74 1 0.058 0.58 1 7.4e-05 8.2e-06 0 1.9e-05 0 4.5e-05 0 0 0 -Inf 4 / 36 (11%) 2 / 7 (29%) 0 / 7 (0%) 0.286 0 0 0 0 1.5e-05 0 3.3e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.1.52.2 The Major Facilitator Superfamily (MFS) 0.25 0.36 1 0.2 0.49 1 0.83 0.92 1 0.72 0.87 1 0.78 0.94 1 0.16 0.67 1 0.00037 4.1e-05 0 0.00013 0 0.00036 6.8e-05 0 0.00018 -0.93 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.5e-06 0 1.2e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
9.B.168.1.2 The DUF3078 Putative Porin (DUF3078) Family 0.17 0.34 1 0.37 0.65 1 0.16 0.46 1 0.056 0.29 1 0.25 0.77 1 0.13 0.65 1 8.6e-05 9.6e-06 0 0 0 0 1.3e-05 0 3.5e-05 Inf 4 / 36 (11%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 2e-05 0 4.5e-05 3e-06 0 1e-05 -2.7 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.8.1.3 The Gluconate:H+ Symporter (GntP) Family 0.13 0.34 1 0.44 0.71 1 0.54 0.76 1 0.13 0.39 1 0.43 0.86 1 0.6 0.85 1 0.00037 5.1e-05 0 0.00012 0 0.00026 0.00014 0 0.00036 0.22 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 2.7e-06 0 8.9e-06 0.054 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.C.1.4.3 The TonB-ExbB-ExbD/TolA-TolQ-TolR Outer Membrane Receptor Energizers and Stabilizers (TonB/TolA) Family 0.81 0.85 1 0.53 0.76 1 0.16 0.45 1 0.55 0.78 1 0.69 0.93 1 0.28 0.73 1 0.00019 2.6e-05 0 1.6e-05 0 4.3e-05 0 0 0 -Inf 5 / 36 (14%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 1.1e-05 0 3.6e-05 6.5e-05 0 0.00014 2.6 1 / 11 (9.1%) 3 / 11 (27%) 0.0909 0.273
2.A.14.1.2 The Lactate Permease (LctP) Family 0.17 0.34 1 0.51 0.75 1 0.21 0.48 1 0.37 0.65 1 0.52 0.87 1 0.74 0.89 1 0.00065 5.5e-05 0 0.00015 0 4e-04 0.00012 0 0.00031 -0.32 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 8.1e-06 0 2.7e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.21.3.21 The Solute:Sodium Symporter (SSS) Family 0.064 0.34 1 0.0076 0.22 1 0.031 0.37 1 0.0095 0.21 1 0.06 0.62 1 0.16 0.67 1 0.00085 9.4e-05 0 0.00027 0 0.00066 0.00021 0 0.00056 -0.36 4 / 36 (11%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
8.A.1.7.1 The Membrane Fusion Protein (MFP) Family 0.14 0.34 1 0.054 0.31 1 0.28 0.54 1 0.32 0.63 1 0.7 0.93 1 0.71 0.88 1 0.00043 4.8e-05 0 0.00015 0 4e-04 8.7e-05 0 0.00023 -0.79 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 3e-06 0 9.9e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
1.A.1.5.25 The Voltage-gated Ion Channel (VIC) Superfamily 0.58 0.64 1 0.51 0.75 1 0.52 0.75 1 0.32 0.63 1 0.46 0.87 1 0.36 0.74 1 0.00067 0.00048 0.00039 0.00032 4e-04 0.00032 0.00044 0.00036 0.00046 0.46 26 / 36 (72%) 4 / 7 (57%) 4 / 7 (57%) 0.571 0.571 0.00051 0.00037 0.00081 0.00059 0.00057 0.00045 0.21 8 / 11 (73%) 10 / 11 (91%) 0.727 0.909
1.B.6.1.21 The OmpA-OmpF Porin (OOP) Family 0.055 0.34 1 0.023 0.24 1 0.067 0.37 1 0.037 0.27 1 0.25 0.77 1 0.44 0.79 1 0.00036 3e-05 0 9.6e-05 0 0.00022 5.8e-05 0 0.00015 -0.73 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
3.A.1.1.3 The ATP-binding Cassette (ABC) Superfamily 0.61 0.66 1 0.13 0.42 1 0.12 0.43 1 0.28 0.6 1 0.029 0.62 1 0.0079 0.46 1 0.00029 4e-05 0 5e-05 0 0.00013 0.00014 0 0.00036 1.5 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 8.5e-06 0 2.1e-05 5.4e-06 0 1.8e-05 -0.65 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
1.B.76.1.8 The Copper Resistance Putative Porin (CopB) Family 0.22 0.35 1 0.16 0.45 1 0.63 0.83 1 0.85 0.94 1 0.9 0.98 1 0.19 0.68 1 6e-04 6.7e-05 0 0.00024 0 0.00062 9.7e-05 0 0.00026 -1.3 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 8.1e-06 0 1.9e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
2.A.8.1.7 The Gluconate:H+ Symporter (GntP) Family 0.1 0.34 1 0.1 0.39 1 0.19 0.48 1 0.099 0.35 1 0.3 0.8 1 0.47 0.81 1 0.00047 6.6e-05 0 0.00019 0 0.00044 0.00015 0 0.00038 -0.34 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 2.7e-06 0 8.9e-06 0.054 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.64.1.1 The Twin Arginine Targeting (Tat) Family 0.2 0.34 1 0.7 0.85 1 0.45 0.71 1 0.45 0.71 1 1 1 1 0.78 0.91 1 0.00062 8.6e-05 0 2e-04 0 0.00053 2e-04 0 0.00054 0 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 3e-06 0 9.9e-06 2.1e-05 0 6.8e-05 2.8 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.27.3 The ATP-binding Cassette (ABC) Superfamily 0.12 0.34 1 0.4 0.68 1 0.7 0.86 1 0.28 0.6 1 0.76 0.94 1 0.82 0.93 1 0.00083 0.00021 0 0.00056 0 0.0014 0.00044 0 0.0011 -0.35 9 / 36 (25%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 1.8e-05 0 3.5e-05 1.9e-05 0 6.2e-05 0.078 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
2.A.47.3.2 The Divalent Anion:Na+ Symporter (DASS) Family 0.038 0.34 1 0.032 0.27 1 0.031 0.37 1 0.042 0.27 1 0.13 0.66 1 0.086 0.61 1 0.00036 6.9e-05 0 0.00024 0 0.00053 7.7e-05 0 2e-04 -1.6 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 2.3e-05 0 6.8e-05 3.1 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
9.B.118.1.1 The 11 or 12 TMS YhfT (YhfT) Family 0.024 0.34 1 0.018 0.23 1 0.02 0.37 1 0.012 0.22 1 0.062 0.62 1 0.051 0.58 1 0.00036 6.9e-05 0 0.00022 0 0.00043 0.00011 0 0.00028 -1 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 1.6e-05 0 3.7e-05 2.6 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
4.A.6.1.7 The PTS Mannose-Fructose-Sorbose (Man) Family 0.23 0.35 1 0.32 0.61 1 0.17 0.46 1 0.067 0.3 1 0.066 0.62 1 0.064 0.58 1 0.00039 0.00027 0.00012 2e-04 0 4e-04 0.00026 0.00013 0.00029 0.38 25 / 36 (69%) 3 / 7 (43%) 6 / 7 (86%) 0.429 0.857 0.00042 0.00019 0.00079 0.00017 8.8e-05 0.00021 -1.3 8 / 11 (73%) 8 / 11 (73%) 0.727 0.727
2.A.1.7.18 The Major Facilitator Superfamily (MFS) 0.48 0.55 1 0.91 0.96 1 0.66 0.84 1 0.79 0.9 1 0.9 0.98 1 0.7 0.88 1 0.00023 1e-04 0 9.5e-05 3.2e-05 0.00012 0.00013 2.7e-05 0.00024 0.45 16 / 36 (44%) 4 / 7 (57%) 4 / 7 (57%) 0.571 0.571 6.7e-05 0 0.00013 0.00012 0 0.00029 0.84 3 / 11 (27%) 5 / 11 (45%) 0.273 0.455
2.A.8.1.4 The Gluconate:H+ Symporter (GntP) Family 0.28 0.38 1 0.99 1 1 0.15 0.44 1 0.89 0.96 1 0.69 0.93 1 0.23 0.7 1 3e-04 5.8e-05 0 0.00012 0 0.00031 0.00012 0 0.00031 0 7 / 36 (19%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 3.9e-05 0 7e-05 3.9 1 / 11 (9.1%) 4 / 11 (36%) 0.0909 0.364
2.A.69.4.6 The Auxin Efflux Carrier (AEC) Family 0.41 0.49 1 0.75 0.88 1 0.91 0.96 1 0.15 0.41 1 0.95 0.98 1 0.71 0.88 1 0.00094 0.00076 0.00057 0.00051 0.00034 0.00057 0.00068 0.00036 0.00076 0.42 29 / 36 (81%) 5 / 7 (71%) 4 / 7 (57%) 0.714 0.571 0.00084 0.00052 0.0011 0.00089 0.00091 0.00075 0.083 10 / 11 (91%) 10 / 11 (91%) 0.909 0.909
2.A.102.3.1 The 4-Toluene Sulfonate Uptake Permease (TSUP) Family 0.72 0.77 1 0.36 0.65 1 0.15 0.45 1 0.018 0.26 1 0.047 0.62 1 0.0084 0.46 1 8.2e-05 1.1e-05 0 1.7e-05 0 4.5e-05 2.9e-05 0 7.7e-05 0.77 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.5e-06 0 1.2e-05 2.7e-06 0 8.9e-06 -1 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.8.1.8 The Gluconate:H+ Symporter (GntP) Family 0.2 0.34 1 0.2 0.49 1 0.62 0.83 1 0.85 0.94 1 0.69 0.93 1 0.31 0.73 1 0.00044 3.7e-05 0 0.00012 0 0.00031 6.8e-05 0 0.00018 -0.82 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
9.B.121.1.1 The AsmA (AsmA) Family 0.24 0.36 1 0.3 0.59 1 0.76 0.9 1 0.51 0.75 1 0.42 0.86 1 0.9 0.97 1 0.00043 8.4e-05 0 2e-04 0 0.00048 0.00016 0 0.00044 -0.32 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 3.5e-05 0 0.00011 8.1e-06 0 2.7e-05 -2.1 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
3.A.1.23.1 The ATP-binding Cassette (ABC) Superfamily 0.86 0.89 1 0.87 0.94 1 0.41 0.67 1 0.9 0.97 1 0.72 0.94 1 0.75 0.89 1 0.00049 0.00029 7.3e-05 0.00025 0.00014 0.00037 0.00025 0.00014 3e-04 0 21 / 36 (58%) 6 / 7 (86%) 4 / 7 (57%) 0.857 0.571 0.00053 0 0.001 9.1e-05 2.9e-05 0.00013 -2.5 5 / 11 (45%) 6 / 11 (55%) 0.455 0.545
4.B.1.1.1 The Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) Family 0.11 0.34 1 0.09 0.39 1 0.12 0.43 1 0.27 0.6 1 0.58 0.91 1 0.56 0.83 1 0.00054 7.5e-05 0 0.00026 0 0.00067 0.00011 0 0.00028 -1.2 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 3e-06 0 9.9e-06 1e-05 0 3.4e-05 1.7 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
9.B.157.1.3 The Cell Shape-determining MreBCD (MreBCD) Family 0.026 0.34 1 0.0048 0.22 1 0.0034 0.35 1 0.0017 0.15 0.97 0.023 0.61 1 0.012 0.46 1 0.00048 9.4e-05 0 0.00029 3.2e-05 0.00065 0.00017 0 0.00046 -0.77 7 / 36 (19%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 0 0 0 1.6e-05 0 4.3e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
1.B.35.2.1 The Oligogalacturonate-specific Porin (KdgM) Family 0.068 0.34 1 0.039 0.28 1 0.099 0.42 1 0.058 0.29 1 0.23 0.76 1 0.44 0.79 1 0.00051 4.3e-05 0 0.00017 0 0.00044 4.8e-05 0 0.00013 -1.8 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.1.57.3 The Major Facilitator Superfamily (MFS) 0.47 0.54 1 0.72 0.87 1 0.87 0.94 1 0.71 0.87 1 0.81 0.95 1 0.6 0.85 1 0.00059 6.6e-05 0 0.00015 0 4e-04 0.00011 0 0.00028 -0.45 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 4.4e-05 0 0.00015 6.8e-06 0 2.3e-05 -2.7 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.D.11.1.1 The Periplasmic Nitrate Reductase Complex (NAP) Complex Family 0.054 0.34 1 0.011 0.23 1 0.048 0.37 1 0.019 0.26 1 0.062 0.62 1 0.17 0.68 1 0.00094 0.00018 0 0.00055 2.8e-05 0.0013 0.00037 0 0.00097 -0.57 7 / 36 (19%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 1.1e-05 0 3.6e-05 6.8e-06 0 2.3e-05 -0.69 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.40.3.3 The Nucleobase/Ascorbate Transporter (NAT) or Nucleobase:Cation Symporter-2 (NCS2) Family 0.099 0.34 1 0.84 0.93 1 0.76 0.9 1 0.11 0.36 1 0.67 0.92 1 0.94 0.99 1 0.00053 7.3e-05 0 0.00017 0 4e-04 0.00019 0 0.00046 0.16 5 / 36 (14%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.B.33.1.3 The Outer Membrane Protein Insertion Porin (Bam Complex) (OmpIP) Family 0.18 0.34 1 0.35 0.64 1 0.17 0.46 1 0.48 0.73 1 0.58 0.91 1 0.29 0.73 1 0.00064 0.00025 0 6e-04 0 0.0015 0.00058 0 0.0015 -0.049 14 / 36 (39%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 2.2e-05 0 3.7e-05 3.9e-05 0 5.3e-05 0.83 4 / 11 (36%) 5 / 11 (45%) 0.364 0.455
3.A.1.17.1 The ATP-binding Cassette (ABC) Superfamily 0.028 0.34 1 0.025 0.25 1 0.027 0.37 1 0.029 0.27 1 0.14 0.66 1 0.067 0.58 1 0.00052 7.2e-05 0 0.00029 0 0.00066 5.8e-05 0 0.00015 -2.3 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.3e-05 0 3.5e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.21.1.1 The Solute:Sodium Symporter (SSS) Family 0.077 0.34 1 0.46 0.73 1 0.32 0.59 1 0.83 0.93 1 0.82 0.95 1 0.58 0.84 1 6.6e-05 7.3e-06 0 1.9e-05 0 4.5e-05 9.7e-06 0 2.6e-05 -0.97 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
4.A.6.1.5 The PTS Mannose-Fructose-Sorbose (Man) Family 0.2 0.34 1 0.97 0.99 1 0.91 0.96 1 0.26 0.6 1 0.9 0.98 1 0.86 0.94 1 0.00058 8.1e-05 0 0.00017 0 0.00044 0.00023 0 0.00061 0.44 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 5.4e-06 0 1.8e-05 1.1 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.7.3.22 The Drug/Metabolite Transporter (DMT) Superfamily 0.39 0.47 1 0.17 0.46 1 0.12 0.43 1 0.68 0.86 1 0.19 0.72 1 0.087 0.61 1 0.00038 3.1e-05 0 5e-05 0 0.00013 0.00011 0 0.00028 1.1 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.42.2.1 The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family 0.14 0.34 1 0.15 0.44 1 0.19 0.48 1 0.56 0.79 1 0.95 0.98 1 0.83 0.93 1 0.00079 8.8e-05 0 0.00034 0 0.00089 9.7e-05 0 0.00026 -1.8 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 1e-05 0 3.4e-05 1.7 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.6.2.1 The Resistance-Nodulation-Cell Division (RND) Superfamily 0.16 0.34 1 0.038 0.28 1 0.25 0.52 1 0.27 0.6 1 0.061 0.62 1 0.35 0.74 1 0.00056 0.00016 0 0.00039 3.2e-05 0.00092 0.00033 0 0.00087 -0.24 10 / 36 (28%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 3.8e-05 0 7.6e-05 1.8e-05 0 4.1e-05 -1.1 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
1.B.55.3.1 The Poly Acetyl Glucosamine Porin (PgaA) Family 0.19 0.34 1 0.14 0.44 1 0.26 0.52 1 0.56 0.79 1 0.48 0.87 1 0.63 0.85 1 0.00071 0.00014 0 0.00039 0 0.00097 0.00026 0 0.00069 -0.58 7 / 36 (19%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.1e-05 0 5.1e-05 1.8e-05 0 4.1e-05 -0.22 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
2.A.58.2.1 The Phosphate:Na+ Symporter (PNaS) Family 0.11 0.34 1 0.25 0.54 1 0.3 0.57 1 0.056 0.29 1 0.25 0.77 1 0.34 0.73 1 0.00038 6.3e-05 0 0.00015 0 0.00035 0.00016 0 0.00044 0.093 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 5.4e-06 0 1.8e-05 1.1 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
9.B.124.2.2 The DUF805 or PF05656 (DUF805) Family 0.16 0.34 1 0.31 0.6 1 0.15 0.45 1 0.39 0.66 1 0.36 0.84 1 0.97 1 1 0.00034 2.8e-05 0 8.4e-05 0 0.00022 5.8e-05 0 0.00015 -0.53 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.B.14.1.4 The Outer Membrane Receptor (OMR) Family 0.1 0.34 1 0.11 0.4 1 0.091 0.41 1 0.18 0.49 1 0.4 0.84 1 0.27 0.73 1 0.00047 7.9e-05 0 0.00024 0 0.00057 0.00014 0 0.00036 -0.78 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 5.1e-06 0 1.7e-05 1.6e-05 0 3.7e-05 1.6 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.27.1.1 The Glutamate:Na+ Symporter (ESS) Family 0.3 0.4 1 0.5 0.75 1 0.96 0.99 1 0.59 0.81 1 0.72 0.93 1 0.67 0.88 1 0.00035 5.8e-05 0 8.6e-05 0 0.00022 0.00018 0 0.00049 1.1 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 1.6e-05 0 3.7e-05 2.6 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.1.2.62 The Major Facilitator Superfamily (MFS) 0.25 0.36 1 0.54 0.76 1 0.77 0.9 1 0.95 0.98 1 0.56 0.91 1 0.18 0.68 1 0.00074 6.1e-05 0 0.00017 0 0.00045 0.00014 0 0.00036 -0.28 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 7.3e-06 0 2.4e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
9.B.75.2.1 The Ethanol Utilization/Transport (Eut) Protein Family 0.079 0.34 1 0.48 0.73 1 0.32 0.59 1 0.093 0.34 1 0.53 0.89 1 0.33 0.73 1 0.00021 2.3e-05 0 5.1e-05 0 9.3e-05 5.8e-05 0 0.00015 0.19 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.15.5 The ATP-binding Cassette (ABC) Superfamily 0.13 0.34 1 0.24 0.53 1 0.052 0.37 1 0.18 0.49 1 0.86 0.96 1 0.18 0.68 1 0.00061 8.5e-05 0 0.00024 0 0.00062 0.00017 0 0.00046 -0.5 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.5e-05 0 3.3e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
8.A.3.2.3 The Cytoplasmic Membrane-Periplasmic Auxiliary-1 (MPA1) Protein with Cytoplasmic (C) Domain (MPA1-C or MPA1+C) Family 0.32 0.41 1 0.24 0.53 1 0.14 0.43 1 0.2 0.51 1 0.14 0.66 1 0.13 0.65 1 0.00019 7.3e-05 0 3.7e-05 0 9e-05 1e-04 2.7e-05 0.00013 1.4 14 / 36 (39%) 2 / 7 (29%) 4 / 7 (57%) 0.286 0.571 0.00012 0 0.00021 3.4e-05 0 5.1e-05 -1.8 4 / 11 (36%) 4 / 11 (36%) 0.364 0.364
3.A.1.2.17 The ATP-binding Cassette (ABC) Superfamily 0.43 0.51 1 0.84 0.92 1 0.82 0.92 1 0.23 0.54 1 0.97 0.99 1 0.79 0.91 1 0.00018 3e-05 0 1.2e-05 0 3.1e-05 3.9e-06 0 1e-05 -1.6 6 / 36 (17%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 6.7e-05 0 0.00019 2e-05 0 4.6e-05 -1.7 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
3.A.1.2.3 The ATP-binding Cassette (ABC) Superfamily 0.078 0.34 1 0.0094 0.22 1 0.041 0.37 1 0.093 0.34 1 0.073 0.62 1 0.2 0.69 1 0.00065 0.00015 0 0.00048 0 0.0012 0.00023 0 0.00061 -1.1 8 / 36 (22%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 1.1e-05 0 2.5e-05 9.2e-06 0 2.2e-05 -0.26 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
2.A.3.2.8 The Amino Acid-Polyamine-Organocation (APC) Family 0.19 0.34 1 0.14 0.44 1 0.42 0.67 1 0.51 0.75 1 0.055 0.62 1 0.21 0.69 1 0.00045 5e-05 0 0.00012 0 0.00031 0.00013 0 3e-04 0.12 4 / 36 (11%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
4.D.2.4.3 The Glycosyl Transferase 2 (GT2) Family 0.21 0.35 1 0.62 0.79 1 0.5 0.74 1 0.54 0.77 1 0.7 0.93 1 0.65 0.86 1 0.00024 3.3e-05 0 6.2e-05 0 0.00013 6.8e-05 0 0.00018 0.13 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 6e-06 0 2e-05 2.1e-05 0 6.8e-05 1.8 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
5.A.3.2.1 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO) Family 0.078 0.34 1 0.54 0.76 1 0.38 0.63 1 0.1 0.35 1 0.51 0.87 1 0.34 0.74 1 0.00037 4.1e-05 0 9e-05 0 0.00016 0.00011 0 0.00028 0.29 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.B.14.6.13 The Outer Membrane Receptor (OMR) Family 0.9 0.93 1 0.64 0.8 1 0.66 0.84 1 0.39 0.66 1 0.92 0.98 1 0.4 0.75 1 9.3e-05 7.8e-06 0 1.2e-05 0 3.2e-05 4.4e-06 0 1.2e-05 -1.4 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.5e-05 0 4.9e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.42.1.2 The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family 0.074 0.34 1 0.046 0.29 1 0.045 0.37 1 0.035 0.27 1 0.26 0.77 1 0.17 0.68 1 7e-04 7.8e-05 0 0.00024 0 0.00057 0.00015 0 0.00041 -0.68 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.8.1.5 The Gluconate:H+ Symporter (GntP) Family 0.19 0.34 1 0.058 0.33 1 0.13 0.43 1 0.44 0.71 1 0.015 0.5 1 0.034 0.58 1 0.00049 4.1e-05 0 1e-04 0 0.00027 0.00011 0 0.00028 0.14 3 / 36 (8.3%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.17.1.4 The Proton-dependent Oligopeptide Transporter (POT/PTR) Family 0.52 0.58 1 0.2 0.49 1 0.63 0.83 1 0.92 0.97 1 0.36 0.84 1 0.72 0.88 1 0.00032 6.3e-05 0 3.6e-05 0 8.8e-05 0.00025 0 0.00067 2.8 7 / 36 (19%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 1.9e-05 0 3.8e-05 2.9 1 / 11 (9.1%) 3 / 11 (27%) 0.0909 0.273
2.A.115.2.9 The Novobiocin Exporter (NbcE) Family 0.67 0.73 1 0.41 0.69 1 0.058 0.37 1 0.62 0.82 1 0.81 0.95 1 0.13 0.65 1 0.00031 5.9e-05 0 6.9e-05 0 0.00018 1.3e-05 0 3.5e-05 -2.4 7 / 36 (19%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.7e-05 0 4e-05 0.00013 0 0.00028 2.9 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
1.B.23.1.16 The Cyanobacterial Porin (CBP) Family 0.83 0.87 1 0.57 0.77 1 0.26 0.52 1 0.28 0.6 1 0.3 0.8 1 0.2 0.69 1 0.00047 9.1e-05 0 1e-04 0 0.00027 0.00012 0 0.00023 0.26 7 / 36 (19%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0.00014 0 0.00039 1.8e-05 0 4.5e-05 -3 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
2.A.7.3.57 The Drug/Metabolite Transporter (DMT) Superfamily 0.93 0.95 1 0.54 0.76 1 0.83 0.92 1 0.44 0.7 1 0.37 0.84 1 0.76 0.9 1 0.00029 6.4e-05 0 2.4e-05 0 6.4e-05 5.3e-05 0 9.8e-05 1.1 8 / 36 (22%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 2.6e-05 0 5.8e-05 0.00013 0 0.00039 2.3 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
4.A.2.1.1 The PTS Fructose-Mannitol (Fru) Family 0.2 0.34 1 0.2 0.49 1 0.62 0.83 1 0.76 0.89 1 0.74 0.94 1 0.26 0.72 1 0.0013 0.00011 0 0.00035 0 0.00094 2e-04 0 0.00054 -0.81 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 8.8e-06 0 2.9e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.1.6.4 The Major Facilitator Superfamily (MFS) 0.17 0.34 1 0.011 0.23 1 0.01 0.37 1 0.34 0.63 1 0.086 0.62 1 0.072 0.59 1 0.00036 7e-05 0 0.00017 0 4e-04 0.00011 0 0.00028 -0.63 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.2e-05 0 7.3e-05 3.4e-05 0 1e-04 0.63 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
9.B.27.2.2 The DedA or YdjX-Z (DedA) Family 0.25 0.36 1 0.54 0.76 1 0.77 0.91 1 0.94 0.98 1 0.18 0.72 1 0.81 0.92 1 0.00021 1.8e-05 0 3.4e-05 0 8.9e-05 4.8e-05 0 0.00013 0.5 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.B.10.1.1 The Nucleoside-specific Channel-forming Outer Membrane Porin (Tsx) Family 0.18 0.34 1 0.77 0.88 1 0.48 0.72 1 0.38 0.66 1 0.7 0.93 1 0.42 0.77 1 0.00018 3e-05 0 5.1e-05 0 9.3e-05 7.7e-05 0 2e-04 0.59 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 3e-06 0 9.9e-06 1.3e-05 0 3.5e-05 2.1 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.B.3.1.3 The Sugar Porin (SP) Family 0.072 0.34 1 0.0097 0.22 1 0.076 0.38 1 0.023 0.27 1 0.1 0.64 1 0.39 0.75 1 0.00077 0.00011 0 0.00031 0 0.00075 0.00023 0 0.00061 -0.43 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 3e-06 0 9.9e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.1.12.1 The Major Facilitator Superfamily (MFS) 0.056 0.34 1 0.12 0.41 1 0.22 0.5 1 0.031 0.27 1 0.23 0.76 1 0.4 0.75 1 0.00065 5.4e-05 0 0.00015 0 0.00031 0.00013 0 0.00033 -0.21 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
1.E.19.1.2 The Clostridium difficile TcdE Holin (TcdE Holin) Family 0.21 0.35 1 1 1 1 0.22 0.5 1 0.064 0.3 1 0.43 0.86 1 0.11 0.65 1 0.00016 1.4e-05 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 3.2e-05 0 9.5e-05 1.3e-05 0 4.3e-05 -1.3 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
1.B.14.7.1 The Outer Membrane Receptor (OMR) Family 0.23 0.35 1 0.81 0.91 1 0.9 0.96 1 0.57 0.79 1 0.78 0.94 1 0.83 0.93 1 0.00074 0.00016 0 0.00036 0 0.00088 0.00043 0 0.0011 0.26 8 / 36 (22%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 1.8e-05 0 4e-05 2.1e-05 0 4.7e-05 0.22 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
4.A.5.1.3 The PTS Galactitol (Gat) Family 0.072 0.34 1 0.014 0.23 1 0.048 0.37 1 0.032 0.27 1 0.17 0.72 1 0.33 0.73 1 0.0015 0.00013 0 0.00042 0 0.0011 0.00023 0 0.00061 -0.87 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
9.B.14.1.17 The Putative Heme Handling Protein (HHP) Family 0.92 0.94 1 0.57 0.77 1 0.7 0.87 1 0.99 0.99 1 0.61 0.91 1 0.39 0.75 1 0.00047 0.00021 0 0.00013 1.6e-05 0.00016 8.1e-05 0 0.00014 -0.68 16 / 36 (44%) 4 / 7 (57%) 3 / 7 (43%) 0.571 0.429 0.00033 0 0.00076 0.00021 5.9e-05 0.00057 -0.65 3 / 11 (27%) 6 / 11 (55%) 0.273 0.545
4.C.1.1.6 The Fatty Acid Transporter (FAT) Family 0.08 0.34 1 0.27 0.55 1 0.27 0.53 1 0.08 0.32 1 0.28 0.78 1 0.31 0.73 1 0.00029 4.8e-05 0 0.00011 0 0.00022 0.00012 0 0.00031 0.13 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 1e-05 0 3.4e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.121.6 The ATP-binding Cassette (ABC) Superfamily 0.21 0.35 1 0.89 0.96 1 0.69 0.86 1 0.1 0.35 1 0.7 0.93 1 0.46 0.8 1 0.00022 9.1e-05 0 4.1e-05 0 8.9e-05 4.8e-05 0 8.6e-05 0.23 15 / 36 (42%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0.00012 9.4e-05 0.00017 0.00012 0 0.00022 0 6 / 11 (55%) 5 / 11 (45%) 0.545 0.455
2.A.7.3.26 The Drug/Metabolite Transporter (DMT) Superfamily 0.11 0.34 1 0.99 1 1 0.81 0.91 1 0.032 0.27 1 0.5 0.87 1 0.4 0.75 1 0.00024 3.3e-05 0 4.8e-05 0 8.8e-05 0.00012 0 0.00031 1.3 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.1.10.3 The Major Facilitator Superfamily (MFS) 0.059 0.34 1 0.06 0.33 1 0.22 0.5 1 0.085 0.33 1 0.082 0.62 1 0.35 0.74 1 2e-04 3.8e-05 0 0.00011 0 0.00018 7.7e-05 0 2e-04 -0.51 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 5.5e-06 0 1.2e-05 2.7e-06 0 8.9e-06 -1 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.86.1.2 The Autoinducer-2 Exporter (AI-2E) Family (Formerly the PerM Family. TC #9.B.22) 0.28 0.38 1 0.83 0.92 1 0.33 0.59 1 0.99 0.99 1 0.27 0.78 1 0.051 0.58 1 0.00059 4.9e-05 0 0.00012 0 0.00031 0.00013 0 0.00033 0.12 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.1e-06 0 1.7e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
1.B.25.1.13 The Outer Membrane Porin (Opr) Family 0.16 0.34 1 0.41 0.69 1 0.11 0.42 1 0.48 0.73 1 0.74 0.94 1 0.36 0.74 1 0.00031 3.5e-05 0 1e-04 0 0.00027 5.8e-05 0 0.00015 -0.79 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 1.3e-05 0 3.5e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
1.B.14.9.5 The Outer Membrane Receptor (OMR) Family 0.083 0.34 1 0.035 0.28 1 0.13 0.43 1 0.11 0.36 1 0.19 0.72 1 0.45 0.79 1 0.00032 5.4e-05 0 0.00017 0 4e-04 9.7e-05 0 0.00026 -0.81 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 7.3e-06 0 2.4e-05 2.7e-06 0 8.9e-06 -1.4 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
9.B.223.1.4 The 4 TMS DUF2979 or YoaS (YoaS) Family 0.51 0.57 1 0.57 0.77 1 0.8 0.91 1 0.91 0.97 1 0.8 0.94 1 1 1 1 0.00025 8.4e-05 0 0.00012 0 0.00016 6.1e-05 0 0.00011 -0.98 12 / 36 (33%) 3 / 7 (43%) 3 / 7 (43%) 0.429 0.429 9.1e-05 0 0.00022 6.9e-05 0 2e-04 -0.4 3 / 11 (27%) 3 / 11 (27%) 0.273 0.273
2.A.1.4.1 The Major Facilitator Superfamily (MFS) 0.05 0.34 1 0.042 0.29 1 0.046 0.37 1 0.054 0.29 1 0.25 0.77 1 0.15 0.67 1 5e-04 5.6e-05 0 0.00021 0 0.00053 5.8e-05 0 0.00015 -1.9 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.1.3.37 The Major Facilitator Superfamily (MFS) 0.9 0.93 1 0.47 0.73 1 0.76 0.9 1 0.34 0.63 1 0.63 0.91 1 0.85 0.94 1 0.00022 1.8e-05 0 1.7e-05 0 4.5e-05 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 3.5e-05 0 0.00012 1.3e-05 0 4.3e-05 -1.4 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.21.2.1 The Solute:Sodium Symporter (SSS) Family 0.057 0.34 1 0.079 0.38 1 0.25 0.52 1 0.094 0.34 1 0.33 0.83 1 0.65 0.86 1 0.00024 4.6e-05 0 0.00014 0 0.00031 7.2e-05 0 0.00018 -0.96 7 / 36 (19%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 1.1e-05 0 3.6e-05 2.7e-06 0 8.9e-06 -2 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.D.2.1.1 The Proton-translocating Transhydrogenase (PTH) Family 0.44 0.51 1 0.19 0.49 1 0.72 0.88 1 0.71 0.87 1 0.16 0.69 1 0.62 0.85 1 0.00033 7.3e-05 0 0.00012 0 0.00031 0.00019 0 0.00046 0.66 8 / 36 (22%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 8.5e-06 0 2.1e-05 3.3e-05 0 7e-05 2 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
2.A.1.26.1 The Major Facilitator Superfamily (MFS) 0.75 0.8 1 0.9 0.96 1 0.49 0.74 1 0.2 0.5 1 0.59 0.91 1 0.26 0.72 1 0.00022 3e-05 0 5e-05 0 0.00013 5.8e-05 0 0.00015 0.21 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.5e-05 0 7.2e-05 5.4e-06 0 1.8e-05 -2.2 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
9.B.125.1.1 The AmpE/CobD (AmpE/CobD) Family 0.32 0.41 1 0.16 0.46 1 0.79 0.91 1 0.33 0.63 1 0.9 0.98 1 0.19 0.68 1 0.00045 6.3e-05 0 0.00024 0 0.00062 5.8e-05 0 0.00015 -2 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.9e-05 0 3.9e-05 0 0 0 -Inf 3 / 11 (27%) 0 / 11 (0%) 0.273 0
9.B.126.1.2 The Putative Lipid IV Exporter (YhjD) Family 0.53 0.59 1 0.86 0.94 1 0.58 0.79 1 0.11 0.36 1 0.47 0.87 1 0.57 0.84 1 6e-04 0.00046 0.00034 4e-04 0.00056 0.00042 0.00032 0.00024 0.00034 -0.32 28 / 36 (78%) 4 / 7 (57%) 5 / 7 (71%) 0.571 0.714 0.00047 0.00026 0.00059 0.00059 0.00038 0.00057 0.33 10 / 11 (91%) 9 / 11 (82%) 0.909 0.818
1.B.44.2.9 The Probable Protein Translocating Porphyromonas gingivalis Porin (PorT) Family 0.24 0.36 1 0.57 0.77 1 0.74 0.89 1 0.97 0.99 1 0.97 0.99 1 0.44 0.79 1 9.8e-05 1.4e-05 0 3e-05 0 5.1e-05 2.1e-05 0 4.6e-05 -0.51 5 / 36 (14%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 1.2e-05 0 3.9e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
3.A.1.12.15 The ATP-binding Cassette (ABC) Superfamily 0.12 0.34 1 0.11 0.4 1 0.052 0.37 1 0.34 0.63 1 0.41 0.85 1 0.17 0.68 1 3e-04 6.7e-05 0 0.00019 0 0.00044 0.00011 0 0.00028 -0.79 8 / 36 (22%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 5.5e-06 0 1.2e-05 2.5e-05 0 4.4e-05 2.2 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
2.A.3.2.1 The Amino Acid-Polyamine-Organocation (APC) Family 0.45 0.52 1 0.63 0.8 1 0.14 0.43 1 0.41 0.68 1 0.38 0.84 1 0.044 0.58 1 0.00036 4e-05 0 8.4e-05 0 0.00022 0.00011 0 0.00028 0.39 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 9.9e-06 0 2.5e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
3.A.3.7.1 The P-type ATPase (P-ATPase) Superfamily 0.23 0.35 1 0.46 0.73 1 0.26 0.52 1 0.75 0.89 1 0.92 0.98 1 0.59 0.85 1 0.00036 6.9e-05 0 0.00017 0 0.00044 0.00014 0 0.00036 -0.28 7 / 36 (19%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 5.5e-06 0 1.2e-05 2.6e-05 0 6.9e-05 2.2 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
2.A.1.36.3 The Major Facilitator Superfamily (MFS) 0.11 0.34 1 0.064 0.35 1 0.048 0.37 1 0.092 0.34 1 0.71 0.93 1 0.37 0.74 1 0.00046 5.1e-05 0 0.00015 0 4e-04 0.00011 0 0.00028 -0.45 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
9.B.29.2.7 The small 4-5 TMS Putative Permease (4-5PP) Family 0.17 0.34 1 0.44 0.71 1 0.18 0.48 1 0.33 0.63 1 0.58 0.91 1 0.68 0.88 1 0.001 8.3e-05 0 0.00024 0 0.00062 0.00017 0 0.00046 -0.5 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 1.1e-05 0 3.6e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.5.10 The ATP-binding Cassette (ABC) Superfamily 0.75 0.8 1 0.91 0.96 1 0.9 0.96 1 0.38 0.65 1 0.83 0.95 1 0.91 0.97 1 3e-04 1e-04 0 9.1e-05 0 0.00018 0.00013 0 0.00036 0.51 12 / 36 (33%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.00013 0 0.00024 6e-05 0 8.2e-05 -1.1 4 / 11 (36%) 5 / 11 (45%) 0.364 0.455
2.A.1.42.1 The Major Facilitator Superfamily (MFS) 0.18 0.34 1 0.48 0.73 1 0.24 0.52 1 0.48 0.73 1 0.93 0.98 1 0.49 0.82 1 0.00025 4.2e-05 0 1e-04 0 0.00027 8.7e-05 0 0.00023 -0.2 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 1.3e-05 0 3.5e-05 2.3 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
3.A.1.4.10 The ATP-binding Cassette (ABC) Superfamily 0.41 0.49 1 0.93 0.97 1 0.33 0.59 1 0.93 0.97 1 0.93 0.98 1 0.48 0.81 1 0.00012 2.4e-05 0 2.2e-05 0 5.2e-05 2.9e-05 0 7.7e-05 0.4 7 / 36 (19%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.8e-06 0 9.4e-06 4.3e-05 0 8.9e-05 3.9 1 / 11 (9.1%) 3 / 11 (27%) 0.0909 0.273
1.B.14.1.2 The Outer Membrane Receptor (OMR) Family 0.12 0.34 1 0.053 0.31 1 0.2 0.48 1 0.32 0.63 1 0.3 0.8 1 0.68 0.88 1 0.00068 0.00011 0 0.00034 0 0.00079 2e-04 0 0.00054 -0.77 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.4e-05 0 3.7e-05 8.1e-06 0 2.7e-05 -0.79 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
9.B.114.1.1 The Vancomycin-sensitivity protein (SanA) Family 0.18 0.34 1 0.54 0.76 1 0.12 0.43 1 0.61 0.82 1 0.81 0.95 1 0.33 0.73 1 0.00035 3.9e-05 0 1e-04 0 0.00027 5.8e-05 0 0.00015 -0.79 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-05 0 7e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.47.3.5 The Divalent Anion:Na+ Symporter (DASS) Family 0.28 0.38 1 0.77 0.88 1 0.94 0.98 1 0.67 0.86 1 0.52 0.87 1 0.79 0.91 1 8.2e-05 6.8e-06 0 1.2e-05 0 3.1e-05 1.9e-05 0 5.1e-05 0.66 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.6.2.2 The Resistance-Nodulation-Cell Division (RND) Superfamily 0.11 0.34 1 0.3 0.59 1 0.47 0.72 1 0.09 0.34 1 0.44 0.86 1 0.71 0.88 1 5e-04 0.00011 0 0.00027 0 0.00066 0.00028 0 0.00072 0.052 8 / 36 (22%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 5.5e-06 0 1.2e-05 8.1e-06 0 2.7e-05 0.56 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.6.2.12 The Resistance-Nodulation-Cell Division (RND) Superfamily 0.49 0.56 1 0.75 0.88 1 0.61 0.82 1 0.78 0.9 1 0.52 0.87 1 0.19 0.68 1 0.00071 0.00018 0 0.00038 0 0.00098 0.00032 0 0.00082 -0.25 9 / 36 (25%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0.00011 0 0.00033 3.4e-05 0 7.8e-05 -1.7 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
8.A.21.2.2 The Stomatin/Podocin/Band 7/Nephrosis.2/SPFH (Stomatin) Family 0.11 0.34 1 0.017 0.23 1 0.055 0.37 1 0.1 0.35 1 0.77 0.94 1 1 1 1 0.00036 3e-05 0 8.6e-05 0 0.00022 6.8e-05 0 0.00018 -0.34 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.3.1.6 The Amino Acid-Polyamine-Organocation (APC) Family 0.13 0.34 1 0.14 0.44 1 0.1 0.42 1 0.33 0.63 1 0.7 0.93 1 0.37 0.74 1 0.00038 6.3e-05 0 2e-04 0 0.00053 9.7e-05 0 0.00026 -1 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 1.3e-05 0 3.5e-05 2.3 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.9.3.1 The Membrane Protein Insertase (YidC/Alb3/Oxa1) Family 0.21 0.35 1 0.24 0.53 1 0.18 0.48 1 0.94 0.98 1 0.93 0.98 1 0.7 0.88 1 0.00053 8.8e-05 0 0.00029 0 0.00076 0.00012 0 0.00031 -1.3 6 / 36 (17%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.5e-06 0 1.2e-05 2.6e-05 0 6.9e-05 2.2 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
1.C.39.13.1 The Membrane Attack Complex/Perforin (MACPF) Family 0.19 0.34 1 1 1 1 0.67 0.85 1 0.045 0.27 1 0.77 0.94 1 0.52 0.82 1 0.00018 1.5e-05 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 3.1e-05 0 7.6e-05 1.8e-05 0 6e-05 -0.78 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
3.A.1.1.48 The ATP-binding Cassette (ABC) Superfamily 0.75 0.81 1 0.64 0.8 1 0.81 0.91 1 0.3 0.62 1 0.61 0.91 1 0.34 0.74 1 0.0021 0.0012 9.7e-05 0.00086 0 0.0012 0.0012 0 0.0017 0.48 21 / 36 (58%) 3 / 7 (43%) 3 / 7 (43%) 0.429 0.429 0.0014 0.00011 0.0031 0.0014 1e-04 0.0021 0 9 / 11 (82%) 6 / 11 (55%) 0.818 0.545
2.A.3.2.2 The Amino Acid-Polyamine-Organocation (APC) Family 0.32 0.41 1 0.34 0.63 1 0.086 0.4 1 0.91 0.97 1 0.33 0.83 1 0.051 0.58 1 0.00076 8.5e-05 0 0.00019 0 0.00049 0.00024 0 0.00064 0.34 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.5e-06 0 1.2e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
2.A.6.1.4 The Resistance-Nodulation-Cell Division (RND) Superfamily 0.18 0.34 1 0.93 0.97 1 0.12 0.43 1 0.31 0.63 1 0.93 0.98 1 0.12 0.65 1 0.00032 5.3e-05 0 1e-04 0 0.00027 0.00013 0 0.00033 0.38 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.8e-05 0 4.9e-05 Inf 0 / 11 (0%) 3 / 11 (27%) 0 0.273
3.A.11.1.2 The Bacterial Competence-related DNA Transformation Transporter (DNA-T) Family 0.91 0.93 1 0.46 0.72 1 0.78 0.91 1 0.38 0.65 1 0.66 0.92 1 0.93 0.98 1 0.00014 1.2e-05 0 1.2e-05 0 3.1e-05 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 2.3e-05 0 7.8e-05 6.8e-06 0 2.3e-05 -1.8 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.15.2.1 The Betaine/Carnitine/Choline Transporter (BCCT) Family 0.16 0.34 1 0.27 0.56 1 0.12 0.43 1 0.28 0.6 1 0.72 0.94 1 0.38 0.75 1 0.00052 8.6e-05 0 0.00022 0 0.00058 0.00019 0 0.00051 -0.21 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 3e-06 0 9.9e-06 1.3e-05 0 3.5e-05 2.1 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.66.1.4 The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily 0.36 0.45 1 0.16 0.46 1 0.52 0.75 1 0.76 0.89 1 0.12 0.66 1 0.63 0.85 1 0.00051 4.2e-05 0 5e-05 0 0.00013 0.00015 0 0.00041 1.6 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 8.1e-06 0 2.7e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
9.B.22.2.1 The Leukotoxin Secretion Morphogenesis Protein C (MorC) Family 0.15 0.34 1 0.49 0.75 1 0.24 0.52 1 0.12 0.38 1 0.95 0.98 1 0.57 0.83 1 5e-04 5.6e-05 0 0.00014 0 0.00036 0.00015 0 0.00038 0.1 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.1.2.20 The Major Facilitator Superfamily (MFS) 0.17 0.34 1 0.079 0.38 1 0.56 0.78 1 0.64 0.84 1 0.38 0.84 1 0.75 0.89 1 0.00029 4.1e-05 0 0.00013 0 0.00031 5.8e-05 0 0.00015 -1.2 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.4e-05 0 3.7e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
2.A.39.3.8 The Nucleobase:Cation Symporter-1 (NCS1) Family 0.25 0.36 1 0.58 0.77 1 0.65 0.84 1 0.7 0.87 1 0.65 0.92 1 0.51 0.82 1 0.00037 5.2e-05 0 0.00011 0 0.00026 0.00014 0 0.00036 0.35 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.1e-05 0 2.5e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
1.B.18.3.1 The Outer Membrane Auxiliary (OMA) Protein Family 0.65 0.7 1 0.81 0.91 1 0.13 0.43 1 0.26 0.59 1 0.85 0.96 1 0.1 0.65 1 0.00031 5.1e-05 0 8.6e-05 0 0.00022 0.00014 0 0.00036 0.7 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.7e-05 0 5.3e-05 0 0 0 -Inf 3 / 11 (27%) 0 / 11 (0%) 0.273 0
1.A.8.3.1 The Major Intrinsic Protein (MIP) Family 0.37 0.45 1 0.9 0.96 1 0.38 0.63 1 0.61 0.82 1 0.62 0.91 1 0.65 0.86 1 0.00013 1.8e-05 0 3.4e-05 0 8.9e-05 2.9e-05 0 7.7e-05 -0.23 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 1.8e-05 0 4e-05 2.8 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.1.15.12 The Major Facilitator Superfamily (MFS) 0.07 0.34 1 0.02 0.23 1 0.062 0.37 1 0.036 0.27 1 0.26 0.78 1 0.45 0.79 1 0.00057 4.7e-05 0 0.00015 0 0.00035 9.7e-05 0 0.00026 -0.63 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.81.1.5 The Aspartate:Alanine Exchanger (AAEx) Family 0.099 0.34 1 0.48 0.73 1 0.18 0.48 1 0.065 0.3 1 0.45 0.86 1 0.13 0.65 1 0.00071 9.8e-05 0 0.00022 0 0.00048 0.00025 0 0.00067 0.18 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.1e-05 0 4.7e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.66.2.7 The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily 0.11 0.34 1 0.099 0.39 1 0.23 0.51 1 0.36 0.64 1 0.62 0.91 1 0.93 0.99 1 0.00035 6.9e-05 0 0.00022 0 0.00053 1e-04 0 0.00025 -1.1 7 / 36 (19%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 8.5e-06 0 2.1e-05 1.1e-05 0 3.6e-05 0.37 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
4.A.6.1.1 The PTS Mannose-Fructose-Sorbose (Man) Family 0.016 0.34 1 0.018 0.23 1 0.019 0.37 1 0.0044 0.16 1 0.079 0.62 1 0.06 0.58 1 0.00028 7e-05 0 0.00022 3.2e-05 0.00043 0.00011 0 0.00028 -1 9 / 36 (25%) 4 / 7 (57%) 2 / 7 (29%) 0.571 0.286 3e-06 0 9.9e-06 1.6e-05 0 3.7e-05 2.4 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.B.54.1.9 The Intimin/Invasin (Int/Inv) or Autotransporter-3 (AT-3) Family 0.11 0.34 1 0.55 0.76 1 0.47 0.72 1 0.35 0.64 1 0.2 0.74 1 0.51 0.82 1 0.00037 4.1e-05 0 0.00015 0 4e-04 5.7e-05 0 0.00013 -1.4 4 / 36 (11%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.7.7.2 The Drug/Metabolite Transporter (DMT) Superfamily 0.078 0.34 1 0.13 0.43 1 0.14 0.43 1 0.097 0.34 1 0.27 0.78 1 0.3 0.73 1 0.00023 3.8e-05 0 9.8e-05 0 0.00022 7.7e-05 0 2e-04 -0.35 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 1e-05 0 3.4e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.5.21 The ATP-binding Cassette (ABC) Superfamily 0.055 0.34 1 0.019 0.23 1 0.017 0.37 1 0.0024 0.15 1 0.088 0.62 1 0.065 0.58 1 0.00076 0.00015 0 0.00041 2.8e-05 0.001 0.00034 0 0.00089 -0.27 7 / 36 (19%) 4 / 7 (57%) 2 / 7 (29%) 0.571 0.286 0 0 0 8.1e-06 0 2.7e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
4.A.2.1.9 The PTS Fructose-Mannitol (Fru) Family 0.064 0.34 1 0.0043 0.22 1 0.042 0.37 1 0.021 0.26 1 0.05 0.62 1 0.3 0.73 1 6e-04 8.3e-05 0 0.00027 0 0.00066 0.00015 0 0.00041 -0.85 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.40.4.2 The Nucleobase/Ascorbate Transporter (NAT) or Nucleobase:Cation Symporter-2 (NCS2) Family 0.27 0.38 1 0.57 0.77 1 0.73 0.89 1 0.94 0.98 1 0.0041 0.36 1 0.029 0.58 1 0.00039 4.3e-05 0 1e-04 0 0.00027 0.00011 0 0.00028 0.14 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 5.4e-06 0 1.8e-05 0.85 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.8.1 The ATP-binding Cassette (ABC) Superfamily 0.15 0.34 1 0.36 0.64 1 0.077 0.38 1 0.17 0.45 1 0.95 0.98 1 0.24 0.7 1 0.00084 0.00012 0 0.00031 0 8e-04 0.00028 0 0.00074 -0.15 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 9.2e-06 0 2.2e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.40.1.2 The Nucleobase/Ascorbate Transporter (NAT) or Nucleobase:Cation Symporter-2 (NCS2) Family 0.13 0.34 1 1 1 1 0.46 0.71 1 0.046 0.27 1 0.7 0.93 1 0.32 0.73 1 0.00013 1.1e-05 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 3e-05 0 7.9e-05 5.3e-06 0 1.8e-05 -2.5 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.1.7.14 The Major Facilitator Superfamily (MFS) 0.024 0.34 1 0.13 0.42 1 0.16 0.46 1 0.0046 0.16 1 0.4 0.85 1 0.39 0.75 1 0.00046 7.7e-05 0 0.00024 0 0.00052 0.00015 0 0.00035 -0.68 6 / 36 (17%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.B.3.1.1 The Sugar Porin (SP) Family 0.084 0.34 1 0.21 0.5 1 0.073 0.38 1 0.061 0.3 1 0.41 0.85 1 0.13 0.65 1 0.00042 5.8e-05 0 0.00015 0 0.00035 0.00013 0 0.00033 -0.21 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.3e-05 0 3.5e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
3.A.1.14.3 The ATP-binding Cassette (ABC) Superfamily 0.067 0.34 1 0.08 0.38 1 0.037 0.37 1 0.067 0.3 1 0.21 0.74 1 0.077 0.6 1 0.00071 0.00014 0 0.00044 0 0.0011 0.00015 0 0.00041 -1.6 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 7e-05 0 0.00018 4.8 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
9.B.20.1.4 The Putative Mg2+ Transporter-C (MgtC) Family 0.12 0.34 1 0.11 0.4 1 0.49 0.74 1 0.36 0.64 1 0.38 0.84 1 0.99 1 1 0.00031 3.4e-05 0 1e-04 0 0.00022 5.8e-05 0 0.00015 -0.79 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.1e-05 0 3.6e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.2.1.1 The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family 0.46 0.53 1 0.11 0.4 1 0.27 0.54 1 0.5 0.75 1 0.31 0.8 1 0.62 0.85 1 7.2e-05 6e-06 0 1.7e-05 0 4.5e-05 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 6e-06 0 2e-05 2.7e-06 0 8.9e-06 -1.2 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.66.1.48 The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily 0.22 0.35 1 0.42 0.7 1 0.91 0.96 1 0.72 0.87 1 0.23 0.76 1 0.037 0.58 1 0.00066 5.5e-05 0 0.00015 0 4e-04 0.00013 0 0.00033 -0.21 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
4.A.1.2.3 The PTS Glucose-Glucoside (Glc) Family 0.17 0.34 1 0.95 0.98 1 0.95 0.99 1 0.72 0.87 1 0.14 0.66 1 0.21 0.69 1 0.00038 5.2e-05 0 0.00017 0 0.00045 9.3e-05 0 2e-04 -0.87 5 / 36 (14%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 2.6e-06 0 8.5e-06 2.7e-06 0 8.9e-06 0.054 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.3.6.4 The Amino Acid-Polyamine-Organocation (APC) Family 0.021 0.34 1 0.018 0.23 1 0.021 0.37 1 0.0073 0.17 1 0.069 0.62 1 0.058 0.58 1 0.00019 2.6e-05 0 8.7e-05 0 0.00018 3.9e-05 0 1e-04 -1.2 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.1.14.2 The Major Facilitator Superfamily (MFS) 0.05 0.34 1 0.0035 0.22 1 0.021 0.37 1 0.037 0.27 1 0.019 0.56 1 0.098 0.65 1 0.00038 7.3e-05 0 0.00025 0 0.00057 0.00011 0 0.00028 -1.2 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 5.5e-06 0 1.2e-05 8.1e-06 0 2.7e-05 0.56 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
9.B.126.2.7 The Putative Lipid IV Exporter (YhjD) Family 0.23 0.35 1 1 1 1 0.9 0.96 1 0.047 0.27 1 0.71 0.93 1 0.7 0.88 1 0.00011 1.5e-05 0 0 0 0 0 0 0 NA 5 / 36 (14%) 0 / 7 (0%) 0 / 7 (0%) 0 0 1.6e-05 0 3e-05 3.3e-05 0 8.7e-05 1 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
2.A.124.1.1 The Lysine Exporter (LysO) Family 0.24 0.36 1 0.95 0.98 1 0.44 0.69 1 0.82 0.93 1 0.15 0.67 1 0.023 0.53 1 0.00056 4.6e-05 0 0.00012 0 0.00031 0.00012 0 0.00031 0 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
8.A.50.1.1 The AcrZ RND auxillary subunit (AcrZ) Family 0.28 0.38 1 0.37 0.65 1 0.99 0.99 1 0.38 0.66 1 0.032 0.62 1 0.36 0.74 1 0.00012 9.7e-06 0 1.7e-05 0 4.5e-05 2.9e-05 0 7.7e-05 0.77 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
5.A.3.3.2 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO) Family 0.017 0.34 1 0.00014 0.081 0.081 0.0015 0.35 0.83 0.00014 0.081 0.081 0.0024 0.31 1 0.016 0.46 1 8e-04 0.00011 0 0.00037 5.7e-05 0.00083 2e-04 0 0.00054 -0.89 5 / 36 (14%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.103.1.2 The Bacterial Murein Precursor Exporter (MPE) Family 0.43 0.51 1 0.24 0.53 1 0.36 0.6 1 0.43 0.69 1 0.088 0.62 1 0.13 0.65 1 0.00021 2.3e-05 0 3.4e-05 0 8.9e-05 7.7e-05 0 2e-04 1.2 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 2.7e-06 0 8.9e-06 0.054 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.C.1.4.2 The TonB-ExbB-ExbD/TolA-TolQ-TolR Outer Membrane Receptor Energizers and Stabilizers (TonB/TolA) Family 0.33 0.42 1 0.12 0.41 1 0.32 0.59 1 0.32 0.63 1 0.21 0.74 1 0.42 0.77 1 0.00064 0.00016 0 8.3e-05 0 0.00013 0.00063 2.7e-05 0.0013 2.9 9 / 36 (25%) 3 / 7 (43%) 4 / 7 (57%) 0.429 0.571 6e-06 0 2e-05 6.3e-05 0 0.00021 3.4 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.66.1.23 The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily 0.23 0.36 1 0.48 0.73 1 0.57 0.79 1 0.9 0.97 1 0.63 0.91 1 0.63 0.85 1 0.00048 5.3e-05 0 0.00015 0 4e-04 0.00011 0 0.00028 -0.45 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.1e-06 0 1.7e-05 5.4e-06 0 1.8e-05 0.082 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
1.B.14.6.1 The Outer Membrane Receptor (OMR) Family 0.91 0.93 1 0.77 0.88 1 0.36 0.6 1 0.63 0.83 1 0.98 0.99 1 0.39 0.75 1 0.00011 2.4e-05 0 1.3e-05 0 2.3e-05 1.3e-05 0 3.5e-05 0 8 / 36 (22%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 3e-05 0 9.9e-05 3.1e-05 0 5.1e-05 0.047 1 / 11 (9.1%) 4 / 11 (36%) 0.0909 0.364
4.D.1.1.13 The Putative Vectorial Glycosyl Polymerization (VGP) Family 0.3 0.39 1 0.28 0.57 1 0.84 0.92 1 0.94 0.98 1 0.11 0.65 1 0.64 0.86 1 0.00026 2.1e-05 0 3.4e-05 0 8.9e-05 6.8e-05 0 0.00018 1 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
9.B.104.1.1 The Rhomboid Protease (Rhomboid) Family 0.11 0.34 1 0.14 0.44 1 0.12 0.43 1 0.41 0.68 1 0.91 0.98 1 0.5 0.82 1 0.00021 1.8e-05 0 6.7e-05 0 0.00018 1.9e-05 0 5.1e-05 -1.8 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.3.2 The ATP-binding Cassette (ABC) Superfamily 0.067 0.34 1 0.091 0.39 1 0.29 0.56 1 0.063 0.3 1 0.083 0.62 1 0.34 0.74 1 0.00021 4.1e-05 0 9.9e-05 0 0.00017 9.7e-05 0 0.00026 -0.029 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 5.5e-06 0 1.2e-05 2.7e-06 0 8.9e-06 -1 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.7.5.3 The Drug/Metabolite Transporter (DMT) Superfamily 0.19 0.34 1 0.26 0.55 1 0.075 0.38 1 0.058 0.29 1 0.13 0.66 1 0.032 0.58 1 0.00013 1.1e-05 0 0 0 0 2.3e-05 0 6.1e-05 Inf 3 / 36 (8.3%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 2.1e-05 0 4.8e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
1.A.23.1.3 The Small Conductance Mechanosensitive Ion Channel (MscS) Family 0.082 0.34 1 0.07 0.36 1 0.033 0.37 1 0.062 0.3 1 0.15 0.66 1 0.067 0.58 1 0.00051 0.00011 0 0.00028 0 0.00066 0.00026 0 0.00069 -0.11 8 / 36 (22%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 6e-06 0 2e-05 1.9e-05 0 3.3e-05 1.7 1 / 11 (9.1%) 3 / 11 (27%) 0.0909 0.273
9.B.22.1.2 The Leukotoxin Secretion Morphogenesis Protein C (MorC) Family 0.16 0.34 1 0.17 0.46 1 0.51 0.75 1 0.59 0.81 1 0.32 0.82 1 0.83 0.93 1 0.00044 7.3e-05 0 2e-04 0 0.00035 9.7e-05 0 0.00026 -1 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 3.9e-05 0 0.00011 8.1e-06 0 2.7e-05 -2.3 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.3.2.5 The Amino Acid-Polyamine-Organocation (APC) Family 0.097 0.34 1 0.033 0.27 1 0.17 0.46 1 0.091 0.34 1 0.22 0.75 1 0.7 0.88 1 0.00075 8.4e-05 0 0.00025 0 0.00062 0.00017 0 0.00046 -0.56 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
1.B.71.1.5 The Proteobacterial/Verrucomicrobial Porin (PVP) Family 0.76 0.81 1 0.79 0.9 1 0.52 0.75 1 0.41 0.68 1 0.86 0.96 1 0.79 0.91 1 0.00034 6.7e-05 0 1e-04 0 0.00027 6.8e-05 0 0.00018 -0.56 7 / 36 (19%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 4.4e-05 0 0.00011 6.7e-05 0 0.00012 0.61 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
3.A.1.19.1 The ATP-binding Cassette (ABC) Superfamily 0.13 0.34 1 0.16 0.46 1 0.12 0.43 1 0.32 0.63 1 0.68 0.92 1 0.73 0.88 1 0.00036 3e-05 0 1e-04 0 0.00027 4.8e-05 0 0.00013 -1.1 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.1.2.14 The Major Facilitator Superfamily (MFS) 0.092 0.34 1 0.048 0.29 1 0.051 0.37 1 0.075 0.31 1 0.5 0.87 1 0.27 0.73 1 0.00041 4.6e-05 0 0.00015 0 4e-04 7.7e-05 0 2e-04 -0.96 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
9.B.42.1.3 The ExeAB (ExeAB) Secretin Assembly/Export Complex 0.04 0.34 1 0.029 0.25 1 0.026 0.37 1 0.013 0.23 1 0.13 0.66 1 0.086 0.61 1 4e-04 5.6e-05 0 0.00017 0 0.00039 9.7e-05 0 0.00026 -0.81 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 1.1e-05 0 3.6e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.3.5.5 The P-type ATPase (P-ATPase) Superfamily 0.082 0.34 1 0.048 0.29 1 0.06 0.37 1 0.066 0.3 1 0.39 0.84 1 0.23 0.7 1 0.00042 4.7e-05 0 0.00017 0 0.00044 6.8e-05 0 0.00018 -1.3 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.37.1.2 The Monovalent Cation:Proton Antiporter-2 (CPA2) Family 0.018 0.34 1 0.0063 0.22 1 0.016 0.37 1 0.012 0.22 1 0.027 0.62 1 0.044 0.58 1 0.00032 7e-05 0 0.00026 1.6e-05 0.00057 6.8e-05 0 0.00018 -1.9 8 / 36 (22%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 7.7e-06 0 2.6e-05 1.2e-05 0 2.7e-05 0.64 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
3.A.1.152.9 The ATP-binding Cassette (ABC) Superfamily 0.42 0.5 1 0.19 0.49 1 0.71 0.87 1 0.59 0.81 1 0.1 0.64 1 0.4 0.75 1 0.00047 0.00012 0 0.00024 0 0.00062 0.00028 0 0.00069 0.22 9 / 36 (25%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 1.7e-05 0 3.7e-05 3.8e-05 0 7.4e-05 1.2 3 / 11 (27%) 3 / 11 (27%) 0.273 0.273
2.A.76.1.1 The Resistance to Homoserine/Threonine (RhtB) Family 0.11 0.34 1 0.51 0.75 1 0.082 0.39 1 0.21 0.51 1 0.6 0.91 1 0.081 0.61 1 0.00023 3.9e-05 0 7e-05 0 0.00014 6.8e-05 0 0.00018 -0.042 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 3.9e-05 0 7.7e-05 Inf 0 / 11 (0%) 3 / 11 (27%) 0 0.273
2.A.1.2.7 The Major Facilitator Superfamily (MFS) 0.25 0.36 1 0.4 0.68 1 0.95 0.99 1 0.69 0.87 1 0.16 0.69 1 0.77 0.9 1 0.00032 2.7e-05 0 5e-05 0 0.00013 7.7e-05 0 2e-04 0.62 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.66.4.3 The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily 0.19 0.34 1 0.17 0.47 1 0.56 0.78 1 0.75 0.89 1 0.51 0.87 1 0.11 0.65 1 5e-04 4.2e-05 0 0.00013 0 0.00036 7.7e-05 0 2e-04 -0.76 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.1.10.2 The Major Facilitator Superfamily (MFS) 0.09 0.34 1 0.098 0.39 1 0.07 0.38 1 0.15 0.42 1 0.61 0.91 1 0.29 0.73 1 0.00045 4.9e-05 0 0.00017 0 0.00044 6.8e-05 0 0.00018 -1.3 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.95.1.7 The 6 TMS Neutral Amino Acid Transporter (NAAT) Family 0.19 0.34 1 0.11 0.4 1 0.21 0.48 1 0.76 0.89 1 0.032 0.62 1 0.069 0.58 1 0.00027 2.2e-05 0 5e-05 0 0.00013 6.4e-05 0 0.00013 0.36 3 / 36 (8.3%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
4.A.1.1.1 The PTS Glucose-Glucoside (Glc) Family 0.085 0.34 1 0.11 0.4 1 0.042 0.37 1 0.08 0.32 1 0.44 0.86 1 0.13 0.65 1 0.00062 8.7e-05 0 0.00026 0 0.00066 0.00015 0 0.00038 -0.79 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.3e-05 0 6.8e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.1.5.1 The Major Facilitator Superfamily (MFS) 0.19 0.34 1 0.98 1 1 0.42 0.67 1 0.49 0.73 1 0.14 0.66 1 0.71 0.88 1 0.00033 2.7e-05 0 6.7e-05 0 0.00018 6.8e-05 0 0.00018 0.021 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.1.21.6 The Major Facilitator Superfamily (MFS) 0.87 0.9 1 0.77 0.88 1 0.42 0.67 1 0.49 0.74 1 0.49 0.87 1 0.27 0.73 1 0.00013 1.4e-05 0 2e-05 0 5.2e-05 1.9e-05 0 4e-05 -0.074 4 / 36 (11%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 2.2e-05 0 7.3e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
3.A.1.3.3 The ATP-binding Cassette (ABC) Superfamily 0.39 0.47 1 0.9 0.96 1 0.54 0.76 1 0.64 0.84 1 0.64 0.92 1 0.27 0.73 1 0.00071 9.8e-05 0 0.00024 0 0.00062 0.00022 0 0.00059 -0.13 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.5e-05 0 7.2e-05 5.4e-06 0 1.8e-05 -2.2 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
3.A.1.9.1 The ATP-binding Cassette (ABC) Superfamily 0.61 0.66 1 0.26 0.55 1 0.2 0.48 1 0.41 0.68 1 0.23 0.76 1 0.14 0.65 1 0.00046 7.7e-05 0 0.00012 0 0.00031 0.00021 0 0.00056 0.81 6 / 36 (17%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.7e-05 0 7.3e-05 1.3e-05 0 3.5e-05 -1.1 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
9.B.146.1.6 The Putative Undecaprenyl-phosphate N-Acetylglucosaminyl Transferase (MurG) Family 0.094 0.34 1 0.098 0.39 1 0.086 0.4 1 0.042 0.27 1 0.37 0.84 1 0.29 0.73 1 0.00059 6.6e-05 0 0.00018 0 0.00044 0.00015 0 0.00041 -0.26 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.25.1.10 The Alanine or Glycine:Cation Symporter (AGCS) Family 0.14 0.34 1 0.46 0.72 1 0.1 0.42 1 0.28 0.6 1 0.93 0.98 1 0.26 0.72 1 3e-04 4.2e-05 0 1e-04 0 0.00027 8.7e-05 0 0.00023 -0.2 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.6e-05 0 4.3e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
1.B.17.1.1 The Outer Membrane Factor (OMF) Family 0.024 0.34 1 0.019 0.23 1 0.058 0.37 1 0.0023 0.15 1 0.035 0.62 1 0.11 0.65 1 0.00055 6.1e-05 0 0.00018 0 0.00035 0.00014 0 0.00036 -0.36 4 / 36 (11%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.1.3.2 The Major Facilitator Superfamily (MFS) 0.3 0.4 1 0.4 0.68 1 0.93 0.98 1 0.71 0.87 1 0.6 0.91 1 0.19 0.68 1 0.00048 6.6e-05 0 0.00019 0 0.00049 0.00014 0 0.00036 -0.44 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1e-05 0 2.5e-05 2.7e-06 0 8.9e-06 -1.9 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
8.A.5.1.6 The Voltage-gated K+ Channel β-subunit (Kvβ) Family 0.54 0.6 1 0.49 0.74 1 0.83 0.92 1 0.31 0.63 1 0.27 0.78 1 0.53 0.82 1 0.00013 1.5e-05 0 1.7e-05 0 4.5e-05 3.9e-05 0 1e-04 1.2 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 1e-05 0 3.4e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.105.16 The ATP-binding Cassette (ABC) Superfamily 0.12 0.34 1 0.16 0.45 1 0.079 0.39 1 0.13 0.39 1 0.78 0.94 1 0.34 0.73 1 0.00052 5.8e-05 0 0.00017 0 0.00044 0.00012 0 0.00031 -0.5 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 8.1e-06 0 2.7e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.2.25 The ATP-binding Cassette (ABC) Superfamily 0.097 0.34 1 0.061 0.33 1 0.14 0.43 1 0.06 0.29 1 0.1 0.64 1 0.21 0.69 1 0.00068 0.00017 0 0.00044 3.2e-05 0.0011 0.00039 0 0.001 -0.17 9 / 36 (25%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 1.6e-05 0 3.9e-05 1.5e-05 0 3.3e-05 -0.093 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
9.B.34.1.4 The Kinase/Phosphatase/Cyclic-GMP Synthase/Cyclic di-GMP Hydrolase (KPSH) Family 0.076 0.34 1 0.052 0.31 1 0.075 0.38 1 0.06 0.29 1 0.31 0.8 1 0.2 0.69 1 0.00051 5.7e-05 0 0.00022 0 0.00058 6.8e-05 0 0.00018 -1.7 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
9.B.169.4.2 The Integral Membrane Protein (8 -10 TMSs) YeiB or DUF418 (YeiB) Family 0.19 0.34 1 0.02 0.23 1 0.062 0.37 1 0.95 0.98 1 0.0015 0.31 0.84 0.0056 0.46 1 1e-04 1.1e-05 0 1.4e-05 0 3.2e-05 4.3e-05 0 9.2e-05 1.6 4 / 36 (11%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
9.B.97.1.1 The Acyltransferase-3/Putative Acetyl-CoA Transporter (ATAT) Family 0.17 0.34 1 0.37 0.65 1 0.17 0.46 1 0.33 0.63 1 0.26 0.78 1 0.92 0.98 1 0.00057 4.8e-05 0 0.00013 0 0.00036 0.00011 0 0.00028 -0.24 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.7.3.19 The Drug/Metabolite Transporter (DMT) Superfamily 0.11 0.34 1 0.15 0.45 1 0.12 0.43 1 0.28 0.6 1 0.92 0.98 1 0.4 0.75 1 0.0011 9.3e-05 0 0.00035 0 0.00094 9.7e-05 0 0.00026 -1.9 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 1.9e-05 0 6.2e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
9.B.14.3.6 The Putative Heme Handling Protein (HHP) Family 0.55 0.61 1 0.42 0.69 1 1 1 1 0.22 0.52 1 0.86 0.96 1 0.29 0.73 1 0.00023 3.8e-05 0 1e-04 0 0.00027 4.8e-05 0 0.00013 -1.1 6 / 36 (17%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2e-05 0 4.8e-05 1.1e-05 0 3.6e-05 -0.86 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
3.D.1.1.1 The H+ or Na+-translocating NADH Dehydrogenase (NDH) Family 0.049 0.34 1 0.011 0.23 1 0.012 0.37 1 0.026 0.27 1 0.084 0.62 1 0.064 0.58 1 0.0011 0.00034 0 0.00099 6.4e-05 0.0023 0.00062 0 0.0016 -0.68 11 / 36 (31%) 4 / 7 (57%) 2 / 7 (29%) 0.571 0.286 1.7e-05 0 3.7e-05 5.1e-05 0 0.00011 1.6 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
8.A.46.2.2 The Glycan-binding Protein (SusD) Family 0.84 0.87 1 0.74 0.88 1 0.87 0.94 1 0.37 0.65 1 0.51 0.87 1 0.7 0.88 1 0.00013 1.8e-05 0 8.1e-06 0 2.1e-05 1.8e-05 0 4.7e-05 1.2 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.4e-05 0 7.9e-05 1.8e-05 0 5e-05 -0.42 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.C.113.1.10 The Hly III (Hly III) Family 0.22 0.35 1 0.99 1 1 0.63 0.83 1 0.84 0.94 1 0.19 0.72 1 0.1 0.65 1 2e-04 2.2e-05 0 6.7e-05 0 0.00018 4.3e-05 0 1e-04 -0.64 4 / 36 (11%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 3e-06 0 9.9e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.1.2.19 The Major Facilitator Superfamily (MFS) 0.057 0.34 1 0.053 0.31 1 0.035 0.37 1 0.12 0.38 1 0.16 0.69 1 0.09 0.62 1 0.00017 3.3e-05 0 9.8e-05 0 0.00022 2.9e-05 0 7.7e-05 -1.8 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 3e-06 0 9.9e-06 2.3e-05 0 6.8e-05 2.9 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.B.48.1.1 The Curli Fiber Subunit Porin. CgsA. CsgG (CsgG) Family 0.34 0.42 1 0.57 0.77 1 0.98 0.99 1 0.99 0.99 1 0.42 0.85 1 0.77 0.9 1 0.00042 4.7e-05 0 8.4e-05 0 0.00022 0.00013 0 0.00033 0.63 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 1.6e-05 0 5.4e-05 2.6 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.1.21.1 The Major Facilitator Superfamily (MFS) 0.83 0.87 1 0.43 0.7 1 0.14 0.43 1 0.48 0.73 1 0.25 0.77 1 0.19 0.68 1 8e-04 0.00024 0 0.00011 0 2e-04 7.1e-05 0 0.00019 -0.63 11 / 36 (31%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0.00018 0 0.00042 5e-04 0 0.0014 1.5 4 / 11 (36%) 4 / 11 (36%) 0.364 0.364
3.A.1.106.13 The ATP-binding Cassette (ABC) Superfamily 0.22 0.35 1 0.26 0.55 1 0.6 0.82 1 0.77 0.89 1 0.87 0.97 1 0.69 0.88 1 0.00054 9e-05 0 0.00025 0 0.00067 0.00018 0 0.00049 -0.47 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 9.9e-06 0 2.5e-05 5.4e-06 0 1.8e-05 -0.87 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.86.2.1 The Autoinducer-2 Exporter (AI-2E) Family (Formerly the PerM Family. TC #9.B.22) 0.14 0.34 1 0.21 0.51 1 0.13 0.43 1 0.35 0.64 1 0.73 0.94 1 0.62 0.85 1 0.00043 3.6e-05 0 0.00012 0 0.00031 5.8e-05 0 0.00015 -1 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.3.29 The ATP-binding Cassette (ABC) Superfamily 0.15 0.34 1 0.069 0.36 1 0.23 0.51 1 0.31 0.63 1 0.28 0.78 1 0.69 0.88 1 0.00072 0.00012 0 0.00032 0 0.00079 0.00027 0 0.00072 -0.25 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 8.5e-06 0 2.1e-05 8.1e-06 0 2.7e-05 -0.07 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.26.1.10 The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family 0.057 0.34 1 0.0065 0.22 1 0.059 0.37 1 0.031 0.27 1 0.07 0.62 1 0.38 0.75 1 0.00036 5e-05 0 0.00017 0 4e-04 8.7e-05 0 0.00023 -0.97 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
4.A.1.2.2 The PTS Glucose-Glucoside (Glc) Family 0.15 0.34 1 0.22 0.51 1 0.2 0.48 1 0.35 0.64 1 0.84 0.96 1 0.7 0.88 1 0.00059 8.2e-05 0 0.00024 0 0.00062 0.00016 0 0.00044 -0.58 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 1e-05 0 3.4e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.5.32 The ATP-binding Cassette (ABC) Superfamily 0.44 0.52 1 0.36 0.64 1 0.42 0.67 1 0.056 0.29 1 0.21 0.74 1 0.27 0.72 1 7.7e-05 6.4e-06 0 0 0 0 9.7e-06 0 2.6e-05 Inf 3 / 36 (8.3%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 8.8e-06 0 2.9e-05 6e-06 0 2e-05 -0.55 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.7.10.1 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family 0.13 0.34 1 0.47 0.73 1 0.26 0.52 1 0.84 0.94 1 0.92 0.98 1 0.47 0.81 1 0.00019 2.1e-05 0 6.8e-05 0 0.00018 1.5e-05 0 4e-05 -2.2 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 1.5e-05 0 3.6e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
3.A.1.5.25 The ATP-binding Cassette (ABC) Superfamily 0.024 0.34 1 0.22 0.51 1 0.019 0.37 1 0.0071 0.17 1 0.061 0.62 1 0.0049 0.46 1 0.00021 5.3e-05 0 0 0 0 2.9e-05 0 5.3e-05 Inf 9 / 36 (25%) 0 / 7 (0%) 2 / 7 (29%) 0 0.286 0.00012 0 0.00019 3.3e-05 0 8.7e-05 -1.9 5 / 11 (45%) 2 / 11 (18%) 0.455 0.182
2.A.1.3.51 The Major Facilitator Superfamily (MFS) 0.18 0.34 1 0.68 0.83 1 0.084 0.39 1 0.42 0.68 1 0.67 0.92 1 0.25 0.71 1 0.00079 0.00011 0 0.00029 0 0.00076 0.00024 0 0.00064 -0.27 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.2e-05 0 4.6e-05 Inf 0 / 11 (0%) 3 / 11 (27%) 0 0.273
9.B.51.1.1 The Uncharacterized DUF202/YidH (YidH) Family 0.03 0.34 1 0.027 0.25 1 0.038 0.37 1 0.027 0.27 1 0.13 0.66 1 0.13 0.65 1 0.00021 2.3e-05 0 8.4e-05 0 0.00018 2.9e-05 0 7.7e-05 -1.5 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.42.1.3 The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family 0.12 0.34 1 0.23 0.51 1 0.14 0.43 1 0.2 0.51 1 0.51 0.87 1 0.3 0.73 1 0.00029 4.9e-05 0 0.00013 0 0.00031 9.7e-05 0 0.00026 -0.42 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 1.3e-05 0 3.5e-05 2.3 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.85.6.1 The Aromatic Acid Exporter (ArAE) Family 0.012 0.34 1 0.00031 0.086 0.17 0.0024 0.35 1 0.0012 0.15 0.68 5e-04 0.28 0.28 0.0041 0.46 1 0.00044 8.6e-05 0 0.00033 8.1e-05 0.00074 8.7e-05 0 0.00023 -1.9 7 / 36 (19%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 6e-06 0 2e-05 8.1e-06 0 2.7e-05 0.43 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.3.32.7 The P-type ATPase (P-ATPase) Superfamily 0.96 0.96 1 0.81 0.91 1 0.62 0.83 1 0.51 0.75 1 1 1 1 0.53 0.82 1 7e-04 0.00021 0 0.00027 0 0.00046 0.00025 0 0.00058 -0.11 11 / 36 (31%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 3e-04 0 8e-04 7.4e-05 0 0.00016 -2 4 / 11 (36%) 3 / 11 (27%) 0.364 0.273
2.A.118.1.8 The Basic Amino Acid Antiporter (ArcD) Family 0.14 0.34 1 0.27 0.56 1 0.047 0.37 1 0.47 0.73 1 0.97 0.99 1 0.13 0.65 1 0.00031 4.2e-05 0 0.00013 0 0.00036 4.8e-05 0 0.00013 -1.4 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.3e-05 0 4.1e-05 Inf 0 / 11 (0%) 3 / 11 (27%) 0 0.273
3.A.1.17.10 The ATP-binding Cassette (ABC) Superfamily 0.17 0.34 1 0.52 0.75 1 0.12 0.43 1 0.42 0.68 1 0.59 0.91 1 0.47 0.81 1 0.00049 5.5e-05 0 0.00015 0 4e-04 0.00012 0 0.00031 -0.32 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 9.5e-06 0 2.3e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
1.A.14.2.1 The Calcium Transporter A (CaTA) (formerly the Testis-Enhanced Gene Transfer (TEGT) Family 0.15 0.34 1 0.67 0.83 1 0.3 0.57 1 0.16 0.43 1 0.92 0.98 1 0.52 0.82 1 0.00034 3.7e-05 0 8.6e-05 0 0.00022 9.7e-05 0 0.00026 0.17 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.C.1.2.1 The TonB-ExbB-ExbD/TolA-TolQ-TolR Outer Membrane Receptor Energizers and Stabilizers (TonB/TolA) Family 0.15 0.34 1 0.11 0.4 1 0.2 0.48 1 0.26 0.59 1 0.79 0.94 1 0.95 1 1 0.00071 9.9e-05 0 0.00029 0 0.00076 0.00021 0 0.00056 -0.47 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 2.7e-06 0 8.9e-06 0.054 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.5.24 The ATP-binding Cassette (ABC) Superfamily 0.073 0.34 1 0.094 0.39 1 0.18 0.48 1 0.015 0.24 1 0.5 0.87 1 0.68 0.88 1 0.00062 8.6e-05 0 0.00023 0 0.00057 0.00021 0 0.00054 -0.13 5 / 36 (14%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
9.B.27.1.2 The DedA or YdjX-Z (DedA) Family 0.12 0.34 1 0.19 0.48 1 0.13 0.43 1 0.41 0.68 1 0.97 0.99 1 0.5 0.82 1 0.00028 2.4e-05 0 8.4e-05 0 0.00022 2.9e-05 0 7.7e-05 -1.5 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
4.A.2.1.25 The PTS Fructose-Mannitol (Fru) Family 0.58 0.64 1 0.53 0.76 1 0.96 0.99 1 0.49 0.73 1 0.94 0.98 1 0.62 0.85 1 8.2e-05 6.8e-06 0 1.7e-05 0 4.5e-05 3.9e-06 0 1e-05 -2.1 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 8.9e-06 0 3e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.1.6.2 The Major Facilitator Superfamily (MFS) 0.028 0.34 1 0.017 0.23 1 0.056 0.37 1 0.014 0.23 1 0.059 0.62 1 0.16 0.67 1 0.00098 8.2e-05 0 0.00035 0 0.00084 6.8e-05 0 0.00018 -2.4 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
1.B.14.3.1 The Outer Membrane Receptor (OMR) Family 0.13 0.34 1 0.26 0.55 1 0.17 0.46 1 0.22 0.52 1 0.5 0.87 1 0.33 0.73 1 0.00054 9e-05 0 0.00024 0 0.00057 0.00018 0 0.00049 -0.42 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 5.1e-06 0 1.7e-05 2.3e-05 0 6.8e-05 2.2 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.46.1.9 The Benzoate:H+ Symporter (BenE) Family 0.25 0.36 1 0.62 0.79 1 0.31 0.58 1 0.99 0.99 1 0.69 0.93 1 0.73 0.88 1 0.00023 3.2e-05 0 8.4e-05 0 0.00022 5.8e-05 0 0.00015 -0.53 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 1.3e-05 0 3.5e-05 2.3 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
5.A.3.3.1 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO) Family 0.21 0.35 1 0.78 0.89 1 0.63 0.83 1 0.57 0.79 1 0.83 0.95 1 0.36 0.74 1 0.00076 0.00013 0 0.00032 0 0.00075 0.00026 0 0.00058 -0.3 6 / 36 (17%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 4.6e-05 0 0.00014 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
2.A.3.1.15 The Amino Acid-Polyamine-Organocation (APC) Family 0.21 0.35 1 0.31 0.6 1 0.89 0.96 1 0.71 0.87 1 0.28 0.78 1 0.047 0.58 1 0.00063 5.3e-05 0 0.00015 0 4e-04 0.00012 0 0.00031 -0.32 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
9.B.127.1.1 The DUF2919 (PF11143) Family 0.16 0.34 1 0.24 0.53 1 0.25 0.52 1 0.72 0.87 1 0.76 0.94 1 0.71 0.88 1 0.00014 1.9e-05 0 5.3e-05 0 0.00013 2.9e-05 0 7.7e-05 -0.87 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 6.8e-06 0 2.3e-05 1.4 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.113.3 The ATP-binding Cassette (ABC) Superfamily 0.62 0.68 1 0.9 0.96 1 0.19 0.48 1 0.2 0.5 1 0.6 0.91 1 0.092 0.62 1 0.00039 6.5e-05 0 0.00013 0 0.00036 0.00015 0 0.00038 0.21 6 / 36 (17%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-05 0 7.3e-05 2.7e-06 0 8.9e-06 -3.5 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
2.A.1.1.114 The Major Facilitator Superfamily (MFS) 0.098 0.34 1 0.044 0.29 1 0.26 0.52 1 0.3 0.62 1 0.31 0.8 1 0.9 0.97 1 0.00038 4.2e-05 0 0.00015 0 0.00035 5.8e-05 0 0.00015 -1.4 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 7.9e-06 0 2.6e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
5.B.7.1.1 The YedZ (YedZ) Family 0.23 0.36 1 0.38 0.65 1 0.99 0.99 1 0.86 0.95 1 0.32 0.83 1 0.057 0.58 1 0.00028 2.3e-05 0 6.7e-05 0 0.00018 4.8e-05 0 0.00013 -0.48 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.2.2.1 The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family 0.11 0.34 1 0.21 0.51 1 0.13 0.43 1 0.041 0.27 1 0.024 0.61 1 0.055 0.58 1 0.00032 0.00021 9.8e-05 0.00012 0 0.00027 0.00019 0.00013 0.00018 0.66 24 / 36 (67%) 2 / 7 (29%) 6 / 7 (86%) 0.286 0.857 0.00038 0.00013 0.00073 0.00012 1e-04 0.00013 -1.7 7 / 11 (64%) 9 / 11 (82%) 0.636 0.818
1.B.22.1.3 The Outer Bacterial Membrane Secretin (Secretin) Family 0.16 0.34 1 0.029 0.25 1 0.15 0.43 1 0.4 0.68 1 0.16 0.69 1 0.49 0.82 1 0.00062 0.00015 0 0.00044 0 0.0011 3e-04 0 0.00079 -0.55 9 / 36 (25%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.1e-05 0 4.1e-05 1.6e-05 0 3.7e-05 -0.39 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
3.A.1.11.1 The ATP-binding Cassette (ABC) Superfamily 0.52 0.58 1 0.77 0.88 1 0.47 0.72 1 0.7 0.87 1 0.64 0.92 1 0.44 0.79 1 0.00074 8.2e-05 0 0.00015 0 4e-04 0.00019 0 0.00051 0.34 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 4.4e-05 0 0.00015 5.4e-06 0 1.8e-05 -3 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.31.1 The ATP-binding Cassette (ABC) Superfamily 0.25 0.36 1 0.37 0.65 1 0.65 0.84 1 0.054 0.29 1 0.29 0.78 1 0.33 0.73 1 0.0016 0.0012 0.00087 0.00071 0.00068 0.00076 0.0012 0.00084 0.0013 0.76 28 / 36 (78%) 4 / 7 (57%) 4 / 7 (57%) 0.571 0.571 0.0014 0.00077 0.002 0.0015 0.0012 0.0013 0.1 10 / 11 (91%) 10 / 11 (91%) 0.909 0.909
8.A.1.1.1 The Membrane Fusion Protein (MFP) Family 0.13 0.34 1 0.048 0.29 1 0.24 0.52 1 0.28 0.6 1 0.57 0.91 1 0.62 0.85 1 0.00047 5.3e-05 0 0.00017 0 0.00044 9.7e-05 0 0.00026 -0.81 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.113.1.1 The Nickel/cobalt Transporter (NicO) Family 0.088 0.34 1 0.51 0.75 1 0.35 0.6 1 0.07 0.3 1 0.45 0.86 1 0.29 0.73 1 0.00055 6.1e-05 0 0.00014 0 0.00027 0.00016 0 0.00044 0.19 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.40.5.1 The Nucleobase/Ascorbate Transporter (NAT) or Nucleobase:Cation Symporter-2 (NCS2) Family 0.28 0.38 1 0.099 0.39 1 0.16 0.45 1 0.94 0.98 1 0.02 0.56 1 0.025 0.55 1 4e-04 4.4e-05 0 1e-04 0 0.00027 0.00012 0 0.00031 0.26 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 2.7e-06 0 8.9e-06 -0.15 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.49.5.1 The Chloride Carrier/Channel (ClC) Family 0.052 0.34 1 0.075 0.38 1 0.069 0.37 1 0.034 0.27 1 0.24 0.77 1 0.17 0.67 1 0.00055 6.1e-05 0 0.00019 0 4e-04 0.00012 0 0.00031 -0.66 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 8.1e-06 0 2.7e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.C.11.1.3 The Pore-forming RTX Toxin (RTX-toxin) Family 0.2 0.34 1 1 1 1 0.26 0.52 1 0.045 0.27 1 0.33 0.83 1 0.036 0.58 1 0.00021 1.7e-05 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 4.6e-05 0 0.00014 1e-05 0 3.4e-05 -2.2 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
9.A.8.1.1 The Ferrous Iron Uptake (FeoB) Family 0.25 0.36 1 0.83 0.92 1 0.97 0.99 1 0.78 0.89 1 0.49 0.87 1 0.68 0.88 1 0.00046 1e-04 0 0.00024 0 0.00062 0.00023 0 0.00056 -0.061 8 / 36 (22%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 1.3e-05 0 3.5e-05 2.1e-05 0 4.7e-05 0.69 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
3.A.1.105.17 The ATP-binding Cassette (ABC) Superfamily 0.38 0.45 1 0.26 0.55 1 0.32 0.59 1 0.71 0.87 1 0.19 0.72 1 0.24 0.7 1 0.00044 8.6e-05 0 0.00019 0 0.00049 0.00022 0 0.00053 0.21 7 / 36 (19%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 1.4e-05 0 3.7e-05 9.5e-06 0 2.3e-05 -0.56 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
2.A.3.7.2 The Amino Acid-Polyamine-Organocation (APC) Family 0.17 0.34 1 0.1 0.4 1 0.14 0.43 1 0.94 0.98 1 0.19 0.72 1 0.23 0.7 1 0.00021 1.8e-05 0 6.8e-05 0 0.00018 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 3e-06 0 9.9e-06 1.1e-05 0 3.6e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.1.2.21 The Major Facilitator Superfamily (MFS) 0.4 0.48 1 0.2 0.49 1 0.13 0.43 1 0.42 0.68 1 0.034 0.62 1 0.0077 0.46 1 0.00025 2.1e-05 0 3.4e-05 0 8.9e-05 6.8e-05 0 0.00018 1 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
4.A.2.1.11 The PTS Fructose-Mannitol (Fru) Family 0.035 0.34 1 0.0074 0.22 1 0.0044 0.35 1 0.0034 0.16 1 0.039 0.62 1 0.014 0.46 1 0.00069 0.00013 0 0.00042 1.6e-05 0.001 0.00023 0 0.00061 -0.87 7 / 36 (19%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 0 0 0 2.3e-05 0 5.6e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
4.A.2.1.2 The PTS Fructose-Mannitol (Fru) Family 0.15 0.34 1 0.3 0.59 1 0.23 0.51 1 0.3 0.62 1 0.4 0.84 1 0.29 0.73 1 0.00037 6.2e-05 0 0.00014 0 0.00031 0.00015 0 0.00038 0.1 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 7.3e-06 0 2.4e-05 1.2e-05 0 2.7e-05 0.72 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.17.1.3 The Proton-dependent Oligopeptide Transporter (POT/PTR) Family 0.18 0.34 1 0.12 0.42 1 0.5 0.74 1 0.63 0.83 1 0.45 0.86 1 0.91 0.97 1 0.00033 5.5e-05 0 0.00016 0 4e-04 9.7e-05 0 0.00026 -0.72 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.2e-05 0 2.8e-05 2.7e-06 0 8.9e-06 -2.2 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
9.B.158.1.2 The Cut Copper Homeostasis (Cut) Family 0.12 0.34 1 0.2 0.49 1 0.13 0.43 1 0.54 0.77 1 0.85 0.96 1 0.41 0.76 1 0.00028 2.3e-05 0 8.4e-05 0 0.00022 1.9e-05 0 5.1e-05 -2.1 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.A.30.1.1 The H+- or Na+-translocating Bacterial Flagellar Motor/ExbBD Outer Membrane Transport Energizer (Mot/Exb) Superfamily 0.011 0.34 1 0.043 0.29 1 0.035 0.37 1 0.0043 0.16 1 0.041 0.62 1 0.032 0.58 1 0.00019 3.2e-05 0 9.1e-05 1.6e-05 0.00014 4.8e-05 0 0.00013 -0.92 6 / 36 (17%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 0 0 0 1.6e-05 0 5.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.1.36.1 The Major Facilitator Superfamily (MFS) 0.095 0.34 1 0.11 0.4 1 0.14 0.43 1 0.21 0.51 1 0.71 0.93 1 0.44 0.79 1 0.00053 4.4e-05 0 0.00019 0 0.00049 3.9e-05 0 1e-04 -2.3 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.1.60.2 The Major Facilitator Superfamily (MFS) 0.048 0.34 1 0.021 0.23 1 0.038 0.37 1 0.02 0.26 1 0.11 0.65 1 0.11 0.65 1 6e-04 6.7e-05 0 0.00025 0 0.00062 8.7e-05 0 0.00023 -1.5 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.A.106.2.3 The Calcium Load-activated Calcium Channel (CLAC) Family 0.59 0.65 1 0.77 0.88 1 0.65 0.84 1 0.22 0.52 1 0.76 0.94 1 0.32 0.73 1 9.1e-05 1.3e-05 0 8.1e-06 0 2.1e-05 4.4e-06 0 1.2e-05 -0.88 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.1e-05 0 4.6e-05 1.3e-05 0 4.3e-05 -0.69 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.115.2.12 The Novobiocin Exporter (NbcE) Family 0.95 0.96 1 0.35 0.63 1 0.047 0.37 1 0.7 0.87 1 0.24 0.77 1 0.065 0.58 1 0.00049 0.00045 0.00023 0.00034 0.00024 0.00025 0.00026 0.00013 0.00031 -0.39 33 / 36 (92%) 7 / 7 (100%) 5 / 7 (71%) 1 0.714 0.00038 0.00021 0.00036 0.00072 0.00097 5e-04 0.92 10 / 11 (91%) 11 / 11 (100%) 0.909 1
2.A.23.1.1 The Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family 0.067 0.34 1 0.079 0.38 1 0.16 0.46 1 0.034 0.27 1 0.26 0.77 1 0.44 0.79 1 5e-04 4.2e-05 0 0.00012 0 0.00026 9.7e-05 0 0.00026 -0.31 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
3.A.1.5.38 The ATP-binding Cassette (ABC) Superfamily 0.36 0.45 1 0.11 0.4 1 0.14 0.43 1 0.69 0.87 1 0.21 0.74 1 0.28 0.73 1 0.00015 1.3e-05 0 3.4e-05 0 9.1e-05 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 6e-06 0 2e-05 1.3e-05 0 4.5e-05 1.1 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.7.3.12 The Drug/Metabolite Transporter (DMT) Superfamily 0.29 0.39 1 0.82 0.91 1 0.53 0.76 1 0.68 0.86 1 0.83 0.95 1 0.49 0.82 1 0.00027 4.6e-05 0 7e-05 0 0.00018 0.00012 0 0.00031 0.78 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 2.9e-05 0 6.8e-05 3.5 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.B.1.1.21 The General Bacterial Porin (GBP) Family 0.19 0.34 1 0.98 1 1 0.42 0.67 1 0.49 0.73 1 0.14 0.66 1 0.71 0.88 1 0.00033 2.7e-05 0 6.7e-05 0 0.00018 6.8e-05 0 0.00018 0.021 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
4.A.4.1.1 The PTS Glucitol (Gut) Family 0.098 0.34 1 0.038 0.28 1 0.18 0.48 1 0.21 0.51 1 0.2 0.74 1 0.58 0.84 1 0.00039 7.5e-05 0 0.00024 0 0.00057 0.00012 0 0.00031 -1 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 1.4e-05 0 3.7e-05 5.4e-06 0 1.8e-05 -1.4 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.6.2.7 The Resistance-Nodulation-Cell Division (RND) Superfamily 0.13 0.34 1 0.044 0.29 1 0.35 0.6 1 0.36 0.64 1 0.37 0.84 1 0.86 0.94 1 0.00082 0.00011 0 0.00037 0 0.00093 0.00019 0 0.00051 -0.96 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.4e-05 0 3.7e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
1.B.39.1.6 The Bacterial Porin. OmpW (OmpW) Family 0.088 0.34 1 0.64 0.8 1 0.47 0.72 1 0.2 0.51 1 0.74 0.94 1 0.53 0.82 1 0.00012 1.4e-05 0 2.8e-05 0 5e-05 3.9e-05 0 1e-04 0.48 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
9.B.27.2.1 The DedA or YdjX-Z (DedA) Family 0.28 0.38 1 0.014 0.23 1 0.048 0.37 1 0.95 0.98 1 0.0069 0.39 1 0.021 0.52 1 0.00025 2.1e-05 0 3.4e-05 0 8.9e-05 7.5e-05 0 0.00018 1.1 3 / 36 (8.3%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
9.B.126.2.1 The Putative Lipid IV Exporter (YhjD) Family 0.079 0.34 1 0.15 0.44 1 0.048 0.37 1 0.099 0.35 1 0.43 0.86 1 0.14 0.65 1 0.00044 6.1e-05 0 0.00017 0 4e-04 0.00013 0 0.00033 -0.39 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.3e-05 0 3e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
4.A.5.1.1 The PTS Galactitol (Gat) Family 0.23 0.35 1 0.098 0.39 1 0.081 0.39 1 0.59 0.81 1 0.095 0.64 1 0.072 0.59 1 5e-04 8.3e-05 0 0.00017 0 0.00044 0.00024 0 0.00053 0.5 6 / 36 (17%) 2 / 7 (29%) 3 / 7 (43%) 0.286 0.429 1.1e-05 0 3.6e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.5.5.1 The Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family 0.27 0.37 1 0.52 0.75 1 0.79 0.91 1 0.77 0.89 1 0.35 0.84 1 1 1 1 0.00034 2.8e-05 0 5e-05 0 0.00013 7.7e-05 0 2e-04 0.62 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.95.1.5 The 6 TMS Neutral Amino Acid Transporter (NAAT) Family 0.23 0.35 1 0.28 0.56 1 0.83 0.92 1 0.63 0.83 1 0.5 0.87 1 0.11 0.65 1 0.00019 1.6e-05 0 5e-05 0 0.00013 2.9e-05 0 7.7e-05 -0.79 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
5.A.2.1.2 The Disulfide Bond Oxidoreductase B (DsbB) Family 0.091 0.34 1 0.048 0.29 1 0.14 0.43 1 0.32 0.63 1 0.28 0.78 1 0.56 0.83 1 0.00059 9.8e-05 0 0.00037 0 0.00093 9.7e-05 0 0.00026 -1.9 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 9.9e-06 0 2.5e-05 1e-05 0 3.4e-05 0.014 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.1.2.22 The Major Facilitator Superfamily (MFS) 0.04 0.34 1 0.0089 0.22 1 0.019 0.37 1 0.0056 0.16 1 0.045 0.62 1 0.054 0.58 1 0.00051 7.1e-05 0 0.00027 0 0.00066 9.7e-05 0 0.00026 -1.5 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.2.23 The ATP-binding Cassette (ABC) Superfamily 0.44 0.52 1 0.51 0.75 1 0.84 0.92 1 0.13 0.39 1 0.97 0.99 1 0.69 0.88 1 0.0033 0.0027 0.0019 0.0017 0.0018 0.0017 0.0026 0.0022 0.0031 0.61 29 / 36 (81%) 5 / 7 (71%) 4 / 7 (57%) 0.714 0.571 0.0028 0.0014 0.0047 0.0033 0.0031 0.0025 0.24 10 / 11 (91%) 10 / 11 (91%) 0.909 0.909
9.B.318.1.1 The YjgJ or DUF898 (DUF898) Family 0.8 0.84 1 0.51 0.75 1 0.87 0.94 1 0.32 0.63 1 0.67 0.92 1 0.95 1 1 0.00018 1.5e-05 0 1.2e-05 0 3.1e-05 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 3.3e-05 0 0.00011 8.1e-06 0 2.7e-05 -2 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.1.64.1 The Major Facilitator Superfamily (MFS) 0.0071 0.34 1 0.036 0.28 1 0.0015 0.35 0.82 0.0024 0.15 1 0.0055 0.36 1 0.00017 0.093 0.093 0.00021 7.7e-05 0 0 0 0 0.00011 3.1e-05 0.00017 Inf 13 / 36 (36%) 0 / 7 (0%) 4 / 7 (57%) 0 0.571 0.00017 8e-05 0.00034 9.5e-06 0 2.3e-05 -4.2 7 / 11 (64%) 2 / 11 (18%) 0.636 0.182
2.A.1.14.7 The Major Facilitator Superfamily (MFS) 0.17 0.34 1 0.98 1 1 0.5 0.74 1 0.19 0.49 1 0.84 0.96 1 0.55 0.83 1 0.00044 4.9e-05 0 1e-04 0 0.00027 0.00014 0 0.00036 0.49 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 8.1e-06 0 2.7e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.1.7.5 The Major Facilitator Superfamily (MFS) 0.069 0.34 1 0.021 0.23 1 0.063 0.37 1 0.033 0.27 1 0.16 0.69 1 0.31 0.73 1 0.0013 0.00011 0 4e-04 0 0.001 0.00016 0 0.00044 -1.3 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
9.B.32.1.1 The DUF3302 or Pfam11742 (YibI) Family 0.043 0.34 1 0.084 0.39 1 0.17 0.46 1 0.051 0.28 1 0.28 0.78 1 0.46 0.8 1 0.00028 2.3e-05 0 7e-05 0 0.00014 4.8e-05 0 0.00013 -0.54 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.10.1.2 The 2-Keto-3-Deoxygluconate Transporter (KdgT) Family 0.14 0.34 1 0.76 0.88 1 0.2 0.48 1 0.27 0.6 1 0.94 0.98 1 0.27 0.73 1 2e-04 2.8e-05 0 5.5e-05 0 0.00013 6.8e-05 0 0.00018 0.31 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.2e-05 0 2.7e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
9.B.50.1.1 The Outer Membrane Beta-barrel Endoprotease. Omptin (Omptin) Family 0.068 0.34 1 0.11 0.4 1 0.076 0.38 1 0.066 0.3 1 0.37 0.84 1 0.23 0.7 1 0.00048 5.4e-05 0 0.00015 0 0.00035 0.00011 0 0.00028 -0.45 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
4.C.1.1.4 The Fatty Acid Transporter (FAT) Family 0.32 0.41 1 0.15 0.44 1 0.26 0.52 1 0.97 0.99 1 0.13 0.66 1 0.22 0.7 1 0.00043 5.9e-05 0 0.00012 0 0.00031 0.00017 0 0.00035 0.5 5 / 36 (14%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 6e-06 0 2e-05 6.8e-06 0 2.3e-05 0.18 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.5.5.5 The Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family 0.28 0.38 1 0.55 0.76 1 0.83 0.92 1 0.55 0.78 1 0.37 0.84 1 0.77 0.9 1 0.00023 8.4e-05 0 0.00011 0 0.00015 0.00015 8.1e-05 0.00021 0.45 13 / 36 (36%) 3 / 7 (43%) 4 / 7 (57%) 0.429 0.571 5.9e-05 0 0.00016 5e-05 0 8.8e-05 -0.24 2 / 11 (18%) 4 / 11 (36%) 0.182 0.364
3.A.1.1.1 The ATP-binding Cassette (ABC) Superfamily 0.15 0.34 1 0.32 0.61 1 0.35 0.6 1 0.35 0.64 1 0.79 0.94 1 0.79 0.91 1 0.00074 0.00019 0 0.00052 0 0.0013 0.00034 0 0.00084 -0.61 9 / 36 (25%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 2.4e-05 0 5.6e-05 3.7e-05 0 8.3e-05 0.62 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
9.B.121.1.3 The AsmA (AsmA) Family 0.24 0.36 1 0.3 0.59 1 0.76 0.9 1 0.51 0.75 1 0.42 0.86 1 0.9 0.97 1 0.00043 8.4e-05 0 2e-04 0 0.00048 0.00016 0 0.00044 -0.32 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 3.5e-05 0 0.00011 8.1e-06 0 2.7e-05 -2.1 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
1.A.23.3.2 The Small Conductance Mechanosensitive Ion Channel (MscS) Family 0.35 0.44 1 0.54 0.76 1 0.76 0.9 1 0.74 0.88 1 0.77 0.94 1 0.29 0.73 1 6e-04 5e-05 0 0.00013 0 0.00036 8.7e-05 0 0.00023 -0.58 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.2e-05 0 7.3e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
1.B.57.4.2 The Legionella Major-Outer Membrane Protein (LM-OMP) Family 0.34 0.42 1 0.39 0.67 1 0.48 0.73 1 0.66 0.85 1 0.43 0.86 1 0.57 0.83 1 2e-04 5.6e-05 0 7.6e-05 3.2e-05 0.00012 3.7e-05 0 6.5e-05 -1 10 / 36 (28%) 4 / 7 (57%) 2 / 7 (29%) 0.571 0.286 5.2e-05 0 0.00012 5.9e-05 0 0.00015 0.18 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
2.A.76.1.4 The Resistance to Homoserine/Threonine (RhtB) Family 0.38 0.45 1 0.88 0.95 1 0.81 0.91 1 0.57 0.79 1 0.48 0.87 1 0.75 0.9 1 0.00016 1.8e-05 0 3.4e-05 0 8.9e-05 3.9e-05 0 1e-04 0.2 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 1e-05 0 3.4e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.75.1.2 The L-Lysine Exporter (LysE) Family 0.1 0.34 1 0.85 0.93 1 0.97 0.99 1 0.13 0.39 1 0.79 0.94 1 0.88 0.96 1 0.00024 4.7e-05 0 9.8e-05 0 0.00022 0.00013 0 3e-04 0.41 7 / 36 (19%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 2.6e-06 0 8.5e-06 5.4e-06 0 1.8e-05 1.1 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
1.A.13.2.3 The Epithelial Chloride Channel (E-ClC) Family 0.22 0.35 1 0.28 0.57 1 0.84 0.92 1 0.82 0.93 1 0.51 0.87 1 0.11 0.65 1 0.00074 6.2e-05 0 0.00019 0 0.00049 0.00013 0 0.00033 -0.55 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.1e-06 0 1.7e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
3.A.1.14.18 The ATP-binding Cassette (ABC) Superfamily 0.071 0.34 1 0.22 0.51 1 0.12 0.43 1 0.074 0.31 1 0.76 0.94 1 0.56 0.83 1 0.00072 1e-04 0 0.00031 0 0.00075 0.00019 0 0.00046 -0.71 5 / 36 (14%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0 0 0 1.1e-05 0 3.6e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.15.3 The ATP-binding Cassette (ABC) Superfamily 0.27 0.37 1 0.45 0.72 1 0.53 0.76 1 0.12 0.38 1 0.2 0.74 1 0.45 0.79 1 0.00014 3.8e-05 0 2.3e-06 0 6.1e-06 2.1e-05 0 4.4e-05 3.2 10 / 36 (28%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 7.6e-05 0 0.00023 3.4e-05 0 5.1e-05 -1.2 3 / 11 (27%) 4 / 11 (36%) 0.273 0.364
2.A.3.1.23 The Amino Acid-Polyamine-Organocation (APC) Family 0.13 0.34 1 0.14 0.44 1 0.1 0.42 1 0.33 0.63 1 0.7 0.93 1 0.37 0.74 1 0.00038 6.3e-05 0 2e-04 0 0.00053 9.7e-05 0 0.00026 -1 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 1.3e-05 0 3.5e-05 2.3 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.A.112.2.5 The Cyclin M Mg2+ Exporter (CNNM) Family 0.013 0.34 1 0.0052 0.22 1 0.019 0.37 1 0.0046 0.16 1 0.016 0.5 1 0.054 0.58 1 0.00025 4.9e-05 0 0.00016 1.6e-05 3e-04 6.8e-05 0 0.00018 -1.2 7 / 36 (19%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 5.1e-06 0 1.7e-05 8.1e-06 0 2.7e-05 0.67 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
9.B.97.7.1 The Acyltransferase-3/Putative Acetyl-CoA Transporter (ATAT) Family 0.23 0.35 1 0.52 0.75 1 0.78 0.91 1 0.76 0.89 1 0.21 0.74 1 0.033 0.58 1 0.00059 5e-05 0 0.00013 0 0.00036 0.00012 0 0.00031 -0.12 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.114.1.1 The Putative Peptide Transporter Carbon Starvation CstA (CstA) Family 0.21 0.35 1 0.99 1 1 0.78 0.91 1 0.74 0.89 1 0.37 0.84 1 0.63 0.85 1 0.00049 0.00011 0 0.00029 0 0.00076 0.00023 0 0.00056 -0.33 8 / 36 (22%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 8.1e-06 0 1.9e-05 1.8e-05 0 4.1e-05 1.2 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
2.A.1.1.115 The Major Facilitator Superfamily (MFS) 0.25 0.36 1 0.58 0.77 1 0.91 0.96 1 0.98 0.99 1 0.075 0.62 1 0.23 0.7 1 0.00024 3.3e-05 0 8.4e-05 0 0.00022 6.4e-05 0 0.00013 -0.39 5 / 36 (14%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 3e-06 0 9.9e-06 1.1e-05 0 3.6e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.1.10.1 The Major Facilitator Superfamily (MFS) 0.36 0.44 1 0.48 0.74 1 0.57 0.79 1 0.51 0.75 1 0.71 0.93 1 0.12 0.65 1 0.00054 6e-05 0 0.00017 0 0.00045 0.00012 0 0.00031 -0.5 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.6e-05 0 3.9e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
2.A.41.1.1 The Concentrative Nucleoside Transporter (CNT) Family 0.52 0.58 1 0.015 0.23 1 0.049 0.37 1 0.59 0.82 1 0.0058 0.36 1 0.019 0.52 1 0.00026 3.6e-05 0 3.4e-05 0 8.9e-05 0.00014 0 0.00033 2 5 / 36 (14%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 3e-06 0 9.9e-06 2.7e-06 0 8.9e-06 -0.15 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.14.2 The ATP-binding Cassette (ABC) Superfamily 0.12 0.34 1 0.4 0.68 1 0.25 0.52 1 0.059 0.29 1 0.5 0.87 1 0.31 0.73 1 0.00086 9.5e-05 0 0.00023 0 0.00057 0.00025 0 0.00067 0.12 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.A.1.13.1 The Voltage-gated Ion Channel (VIC) Superfamily 0.32 0.41 1 0.65 0.81 1 0.67 0.85 1 0.97 0.99 1 0.41 0.85 1 0.95 1 1 3e-04 4.2e-05 0 8.4e-05 0 0.00022 0.00011 0 0.00028 0.39 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 1.3e-05 0 3.5e-05 2.1 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.33.1.1 The NhaA Na+:H+ Antiporter (NhaA) Family 0.11 0.34 1 0.19 0.49 1 0.09 0.41 1 0.12 0.38 1 0.67 0.92 1 0.34 0.73 1 0.00061 6.8e-05 0 0.00019 0 0.00049 0.00015 0 0.00038 -0.34 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.1.5.41 The ATP-binding Cassette (ABC) Superfamily 0.12 0.34 1 0.015 0.23 1 0.022 0.37 1 0.28 0.6 1 0.098 0.64 1 0.092 0.62 1 0.00088 0.00027 0 0.00076 0 0.0018 5e-04 0 0.0013 -0.6 11 / 36 (31%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 3.3e-05 0 7.3e-05 4.5e-05 0 7.4e-05 0.45 3 / 11 (27%) 4 / 11 (36%) 0.273 0.364
9.A.41.1.2 The Capsular Polysaccharide Exporter (CPS-E) Family 0.16 0.34 1 0.59 0.77 1 0.79 0.91 1 0.31 0.62 1 0.11 0.65 1 0.021 0.52 1 0.00058 8e-05 0 0.00022 0 0.00058 0.00019 0 0.00048 -0.21 5 / 36 (14%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 2.6e-06 0 8.5e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.56.1.2 The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family 0.038 0.34 1 0.13 0.42 1 0.12 0.43 1 0.011 0.22 1 0.14 0.66 1 0.12 0.65 1 0.00033 4.6e-05 0 0.00012 0 0.00022 0.00011 0 0.00028 -0.13 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
3.A.6.2.1 The Type III (Virulence-related) Secretory Pathway (IIISP) Family 0.79 0.84 1 0.17 0.47 1 0.51 0.75 1 0.33 0.63 1 0.08 0.62 1 0.48 0.81 1 0.00022 2.4e-05 0 2.3e-06 0 6.1e-06 0.00011 0 0.00028 5.6 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 9.5e-06 0 2.3e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.19.5.1 The Ca2+:Cation Antiporter (CaCA) Family 0.14 0.34 1 0.47 0.73 1 0.88 0.95 1 0.2 0.51 1 0.45 0.86 1 0.98 1 1 0.00054 6e-05 0 0.00014 0 0.00031 0.00016 0 0.00044 0.19 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 5.1e-06 0 1.7e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
4.A.7.1.1 The PTS L-Ascorbate (L-Asc) Family 0.63 0.68 1 0.28 0.57 1 0.78 0.91 1 0.28 0.6 1 0.7 0.93 1 0.67 0.88 1 0.00022 3.1e-05 0 8.4e-05 0 0.00022 9.7e-06 0 2.6e-05 -3.1 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3.6e-05 0 0.00011 5.4e-06 0 1.8e-05 -2.7 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
9.A.69.1.1 The Intermembrane Phospholipid Translocase (IMPL-T) Family 0.14 0.34 1 0.32 0.61 1 0.066 0.37 1 0.13 0.4 1 0.79 0.94 1 0.18 0.68 1 0.0011 0.00015 0 0.00039 0 0.001 0.00034 0 9e-04 -0.2 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.8e-05 0 4.1e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.21.7.2 The Solute:Sodium Symporter (SSS) Family 0.096 0.34 1 0.09 0.39 1 0.11 0.42 1 0.23 0.55 1 0.38 0.84 1 0.35 0.74 1 0.00039 6.5e-05 0 2e-04 0 0.00048 9.7e-05 0 0.00026 -1 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 7.3e-06 0 2.4e-05 1.3e-05 0 3.5e-05 0.83 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.85.1.1 The Aromatic Acid Exporter (ArAE) Family 0.18 0.34 1 0.71 0.86 1 0.84 0.92 1 0.14 0.4 1 0.74 0.94 1 0.73 0.88 1 0.00065 7.2e-05 0 0.00015 0 4e-04 0.00021 0 0.00056 0.49 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.36.6.11 The Monovalent Cation:Proton Antiporter-1 (CPA1) Family 0.21 0.35 1 0.73 0.87 1 0.9 0.96 1 0.15 0.41 1 0.63 0.91 1 0.61 0.85 1 0.00032 5.3e-05 0 6.4e-05 0 0.00013 0.00019 0 0.00051 1.6 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 8.1e-06 0 2.7e-05 1.6 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
8.A.1.6.3 The Membrane Fusion Protein (MFP) Family 0.5 0.57 1 0.79 0.9 1 0.64 0.83 1 0.6 0.82 1 0.6 0.91 1 0.51 0.82 1 0.00042 4.6e-05 0 8.4e-05 0 0.00022 0.00011 0 0.00028 0.39 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.2e-05 0 7.3e-05 8.1e-06 0 2.7e-05 -1.4 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.2.22 The ATP-binding Cassette (ABC) Superfamily 0.37 0.45 1 0.64 0.8 1 0.81 0.91 1 0.11 0.37 1 0.54 0.89 1 0.61 0.85 1 0.0032 0.0026 0.0021 0.0018 0.0012 0.002 0.0022 0.002 0.0022 0.29 30 / 36 (83%) 5 / 7 (71%) 5 / 7 (71%) 0.714 0.714 0.0028 0.0021 0.0037 0.0033 0.0026 0.0026 0.24 10 / 11 (91%) 10 / 11 (91%) 0.909 0.909
1.C.126.1.2 The HlyC HlyC) Family of Haemolysins 0.091 0.34 1 0.018 0.23 1 0.057 0.37 1 0.12 0.38 1 0.72 0.94 1 0.97 1 1 0.00021 1.8e-05 0 5.3e-05 0 0.00013 3.9e-05 0 1e-04 -0.44 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.15.1.4 The Betaine/Carnitine/Choline Transporter (BCCT) Family 0.17 0.34 1 0.087 0.39 1 0.22 0.51 1 0.65 0.85 1 0.46 0.87 1 0.78 0.91 1 0.00049 0.00011 0 0.00035 0 0.00089 0.00017 0 0.00046 -1 8 / 36 (22%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.3e-05 0 2.6e-05 1.3e-05 0 3.5e-05 0 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
2.A.7.3.2 The Drug/Metabolite Transporter (DMT) Superfamily 0.31 0.4 1 0.74 0.88 1 0.29 0.56 1 0.66 0.85 1 0.009 0.46 1 0.051 0.58 1 2e-04 2.2e-05 0 5e-05 0 0.00013 4.8e-05 0 0.00013 -0.059 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 5.4e-06 0 1.8e-05 0.85 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
8.A.4.1.1 The Cytoplasmic Membrane-Periplasmic Auxiliary-2 (MPA2) Family 0.23 0.35 1 0.62 0.8 1 0.31 0.58 1 0.76 0.89 1 0.65 0.92 1 0.76 0.9 1 0.00041 5.7e-05 0 0.00015 0 4e-04 0.00012 0 0.00031 -0.32 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 1.3e-05 0 3.5e-05 2.3 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.1.2.55 The Major Facilitator Superfamily (MFS) 0.087 0.34 1 0.034 0.27 1 0.35 0.6 1 0.2 0.51 1 0.13 0.66 1 0.79 0.91 1 0.00025 4.2e-05 0 0.00013 0 0.00026 6.8e-05 0 0.00018 -0.93 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 1.4e-05 0 3.7e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
3.A.1.5.11 The ATP-binding Cassette (ABC) Superfamily 0.039 0.34 1 0.016 0.23 1 0.021 0.37 1 0.013 0.23 1 0.1 0.64 1 0.082 0.61 1 0.00067 9.3e-05 0 0.00031 0 7e-04 0.00015 0 0.00041 -1 5 / 36 (14%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 1e-05 0 3.4e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
4.D.1.1.3 The Putative Vectorial Glycosyl Polymerization (VGP) Family 0.24 0.36 1 0.17 0.47 1 0.69 0.86 1 0.71 0.87 1 0.95 0.98 1 0.18 0.68 1 0.00047 5.2e-05 0 0.00019 0 0.00049 6.8e-05 0 0.00018 -1.5 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 9.9e-06 0 2.5e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
9.B.169.1.2 The Integral Membrane Protein (8 -10 TMSs) YeiB or DUF418 (YeiB) Family 0.083 0.34 1 0.02 0.23 1 0.1 0.42 1 0.2 0.51 1 0.11 0.64 1 0.47 0.81 1 0.00035 5.8e-05 0 0.00022 0 0.00053 6.8e-05 0 0.00018 -1.7 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 5.5e-06 0 1.2e-05 2.7e-06 0 8.9e-06 -1 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
3.A.1.19.4 The ATP-binding Cassette (ABC) Superfamily 0.19 0.34 1 0.12 0.41 1 0.52 0.75 1 0.45 0.71 1 0.5 0.87 1 0.82 0.93 1 0.00058 9.7e-05 0 0.00026 0 0.00066 0.00022 0 0.00059 -0.24 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 8.1e-06 0 1.9e-05 2.7e-06 0 8.9e-06 -1.6 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
9.B.223.1.9 The 4 TMS DUF2979 or YoaS (YoaS) Family 0.32 0.41 1 0.53 0.76 1 0.21 0.5 1 0.98 0.99 1 0.82 0.95 1 0.38 0.75 1 0.00023 1.9e-05 0 2.8e-05 0 7.5e-05 4.4e-06 0 1.2e-05 -2.7 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 4.1e-05 0 0.00014 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.B.11.3.9 The Outer Membrane Fimbrial Usher Porin (FUP) Family 0.15 0.34 1 0.15 0.44 1 0.099 0.42 1 0.55 0.78 1 0.94 0.98 1 0.4 0.75 1 0.00097 0.00013 0 0.00047 0 0.0012 0.00018 0 0.00049 -1.4 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 2.2e-05 0 5e-05 2.9 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
9.A.69.1.2 The Intermembrane Phospholipid Translocase (IMPL-T) Family 0.017 0.34 1 0.0011 0.16 0.62 0.0049 0.35 1 0.0036 0.16 1 0.0028 0.31 1 0.01 0.46 1 0.00054 0.00012 0 0.00043 3.2e-05 0.00096 0.00017 0 4e-04 -1.3 8 / 36 (22%) 4 / 7 (57%) 2 / 7 (29%) 0.571 0.286 3e-06 0 9.9e-06 8.1e-06 0 2.7e-05 1.4 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.108.2.3 The Iron/Lead Transporter (ILT) Family 0.022 0.34 1 0.0043 0.22 1 0.02 0.37 1 0.0065 0.17 1 0.026 0.62 1 0.087 0.61 1 0.00032 5.4e-05 0 2e-04 0 0.00043 6.8e-05 0 0.00018 -1.6 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 2.7e-06 0 8.9e-06 0.054 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.7.3.61 The Drug/Metabolite Transporter (DMT) Superfamily 0.037 0.34 1 0.029 0.25 1 0.013 0.37 1 0.018 0.26 1 0.15 0.66 1 0.042 0.58 1 0.00038 6.3e-05 0 0.00021 0 0.00048 8.7e-05 0 0.00023 -1.3 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 0 0 0 1.8e-05 0 4.1e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
3.A.1.12.1 The ATP-binding Cassette (ABC) Superfamily 0.22 0.35 1 0.32 0.61 1 0.26 0.52 1 0.75 0.89 1 0.91 0.98 1 0.66 0.87 1 0.00059 0.00013 0 0.00036 0 0.00093 0.00027 0 0.00072 -0.42 8 / 36 (22%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1.1e-05 0 2.6e-05 1.6e-05 0 3e-05 0.54 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
3.A.3.32.6 The P-type ATPase (P-ATPase) Superfamily 0.99 0.99 1 0.83 0.92 1 0.59 0.8 1 0.61 0.82 1 0.79 0.94 1 0.73 0.89 1 0.00039 5.4e-05 0 4.1e-05 0 0.00011 2.6e-05 0 7e-05 -0.66 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 6.7e-05 0 0.00022 6.7e-05 0 0.00015 0 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.7.3.18 The Drug/Metabolite Transporter (DMT) Superfamily 0.33 0.42 1 0.24 0.53 1 0.14 0.43 1 0.84 0.94 1 0.25 0.77 1 0.11 0.65 1 0.00042 3.5e-05 0 6.7e-05 0 0.00018 0.00011 0 0.00028 0.72 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3e-06 0 9.9e-06 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.3.7.3 The Amino Acid-Polyamine-Organocation (APC) Family 0.27 0.38 1 0.56 0.76 1 0.87 0.94 1 0.84 0.94 1 0.78 0.94 1 0.73 0.88 1 0.00029 4.8e-05 0 0.00011 0 0.00027 0.00012 0 0.00031 0.13 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 8.1e-06 0 1.9e-05 8.1e-06 0 2.7e-05 0 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.127.1.2 The Enterobacterial Cardiolipin Transporter (CLT) Family 0.11 0.34 1 0.18 0.48 1 0.045 0.37 1 0.11 0.37 1 0.66 0.92 1 0.15 0.65 1 0.00056 7.8e-05 0 0.00022 0 0.00058 0.00015 0 0.00041 -0.55 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.6e-05 0 3.7e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
8.A.5.1.7 The Voltage-gated K+ Channel β-subunit (Kvβ) Family 0.28 0.38 1 0.95 0.99 1 0.75 0.9 1 0.99 0.99 1 0.53 0.88 1 0.8 0.91 1 0.00034 3.7e-05 0 8.4e-05 0 0.00022 8.7e-05 0 0.00023 0.051 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 1e-05 0 3.4e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
1.A.77.3.5 The Mg2+/Ca2+ Uniporter (MCU) Family 0.99 0.99 1 0.1 0.4 1 0.22 0.5 1 0.57 0.79 1 0.098 0.64 1 0.21 0.69 1 0.00011 3.4e-05 0 1.7e-05 0 3e-05 8.1e-05 3.1e-05 1e-04 2.3 11 / 36 (31%) 2 / 7 (29%) 4 / 7 (57%) 0.286 0.571 2.7e-05 0 6.3e-05 2.2e-05 0 4.3e-05 -0.3 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
1.B.1.1.3 The General Bacterial Porin (GBP) Family 0.2 0.34 1 0.89 0.96 1 0.21 0.48 1 0.6 0.82 1 0.6 0.91 1 0.53 0.82 1 0.00032 3.5e-05 0 8.4e-05 0 0.00022 7.7e-05 0 2e-04 -0.13 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 1.3e-05 0 3.5e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
3.A.1.24.1 The ATP-binding Cassette (ABC) Superfamily 0.25 0.36 1 0.68 0.83 1 0.79 0.91 1 0.31 0.63 1 0.79 0.94 1 0.83 0.93 1 0.00049 6.9e-05 0 9.1e-05 0 0.00018 0.00024 0 0.00064 1.4 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 5.1e-06 0 1.7e-05 8.1e-06 0 2.7e-05 0.67 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.1.106.1 The ATP-binding Cassette (ABC) Superfamily 0.065 0.34 1 0.093 0.39 1 0.061 0.37 1 0.083 0.32 1 0.18 0.72 1 0.1 0.65 1 0.00026 5.1e-05 0 0.00014 0 0.00031 7.7e-05 0 2e-04 -0.86 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 5.1e-06 0 1.7e-05 2.4e-05 0 5.3e-05 2.2 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.E.19.1.15 The Clostridium difficile TcdE Holin (TcdE Holin) Family 0.21 0.35 1 0.74 0.88 1 0.38 0.63 1 0.063 0.3 1 1 1 1 0.27 0.72 1 0.00015 1.3e-05 0 2.3e-06 0 6.1e-06 0 0 0 -Inf 3 / 36 (8.3%) 1 / 7 (14%) 0 / 7 (0%) 0.143 0 4.1e-05 0 0.00011 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
2.A.85.1.2 The Aromatic Acid Exporter (ArAE) Family 0.15 0.34 1 0.093 0.39 1 0.12 0.43 1 0.35 0.64 1 0.38 0.84 1 0.39 0.75 1 0.00052 1e-04 0 0.00029 0 0.00071 0.00019 0 0.00051 -0.61 7 / 36 (19%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 8.5e-06 0 2.1e-05 1.6e-05 0 3.7e-05 0.91 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
3.A.1.140.1 The ATP-binding Cassette (ABC) Superfamily 0.082 0.34 1 0.48 0.73 1 0.38 0.63 1 0.073 0.31 1 0.71 0.93 1 0.96 1 1 0.00073 1e-04 0 0.00031 0 8e-04 2e-04 0 0.00048 -0.63 5 / 36 (14%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
9.B.142.2.9 The Integral membrane Glycosyltransferase family 39 (GT39) Family 0.11 0.34 1 0.22 0.51 1 0.1 0.42 1 0.22 0.52 1 0.75 0.94 1 0.34 0.73 1 0.00046 5.1e-05 0 0.00015 0 4e-04 7.7e-05 0 2e-04 -0.96 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.1e-05 0 6.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.C.105.2.8 The Bacillus thuringiensis Vegetative Insecticidal Protein-3 (Vip3) Family 0.34 0.43 1 0.7 0.85 1 0.58 0.79 1 0.14 0.4 1 0.93 0.98 1 0.45 0.79 1 0.00015 2.6e-05 0 2e-05 0 5.2e-05 3.9e-06 0 1e-05 -2.4 6 / 36 (17%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.5e-05 0 0.00011 1.4e-05 0 4.5e-05 -2 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
3.A.1.106.20 The ATP-binding Cassette (ABC) Superfamily 0.065 0.34 1 0.093 0.39 1 0.061 0.37 1 0.083 0.32 1 0.18 0.72 1 0.1 0.65 1 0.00026 5.1e-05 0 0.00014 0 0.00031 7.7e-05 0 2e-04 -0.86 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 5.1e-06 0 1.7e-05 2.4e-05 0 5.3e-05 2.2 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.40.7.6 The Nucleobase/Ascorbate Transporter (NAT) or Nucleobase:Cation Symporter-2 (NCS2) Family 0.15 0.34 1 0.34 0.63 1 0.78 0.91 1 0.21 0.51 1 0.19 0.72 1 0.54 0.82 1 0.00053 7.4e-05 0 0.00017 0 0.00044 2e-04 0 0.00048 0.23 5 / 36 (14%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.B.38.4.2 The Treponema Porin Major Surface Protein (TP-MSP) Family 0.98 0.98 1 0.86 0.94 1 0.64 0.83 1 0.39 0.66 1 0.85 0.96 1 0.89 0.97 1 8e-05 1.1e-05 0 8.1e-06 0 2.1e-05 4.4e-06 0 1.2e-05 -0.88 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.2e-05 0 3.9e-05 1.6e-05 0 3.8e-05 0.42 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
8.A.7.1.1 The Phosphotransferase System Enzyme I (EI) Family 0.14 0.34 1 0.46 0.72 1 0.22 0.5 1 0.12 0.38 1 0.96 0.98 1 0.56 0.83 1 0.00044 4.9e-05 0 0.00012 0 0.00031 0.00013 0 0.00033 0.12 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
9.B.156.1.1 The Putative 4. 5. 8. 10 TMS Permease (4.5.8.10P) Family 0.22 0.35 1 0.57 0.77 1 0.8 0.91 1 0.22 0.52 1 0.89 0.98 1 0.85 0.94 1 0.00029 3.2e-05 0 3.4e-05 0 5.8e-05 0.00013 0 0.00033 1.9 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.42.1.1 The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family 0.77 0.81 1 0.2 0.49 1 0.33 0.59 1 0.36 0.64 1 0.064 0.62 1 0.2 0.69 1 0.00025 3.4e-05 0 3.4e-05 0 8.9e-05 8.7e-05 0 0.00023 1.4 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.2e-05 0 7.3e-05 1.3e-05 0 3.5e-05 -0.76 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
1.B.14.8.7 The Outer Membrane Receptor (OMR) Family 0.2 0.34 1 0.42 0.69 1 0.19 0.48 1 0.67 0.85 1 0.77 0.94 1 0.57 0.83 1 0.00054 7.5e-05 0 0.00022 0 0.00058 0.00014 0 0.00036 -0.65 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 1.8e-05 0 4.1e-05 2.8 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
4.A.3.2.4 The PTS Lactose-N.N'-Diacetylchitobiose-β-glucoside (Lac) Family 0.37 0.45 1 0.34 0.63 1 0.28 0.54 1 0.12 0.38 1 0.18 0.72 1 0.16 0.67 1 8.5e-05 7.1e-06 0 0 0 0 1.2e-05 0 3.1e-05 Inf 3 / 36 (8.3%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 1.3e-05 0 4.3e-05 2.7e-06 0 8.8e-06 -2.3 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.1.27.1 The Major Facilitator Superfamily (MFS) 0.11 0.34 1 0.067 0.36 1 0.2 0.48 1 0.31 0.63 1 0.34 0.83 1 0.68 0.88 1 0.00033 4.5e-05 0 0.00016 0 4e-04 5.8e-05 0 0.00015 -1.5 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 7.7e-06 0 2.6e-05 2.7e-06 0 8.9e-06 -1.5 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.D.1.9.2 The H+ or Na+-translocating NADH Dehydrogenase (NDH) Family 0.36 0.44 1 0.31 0.6 1 0.63 0.83 1 0.53 0.76 1 0.65 0.92 1 0.32 0.73 1 0.00088 0.00017 0 0.00047 0 0.0012 0.00032 0 0.00084 -0.55 7 / 36 (19%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 3.3e-05 0 7.4e-05 2.6e-05 0 6.1e-05 -0.34 3 / 11 (27%) 2 / 11 (18%) 0.273 0.182
1.A.29.1.4 The Urea/Amide Channel (UAC) Family 0.89 0.92 1 0.22 0.51 1 0.16 0.46 1 0.8 0.92 1 0.25 0.77 1 0.12 0.65 1 0.00017 7.7e-05 0 7.1e-05 1.6e-05 1e-04 1.9e-05 0 4e-05 -1.9 16 / 36 (44%) 4 / 7 (57%) 2 / 7 (29%) 0.571 0.286 9.8e-05 0 2e-04 9.6e-05 7.5e-05 0.00011 -0.03 4 / 11 (36%) 6 / 11 (55%) 0.364 0.545
4.C.1.1.16 The Fatty Acid Transporter (FAT) Family 0.16 0.34 1 0.27 0.56 1 0.12 0.43 1 0.31 0.63 1 0.76 0.94 1 0.4 0.75 1 0.00047 7.9e-05 0 0.00021 0 0.00053 0.00017 0 0.00046 -0.3 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 3e-06 0 9.9e-06 1.3e-05 0 3.5e-05 2.1 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
3.A.1.2.6 The ATP-binding Cassette (ABC) Superfamily 0.08 0.34 1 0.22 0.51 1 0.27 0.53 1 0.034 0.27 1 0.16 0.69 1 0.23 0.7 1 0.00052 8.6e-05 0 2e-04 0 0.00044 0.00023 0 0.00061 0.2 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 2.6e-06 0 8.5e-06 6.8e-06 0 2.3e-05 1.4 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.1.6.10 The Major Facilitator Superfamily (MFS) 0.49 0.56 1 0.33 0.61 1 0.35 0.6 1 0.61 0.82 1 0.4 0.84 1 0.37 0.75 1 0.00042 4.6e-05 0 6.7e-05 0 0.00018 0.00015 0 0.00038 1.2 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1.1e-05 0 3.6e-05 5.4e-06 0 1.8e-05 -1 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
9.A.5.4.2 The Putative Arginine Transporter (ArgW) Family 0.32 0.41 1 0.23 0.52 1 0.71 0.88 1 0.94 0.98 1 0.098 0.64 1 0.58 0.84 1 0.00028 2.3e-05 0 3.4e-05 0 8.9e-05 7.7e-05 0 2e-04 1.2 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.7.6.1 The Drug/Metabolite Transporter (DMT) Superfamily 0.21 0.35 1 0.28 0.57 1 0.35 0.6 1 0.95 0.98 1 0.88 0.98 1 0.92 0.98 1 0.00037 4.2e-05 0 0.00013 0 0.00036 5.8e-05 0 0.00015 -1.2 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.1e-06 0 1.7e-05 8.1e-06 0 2.7e-05 0.67 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.42.2.4 The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family 0.17 0.34 1 0.072 0.37 1 0.25 0.52 1 0.61 0.82 1 0.37 0.84 1 0.8 0.92 1 0.00026 4.4e-05 0 0.00013 0 0.00031 6.8e-05 0 0.00018 -0.93 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 1e-05 0 2.5e-05 8.1e-06 0 2.7e-05 -0.3 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
9.B.36.1.1 The Acid Resistance Membrane Protein (HdeD) Family 0.093 0.34 1 0.014 0.23 1 0.049 0.37 1 0.1 0.35 1 0.67 0.92 1 0.92 0.98 1 0.00028 2.3e-05 0 7e-05 0 0.00018 4.8e-05 0 0.00013 -0.54 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.20.1.2 The Inorganic Phosphate Transporter (PiT) Family 0.34 0.42 1 0.69 0.84 1 0.64 0.83 1 0.87 0.95 1 0.27 0.78 1 0.31 0.73 1 0.00048 6.7e-05 0 0.00017 0 0.00045 0.00013 0 0.00026 -0.39 5 / 36 (14%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 2.2e-05 0 7.3e-05 1e-05 0 3.4e-05 -1.1 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.3.7.5 The Amino Acid-Polyamine-Organocation (APC) Family 0.15 0.34 1 0.17 0.47 1 0.076 0.38 1 0.36 0.64 1 0.78 0.94 1 0.29 0.73 1 0.00067 0.00011 0 0.00034 0 0.00089 0.00019 0 0.00051 -0.84 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 3e-06 0 9.9e-06 2.6e-05 0 6.9e-05 3.1 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
2.A.37.1.5 The Monovalent Cation:Proton Antiporter-2 (CPA2) Family 0.17 0.34 1 0.51 0.75 1 0.21 0.48 1 0.41 0.68 1 0.44 0.86 1 0.83 0.93 1 0.00044 3.6e-05 0 1e-04 0 0.00027 7.7e-05 0 2e-04 -0.38 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 5.4e-06 0 1.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
9.B.143.2.2 The 6 TMS DUF1275/Pf06912 (DUF1275) Family 0.084 0.34 1 0.22 0.51 1 0.19 0.48 1 0.041 0.27 1 0.12 0.65 1 0.11 0.65 1 0.00014 3.5e-05 0 0 0 0 3.4e-05 0 5.9e-05 Inf 9 / 36 (25%) 0 / 7 (0%) 2 / 7 (29%) 0 0.286 5.8e-05 0 0.00011 3.6e-05 0 6.8e-05 -0.69 4 / 11 (36%) 3 / 11 (27%) 0.364 0.273
9.B.221.1.1 The 5 TMS YgjV (YgjV) Family 0.44 0.52 1 0.24 0.53 1 0.51 0.75 1 0.79 0.9 1 0.27 0.78 1 0.52 0.82 1 0.00036 4e-05 0 5e-05 0 0.00013 0.00014 0 0.00036 1.5 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.6e-06 0 8.5e-06 1e-05 0 3.4e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
2.A.1.35.1 The Major Facilitator Superfamily (MFS) 0.12 0.34 1 0.24 0.53 1 0.68 0.85 1 0.39 0.66 1 0.45 0.86 1 0.98 1 1 0.00024 2.7e-05 0 7e-05 0 0.00014 5.8e-05 0 0.00015 -0.27 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 7.3e-06 0 2.4e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
3.A.1.101.1 The ATP-binding Cassette (ABC) Superfamily 0.043 0.34 1 0.018 0.23 1 0.057 0.37 1 0.028 0.27 1 0.17 0.72 1 0.33 0.73 1 0.00048 4e-05 0 0.00014 0 0.00031 6.8e-05 0 0.00018 -1 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
1.B.42.1.2 The Outer Membrane Lipopolysaccharide Export Porin (LPS-EP) Family 0.21 0.35 1 0.33 0.62 1 0.31 0.58 1 0.43 0.7 1 0.53 0.89 1 0.52 0.82 1 0.0013 0.00043 0 0.001 2.8e-05 0.0027 0.00095 0 0.0025 -0.074 12 / 36 (33%) 4 / 7 (57%) 2 / 7 (29%) 0.571 0.286 6e-05 0 0.00014 7.6e-05 0 0.00015 0.34 3 / 11 (27%) 3 / 11 (27%) 0.273 0.273
1.A.11.1.1 The Ammonium Transporter Channel (Amt) Family 0.18 0.34 1 0.58 0.77 1 0.23 0.51 1 0.37 0.65 1 0.21 0.74 1 0.84 0.93 1 0.00045 3.7e-05 0 1e-04 0 0.00027 8.7e-05 0 0.00023 -0.2 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.E.52.1.1 The Flp/Fap Pilin Putative Holin (FFPP-Hol) Family 0.14 0.34 1 1 1 1 0.65 0.84 1 0.043 0.27 1 0.75 0.94 1 0.55 0.83 1 0.00011 1.2e-05 0 0 0 0 0 0 0 NA 4 / 36 (11%) 0 / 7 (0%) 0 / 7 (0%) 0 0 3e-05 0 7.5e-05 9.8e-06 0 2.4e-05 -1.6 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
9.B.99.1.2 The MipA-interacting Protein (MipA) Family 0.07 0.34 1 0.099 0.39 1 0.06 0.37 1 0.092 0.34 1 0.39 0.84 1 0.2 0.69 1 0.00051 5.6e-05 0 0.00018 0 0.00044 7.7e-05 0 2e-04 -1.2 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.1e-05 0 6.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.B.9.1.1 The FadL Outer Membrane Protein (FadL) Family 0.065 0.34 1 0.35 0.64 1 0.33 0.59 1 0.042 0.27 1 0.35 0.84 1 0.31 0.73 1 0.00037 4.1e-05 0 1e-04 0 0.00019 0.00011 0 0.00028 0.14 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 2.7e-06 0 8.9e-06 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.73.1.1 The Short Chain Fatty Acid Uptake (AtoE) Family 0.37 0.45 1 0.76 0.88 1 0.87 0.94 1 0.96 0.99 1 0.99 1 1 1 1 1 0.00026 4.3e-05 0 8.6e-05 0 0.00022 8.7e-05 0 0.00023 0.017 6 / 36 (17%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.2e-05 0 7.3e-05 9.2e-06 0 2.2e-05 -1.3 1 / 11 (9.1%) 2 / 11 (18%) 0.0909 0.182
4.D.3.1.6 The Glycan Glucosyl Transferase (OpgH) Family 0.08 0.34 1 0.045 0.29 1 0.064 0.37 1 0.15 0.41 1 0.13 0.66 1 0.16 0.67 1 0.00059 0.00016 0 0.00044 0 0.00096 0.00032 0 0.00084 -0.46 10 / 36 (28%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 1.6e-05 0 3e-05 3.1e-05 0 5.5e-05 0.95 3 / 11 (27%) 3 / 11 (27%) 0.273 0.273
2.A.96.1.1 The Acetate Uptake Transporter (AceTr) Family 0.056 0.34 1 0.26 0.55 1 0.37 0.63 1 0.071 0.3 1 0.39 0.84 1 0.58 0.84 1 0.00023 1.9e-05 0 5.1e-05 0 9.3e-05 4.8e-05 0 0.00013 -0.087 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
1.B.14.6.5 The Outer Membrane Receptor (OMR) Family 0.78 0.83 1 0.81 0.91 1 0.54 0.77 1 0.62 0.82 1 0.5 0.87 1 0.87 0.95 1 0.00042 3.5e-05 0 4.1e-06 0 1.1e-05 1.5e-05 0 4e-05 1.9 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 1e-04 0 0.00034 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.86.1.1 The Autoinducer-2 Exporter (AI-2E) Family (Formerly the PerM Family. TC #9.B.22) 0.2 0.34 1 0.95 0.98 1 0.73 0.89 1 0.5 0.75 1 0.89 0.98 1 0.58 0.84 1 0.00018 3.6e-05 0 7e-05 0 0.00014 1e-04 0 0.00025 0.51 7 / 36 (19%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 5.5e-06 0 1.2e-05 2.7e-06 0 8.9e-06 -1 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
4.A.3.2.1 The PTS Lactose-N.N'-Diacetylchitobiose-β-glucoside (Lac) Family 0.24 0.36 1 0.14 0.44 1 0.44 0.7 1 0.69 0.86 1 0.98 0.99 1 0.31 0.73 1 0.00034 4.7e-05 0 0.00017 0 0.00045 5.8e-05 0 0.00015 -1.6 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 8.1e-06 0 1.9e-05 2.7e-06 0 8.9e-06 -1.6 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
3.A.1.122.1 The ATP-binding Cassette (ABC) Superfamily 0.14 0.34 1 0.048 0.29 1 0.33 0.59 1 0.36 0.64 1 0.11 0.65 1 0.62 0.85 1 0.00023 5.2e-05 0 0.00013 0 0.00026 0.00011 0 0.00028 -0.24 8 / 36 (22%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 1.3e-05 0 2.6e-05 6.8e-06 0 2.3e-05 -0.93 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
3.A.1.3.4 The ATP-binding Cassette (ABC) Superfamily 0.029 0.34 1 0.069 0.36 1 0.024 0.37 1 0.0042 0.16 1 0.18 0.72 1 0.048 0.58 1 0.00064 0.00014 0 0.00039 1.6e-05 0.00087 3e-04 0 0.00074 -0.38 8 / 36 (22%) 4 / 7 (57%) 2 / 7 (29%) 0.571 0.286 0 0 0 2.6e-05 0 6.1e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
3.A.2.3.2 The H+- or Na+-translocating F-type. V-type and A-type ATPase (F-ATPase) Superfamily 0.92 0.93 1 0.53 0.76 1 0.81 0.91 1 0.44 0.7 1 0.91 0.98 1 0.53 0.82 1 0.00017 2.3e-05 0 3.2e-05 0 8.6e-05 1.3e-05 0 3.5e-05 -1.3 5 / 36 (14%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 2.1e-05 0 4.6e-05 2.6e-05 0 8.6e-05 0.31 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
9.B.15.1.1 The 4 TMS YbhQ (YbhQ) Family 0.76 0.81 1 0.086 0.39 1 0.059 0.37 1 0.27 0.6 1 0.051 0.62 1 0.03 0.58 1 0.00016 1.8e-05 0 1.7e-05 0 4.5e-05 5.7e-05 0 0.00011 1.7 4 / 36 (11%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 1.1e-05 0 3.6e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
3.A.1.3.10 The ATP-binding Cassette (ABC) Superfamily 0.081 0.34 1 0.42 0.69 1 0.18 0.48 1 0.066 0.3 1 0.44 0.86 1 0.15 0.65 1 0.00043 5.9e-05 0 0.00014 0 0.00027 0.00015 0 0.00038 0.1 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.6e-05 0 3.7e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
2.A.38.1.1 The K+ Transporter (Trk) Family 0.036 0.34 1 0.0039 0.22 1 0.0039 0.35 1 0.0052 0.16 1 0.013 0.5 1 0.012 0.46 1 0.00046 0.00015 0 0.00041 8.1e-05 0.00091 0.00029 0 0.00077 -0.5 12 / 36 (33%) 5 / 7 (71%) 2 / 7 (29%) 0.714 0.286 1.4e-05 0 4e-05 3.6e-05 0 6.9e-05 1.4 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
5.A.3.1.2 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO) Family 0.19 0.34 1 0.66 0.82 1 0.35 0.6 1 0.4 0.68 1 0.81 0.95 1 0.47 0.81 1 0.00048 0.00013 0 3e-04 0 0.00075 3e-04 0 0.00079 0 10 / 36 (28%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 1.6e-05 0 4.3e-05 3.7e-05 0 6.3e-05 1.2 2 / 11 (18%) 3 / 11 (27%) 0.182 0.273
2.A.72.1.3 The K+ Uptake Permease (KUP) Family 0.088 0.34 1 0.54 0.76 1 0.18 0.48 1 0.034 0.27 1 0.34 0.83 1 0.12 0.65 1 9.4e-05 1.3e-05 0 0 0 0 7.7e-06 0 2e-05 Inf 5 / 36 (14%) 0 / 7 (0%) 1 / 7 (14%) 0 0.143 3.1e-05 0 6.8e-05 6.8e-06 0 2.3e-05 -2.2 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
1.B.1.1.2 The General Bacterial Porin (GBP) Family 0.17 0.34 1 0.55 0.76 1 0.99 0.99 1 0.68 0.86 1 0.97 0.99 1 0.51 0.82 1 0.00026 5.7e-05 0 0.00015 0 0.00031 0.00011 0 0.00025 -0.45 8 / 36 (22%) 2 / 7 (29%) 2 / 7 (29%) 0.286 0.286 1.3e-05 0 2.7e-05 5.4e-06 0 1.8e-05 -1.3 3 / 11 (27%) 1 / 11 (9.1%) 0.273 0.0909
2.A.34.1.1 The NhaB Na+:H+ Antiporter (NhaB) Family 0.31 0.4 1 0.96 0.99 1 0.32 0.59 1 0.93 0.97 1 0.82 0.95 1 0.19 0.68 1 0.00025 3.4e-05 0 7e-05 0 0.00018 9.7e-05 0 0.00026 0.47 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 5.5e-06 0 1.2e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
2.A.28.2.6 The Bile Acid:Na+ Symporter (BASS) Family 0.17 0.34 1 0.083 0.39 1 0.3 0.57 1 0.057 0.29 1 0.011 0.46 1 0.043 0.58 1 0.00068 0.00047 0.00028 0.00022 0 4e-04 0.00037 0.00034 0.00039 0.75 25 / 36 (69%) 3 / 7 (43%) 5 / 7 (71%) 0.429 0.714 0.00058 0.00039 0.0011 6e-04 0.00053 0.00054 0.049 9 / 11 (82%) 8 / 11 (73%) 0.818 0.727
3.A.1.11.9 The ATP-binding Cassette (ABC) Superfamily 0.14 0.34 1 0.91 0.96 1 0.56 0.78 1 0.08 0.32 1 0.59 0.91 1 0.33 0.73 1 0.00073 8.1e-05 0 0.00015 0 0.00035 0.00024 0 0.00064 0.68 4 / 36 (11%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 1.3e-05 0 4.5e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
2.A.72.1.1 The K+ Uptake Permease (KUP) Family 0.044 0.34 1 0.24 0.53 1 0.11 0.42 1 0.05 0.28 1 0.6 0.91 1 0.22 0.7 1 0.00034 8.6e-05 0 0.00025 0 0.00057 0.00016 0 0.00033 -0.64 9 / 36 (25%) 3 / 7 (43%) 2 / 7 (29%) 0.429 0.286 2.6e-06 0 8.5e-06 1.9e-05 0 3.8e-05 2.9 1 / 11 (9.1%) 3 / 11 (27%) 0.0909 0.273
4.A.7.1.2 The PTS L-Ascorbate (L-Asc) Family 0.15 0.34 1 0.28 0.56 1 0.14 0.43 1 0.35 0.64 1 0.81 0.95 1 0.58 0.84 1 0.0014 0.00011 0 0.00035 0 0.00094 0.00019 0 0.00051 -0.88 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 2.1e-05 0 6.8e-05 Inf 0 / 11 (0%) 1 / 11 (9.1%) 0 0.0909
1.A.104.1.1 The Proposed Flagellar Biosynthesis Na+ Channel. FlaH (FlaH) Family 0.79 0.84 1 0.17 0.47 1 0.51 0.75 1 0.33 0.63 1 0.08 0.62 1 0.48 0.81 1 0.00022 2.4e-05 0 2.3e-06 0 6.1e-06 0.00011 0 0.00028 5.6 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 0 0 0 9.5e-06 0 2.3e-05 Inf 0 / 11 (0%) 2 / 11 (18%) 0 0.182
3.A.1.11.2 The ATP-binding Cassette (ABC) Superfamily 0.15 0.34 1 0.17 0.46 1 0.34 0.6 1 0.28 0.6 1 0.34 0.83 1 0.65 0.86 1 0.00079 0.00015 0 0.00041 0 0.001 0.00033 0 0.00087 -0.31 7 / 36 (19%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 1.6e-05 0 3.9e-05 1.9e-05 0 6.2e-05 0.25 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
2.A.78.1.3 The Branched Chain Amino Acid Exporter (LIV-E) Family 0.32 0.41 1 0.77 0.88 1 0.55 0.78 1 0.75 0.89 1 0.5 0.87 1 0.12 0.65 1 0.00048 4e-05 0 1e-04 0 0.00027 8.7e-05 0 0.00023 -0.2 3 / 36 (8.3%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 1e-05 0 3.4e-05 0 0 0 -Inf 1 / 11 (9.1%) 0 / 11 (0%) 0.0909 0
2.A.35.1.8 The NhaC Na+:H+ Antiporter (NhaC) Family 0.26 0.37 1 0.41 0.69 1 0.073 0.38 1 0.41 0.68 1 0.45 0.86 1 0.14 0.65 1 0.00027 9.6e-05 0 8.3e-05 8.5e-05 9.1e-05 4.9e-05 0 9.2e-05 -0.76 13 / 36 (36%) 4 / 7 (57%) 3 / 7 (43%) 0.571 0.429 3e-05 0 7.3e-05 2e-04 0 5e-04 2.7 2 / 11 (18%) 4 / 11 (36%) 0.182 0.364
3.A.1.5.3 The ATP-binding Cassette (ABC) Superfamily 0.14 0.34 1 0.23 0.53 1 0.13 0.43 1 0.16 0.43 1 0.2 0.73 1 0.14 0.65 1 0.00062 0.00014 0 0.00031 0 0.00075 0.00032 0 0.00084 0.046 8 / 36 (22%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 8.5e-06 0 2.1e-05 3.9e-05 0 8.8e-05 2.2 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
2.A.85.1.6 The Aromatic Acid Exporter (ArAE) Family 0.27 0.37 1 0.52 0.75 1 0.52 0.75 1 0.9 0.97 1 0.51 0.87 1 0.086 0.61 1 0.00061 6.8e-05 0 0.00019 0 0.00049 0.00015 0 0.00041 -0.34 4 / 36 (11%) 1 / 7 (14%) 1 / 7 (14%) 0.143 0.143 5.5e-06 0 1.2e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0
2.A.3.1.2 The Amino Acid-Polyamine-Organocation (APC) Family 0.063 0.34 1 0.015 0.23 1 0.051 0.37 1 0.027 0.27 1 0.16 0.69 1 0.32 0.73 1 8e-04 6.7e-05 0 0.00022 0 0.00053 0.00013 0 0.00033 -0.76 3 / 36 (8.3%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 0 0 0 0 0 0 NA 0 / 11 (0%) 0 / 11 (0%) 0 0
2.A.3.3.23 The Amino Acid-Polyamine-Organocation (APC) Family 0.12 0.34 1 1 1 1 0.33 0.59 1 0.046 0.27 1 0.64 0.92 1 0.16 0.67 1 2e-04 1.7e-05 0 0 0 0 0 0 0 NA 3 / 36 (8.3%) 0 / 7 (0%) 0 / 7 (0%) 0 0 4.8e-05 0 0.00012 6.8e-06 0 2.2e-05 -2.8 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
1.B.55.1.1 The Poly Acetyl Glucosamine Porin (PgaA) Family 0.1 0.34 1 0.32 0.61 1 0.32 0.59 1 0.16 0.43 1 0.44 0.86 1 0.45 0.79 1 0.00049 6.8e-05 0 0.00017 0 0.00035 0.00016 0 0.00044 -0.087 5 / 36 (14%) 2 / 7 (29%) 1 / 7 (14%) 0.286 0.143 2.6e-06 0 8.5e-06 1e-05 0 3.4e-05 1.9 1 / 11 (9.1%) 1 / 11 (9.1%) 0.0909 0.0909
3.A.5.1.1 The General Secretory Pathway (Sec) Family 0.093 0.34 1 0.032 0.27 1 0.05 0.37 1 0.039 0.27 1 0.053 0.62 1 0.087 0.61 1 0.0012 0.00029 0 0.00078 4.8e-05 0.0019 0.00064 0 0.0017 -0.29 9 / 36 (25%) 4 / 7 (57%) 1 / 7 (14%) 0.571 0.143 1.8e-05 0 5.1e-05 3.4e-05 0 7.8e-05 0.92 2 / 11 (18%) 2 / 11 (18%) 0.182 0.182
3.D.6.1.4 The Putative Ion (H+ or Na+)-translocating NADH:Ferredoxin Oxidoreductase (NFO or RNF) Family 0.27 0.37 1 0.47 0.73 1 0.99 0.99 1 0.76 0.89 1 0.48 0.87 1 0.18 0.68 1 0.00086 0.00014 0 0.00045 0 0.0012 0.00024 0 0.00061 -0.91 6 / 36 (17%) 1 / 7 (14%) 2 / 7 (29%) 0.143 0.286 2.7e-05 0 7.3e-05 2.7e-06 0 8.9e-06 -3.3 2 / 11 (18%) 1 / 11 (9.1%) 0.182 0.0909
4.A.1.2.4 The PTS Glucose-Glucoside (Glc) Family 0.069 0.34 1 0.048 0.29 1 0.36 0.6 1 0.082 0.32 1 0.086 0.62 1 0.6 0.85 1 0.00054 9e-05 0 0.00024 0 0.00047 0.00019 0 0.00051 -0.34 6 / 36 (17%) 3 / 7 (43%) 1 / 7 (14%) 0.429 0.143 1.6e-05 0 3.9e-05 0 0 0 -Inf 2 / 11 (18%) 0 / 11 (0%) 0.182 0

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Methods:

P lmer study group effect (sqrt): Differentially abundant functions were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Fibre_Intake, Treatment, Fibre_Intake vs Treatment. Effect tested: Fibre_Intake.

P lmer study group effect (clr): Differentially abundant functions were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Fibre_Intake, Treatment, Fibre_Intake vs Treatment. Effect tested: Fibre_Intake.

P lmer time effect (sqrt): Differentially abundant functions were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Fibre_Intake, Treatment, Fibre_Intake vs Treatment. Effect tested: Treatment.

P lmer time effect (clr): Differentially abundant functions were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Fibre_Intake, Treatment, Fibre_Intake vs Treatment. Effect tested: Treatment.

P lmer treatment effect (interaction) (sqrt): Differentially abundant functions were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Fibre_Intake, Treatment, Fibre_Intake vs Treatment. Effect tested: Fibre_Intake vs Treatment.

P lmer treatment effect (interaction) (clr): Differentially abundant functions were identified by linear mixed effect regression without confounders. Random effects: Participant (intercept). Fixed effects: Fibre_Intake, Treatment, Fibre_Intake vs Treatment. Effect tested: Fibre_Intake vs Treatment.

Glossary:

clr: Centered log-ratio transformation. P Welch's ANOVA (sqrt): Welch's ANOVA p-values (Anova was run on sqrt transformed abundances). It is an alternative to the classic ANOVA and can be used even if the samples have unequal variances and/or unequal sample sizes. P Welch's t-test (sqrt): Welch's T-test p-values (run on sqrt transformed abundances). It is an alternative to the classic Student's t-test and is more reliable if the data violates the assumption of homogeneity of variances and/or if the study conditions have unequal sample sizes. P Welch's ANOVA (clr): Welch's ANOVA p-values (Anova was run on clr transformed abundances). It is an alternative to the classic ANOVA and can be used even if the samples have unequal variances and/or unequal sample sizes. P Welch's t-test (clr): Welch's T-test p-values (run on clr transformed abundances). It is an alternative to the classic Student's t-test and is more reliable if the data violates the assumption of homogeneity of variances and/or if the study conditions have unequal sample sizes. P lmer XXX (clr): P-value of Linear Mixed-Effects Regression on clr transformed abundances, testing significance of XXX effect. Varying intercepts per subjects are used to control for repeated measures. Pbonf: Bonferroni corrected p-value. FDR: False Discovery Rate q-value. Mean Pos: Mean abundance in positive samples. Positive samples: The number and percentage of samples in which each function has been detected. Positive XXX: The number and percentage of positive samples in study group XXX. Positive_XXX_percent: Percentage of positive samples in study group XXX. P Welch's t-test (Aldex2): Expected P value of Welch’s t-test computed by Aldex2. FDR Welch's t-test (Aldex2): Expected Benjamini-Hochberg corrected P value for Welch’s t-test. P Wilcoxon rank test (Aldex2): Expected P value of Wilcoxon rank test computed by Aldex2. FDR Wilcoxon rank test (Aldex2): Expected Benjamini-Hochberg corrected P value of Wilcoxon test. P Kruskal-Wallace test (Aldex2): Expected P value of Kruskal-Wallace test. FDR Kruskal-Wallace test (Aldex2): Expected Benjamini-Hochberg corrected P value of Kruskal-Wallace test. P GLM test (Aldex2): Expected P value of generalized linear model. FDR GLM test (Aldex2): Expected Benjamini-Hochberg corrected P value of generalized linear model.

Differentially Abundant Microbial Functions

The following plots present the distribution of the top most differentially abundant microbial functions across all applied statistical analysis. Plots are ordered alphabetically.

Glossary:

"Rel. Abundance": Relative abundance data; "Rel. Abundance (sqrt)": sqrt (Hellinger) transformed relative abundances; "Rel. Abundance (clr)": centered log-ratio (clr) transformed read counts.
2 A 1 2 21
2 A 1 6 4
2 A 1 15 13
2 A 1 64 1
2 A 17 1 6
2 A 38 1 1
2 A 66 2 3
2 A 85 6 1
2 A 102 3 1
3 A 1 1 3
3 A 1 2 4
3 A 1 5 25
3 A 1 147 4
4 A 2 1 11
5 A 1 1 1
5 A 3 3 2
8 A 1 6 2
9 A 69 1 2
9 B 157 1 3
9 B 169 4 2